Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences인도-아프리카 서열을 기반으로 하는 EDIII-NS1 컨센서스 디자인을 암호화하는 새로운 뎅기열 DNA 백신의 면역 프로필 및 반응Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] MERS, 변종, 진단, [키워드] antibody Antibody-dependent enhancement Antigen antigens clinical isolates coding sequence Consensus consensus sequence conserved COVID-19 pandemic Dengue dengue surveillance. dengue virus DENV-2 DNA DNA vaccine domain domain III EDIII domain emerging viruses envelope protein epitope Epitopes expand Genotype highlight IgG1 immune immune response immunogenic Immunoglobulin India Indo-African interferon isolate mice neutralizing antibody non-structural protein NS1 protein passive transfer protein expression response sequence Sequencing sera serotype serotype-specific staining Stand Structural analysis Surveillance T cell T cell responses transfer translation vaccination Vaccine vaccine candidate Vaccine design Viral Viral variants virulent viruses whole genome Whole genome sequencing [DOI] 10.1016/j.ymthe.2022.01.013 PMC 바로가기 [Article Type] Article
Structural insights into the substrate-binding site of main protease for the structure-based COVID-19 drug discoveryArticle Published on 2022-05-012023-07-08 Journal: Proteins [Category] COVID19(2023년), [키워드] COVID-19 crystallographic waters docking simulations drug design hot-spot residues main protease Structural analysis [DOI] 10.1002/prot.26318
A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2Article Published on 2022-03-252023-06-15 Journal: Immunity [Category] COVID19(2023년), MERS, SARS, [키워드] Affinity maturation antibody COVID-19 Data mining deep learning public antibody response SARS-CoV-2 Sequence analysis Somatic hypermutation Structural analysis [DOI] 10.1016/j.immuni.2022.03.019 PMC 바로가기 [Article Type] Article
Short-Term Instantaneous Prophylaxis and Efficient Treatment Against SARS-CoV-2 in hACE2 Mice Conferred by an Intranasal Nanobody (Nb22)비강 나노바디(Nb22)에 의해 부여된 hACE2 마우스의 SARS-CoV-2에 대한 단기 순간 예방 및 효율적인 치료Article Published on 2022-03-172022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] addition Administered Against alpaca binding blocked Breakthrough infection breakthrough infections caused circulating Community Complete COVID-19 vaccine current Delta delta variant demonstrated doses effective Efficacy efficient exhibited exhibiting hACE2 highlight immunized Inhaled inoculation instantaneous instantaneous prophylaxis instantaneous protection intranasal long-lasting nanobodies nanobody Nb22 neutralization PrEP Prophylaxis RBD reported respiratory Respiratory system SARS-CoV-2 Seven single dose Spike protein stability STIP Structural analysis Structure the spike protein therapeutic unmet need variants [DOI] 10.3389/fimmu.2022.865401 PMC 바로가기 [Article Type] Article
Discovery of a Natural Product with Potent Efficacy Against SARS-CoV-2 by Drug Screening약물 스크리닝을 통해 SARS-CoV-2에 강력한 효능을 지닌 천연물 발견Article Published on 2022-03-012022-09-11 Journal: Interdisciplinary sciences, computational life sci [Category] SARS, 신약개발, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against alveolar epithelial cells Analysis angiotensin angiotensin-converting enzyme-2 Antiviral antiviral peptides antiviral properties attachment AVP binding binding affinity binding free energies binding free energy caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyanovirin-N demonstrated domain drug Drug screening enzyme epithelial cells half-maximal inhibitory concentration host cell host cells human Angiotensin-converting enzyme Infection inhibit inhibited Interaction Molecular simulation natural Novel coronavirus novel coronavirus disease peptide peptides potent Prevent product provided RBD RBD binding RBD complex Receptor-binding domain recruitment residue SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S Screening severe acute respiratory syndrome Coronavirus spike glycoprotein Spread Structural analysis suppressed Therapeutic approach [DOI] 10.1007/s12539-021-00477-w PMC 바로가기 [Article Type] Article
