Evolution of SARS-CoV-2 Envelope, Membrane, Nucleocapsid, and Spike Structural Proteins from the Beginning of the Pandemic to September 2020: A Global and Regional Approach by Epidemiological Week팬데믹 시작부터 2020년 9월까지 SARS-CoV-2 봉투, 막, 뉴클레오캡시드 및 스파이크 구조 단백질의 진화: 전염병 주간의 글로벌 및 지역적 접근Article Published on 2021-02-042022-09-10 Journal: Viruses [Category] MERS, 변종, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid Analysis bioinformatics change changes changes in Combination Complete coronavirus coronavirus disease country COVID-19 D614G diagnostic tests downloaded envelope epidemiological Evolution followed by functional G204R genetic diversity genetic variability GISAID highlight Highlights house Influenza initiative Local membrane monitoring Mutation nucleocapsid nucleocapsid protein pandemic partial sequence partial sequences prevalent processed R203K Region Regional residue respiratory SARS-CoV-2 spike Spike protein structural protein structural proteins the spike protein therapy Vaccines Week [DOI] 10.3390/v13020243 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Genomes From Oklahoma, United StatesGenetics Published on 2021-02-032022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] acute respiratory syndrome Analysis clinical sample conformational flexibility coronavirus D614G determine different time point FIVE Genome genomes sequenced genomic geographical locations globe indicate influence initial linker Modification Mutation mutations N gene nCoV-19 nucleocapsid protein Oklahoma ORF1ab ORF7b ORF8 pandemic pathogenicity reported S gene SARS-CoV-2 SARS-CoV-2 virus sequenced Sequencing similarity the spike protein United State [DOI] 10.3389/fgene.2020.612571 PMC 바로가기 [Article Type] Genetics
Sixteen novel lineages of SARS-CoV-2 in South Africa Research Published on 2021-02-022022-10-05 Journal: Nature Medicine [Category] SARS, 변종, 진단, [키워드] 501Y.V2 accounted acute respiratory syndrome African Amino acid analyzed coronavirus country D614G early response First wave genomic identify Infection Lineage lockdown measure MOST Mutation nosocomial outbreak novel lineage nucleotide mutation Oxford SARS-CoV-2 sequence shown South South Africa Spread Surveillance the spike protein unique variant were infected whole genome widespread Wuhan [DOI] 10.1038/s41591-021-01255-3 [Article Type] Research
Clinical and whole genome characterization of SARS-CoV-2 in India인도에서 SARS-CoV-2의 임상 및 전체 게놈 특성화Research Article Published on 2021-02-022022-09-10 Journal: PLoS ONE [Category] MERS, 변종, [키워드] A2a ACE2 Analysis binding affinities binding affinity blood urea cardiovascular disease clinical Comorbidities D614G decrease deficiency diabetes disease severity Europe functional GISAID heart Host hypertension immune increase India Infection International isolate kidney liver lymphocyte Lymphocyte count lymphocyte counts Lymphocytes Middle East neutrophil neutrophil count neutrophil counts nine organ damage Patient patients with SARS Phylogeny predicted recovered patients reported S protein SARS CoV SARS CoV-2 infection SARS-CoV-2 Seven Severe infection severity SGOT SGPT the disease Transmission Travel urea virus isolate WBC WGS whole genome whole genome sequence Wuhan [DOI] 10.1371/journal.pone.0246173 PMC 바로가기 [Article Type] Research Article
The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine designSARS-CoV-2 스파이크 단백질의 D614G 돌연변이: 바이러스 감염성, 질병 중증도 및 백신 설계에 대한 의미Review Published on 2021-01-292022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, [키워드] Asia Characteristics Clinical outcome coronavirus D614G D614G mutation D614G variant disease severity dominant effort Europe Evidence Evolution Host immune response Infection molecular molecular evolution Mutation neutralising antibody pandemic Point mutation SARS-CoV-2 SARS-CoV-2 pandemic Sequencing spike Spike protein Spread the SARS-CoV-2 the spike protein USA Vaccine design viral infectivity virus virus spread [DOI] 10.1016/j.bbrc.2020.10.109 PMC 바로가기 [Article Type] Review
One Year of SARS-CoV-2: How Much Has the Virus Changed?Article Published on 2021-01-262022-10-28 Journal: Biology [Category] COVID-19, [키워드] 3D proteins 3D structure A222V accumulating acute respiratory syndrome Analysis anticipated caused coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine D614G Effect effective Europe exhibiting GISAID globe group highest identify Immune escape initiative L18F likelihood molecular analysis mutant Mutation mutation rate mutations nonsynonymous observé over P323L pandemic Protein Proteins proteome provide public health reported Research resource SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 proteome sequence simple spike Spread Surveillance target the SARS-CoV-2 the SARS-CoV-2 virus the Spike therapy These data Vaccine Variability viral genome sequence Viral protein virus worldwide crisis Year [DOI] 10.3390/biology10020091 PMC 바로가기 [Article Type] Article
