Transmission cluster of COVID-19 cases from Uruguay: emergence and spreading of a novel SARS-CoV-2 ORF6 deletion우루과이의 COVID-19 사례 전파 클러스터: 새로운 SARS-CoV-2 ORF6 결실의 출현 및 확산Research Article Published on 2022-01-102022-09-10 Journal: Memórias do Instituto Oswaldo Cruz [Category] 변종, 치료기술, [키워드] accessory gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amino acids analysed Care changes in Cluster coding coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 cases Deletion deletion variant Deletion variants detect epidemiological link epidemiological links epidemiological studies Evidence Genes genetics Genome genomic data Health Health care Illumina immune modulation include INDEL indels information nucleotide deletion Open reading frame open reading frames ORF ORF6 ORFs outbreak Outbreaks Protein regions repeat unit repeated repetitive sequence reported respiratory SARS-CoV-2 SARS-CoV-2 genome sequence sequenced severe acute respiratory syndrome Coronavirus Spread Substitution substitutions the SARS-CoV-2 genome Transmission unique [DOI] 10.1590/0074-02760210275 PMC 바로가기 [Article Type] Research Article
Intra-Host SARS-CoV-2 Evolution in the Gut of Mucosally-Infected Chlorocebus aethiops (African Green Monkeys)점막에 감염된 클로로세 부스 아티 옵스 (African Green Monkeys)의 장에서 호스트 내 SARS-COV-2 진화Brief Report Published on 2022-01-012022-09-10 Journal: Viruses [Category] 변종, 치료기술, [키워드] African African green monkey (Chlorocebus aethiops) African green monkeys Amino acid amino acid change Cell culture Chlorocebus collected D215G ENhance Evolution furin furin cleavage site green green monkeys H655Y Host human disease Humoral immunity identify in viral in vivo motif Mutation ORF rectal swab Rectal swabs respiratory RNA SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants sequenced therapy trajectory Transmissibility Vaccine variant of SARS-CoV-2 Viral viral evolution viral infection Viral RNA virus [DOI] 10.3390/v14010077 PMC 바로가기 [Article Type] Brief Report
Validation of the analytical performance of nine commercial RT-qPCR kits for SARS-CoV-2 detection using certified reference material인증된 참조 물질을 사용하여 SARS-CoV-2 검출을 위한 9개의 상용 RT-qPCR 키트의 분석 성능 검증Article Published on 2021-12-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료기술, [키워드] analytical sensitivity approved Certified reference material clinical risk conducted Contact coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity diagnostic diagnostics false-negative false-negative results genomic RNA human coronavirus human coronaviruses IMPROVE in vitro less limit of detection limits Limits of detection N gene nine ORF pandemic PCR Probability public health emergency qPCR reaction reduce reference material respiratory viruses RT-PCR RT-qPCR SARS-CoV-2 SARS-CoV-2 detection selected sensitivity Sensitivity and specificity specimen Template tested two groups validation Variation variations [DOI] 10.1016/j.jviromet.2021.114285 PMC 바로가기 [Article Type] Article
Advances and insights in the diagnosis of viral infectionsReview Published on 2021-10-302022-10-29 Journal: Journal of Nanobiotechnology [Category] COVID-19, MERS, SARS, [키워드] Accuracy advance antibody Antibody-antigen complex biosensors Care changes in complex COVID-19 CRISPR-Ca CRISPR-Cas for DNA-Sensors Diagnosis diagnostic disease equipment Frame genome sequence HIV Immunosensors Incubation period Infection Laboratory lack Microscopy molecular molecular analysis nucleic acid amplification ORF organism outlined pandemic Pandemics Patient performed Photoluminescence Polymerase chain reaction (PCR) Protein Region SARS-CoV-2 SARS-CoV-2 virus detection selected sensitivity shown surface plasmon resonance (SPR) Symptom tissue Validity Viral diseases viral genome viral infection viral infections virus virus detection [DOI] 10.1186/s12951-021-01081-2 PMC 바로가기 [Article Type] Review
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery항바이러스 약물 발견을 위한 SARS-CoV-2-호스트 프로테옴 상호작용Article Published on 2021-10-282022-09-10 Journal: Molecular Systems Biology [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] addition Affinity purification analyses Analysis antiviral activity antiviral drug Antiviral effect antiviral effects applied approach biological significance candidate drug caused cofactor cofactors complementary Compound COVID‐19 criterion Critical develop downstream drug Drug discovery effective therapy Host host cell host cell proteases host protein host proteins hub protein identify in viral inhibitory effect Interaction labeling list mass spectrometry methotrexate Microbiology, Virology & Host Pathogen Interaction molecular ORF Pharmacology & Drug Discovery protein targets protein–protein interactions proteome proteomics provided receptors Replication resource SARS‐CoV‐2 SARS‐CoV‐2 suggested understanding Viral viral pathogenesis viral replication Virtual screening virus–host interactions [DOI] 10.15252/msb.202110396 PMC 바로가기 [Article Type] Article
