Declining Levels of Neutralizing Antibodies Against SARS-CoV-2 in Convalescent COVID-19 Patients One Year Post Symptom Onset증상 발병 1년 후 회복기 COVID-19 환자에서 SARS-CoV-2에 대한 중화 항체 수준 감소Immunology Published on 2021-06-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] Against antibody Antibody Response Antibody responses B.1.351 collected concerning convalescent patient Convalescent patients coronavirus disease Coronavirus disease 2019 COVID-19 declining detectable donors E484K fraction Humoral immunity IgG antibodies IgG titers IgM and IgG immune responses individual Infection Kinetics knowledge Level long-term immune response long-term immune responses Major natural infection neutralization test neutralization tests neutralize Neutralizing Neutralizing activity nucleocapsid Onset Patient patients performed PROTECT Protein quantified RBD Receptor binding domain recognizing recovered patient recovered patients SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG South Africa specific IgG antibodies spike Spike protein symptom onset symptomatic symptomatic COVID-19 the spike protein vaccination Vaccinations variant virus VoC Year [DOI] 10.3389/fimmu.2021.708523 PMC 바로가기 [Article Type] Immunology
Serologic Testing of US Blood Donations to Identify Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Reactive Antibodies: December 2019-January 2020중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)-반응성 항체를 식별하기 위한 미국 헌혈의 혈청학적 검사: 2019년 12월-2020년 1월Article Published on 2021-06-152022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome American Red Cross anti-SARS-CoV-2 antibodies antibodies antibody binding activity blocking activity Blood Blood donors cause center collected Connecticut Control coronavirus coronavirus 2 coronavirus disease COVID-19 determine donation Donor ELISA ELISAs enzyme-linked immunosorbent first identified case IgG and IgM introduced Massachusetts Microneutralization test Neutralizing activity occurred prevention reactive reactivity respiratory Rhode Island SARS-CoV-2 sera serologic specimens Spike protein Spread subsequent tested Testing the United State total Ig virus Washington Wuhan, China [DOI] 10.1093/cid/ciaa1785 PMC 바로가기 [Article Type] Article
Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients강력한 SARS-CoV-2-특이적 T 세포 면역 및 낮은 아나필라톡신 수치는 COVID-19 환자의 경증 질병 진행과 상관관계가 있습니다Immunology Published on 2021-06-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] addition analyzed anaphylatoxin anaphylatoxin C3a Antibody titer Antibody titers Blood C5a caused CD4 CD8 cellular characterized clearance Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient disease severity elevated ELISA ELISPOT ELISpot assay evaluated flow cytometry healthy individual highest humoral immune response IFNγ IgG immune complex immune responses immunodominant indicate infected individuals Level Lymphocytes lymphopenia Mild mild infections mononuclear cell mononuclear cells Mortality neutralization ability neutralizing Abs Neutralizing activity nucleocapsid Patient patients peptide peptide pool peripheral Peripheral blood Peripheral blood mononuclear cells potent reduced respiratory Respiratory system robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2-infected individuals SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody severe disease progression significantly specific antibodies Spike proteins T cell T cell immunity T cell response T cell responses T cells T lymphocyte Viral viral infection viral infections [DOI] 10.3389/fimmu.2021.684014 PMC 바로가기 [Article Type] Immunology
Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection감염 1년 후 SARS-CoV-2에 대한 자연적으로 강화된 중화 폭Article Published on 2021-06-142022-09-10 Journal: Nature [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus addition antibodies antibody antibody reactivity Antimicrobial responses B cell breadth caused Cell circulating SARS-CoV-2 variants clone Cohort component convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 expand expected expressing greater humoral Humoral response Immunity increase individual Infection mechanism memory B memory B cell memory B cells monoclonal antibodies monoclonal antibody mRNA vaccine mRNA vaccines Mutation mutations naïve individuals Naturally Neutralizing Neutralizing activity pandemic Patient potency Progress Protective RBD RBD-specific memory B cells receive Receptor binding domain repertoire respiratory response retained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD serum severe acute respiratory syndrome Coronavirus somatic mutation vaccination Vaccines variant variants variants of concern Wuhan [DOI] 10.1038/s41586-021-03696-9 PMC 바로가기 [Article Type] Article
