Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia뚜렷한 면역학적 특징은 심각한 COVID-19를 SARS-CoV-2에 의해 유발되지 않은 치명적인 폐렴과 구별합니다.Comparative Study Published on 2021-07-132022-09-11 Journal: Immunity [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, [키워드] adaptive alteration Analysis binding Biomarker cascade Cell change circulating ClinicalTrials COVID-19 COVID-19 patient Critical Cytometry driven by feature flow cytometry Frequency GM-CSF high-dimensional single cell analysis HLA HLA typing ICU patient ICU Patients immune Immune profile immune profiling immune signature Immunity immunological immunopathology Immunophenotyping Inflammatory response integration interfere longitudinal NKT outcome paralysis Patient peptide peptide binding strength peptides Pneumonia predicted Predictive SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides severe COVID-19 Single Cell single-cell spectral flow cytometry. T cell the patient translation Treatment strategies treatment strategy virus recognition [DOI] 10.1016/j.immuni.2021.05.002 PMC 바로가기 [Article Type] Comparative Study
Comparative Anti-Inflammatory Effects of Salix Cortex Extracts and Acetylsalicylic Acid in SARS-CoV-2 Peptide and LPS-Activated Human In Vitro SystemsSARS-COV-2 펩티드 및 LPS- 활성화 된 인간 시험 관내 시스템에서 살릭 피질 추출물 및 아세틸 살리실산의 비교 항 염증 효과Comparative Study Published on 2021-06-232022-08-31 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 치료제, [키워드] Salix species Acetylsalicylic acid acetylsalicylic acid (ASA) acid activated Anti-inflammatory anti-inflammatory drug Anti-inflammatory drugs Anti-inflammatory effects anti-inflammatory treatment Cell cells co-culture Comparative compounds cortex COVID-19 patient Culture cytokine Cytokines Effect Efficacy enzyme activity Extract Fever Human human body human PBMC IL-10 IL-1β IL-6 IMPROVE in vitro in vitro data Inflammation Inflammatory ingredient intestinal liver cell LPS-activated mediator metabolism outcome Pain PBMCs peptide peptides PGE PGE2 precursor prostaglandin prostaglandin E2 protein expression retained salicin salicylic acid SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides suppressed suppression System therapy Willow willow bark [DOI] 10.3390/ijms22136766 PMC 바로가기 [Article Type] Comparative Study
Bioinformatic HLA Studies in the Context of SARS-CoV-2 Pandemic and Review on Association of HLA Alleles with Preexisting Medical ConditionsReview Article Published on 2021-05-282022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] alleles association Bioinformatic cardiovascular disease changed China Chronic diseases Comorbidity condition connection Context COVID-19 patients Diabetes Mellitus Effective vaccines Genes healthcare worker help high mortality rate HLA HLA allele human leukocyte antigen Infection medical condition mortality rate New coronavirus pandemic Patient Perspective reported review SARS-CoV-2 SARS-CoV-2 peptide severity the disease Vaccines virus WHO [DOI] 10.1155/2021/6693909 PMC 바로가기 [Article Type] Review Article
Bioinformatic HLA Studies in the Context of SARS-CoV-2 Pandemic and Review on Association of HLA Alleles with Preexisting Medical ConditionsReview Article Published on 2021-05-282022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] alleles association Bioinformatic cardiovascular disease changed China Chronic diseases Comorbidity condition connection Context COVID-19 patients Diabetes Mellitus Effective vaccines Genes healthcare worker help high mortality rate HLA HLA allele human leukocyte antigen Infection medical condition mortality rate New coronavirus pandemic Patient Perspective reported review SARS-CoV-2 SARS-CoV-2 peptide severity the disease Vaccines virus WHO [DOI] 10.1155/2021/6693909 PMC 바로가기 [Article Type] Review Article
Application of spectral library prediction for parallel reaction monitoring of viral peptides바이러스 펩타이드의 병렬 반응 모니터링을 위한 스펙트럼 라이브러리 예측 적용Article Published on 2021-04-012022-09-11 Journal: Proteomics [Category] SARS, 유전자 메커니즘, [키워드] acquisition Algorithm Analysis analyzed applicability application can be used Data analysis example identify IMPROVE in silico intensity oropharyngeal swab parallel reaction monitoring peptide peptides precursor predict predicted PRM proteomics SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides significantly tandem mass spectra prediction viral peptide viral peptides Virology virus virus proteomics. [DOI] 10.1002/pmic.202000226 PMC 바로가기 [Article Type] Article
Predictive immunogenetic markers in COVID-19COVID-19의 예측 면역유전 마커Article Published on 2021-04-012022-09-11 Journal: Human immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] affinity allele Case fatality rate CFR coronavirus disease Coronavirus disease 2019 correlated correlation correlations COVID-19 COVID-19 cytokine storm cytokine Cytokine polymorphisms Cytokines Daily data set DDR eight Ensembl Frequency functional genetic marker HLA-B HLA-B allele HLA-B alleles Host host genetics IL10 IL12B IL6 KIR KIR gene KIR genes KIR. marker nucleotide pandemic peptides polymorphism Polymorphisms Prognosis progression Rate rationale retrieved SARS-CoV-2 peptide SARS-CoV-2 peptides Single nucleotide polymorphism SNPs [DOI] 10.1016/j.humimm.2021.01.008 PMC 바로가기 [Article Type] Article