In silico comparative genomics of SARS-CoV-2 to determine the source and diversity of the pathogen in Bangladesh방글라데시에서 병원체의 근원과 다양성을 결정하기 위한 SARS-CoV-2의 in silico 비교 게놈Research Article Published on 2021-01-202022-08-13 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] affected Analysis caused China Clusters coding region Comparative analysis conducted country COVID19 D614G determine epidemiological France Genome genomic variation genomic variations indicated isolate isolates leads Missense Missense mutation Missense mutations Mutation NSP2 pandemic pathogen Phylogenetic analysis predict predicted prevalent Protein protein structures reported SARS-CoV-2 SARS-CoV-2 genomic sequences SARS-CoV-2 isolate SARS-CoV-2 sequence SARS-CoV-2 virus Saudi Arabia Spike protein strain Strains structures the spike protein transmission route United Kingdom virus viruses Whole-genome sequence whole-genome sequences [DOI] 10.1371/journal.pone.0245584 PMC 바로가기 [Article Type] Research Article
Structural Mapping of Mutations in Spike, RdRp and Orf3a Genes of SARS-CoV-2 in Influenza Like Illness (ILI) Patients인플루엔자 유사 질병(ILI) 환자에서 SARS-CoV-2의 스파이크, RdRp 및 Orf3a 유전자 돌연변이의 구조적 매핑Article Published on 2021-01-192022-09-10 Journal: Viruses [Category] 치료기술, [키워드] Affect ambulatory patients Amino acid amino acid substitution Analysis binding site cause characterized China clade Clustering collected community transmission confirmation conformational change COVID-19 COVID-19 case COVID-19 illness D614G epidemiological link Extracellular followed by functional ILI illness incidence independent indicated Influenza influenza like illness influenza vaccine isolate Like mapping membrane mild COVID-19 illness mitigate Nasopharyngeal swab nasopharyngeal swabs next generation sequencing NGS oligomerization overlap P323L pandemic Patient PCR Public health interventions Q57H RdRP replaced SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 virus Sequencing silent silent transmission spike spike gene Substitution Surveillance thought Transcription Transmission transmission of SARS-CoV-2 virus virus replication [DOI] 10.3390/v13010136 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the SpikeSARS-CoV-2 감염 심각도는 스파이크에 대한 우수한 체액 면역과 관련이 있습니다.Research Article Published on 2021-01-192022-09-10 Journal: mBio [Category] 변종, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody Response antibody response against Antigen binding Cell coronavirus COVID-19 COVID-19 disease Critical cross-react D614G epitope Frame global pandemic greater Humoral immunity Infection infection severity memory B memory B cell memory B cells mounted mutant natural immunity Neutralizing antibodies Neutralizing antibody response nonstructural proteins nucleocapsid protein Open reading frame pandemic Receptor binding domain respiratory reveal robust SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 disease severe SARS-CoV-2 specificity Spike protein subject Superior the antibody response the Spike Viral viral antigens virus [DOI] 10.1128/mBio.02940-20 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 genomic characterization and clinical manifestation of the COVID-19 outbreak in Uruguay우루과이에서 발생한 COVID-19 발병의 SARS-CoV-2 게놈 특성 및 임상 징후Coronaviruses Published on 2021-01-152022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Arterial hypertension association caused clade clinical correlations clinical parameter Cohort contribute coronavirus correlated correlation COVID-19 COVID-19 outbreak D614G D614G mutation disease dominance FIVE full genome amplicon sequencing Genetic genomic global public health global public health emergency Health Organization Healthcare system hypertension ICU admission independent Inpatients kidney Kidney failure Latin America Local make up minimum Mutation non-structural protein outbreak outcome outpatients and inpatient pandemic partial lockdown performed phylodynamic phylogeographic analysis phylogeographic BEAST analysis respiratory Respiratory illness resulting SARS-CoV-2 SARS-COV-2 infection sequence sequenced sequences severe acute respiratory syndrome Coronavirus significantly South South America spike D614G genetic mutation the SARS-CoV-2 Transmission transmission clusters transmissions Uruguay Viral viral genome viral genomes viral strain viral strains virus World Health Organization [DOI] 10.1080/22221751.2020.1863747 PMC 바로가기 [Article Type] Coronaviruses