STING – Page 3 – Communicable Diseases Research

The cGAS-STING pathway drives type I IFN immunopathology in COVID-19

cGAS-STING 경로는 COVID-19에서 I형 IFN 면역병리를 유발합니다

Article

Published on 2022-03-012022-09-11
Journal: Nature [Category] SARS, 진단, 치료기술, 치료법,

Effect of Different Adjuvants on Immune Responses Elicited by Protein-Based Subunit Vaccines against SARS-CoV-2 and Its Delta Variant

SARS-CoV-2 및 델타 변이체에 대한 단백질 기반 서브유닛 백신에 의해 유도된 면역 반응에 대한 다양한 보조제의 효과

Article

Published on 2022-02-282022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adjuvants aluminum Candidates caused cell culture supernatants cGAS coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Delta delta variant Effect Efficacy elicited enhancing the immunogenicity facilitate global pandemic greater highest IgG1 IgG2a immunogenicity Infection manganese MF59 nanoparticle manganese Neutralizing antibodies neutralizing antibody pseudotyped SARS-CoV-2 RBD RBD-Fc RBD-specific IgG reduced response SARS-CoV-2 SARS-CoV-2 RBD severe acute respiratory syndrome Coronavirus STING subunit subunit vaccines Vaccine variants variants of concern Viral load VoC
[DOI] 10.3390/v14030501 PMC 바로가기 [Article Type] Article

Combination strategies with PD-1/PD-L1 blockade: current advances and future directions

Review

Published on 2022-01-212023-08-30
Journal: Molecular Cancer [Category] E형 간염,

[키워드] Angiogenesis inhibitor bispecific antibody combination therapy gut microbiota PD-1 PD-L1 Radiotherapy STING
[DOI] 10.1186/s12943-021-01489-2 PMC 바로가기 [Article Type] Review

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

새로운 STING 효능제가 첨가된 범-사베코바이러스 백신은 마우스, 토끼 및 NHP에서 강력하고 내구성 있는 중화 항체 및 T 세포 반응을 이끌어냅니다.

Article

Published on 2022-01-192022-09-11
Journal: Cell Research [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

SARS-CoV-2 감염은 cGAS-STING 및 NF-κB를 통해 전염증성 사이토카인 반응을 유도합니다

Article

Published on 2022-01-122022-09-10
Journal: Communications Biology [Category] 치료기술, 치료제,

[키워드] Activation antiviral responses block building Cell cGAS complications contribute cytokine cytokine secretion profile Cytokines death detect develop drugs epithelial cells evaluate evaluated global pandemic human epithelial cell human epithelial cells individual induce infected cell culture infected patients infections Inflammatory cytokine Inflammatory cytokines inflammatory immune response Inflammatory response Inflammatory responses IRF3 lead leads long-lasting lung damage majority Mild Mild disease NF-κB nuclear translocation Patient patient sera pro-inflammatory cytokine pro-inflammatory cytokines proportion SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection Severe case severe disease severe symptom severe symptoms Spread STING suppress Symptoms therapy transcriptional upregulation viral pathogenesis virus
[DOI] 10.1038/s42003-021-02983-5 PMC 바로가기 [Article Type] Article

Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection

cGAS에 의한 세포질 염색질 감지는 SARS-CoV-2 감염에서 타고난 면역 반응을 활성화합니다

Article

Published on 2021-11-032022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] ACE2 activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition caused Cell Cell fusion cellular cGAS chromatin contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytoplasmic cytosolic Defense DNA expression Host host antiviral response host antiviral responses host cell host cells host defense host immune system immune system induce infected cells Infectious diseases inhibit innate immune response innate immune system Innate immunity interferon knowledge MAVS mechanism nucleic acids nucleus offer pandemic pathway positive-sense RNA virus pro-inflammatory gene expression recognize reported required respiratory respond RNA virus SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein STING targeting therapeutic treating COVID-19 Trigger Viral viral infection viral replication Viral RNA
[DOI] 10.1038/s41392-021-00800-3 PMC 바로가기 [Article Type] Article

eccDNAs are apoptotic products with high innate immunostimulatory activity

Research

Published on 2021-10-222022-10-05
Journal: Nature [Category] 유전자 메커니즘,

Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection

SARS-COV-2 감염에 의해 유도 된 Syncytia에서 미세 핵 생산, DNA 손상 반응의 활성화 및 CGAS- 스팅 신호 전달

Research

Published on 2021-10-212022-09-10
Journal: Biology Direct [Category] Fulltext, MERS, SARS, 유전자 메커니즘,

[키워드] γH2Ax ACE2 Activation acute respiratory syndrome average Cell Cell fusion cellular cellular and molecular cGAS COVID-19 COVID-19 therapy DNA damage DNA damage signaling downstream dysregulated Effect explain expressing H2Ax help immune activation indicated induce lung tissue manifested mechanism Micronuclei micronucleus reported respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Severe acute respiratory syndrome Signaling signaling pathway Spike protein STING Syncytia syncytia formation syncytium target Target genes the SARS-CoV-2 therapy translocation upregulation Viral viral infection
[DOI] 10.1186/s13062-021-00305-7 PMC 바로가기 [Article Type] Research

Interactions between SARS coronavirus 2 papain-like protease and immune system: A potential drug target for the treatment of COVID-19

SARS 코로나바이러스 2 파파인 유사 프로테아제와 면역 체계 간의 상호 작용: COVID-19 치료를 위한 잠재적 약물 표적

Review

Published on 2021-10-012022-09-11
Journal: Scandinavian journal of immunology [Category] SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 complex complex system Compound coronavirus CoV COVID-19 CoVs cytokine production DeISGylating deubiquitinating drug drug target DUB dysregulation Effect enzyme evade Host host immunity immune immune response immune responses immune system infections inhibit inhibitor Innate innate immune responses MAPK Mild mild to moderate moderate molecules multifunctional New coronavirus NF-κB Papain Papain-like protease pathway Pathways PLPro protease public health regulate Respiratory tract infections respiratory virus respiratory viruses SARS Coronavirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 STING suppress TGF-β Treatment treatment of COVID-19 upper respiratory tract upper respiratory tract infections viral spread viruses
[DOI] 10.1111/sji.13044 PMC 바로가기 [Article Type] Review

cGAS–STING and MyD88 Pathways Synergize in Ly6C hi Monocyte to Promote Streptococcus pneumoniae -Induced Late-Stage Lung IFNγ Production

cGAS–STING 및 MyD88 경로가 Ly6C hi 단핵구에서 협력하여 Streptococcus pneumoniae 유도 지연 단계 폐 IFNγ 생성을 촉진한다.

Original Research

Published on 2021-08-262024-07-30
Journal: Frontiers in immunology [Category] 폐렴구균 감염증,

[키워드] IFNγ monocyte MYD88 STING Streptococcus pneumoniae (pneumococcus)
[DOI] 10.3389/fimmu.2021.699702 PMC 바로가기 [Article Type] Original Research