Thromboelastometry demonstrates endogenous coagulation activation in nonsevere and severe COVID-19 patients and has applicability as a decision algorithm for intervention혈전탄성측정법은 중증이 아닌 중증 COVID-19 환자에서 내인성 응고 활성화를 보여주고 중재를 위한 결정 알고리즘으로 적용 가능Observational Study Published on 2022-01-142022-09-12 Journal: PLoS ONE [Category] 임상, 진단, [키워드] Accuracy Activation age Algorithm All participants applicability blood sample Blood samples calculated Clotting time Coagulation COVID-19 COVID-19 case COVID-19 patient Decision tree examined exhibited extrinsic fibrinogen form functional Functional assessment groups healthy control healthy controls hypercoagulability Intervention intrinsic parameter participant Patient POLE positive qRT-PCR reduced reported SARS-CoV-2 severe COVID-19 severe COVID-19 patient severe COVID-19 patients severe forms of COVID-19 Severe patient severe patients severity significantly suggested tested therapeutic intervention thrombotic [DOI] 10.1371/journal.pone.0262600 PMC 바로가기 [Article Type] Observational Study
Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single-cell analysis긴 비 코딩 RNA (LNCRNA) NEAT1 및 MALAT1은 심각한 COVID-19 환자에서 차등 적으로 발현됩니다. 통합 된 단일 세포 분석Research Article Published on 2022-01-102022-09-10 Journal: PLoS ONE [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] Analysis analyzed Apoptosis applied BAL Bronchoalveolar lavage Cell cell population cell stress cell types cellular stress response component coronavirus disease Coronavirus disease 2019 COVID-19 damage diagnostic differentially expressed differentiator disease severity dysregulation focus foster hallmark immune dysregulation immunomodulatory Inflammation Inflammatory involved lncRNA Long long non-coding RNA MALAT1 measure Mild mononuclear cell mononuclear cells NEAT1 non-coding RNA Patient PBMCs Peripheral blood Peripheral blood mononuclear cells pro-inflammatory function pro-inflammatory functions Regulation sequenced severe COVID-19 Severe patient severity single-cell single-cell RNA-seq dataset single-cell transcriptomic analysis stress response target targets therapy with COVID-19 [DOI] 10.1371/journal.pone.0261242 PMC 바로가기 [Article Type] Research Article
5-Hydroxymethylcytosine Signatures in Circulating Cell-Free DNA as Early Warning Biomarkers for COVID-19 Progression and Myocardial InjuryCell and Developmental Biology Published on 2022-01-062022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] 5-Hydroxymethylcytosine 5hmC 95% CI AUC carried cell-free DNA cfDNA conditions coronavirus disease COVID-19 COVID-19 disease COVID-19 progression Critical death demonstrated develop Disease progression DNA healthy volunteers hospital identify machine learning marker moderate myocardial injury Occurrence Patient patients patients with COVID-19 patients with moderate PDE4D phosphodiesterase 4D plasma Pneumonia profile progression prospective cohort study risk factor serious complication severe COVID-19 Severe patient signature Symptom ten-eleven translocation utility was used Wuhan [DOI] 10.3389/fcell.2021.781267 PMC 바로가기 [Article Type] Cell and Developmental Biology
A nomogram prediction of outcome in patients with COVID-19 based on individual characteristics incorporating immune response-related indicators면역 반응 관련 지표를 통합한 개인 특성을 기반으로 한 코로나19 환자의 결과에 대한 노모그램 예측Article Published on 2022-01-012022-09-12 Journal: Journal of medical virology [Category] Fulltext, MERS, 진단, [키워드] age albumin Analysis Blood urea nitrogen Characteristics Clinical outcome coronavirus disease COVID-19 COVID-19 patient Disease progression disease severity effective Factor follow-up time high risk identify IgG immune immune response indicated Intensive lactate dehydrogenase Logistic median Monocytes Neutrophil-to-lymphocyte ratio NLR nomogram outcome Patient patients with COVID-19 phenotype Platelet predict prediction predictors procalcitonin Prognosis prognostic progression public health risk severe disease Severe patient severe patients severity of COVID-19 significantly supportive care Therapeutic strategies [DOI] 10.1002/jmv.27275 PMC 바로가기 [Article Type] Article
Model-based cost-effectiveness analysis of oral antivirals against SARS-CoV-2 in Korea국내 SARS-CoV-2에 대한 경구용 항바이러스제의 모델 기반 비용 효율성 분석Article Published on 2022-01-012022-09-11 Journal: Epidemiology and Health [Category] SARS, 치료제, [키워드] Admission Adult patients Adults Analysis Antiviral antiviral agent Antiviral agents calculated Care coronavirus disease Coronavirus disease 2019 Cost-effectiveness analysis country COVID-19 COVID-19 patient Efficacy Elderly patient elderly patients Emergency use group health system Hospital admission Hospitalization ICU less medical system Mild-to-moderate molnupiravir Nirmatrelvir Patient patients predicted reduce reducing Ritonavir SARS-CoV-2 Severe case severe COVID-19 Severe patient standard care symptomatic Treatment underlying disease underlying diseases [DOI] 10.4178/epih.e2022034 PMC 바로가기 [Article Type] Article
