Antigen Specific Humoral and Cellular Immunity Following SARS-CoV-2 Vaccination in ANCA-Associated Vasculitis Patients Receiving B-Cell Depleting TherapyB 세포 고갈 요법을 받는 ANCA 관련 혈관염 환자에서 SARS-CoV-2 백신 접종 후 항원 특이적 체액 및 세포 면역Immunology Published on 2022-01-282022-09-11 Journal: Frontiers in Immunology [Category] 진단, 치료법, [키워드] ANCA-associated vasculitis anti-CD20 anti-CD20 therapy anti-SARS-CoV-2 Anti-spike antibody assays B-cell B-cells cellular Cellular immune response characterized control subjects controls COVID-19 vaccination elicit ELISPOT enzyme-linked immunosorbent humoral humoral immune response Humoral response immune responses immunoassays interferon lack mounted Patient patients peptide peptide pool positive Protective protective effect receiving Receptor binding domain recovered patient Research response rituximab robust S glycoprotein SARS-CoV-2 SARS-CoV-2 vaccination Specific Specific T-cell response subject subjects subunit T-cell immunity T-cell Response T-cell responses targeted therapy vaccination Vaccine vaccine response Vasculitis were measured [DOI] 10.3389/fimmu.2022.834981 PMC 바로가기 [Article Type] Immunology
Sequential infections with rhinovirus and influenza modulate the replicative capacity of SARS-CoV-2 in the upper respiratory tractCoronaviruses Published on 2022-01-272022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] air–liquid interface airway epithelial cell Alpha variant blockade circulating circulation coronavirus 2 correlated COVID-19 had no IAV IBV immune response Infection Influenza Influenza virus inhibition Interaction interferon interferons investigated modulate modulated neutralizing antibody other respiratory virus pandemic patients prevalent prevented question Replication replicative reported respiratory respiratory virus respiratory viruses restored rhinovirus SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 replication suggested These data triggered type I upper respiratory tract variants of concern viral co-infections virus virus entry was impaired [DOI] 10.1080/22221751.2021.2021806 PMC 바로가기 [Article Type] Coronaviruses
Studying the clinical, radiological, histological, microbiological, and immunological evolution during the different COVID-19 disease stages using minimal invasive autopsy최소 침습성 부검을 사용하여 상이한 COVID-19 질병 단계 동안 임상, 방사선 학적, 조직 학적, 미생물 학적 및 면역 학적 진화 연구Clinical Trial Published on 2022-01-252022-09-01 Journal: Scientific Reports [Category] 임상, 진단, 치료법, [키워드] alveolar damage America Autopsy change Characteristics clinical microbiology Cohort COVID-19 COVID-19 disease COVID-19 patients diffuse Diffuse alveolar damage disease evaluated Evolution had no heart histological histopathological IgG immunological immunological characteristics Immunopathogenesis Infection Inflammation interferon interferon-γ invasive liver organ Other other organs Pathogenesis pathophysiological mechanism pathophysiological mechanisms Patient PCR-confirmed COVID-19 patient positive radiological Significant significant differences significantly higher Society Stage stages Treatment viral infection WHO with COVID-19 [DOI] 10.1038/s41598-022-05186-y PMC 바로가기 [Article Type] Clinical Trial
Elimination of Aicardi–Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replicationAicardi-Goutières 증후군 단백질 SAMHD1 제거는 세포 선천 면역을 활성화하고 SARS-CoV-2 복제를 억제합니다Research Article Published on 2022-01-252022-09-10 Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 치료제, [키워드] 293T ACE2, angiotensin-converting enzyme 2 activate activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect AGS, Aicardi–Goutières syndrome Antiviral ARHGEF5, Rho guanine nucleotide exchange factor 5 Baricitinib cDNA, complementary DNA Cell cell lines cells cellular characterized clearance coronavirus COVID-19, Coronavirus disease 2019 CRISPR Culture Degradation demonstrated DMEM, Dulbecco's modified Eagle's medium downregulated elevated Elimination expression FBS, fetal bovine serum FDA, US Food and Drug Administration Gene Expression Genetic HCoV-OC43, human coronavirus OC43 human coronavirus human coronavirus OC43 IFN IFN signaling IFN, interferon IFNs immune responses Infection innate immune response Innate immunity interferon interferons interferons (IFNs) IRF3, IFN regulatory factor 3 ISG, IFN-stimulated gene JAK inhibitor JAK pathway JAK, Janus kinase lack lentiviral Macrophage macrophages MDM, monocyte-derived macrophage model system MOI, multiplicity of infection Monocyte-derived macrophages mRNA NSP, nonstructural protein Pathways Phosphorylation Protein protein expression pSTAT1, phosphorylated form of STAT1 qRT–PCR, quantitative RT–PCR regulate Replication respiratory SAMHD1 SAMHD1, sterile alpha motif and histidine–aspartate domain–containing protein 1 SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2–infected patient SARS-CoV-2–infected patients SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus shown Signaling signaling pathway significantly increased Stat1 STAT1, signal transducer and activator of transcription 1 suppresse suppressed syndrome THP-1 tissue tissue culture Treatment upregulated Viral Viral protein Virus-like particle virus-like particles VLP, virus-like particle Vpx, viral protein X [DOI] 10.1016/j.jbc.2022.101635 PMC 바로가기 [Article Type] Research Article
Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model연령 관련 SARS-CoV-2 돌발 감염 및 마우스 모델의 면역 반응 변화Coronaviruses Published on 2022-01-242022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] adaptive Adaptive immune response addition age Antibody Response Breakthrough infection changes in COVID-19 COVID-19 mRNA Vaccination demonstrated effective higher risk immune breakthrough immune protection immune response immune responses individual individuals interferon investigated mechanism mice modulate Occurrence Older outcomes prevention strategies Primary infection Re-infection respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis severe disease manifestation severe disease manifestations significantly susceptibility susceptible Treatment vaccination Vaccine vaccine breakthrough infection vaccine breakthrough infections virus replication wild-type [DOI] 10.1080/22221751.2022.2026741 PMC 바로가기 [Article Type] Coronaviruses
What’s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability?Review Published on 2022-01-222022-10-30 Journal: Immunity & Ageing : I & A [Category] COVID-19, [키워드] age Characteristics COVID-19 COVID-19 pandemic cytokine response demographic group dendritic cell explain Infection interferon Macrophage macrophages MAFB Male sex miR-146a obese obesity pathway Patient patient groups plasmacytoid dendritic cells pro-inflammatory cytokine SARS-CoV-2 sensitivity severe COVID-19 disease Severe infection skewed TLR-tolerance TLR7 vulnerable patients [DOI] 10.1186/s12979-022-00262-3 PMC 바로가기 [Article Type] Review
RNA-RNA interactions between SARS-CoV-2 and host benefit viral development and evolution during COVID-19 infectionSARS-CoV-2와 숙주 사이의 RNA-RNA 상호 작용은 COVID-19 감염 동안 바이러스 발달 및 진화에 도움이 됩니다Article Published on 2022-01-172022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 변종, [키워드] Absorption addition approach benefit coincidence collected COVID-19 COVID-19 infection dataset Diseases Evolution FIVE five group five groups Genes Genome genomic genomic RNA Host host cells host immune system host miRNA IL6R immune immune response immune system immune-related gene immune-related genes infect Infectious diseases Interaction interferon interleukin miRNA miRNAs mutant strain Pathogenesis pathogenicity pathway Pathways Perspective PPI predicted protein-protein interaction regulate reported RNA-RNA interaction RNA–RNA interaction SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection signaling pathway signaling pathways significantly survival target targets the interferon the SARS-CoV-2 genome [DOI] 10.1093/bib/bbab397 PMC 바로가기 [Article Type] Article
Humoral and cellular immunity in convalescent COVID-19 people with multiple sclerosis treated with ofatumumab오파투무맙으로 치료받은 다발성 경화증 환자의 회복기 COVID-19 환자의 체액 및 세포 면역Article Published on 2022-01-152022-09-11 Journal: Journal of neuroimmunology [Category] 임상, 진단, [키워드] Administered all subject all subjects antibodies Antibody Response Antibody testing CD19 CD19+ Cell cellular immunity Clinical outcome convalescent COVID-19 COVID-19 infection COVID-19 symptoms COVID-19 vaccination COVID-19 vaccinations dose ELISPOT four subject humoral IgG antibodies IgG antibody IgM IgM and IgG Immunity interferon interferon-γ lymphocyte mediated immunity Mild Multiple multiple sclerosis not performed Ofatumumab PCR performed Quotient reactive SARS-CoV-2 secreting single center subject T cell T-cell T-cell immunity Testing treated U/mL was performed was used while [DOI] 10.1016/j.jneuroim.2021.577788 PMC 바로가기 [Article Type] Article
Type-III interferon stimulated gene TRIM31 mutation in an HBV patient blocks its ability in promoting HBx degradationCase Reports Published on 2022-01-152023-06-13 Journal: Virus research [Category] B형 간염, [키워드] HBx Hepatitis B virus (HBV) interferon TRIM31. [DOI] 10.1016/j.virusres.2021.198650 [Article Type] Case Reports
Inflammatory laboratory findings associated with severe illness among hospitalized individuals with COVID-19 in Medan, Indonesia: a cross-sectional studyResearch Article Published on 2022-01-142022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] 24 hour acute respiratory distress Admission Analysis Blood BMI body mass index C-reactive protein (CRP Characteristics comorbid Comorbidities Comorbidity Comparative conducted COVID-19 COVID-19 patient COVID-19 vaccination Critical Critically ill cross-sectional CRP cytokine Cytokine storm D-dimer diabete disease enzyme Factor good health groups Health higher risk Hospitalized ICU IFN-gamma IL-10 IL-6 increase indicated individuals with COVID-19 Inflammatory Inflammatory cytokine inflammatory markers inflammatory parameter Inflammatory response intensive care interferon Laboratory laboratory result Lipase Liver function MCP-1 men monocyte chemoattractant protein-1 Most patient Necrosis NLR obesity pancrea parameters peripheral renal function serum electrolyte severe COVID-19 severe COVID-19 patient severe pneumonia severity of COVID-19 Sex significant difference significantly higher subject syndrome the cytokine storm TNF-alpha vaccination Well-being were assessed [DOI] 10.12688/f1000research.74758.2 PMC 바로가기 [Article Type] Research Article