Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variantsSARS-CoV-2 스파이크 항원으로 과면역된 트랜스염색체 소의 인간 면역글로불린은 바이러스 변이체를 효율적으로 중화합니다Article Published on 2022-04-292022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus amino-acid anti-SARS-CoV-2 anti-SARS-CoV-2 immunoglobulin bovine convalescent coronavirus COVID-19 Deletion deletions DNA dose E484K effective Effectiveness followed by Human human immunoglobulin Human plasma Immunity immunization Immunoglobulin in vitro inhibit insect cells mAb mAbs monoclonal antibodies monoclonal antibody mutant N501Y neutralization neutralization potency neutralize Plasmid plasmid DNA polyclonal polyclonal antibodies produced purified reduce repeated respiratory resulting retained S gene S protein S variant S477N SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike antigen severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein stomatitis Substitution substitutions the SARS-CoV-2 therapeutic transchromosomic bovines Vaccines variant variants variants of concern vesicular stomatitis vesicular stomatitis virus viral variant VSV Wuhan strain [DOI] 10.1080/21645515.2021.1940652 PMC 바로가기 [Article Type] Article
Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interactionSARS-CoV-2 스파이크 단백질의 수용체 결합 도메인에 있는 Y380Q 신규 돌연변이는 C379W와 함께 중화 항체 상호작용을 방해합니다Article Published on 2022-04-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] All participant All participants B.1.1.28 B.1.1.33 binding Brazil children circulating COVID-19 CR3022 cycle threshold domain enrolled EY6A High-throughput sequencing Interaction interfere Lineage Mutation Neutralizing antibodies neutralizing antibody novel Novel mutation Older pandemic participant performed Porto positive RBD Receptor-binding domain RT-PCR assay S gene SARS-CoV-2 SARS-CoV-2 spike protein Sequencing Signs and symptoms Spike protein submitted symptoms of COVID-19 tested the receptor-binding domain the SARS-CoV-2 the spike protein variants Viral viral spike protein [DOI] 10.1016/j.diagmicrobio.2022.115636 PMC 바로가기 [Article Type] Article
Can periodontal pockets and caries lesions act as reservoirs for coronavirus?치주낭과 충치 병변이 코로나바이러스의 저장소 역할을 할 수 있습니까?Article Published on 2022-04-012022-09-11 Journal: Molecular oral microbiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplify approach Asymptomatic Can caries Chain Reaction coronavirus cross-sectional cross-sectional study Ct value detect dissemination evaluate Genes infections information knowledge lesion lesions negative control participant Patient patients periodontal pocket polymerase chain polymerase chain reaction positive positive control positive COVID-19 real-time polymerase chain reaction reservoir reservoirs RT-PCR S gene SARS-CoV-2 SARS-CoV-2 detection sensitivity severe acute respiratory syndrome Coronavirus specificity symptomatic the mean the SARS-CoV-2 virus while [DOI] 10.1111/omi.12362 PMC 바로가기 [Article Type] Article
Genomic and epidemiological report of the recombinant XJ lineage SARS-CoV-2 variant, detected in northern Finland, January 20222022년 1월 핀란드 북부에서 검출된 재조합 XJ 계통 SARS-CoV-2 변이체의 게놈 및 역학 보고서Article Published on 2022-04-012022-09-11 Journal: Eurosurveillance [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] breakpoint circulating collected community transmission epidemiological epidemiological data Genome genomic Lineage nucleotide nucleotide position omicron ORF1 ORF1b recombinant Recombination S gene SARS-CoV-2 SARS-CoV-2 variant sequence Surveillance sustained the SARS-CoV-2 variant XJ-lineage [DOI] 10.2807/1560-7917.ES.2022.27.16.2200257 PMC 바로가기 [Article Type] Article
An evolutionary insight into Severe Acute Respiratory Syndrome Coronavirus 2 Omicron variant of concern.Article Published on 2022-03-222022-10-04 Journal: Virus research [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] acute respiratory syndrome analyses ancestor Beta circulating circulation codon usage Complete coronavirus coronavirus 2 coronavirus disease COVID-19 Delta enrolled Evolution family Coronaviridae Gamma Genetic genetic information genomic study genotypes Lineage Mutation new SARS-CoV-2 omicron pandemic of COVID-19 Phylogenetic respiratory Respiratory illness S gene SARS-CoV-2 SARS-CoV-2 variants significant difference South Africa Spread strain the WHO variant variants of concern virus VoC VOCs was performed [DOI] 10.1016/j.virusres.2022.198753 PMC 바로가기 [Article Type] Article