Wastewater surveillance-based city zonation for effective COVID-19 pandemic preparedness powered by early warning: A perspectives of temporal variations in SARS-CoV-2-RNA in Ahmedabad, India조기 경보를 통한 효과적인 COVID-19 전염병 대비를 위한 폐수 감시 기반 도시 구역 지정: 인도 아마다바드에서 SARS-CoV-2-RNA의 시간적 변화에 대한 관점Article Published on 2021-10-202022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] analyzed average Community Concentration confirmed cases coronavirus 2 COVID-19 COVID-19 pandemic descending detect effective Epidemiology followed by Gujarat heat map hotspot India lead limitation ORF pandemic Perspective predicted prediction respiratory RNA SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes SARS-CoV-2 RNA severe acute respiratory coronavirus severe acute respiratory coronavirus 2 shown Surveillance surveillance data utility Variation wastewater Wastewater based epidemiology (WBE) [DOI] 10.1016/j.scitotenv.2021.148367 PMC 바로가기 [Article Type] Article
Origin, phylogeny, variability and epitope conservation of SARS-CoV-2 worldwide전 세계적으로 SARS-CoV-2의 기원, 계통 발생, 가변성 및 에피토프 보존Article Published on 2021-10-152022-09-11 Journal: Virus research [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acid change amino acid changes analyzed antibodies caused Cluster Comparative genomics conserved contributed coronavirus Coronavirus comparative genomics coronavirus disease Coronavirus disease 2019 COVID-19 distribution Efficacy epitope epitope conservation Epitope prediction Epitopes Evidence evidence of favor GenBank Genome genomes Geographic distribution GISAID database hotspot identify Multiple Mutation N protein nucleotide ORF origin pandemic pangolin Phylogeny predicted primary structure Protein Recombination Region RNA virus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomics severe acute respiratory syndrome Coronavirus Single nucleotide variant SNV SNVs spike spike gene spike glycoprotein Spike protein structural proteins target targets the spike protein triggered Vaccine vaccine efficacy Variability variable variant viral genome virus VoC VOCs [DOI] 10.1016/j.virusres.2021.198526 PMC 바로가기 [Article Type] Article
SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatmentRNAi에 의한 SARS-CoV-2 표적화 및 숙주 보체 억제: COVID-19 치료를 위한 두 갈래의 속임수Review Published on 2021-10-132022-09-10 Journal: Immunity, Inflammation and Disease [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach C3a clinical manifestation clinical manifestations complement Complement inhibitor component conjunction coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patients curtail cytokine Cytokine storm degrade detrimental Disease progression disease progression and severity downstream effective Evidence exacerbate gene regulation processes globe Host immune responses infections information inhibitor knowledge lack less Local mitigate molecules ORF Perspective preventive measure preventive measures progression Proinflammatory cytokine protective immunity Replication required respiratory Result RNA interference RNAi robust SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severity Spread suppress symptomatic and asymptomatic systemic immune response systemic immune responses the cytokine storm transcript transmissible variant Treatment vaccinate Vaccine variants Viral viral spread viral/retroviral virus [DOI] 10.1002/iid3.549 PMC 바로가기 [Article Type] Review
Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses리포터 발현 바이러스를 이용한 생체 내 SARS-CoV-2 감염 역학 분석423 Published on 2021-10-122022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme antibody causative agent coronavirus COVID-19 COVID-19 pandemic CoVs cultured cell deleted deleting dissemination dynamic effective enzyme exhibited expressed expressing expression level fluorescent followed by Frame Genes hACE2 high stability identify in vitro in vivo in vivo imaging Infection K18 locus lung MONITOR neutralize noninvasive nucleocapsid Open reading frame ORF Pathogenesis pathogenicity Protein proteolytic cleavage public health replaced REPLACED BY Replication reporter reporter expression reporter gene reporter genes reporter viruses respiratory retained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance the SARS-CoV-2 the viral nucleocapsid therapeutic intervention therapeutic interventions threat transgenic mice Treatment upstream Venus Viral viral infection viral replication virus viruses whole organism wild-type [DOI] 10.1073/pnas.2111593118 PMC 바로가기 [Article Type] 423
Tracking the Transcription Kinetic of SARS-CoV-2 in Human Cells by Reverse Transcription-Droplet Digital PCRArticle Published on 2021-10-022022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Caco-2 cells Cell contribute coronavirus COVID-19 patients detect develop Digital Digital droplet PCR drug help Human human cells Infection Invasion mechanism ORF PCR Postinfection Remdesivir RNA SARS-CoV-2 SARS-COV-2 infection subgenomic RNA target target cells Therapeutic treatment Transcription transcriptional treat understanding viral gene viral RNA synthesis viral transcription virus replication [DOI] 10.3390/pathogens10101274 PMC 바로가기 [Article Type] Article