T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individualsT 세포 및 항체 동역학은 COVID-19 회복기 개인에서 장기 면역 반응을 매개하는 SARS-CoV-2 펩티드를 묘사합니다Research Article Published on 2021-03-152022-09-10 Journal: Science Translational Medicine [Category] MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody kinetics Antibody titer Antibody titers approaches Cell convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine design dominant Efficacy epitope Epitopes Frequency functional Humoral immunity identification identify Immunity Immunological memory intensity investigated long-term immune response longitudinal longitudinal analysis memory T memory T cell nucleocapsid nucleocapsid-specific antibody open Open reading frame peptide Post-infection question remained report respiratory response responses robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 peptide severe acute respiratory syndrome Coronavirus spike T cell T cell epitope T cell memory T cell response T cell responses target vaccination [DOI] 10.1126/scitranslmed.abf7517 PMC 바로가기 [Article Type] Research Article
Immunoreactive peptide maps of SARS-CoV-2SARS-CoV-2의 면역반응성 펩타이드 지도Article Published on 2021-02-122022-09-12 Journal: Communications Biology [Category] MERS, 진단, [키워드] 229E Asymptomatic collected cross-reactivity determine healthy high-density HKU1 human coronavirus human coronaviruses humoral immune response identify IgG antibody immunological individual Infection infections Infectious-disease diagnostics linear Linear regression MERS-CoV Mild multidimensional NL63 OC43 peptide peptide microarray plasma plasma sample qPCR required SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 epitope SARS-COV-2 infection SARS-CoV-2 peptide severe SARS-CoV-2 statistical subject subjects viral infection [DOI] 10.1038/s42003-021-01743-9 PMC 바로가기 [Article Type] Article
Human Leukocyte Antigen (HLA) Class I Susceptible Alleles Against COVID-19 Increase Both Infection and Severity RateInfectious Disease Published on 2020-12-232022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome addition Affect Against allele allele frequency Antigen binding calculated class coronavirus correlation correlation coefficient country COVID-19 CTL cytotoxic T lymphocyte cytotoxic t lymphocyte (ctl) death explained had no Haplotype HLA HLA class I HLA-A hla-a/b haplotype HLA-A1 HLA-B HLA-B allele Human increase infected case Infection infection rate less leukocyte linear no correlation Rate reactivity Result SARS-CoV-2 SARS-CoV-2 peptide Severity rate susceptibility susceptible was obtained [DOI] 10.7759/cureus.12239 PMC 바로가기 [Article Type] Infectious Disease
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severityCOVID-19 환자의 바이러스 에피토프 프로파일링은 교차 반응성과 심각도의 상관 관계를 보여줍니다Research Article Published on 2020-11-272022-09-12 Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect age Alanine Analysis antibody Antibody detection antibody epitope antibody epitopes antibody repertoire Antibody Response Antibody responses Antibody-dependent enhancement antiviral antibodies antiviral antibody Asymptomatic caused circulating clinical outcomes colds common-cold Control controls coronavirus coronavirus disease Coronavirus disease 2019 coronavirus strains Coronaviruses correlation Course covariates COVID-19 COVID-19 patient COVID-19 severity Critical cross-react cross-reactive antibody cross-reactivity cytomegalovirus death deep Demographic variables detect diagnostic diagnostics disease disease severity distress enzyme-linked immunosorbent assays epitope epitope mapping Epitopes exacerbate examination exhibited explain females Fever functional Gender generate gold herpes simplex herpes simplex virus Herpes Simplex Virus 1 Hospitalization Hospitalized hospitalized patients human coronaviruses human sera humans humoral Humoral response humoral responses hypothese hypotheses immune immunogenicity incidence individual individuals infect infected with SARS-CoV-2 Infection infections interactions Isolation knowledge machine machine-learning male mapped Mild Mutagenesis Neutralizing Neutralizing antibodies neutralizing antibody not need notable nucleoprotein ORF1 outcome outcomes Patient patient cohort peptide peptides performed predicted probe Profiling Protein proteome proteomes raise rationale required respiratory respiratory distress Respiratory system response responses reveal SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 proteome Science screened sensitivity Sequence conservation sera serological Serological assay severe acute respiratory syndrome Coronavirus severe COVID-19 severe infections severity severity of COVID-19 specificity Spike protein stratified strength suggested target targets tested the antibody response the SARS-CoV-2 the spike protein Therapeutics Therapies two groups understanding Vaccine Vaccines Viral virus [DOI] 10.1126/science.abd4250 PMC 바로가기 [Article Type] Research Article