Molecular Epidemiology of SARS-CoV-2 in Tunisia (North Africa) through Several Successive Waves of COVID-19COVID-19의 여러 연속적인 물결을 통한 튀니지(북아프리카)의 SARS-CoV-2 분자 역학Article Published on 2022-03-172022-09-11 Journal: Viruses [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] African Alpha Alpha VOC assigned Beta characterized circulating circulation combating contributing to COVID-19 deaths Delta Delta VOC Documenting Eta First wave genetic information genomic data global effort global efforts highlight Infection Lineage lineages molecular molecular characterization Next-generation sequencing North pandemic partial sequencing positive sample provide real-time RT-PCR Region RT-PCR tests S gene SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants second wave Sequencing spike gene Strains Tunisia variant variant of concern variant of interest variants variants of concern variants of interest virus transmission VOCs VOIs Wave whole-genome sequencing Zeta [DOI] 10.3390/v14030624 PMC 바로가기 [Article Type] Article
Intelligent system based comparative analysis study of SARS-CoV-2 spike protein and antigenic proteins in different types of vaccinesResearch Published on 2022-03-072022-10-28 Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19, [키워드] Amino acid Analysis And PCV10 antigenic protein caused China coding Combination comparison coronavirus coronavirus 2 Coronavirus disease 2019 correlation country COVID-19 COVID-19 virus death deaths disease explain Genome Genome signature Genomic coding techniques hepatitis B HIB humans immune response implicated in silico infect intestinal investigated less measles membrane fusion MMR Novel coronavirus pandemic Poliovirus PROTECT protective effect Protein receptor respiratory respiratory infections Result RNA virus rubella S gene S protein SARS-CoV-2 SARS-CoV-2 spike protein sequence severity spike Spread symptomatic case the Coronaviridae the SARS-CoV-2 genome Vaccine Vaccines Variation WHO World Health Organization [DOI] 10.1186/s43088-022-00216-0 PMC 바로가기 [Article Type] Research
SARS-CoV-2 variant with mutations in N gene affecting detection by widely used PCR primers널리 사용되는 PCR 프라이머에 의한 검출에 영향을 미치는 N 유전자 돌연변이가 있는 SARS-CoV-2 변이체Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Analysis Beta Beta variant causing Chain Reaction clinical consequences collected coronavirus coronavirus disease Coronavirus disease 2019 Deletion deletions Diagnosis diagnostic E484K mutation example functional Lineage member Mutation N gene nucleotide PCR PCR primer polymerase chain polymerase chain reaction primer recognize S gene SARS CoV SARS CoV-2 SARS-CoV-2 variant Sequencing severe acute respiratory syndrome Coronavirus Single nucleotide polymorphism strain Strains subsequent target gene Vaccine variant viral genome viral genome sequence virus variant virus variants while [DOI] 10.1002/jmv.27418 PMC 바로가기 [Article Type] Article
Enhancing epidemiological surveillance of the emergence of the SARS-CoV-2 Omicron variant using spike gene target failure data, England, 15 November to 31 December 2021스파이크 유전자 표적 실패 데이터를 사용하여 SARS-CoV-2 Omicron 변이의 출현에 대한 역학 감시 강화, 2021년 11월 15일부터 12월 31일까지 영국Article Published on 2022-03-012022-09-11 Journal: Eurosurveillance [Category] SARS, 변종, [키워드] applied COVD-19 delta variant differentiation disease Disease surveillance dominant England Enhancing epidemiological growth management omicron public health S gene S gene target failure s-gene target failure. sample collection SARS-CoV-2 spike gene Surveillance the SARS-CoV-2 variant [DOI] 10.2807/1560-7917.ES.2022.27.11.2200143 PMC 바로가기 [Article Type] Article
A thermostable Cas12b from Brevibacillus leverages one-pot discrimination of SARS-CoV-2 variants of concernBrevibacillus의 열안정성 Cas12b는 우려되는 SARS-CoV-2 변이체의 원팟 식별을 활용합니다.Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] SARS, 변종, 치료기술, [키워드] Accuracy activity Alicyclobacillus Alpha amplification applied B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Breast Breast cancer Cas12b center clinical samples college Complete Control COVID-19 CRISPR Ct value current Delta detection system diagnostics differential scanning fluorimetry disease control dissemination Dual-detection Engineering facilitate foundation fraction Gamma guide RNA high viral load house implementation isothermal amplification lack landscape Loop-mediated isothermal amplification Medicine Negative predictive value NIAID offer office omicron One-pot detection overcome P.1 Palindromic Pathogens platform point-of-care positive Predictive value President prevention primer Protein purified qPCR reaction reagent Real-time monitoring reverse transcription robust RT-LAMP S gene SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 variant Science sensitivity Sequencing SPADE specificity technology the SARS-CoV-2 Thermophillic university variants variants of concern veterinary medicine vice Vice President Viral load VoC VOCs were expressed [DOI] 10.1016/j.ebiom.2022.103926 PMC 바로가기 [Article Type] Article