Iron dysregulation in COVID-19 and reciprocal evolution of SARS-CoV-2: Natura nihil frustra facitCOVID-19의 철 조절 장애와 SARS-CoV-2의 상호 진화: 자연적 현실Meta-Analysis Published on 2022-03-012022-09-11 Journal: Journal of cellular biochemistry [Category] SARS, 변종, [키워드] accompanied acquired immunity Analysis binding booster component conserved COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 patients Defense Deterioration docking dysregulated dysregulation Evolution evolved variants Extensive ferritin ferritin-transferrin paradox Ferroportin followed by functional greater transmissibility Healthcare system hepcidin hospitalized patients Host host defense host proteases host range human host hypoxia immune evasion Immunity immunopathology in-silico Infection internalization involved iron iron homeostasis Iron metabolism iron overload lung MD simulation MD simulations mechanism Meta-analysis metabolism molecular molecular mimicry Mutation New omicron Omicron variant Pathogenesis pathway Patient peptide positive Prognosis protease Proteases provide responsible SARS-COV-2 infection selective Septic shock sequence serum severe COVID-19 severe disease Severe infection Severe patient severe patients shown Spike protein Spike protein sequence strain Structural analysis the spike protein tissue Transferrin vaccination variant variants variants of SARS-CoV-2 Viral load viral spike protein [DOI] 10.1002/jcb.30207 PMC 바로가기 [Article Type] Meta-Analysis
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice광범위 교차 반응성 항체는 마우스에서 사베코바이러스 공격을 중화하고 보호합니다.Article Published on 2022-02-232022-09-14 Journal: Science Translational Medicine [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome against SARS-CoV antibody B.1.1.7 B.1.351 B.1.429 B.1.526 B.1.617.1 B.1.617.2 bat coronavirus binding caused conserved coronavirus cross-reactive antibody D614G domain effective epitope events high affinity in vivo Infection infections mice mitigate Mortality neutralization neutralize outbreak P.1 Prevent PROTECT Protective RBD RsSHC014 sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-related viruses strain Structural analysis Therapeutic treatment Vaccine zoonotic [DOI] 10.1126/scitranslmed.abj7125 PMC 바로가기 [Article Type] Article
Structural modeling of Omicron spike protein and its complex with human ACE-2 receptor: Molecular basis for high transmissibility of the virusOmicron 스파이크 단백질 및 인간 ACE-2 수용체와의 복합체 구조 모델링: 바이러스의 높은 전염성을 위한 분자 기반Article Published on 2022-02-122022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, [키워드] ACE-2 ACE-2 receptor analysed Analysis binding complex domain eight explain glycoprotein Human Human ACE-2 receptor hydrogen Hydrogen bond infecting Infection Interaction interactions interface intra-molecular ionic interactions mutant Mutation mutations omicron Omicron variant parameter Pathogenesis Protein RBD RBD domain receptor Receptor binding domain residue Result Salt Bridge Seven simulation studies spike spike glycoprotein Spike protein Structural analysis Transmissibility trimeric Van variant of SARS-CoV-2 virus wild type [DOI] 10.1016/j.bbrc.2021.12.082 PMC 바로가기 [Article Type] Article
In Silico Molecular Characterization of Human TMPRSS2 Protease Polymorphic Variants and Associated SARS-CoV-2 SusceptibilityArticle Published on 2022-02-032022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] 2019 coronavirus disease acute respiratory syndrome addition Alter Analysis analyzed Camostat mesylate cell entry characterization complex coronavirus COVID-19 develop docking drug examined global pandemic glycoprotein Health care system high affinity host susceptibility Human Infection inhibitors Interaction interactions intermolecular interaction investigated molecular molecular docking nafamostat pandemic Polymorphic Polymorphisms predicted protease inhibitors Protective proteolytic cleavage reported responsible S glycoprotein SARS-CoV-2 SARS-CoV-2 spike serine protease serine protease inhibitors Spike protein Spread Structural analysis susceptibility the SARS-CoV-2 TMPRSS2 transmembrane serine protease treating COVID-19 patients Type variant variants Variation [DOI] 10.3390/life12020231 PMC 바로가기 [Article Type] Article
A structural view of the SARS-CoV-2 virus and its assemblyArticle Published on 2022-02-012022-10-31 Journal: Current opinion in virology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] advance cellular complexes components dead disease highlighting respond SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 protein SARS-CoV-2 vaccine SARS-CoV-2 virus Structural analysis structural biology Structure Support the SARS-CoV-2 virus tomography Treatment viral infections [DOI] 10.1016/j.coviro.2021.11.011 PMC 바로가기 [Article Type] Article