Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium사람의 기도 상피에서 SARS-CoV-2 진입 및 발아에 대한 미세구조적 통찰력Article Published on 2022-03-252022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] ACE2 airway epithelium B.1.1.7 B.1.1.7 variant budding cilia ciliary ciliated ciliated cell ciliated cells Concentration direct fusion envelope epithelial cells examined excluded explain Extracellular Genome goblet host cells Human airway epithelium Intact isolate isolates mechanism membrane membranes microvilli nucleocapsid nucleocapsids periphery plasma membrane profile profiles S glycoprotein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 infected cell SARS-CoV-2 infected cells TMPRSS2 tomography transmission electron microscopy Viral viral entry viral membrane virion virions virus [DOI] 10.1038/s41467-022-29255-y PMC 바로가기 [Article Type] Article
A reduced graphene oxide-Fe 3 O 4 composite functionalized with cetyltrimethylammonium bromide for efficient adsorption of SARS-CoV-2 spike pseudovirus and human enteric virusesSARS-CoV-2 스파이크 슈도바이러스 및 인간 장내 바이러스의 효율적인 흡착을 위해 세틸트리메틸암모늄 브로마이드로 기능화된 환원그래핀옥사이드-Fe 3 O 4 복합체Article Published on 2022-03-012022-09-11 Journal: Chemosphere [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Adsorption cetyltrimethylammonium bromide Combination complex Composite coronavirus CTAB Detection limit electrostatic interaction electrostatic interactions exhibited Fourier-transform infrared spectroscopy Genome HRV Human Human enteric viruses infrared spectroscopy intrinsic pseudovirus public health qPCR analysis reduced Reduced graphene oxide SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike pseudovirus severe acute respiratory syndrome Coronavirus significantly tap transmission electron microscopy Viral transmission virion Virion adsorption. virions virus virus particle virus particles water X-ray diffraction zeta potential [DOI] 10.1016/j.chemosphere.2021.132995 PMC 바로가기 [Article Type] Article
Modelling airborne transmission of SARS-CoV-2 using CARA: risk assessment for enclosed spacesArticles Published on 2022-02-112022-10-29 Journal: Interface Focus [Category] COVID-19, [키워드] Airborne transmission approach assessment CARA Clinical data Concentration COVID COVID-19 COVID-19 pandemic Critical decrease domains effective Effectiveness Emissions Factor Hospitalization Host immunological Infection Intervention magnitude Mask Masks Measures methodology modelling natural ventilation Outbreaks Particles physical Probability provide quantification reduction in respiratory pathogen risk Risk assessment SARS-CoV-2 SARS-CoV-2 viruses supported threshold to define Transmission transmission of SARS-CoV-2 vaccination Ventilation venting virions Virological [DOI] 10.1098/rsfs.2021.0076 PMC 바로가기 [Article Type] Articles
Coronavirus Infection-Associated Cell Death Signaling and Potential Therapeutic Targets코로나바이러스 감염 관련 세포 사멸 신호 및 잠재적 치료 표적Review Published on 2021-12-092022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] (RdRp 3CLpro ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-apoptotic Anti-inflammatory antiviral properties Apoptosis assembly autophagy BCL-2 can be used caused celastrol cell death cell death pathways Chloroquine chloroquine/hydroxychloroquine Compound coronavirus CoV infection COVID-19 COVID-19 treatment Critical Curcumin cysteine Cytokines death deaths Effect Efficacy enzyme expression FIVE flavonoids Frame group Helicase host cell Hydroxychloroquine induce Infection Inflammation inhibiting inhibitor Inhibitory effects interactions involved L-cysteine life cycle mechanism mitigate modify molecular target molecules MPro name natural natural compounds necroptosis NF-κB NF-κB signaling NLRP3 inflammasome non-structural protein nonstructural protein 1 nsp1 Nsp12 occurred Open reading frame ORF7a outcomes Papain play roles PLPro Potential progression proliferation promote Propagation protease Protein proteinase pyroptosis RdRP Regulated cell death Replication responsible RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV infection SARS-CoV-2 SARS-CoV-2-infected patients Serine serine 2 severe acute respiratory syndrome Coronavirus Signaling small molecule specific inhibitor spike Spike protein survival target targeted therapy the disease therapeutic targeting TMPRSS2 TNF transmembrane transmembrane protease serine 2 Treatment variety Viral viral entry viral infection viral life cycle virions XIAP yielding [DOI] 10.3390/molecules26247459 PMC 바로가기 [Article Type] Review
Rapid determination of infectious SARS-CoV-2 in PCR-positive samples by SDS-PMA assisted RT-qPCRSDS-PMA 지원 RT-qPCR을 통한 PCR 양성 샘플의 감염성 SARS-CoV-2의 신속한 측정Article Published on 2021-11-252022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] assistance circumvent comparable conditions conjugate COVID-19 COVID-19 pandemic Ct value Culture Cutoff dead detect experiment facilitate Formation gold gold standard groups Health Health crisis heat heat-inactivated inactivated inactivation infectious particles less Live virus management MONITOR nucleic acid Patient PCR amplification PCR-positive Plaque assay PMA Prevent Rapid reduce released RT-qPCR SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 transmission SARS-CoV-2 virion SDS storage Viral particles Viral RNA virion virions [DOI] 10.1016/j.scitotenv.2021.149085 PMC 바로가기 [Article Type] Article
Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individualsBNT162B2- 암시 처리 된 개체에서 부작용 및 면역 동역학과의 중화/SARS-COV-2-S1- 결합 항체 반응의 상관 관계Article Published on 2021-11-242022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] adverse effect adverse effects Antibody Response average B.1.351 blocked BNT162b2 determinant dose doses effective enrolled examined feature greater healthy individual IgG levels immune immune response Immunity individual individuals inverse correlation Japan measure men moderate mRNA vaccine mRNA vaccines neutralization Neutralizing activity no correlation Pain Participants potency Prospective Study Protective RNA vaccines SARS-CoV-2 sera Significant symptomatic infection Vaccine variants variants of concern viral infection virions was determined while women [DOI] 10.1038/s41598-021-01930-y PMC 바로가기 [Article Type] Article
A direct capture method for purification and detection of viral nucleic acid enables epidemiological surveillance of SARS-CoV-2바이러스 핵산의 정제 및 검출을 위한 직접 포획 방법으로 SARS-CoV-2의 역학 감시 가능Article Published on 2021-11-152022-09-11 Journal: The Science of the total environment [Category] SARS, 변종, 치료기술, 치료법, [키워드] added addition appearance binding capture method compatibility complexes Concentration COVID-19 demonstrated detect Effect enzyme epidemiological Epidemiology fecal feces genetic material Genome infected individuals infectious agent inhibitor inhibitors initial MONITOR Mottle nucleic acid Nucleic acid purification nucleocapsid overcome plant primer Primers probe probes protocols purification purified qPCR qPCR assays RNA RNA virus RT-qPCR RT-qPCR assay RT-qPCR assays SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant sequenced silica spread of COVID-19 subset Surveillance Treatment utility Variability viral nucleic acid virion virions virus isolation wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.148834 PMC 바로가기 [Article Type] Article
Epigenetic glycosylation of SARS-CoV-2 impact viral infection through DC&L-SIGN receptorsArticle Published on 2021-11-112022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract ACE2 acute respiratory syndrome Affect affinity Cell Cell Biology changed CLR CLRs co-expression coronavirus dependent on Epigenetic genetic code GlcNAc glycomics glycoprotein glycosylation high-mannose highlight host cell Immune escape Immunity Infection L-SIGN Man Modification post-translational modification postfusion producing receptor respiratory tract cells S trimer SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virion spike glycoprotein Spike protein supported trimer viral entry viral infection virion virions Virology virus while [DOI] 10.1016/j.isci.2021.103426 PMC 바로가기 [Article Type] Article
Cell-based Culture Informs Infectivity and Safe De-Isolation Assessments in Patients with Coronavirus Disease 2019세포 기반 배양으로 코로나바이러스 질병 2019 환자의 감염성 및 안전한 분리 제거 평가 정보 제공Article Published on 2021-11-022022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assessment Cell Chain Reaction collected coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 CPE Culture culture supernatant cycle threshold Cytopathic effect De-isolation defined ICU patient ICU Patients indicate Infection infection control infective Infectivity Inpatient Inpatients intensive care intensive care unit Isolation marker outpatients Patient patients PCR PCR-positive polymerase chain polymerase chain reaction positive protocols RNA SARS-CoV-2 SARS-CoV-2 PCR severe acute respiratory syndrome Coronavirus shedding significantly more symptom onset tested upper respiratory tract Vero viral culture virions virus replication was performed [DOI] 10.1093/cid/ciaa1579 PMC 바로가기 [Article Type] Article
Development of a rapid viability RT-PCR (RV-RT-PCR) method to detect infectious SARS-CoV-2 from swabs면봉에서 감염성 SARS-CoV-2를 검출하는 신속한 생존력 RT-PCR(RV-RT-PCR) 방법 개발Article Published on 2021-11-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료기술, [키워드] 96-well plate acute respiratory syndrome coronavirus Algorithm Analysis antiviral drug COVID-19 COVID-19 pandemic Culture cycle threshold detect determine development enrichment epidemiological include increase in Incubation period Infectious SARS-CoV-2 Infectious virus PCR method Post-infection potential surface Rapid Rapid viability representing required respiratory resulting reverse transcriptase reverse transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 virion SARS-CoV-2 virions Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spread Swab swab sample swab samples swabs Transmission Ultrafiltration viability Viral detection viral infection virions virus [DOI] 10.1016/j.jviromet.2021.114251 PMC 바로가기 [Article Type] Article