Extracorporeal Blood Purification in Moderate and Severe COVID-19 Patients: A Prospective Cohort StudyClinical Trial Published on 2022-01-012022-10-05 Journal: Blood purification [Category] SARS, 임상, [키워드] acute respiratory distress Admission Analysis anticoagulation biochemical Blood Blood purification C-reactive protein characterized Coagulopathy Cohort Control coronavirus Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 patient Critical case Critically ill CRP cytokine cytopenias decrease develop disease distress EBP evaluated Extracorporeal ferritin fibrinogen haemofiltration heparin Hospitalization hyperinflammation IL-6 Inflammation Inflammatory inflammatory markers interleukin-6 Local longitudinal change mechanical ventilation Mild-to-moderate Mortality offer oXiris parameter Patient performed procalcitonin progressed Prospective recognizing reduction severe disease Severe patient Symptom syndrome systemic inflammatory marker systemic level therapeutic treated Treatment [DOI] 10.1159/000515627 PMC 바로가기 [Article Type] Clinical Trial
Learning From Biological and Computational Machines: Importance of SARS-CoV-2 Genomic Surveillance, Mutations and Risk Stratification생물학 및 전산 기계에서 배우기: SARS-CoV-2 게놈 감시, 돌연변이 및 위험 계층화의 중요성Cellular and Infection Microbiology Published on 2021-12-242022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Algorithm approach best Biological blood urea breathlessness C-reactive protein C-reactive protein (CRP characteristic Clinical data clinically Cohort coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation cough country COVID-19 dataset demonstrated develop diagnostic disease manifestation disease severity Evolution feature FIVE Frequency functional genomic Genomic analysis genomic mutations genomic sequencing Genomic surveillance healthcare highlight Importance India information learning leukocyte machine learning management ML model ML models Mutation Observing pandemic parameter parameters pathogen Patient patient severity performed physical symptoms predict Probability receiver operating characteristic resource respiratory respiratory rate Respiratory Support risk Risk assessment risk stratification ROC SARS-CoV-2 SARS-CoV-2 genomic surveillance severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease Severe patient significantly singular statistical statistical analysis Symptom tested the patient urea variants variants of concern variants of interest virus VOCs VOIs [DOI] 10.3389/fcimb.2021.783961 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Epidemiological Characteristics of Hospitalized Patients with Moderate versus Severe COVID-19 Infection: A Retrospective Cohort Single Centre StudyArticle Published on 2021-12-232022-11-01 Journal: Diseases [Category] COVID-19, [키워드] age Analysis ARDS average C-reactive protein CDC Clinical characteristics clinical factor Clinical outcome clinical outcomes Comorbidity conducted COVID-19 COVID-19 severity CRP D-dimer Demographic factors elevated epidemiological Epidemiological factors Factor Factors fatality FIVE Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients identify intensive care Intervention Laboratory Laboratory parameters LDH majority male management marker mechanical ventilation moderate Mortality NIV non-invasive ventilation non-severe patient noticeable difference Older Oman Patient prevalent progression reduce resource Respiratory disease retrospective cohort study SARS-CoV-2 selected Sepsis severe COVID-19 illness Severe patient severity single-center steroid syndrome therapeutic therapeutic intervention WBC were assessed white cell with COVID-19 [DOI] 10.3390/diseases10010001 PMC 바로가기 [Article Type] Article
Presence of Anti-MDA5 Antibody and Its Value for the Clinical Assessment in Patients With COVID-19: A Retrospective Cohort StudyCOVID-19 환자의 임상 평가를 위한 항MDA5 항체의 존재 및 가치: 후향적 코호트 연구Immunology Published on 2021-12-202022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory distress syndrome (ARDS) adverse outcome Analysis anti-melanoma differentiation-associated gene 5 (MDA5) antibody antibody assessment Autoimmune Blotting clinical conducted coronavirus disease correlated COVID-19 COVID-19 patient COVID-19 patients deaths demonstrated dermatomyositis elevated ELISA finding indicated Innate immunity Inpatient Laboratory features MDA5 non-severe patient outcome outcomes Patient positive positive patient positive rate Presence prevalent recruited severe COVID-19 patients severe disease Severe patient severity significantly similarity survival value was determined with COVID-19 [DOI] 10.3389/fimmu.2021.791348 PMC 바로가기 [Article Type] Immunology
Liver Injury and Elevated Levels of Interleukins, Interleukin-2 Receptor, and Interleukin-6 Predict the Severity in Patients With COVID-19Public Health Published on 2021-12-142022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, [키워드] acute respiratory syndrome addition association caused Characteristics clinical clinician coronavirus COVID-19 Diagnosis disorder Epidemiology feature IL-2R IL-6 infected with SARS-CoV-2 information interleukin-2 interleukin-6 Interleukins Level liver liver dysfunction Liver function Liver injury novel coronavirus disease pandemic Patient patients patients with COVID-19 predict Prognosis prognosis of patient receptor SARS-CoV-2 Severe patient severity of COVID-19 Spread the WHO Treatment with COVID-19 [DOI] 10.3389/fpubh.2021.778340 PMC 바로가기 [Article Type] Public Health