Seroprevalence of SARS-CoV-2 (COVID-19) exposure in pet cats and dogs in Minnesota, USA미국 미네소타의 애완 동물 고양이와 개에서 SARS-COV-2 (COVID-19) 노출의 혈청 유병률Research Article Published on 2021-06-142022-09-01 Journal: Virulence [Category] SARS, 진단, 치료기술, 치료법, [키워드] antibody Antigen antigens assays average canine cat cats caused coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic cross cutoff value detect dog early phase ELISA ELISAs enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays Evidence evidence of exhibited experiment feline coronaviruses Households identify IgG antibodies IgG antibody neutralization antibodies Neutralization assay neutralizing activities Neutralizing activity pandemic Protein RBD RBD-specific antibodies RBD-specific antibody RBD-specific IgG reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid sensitivity sera seropositive seropositive sample seropositive samples Seroprevalence serum sample serum samples Seven specific antibodies specific IgG antibodies specificity Spike protein Spread stomatitis the SARS-CoV-2 the spike protein USA vesicular stomatitis vesicular stomatitis virus was used zoonoses [DOI] 10.1080/21505594.2021.1936433 PMC 바로가기 [Article Type] Research Article
Different Neutralization Sensitivity of SARS-CoV-2 Cell-to-Cell and Cell-Free Modes of Infection to Convalescent SeraArticle Published on 2021-06-122022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] caused Cell cell-to-cell infection Comparative analysis Complete convalescent sera coronavirus COVID-19 pandemic determine experiment Infection intron-containing reporter lentiviral mechanism mode Multiple neutralization Neutralizing activity Particle Particles performed prevention of COVID-19 producing Protein pseudotyped purified reporter vector Safe SARS-CoV-2 SARS-CoV-2 transmission serum antibodies Serum Neutralization stomatitis Treatment virus [DOI] 10.3390/v13061133 PMC 바로가기 [Article Type] Article
Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals이전의 SARS-COV-2 감염은 백신 접종 된 개인에 의한 B.1.1.7 교차 중립화를 증가시킨다Article Published on 2021-06-122022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B.1.1.7 B.1.1.7 variant boost coronavirus cross-neutralization D614G expressing Humoral response increase individual infected individual infecting Infection mutant natural infection neutralization neutralization breadth Neutralizing activity neutralizing response parameter pseudovirus pseudoviruses reduction in respiratory robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread tested vaccinated individual vaccinated individuals vaccination Vaccine vaccinee variant Wuhan Wuhan-Hu-1 [DOI] 10.3390/v13061135 PMC 바로가기 [Article Type] Article
Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset초기 T 세포 및 결합 항체 반응은 COVID-19 RNA 백신 효능 발병과 관련이 있습니다Article Published on 2021-06-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Adaptive immune response adaptive immune responses Analysis binding binding antibodies binding antibody BNT162b2 BNT162b2 vaccine clinical trials Cohort Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 research demonstrated detectable doses Efficacy element first dose glass healthcare worker hour immune responses Immunity Neutralizing Neutralizing activity Neutralizing antibodies Pfizer/BioNTech Phase III clinical trials primary endpoint receiving respiratory response responses RNA RNA vaccine RNA vaccines SARS-CoV-2 Severe acute respiratory syndrome single dose Support T cell T cells the vaccine undetectable vaccination Vaccine vaccine efficacy virus was performed with COVID-19 [DOI] 10.1016/j.medj.2021.04.003 PMC 바로가기 [Article Type] Article
Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans인간의 SARS-CoV-2 감염에 대한 중화 항체 반응의 동역학 및 상관 관계Article Published on 2021-06-092022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, 치료기술, [키워드] age antibody antibody kinetics Antibody Response broad spectrum correlates of neutralization COVID-19 COVID-19 pandemic Critical cross-neutralizing demonstrated disease severity evaluated exceptional exhibiting Gender half-live half-lives Human IgG IgG antibody individual individuals Infection initial key factor Kinetics longitudinal cohort Mild multivariate neutralization Neutralizing Neutralizing activity Neutralizing antibodies Neutralizing antibody response purified reactivity SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 immunity SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2-neutralizing antibody serum Spike protein statistical sustained symptomatic infection understanding Vaccination strategies virus spike protein [DOI] 10.1016/j.chom.2021.04.015 PMC 바로가기 [Article Type] Article
Antibody Responses to SARS-CoV-2 Following an Outbreak Among Marine Recruits With Asymptomatic or Mild Infection무증상 또는 경증 감염이 있는 해병 모집단의 발병 후 SARS-CoV-2에 대한 항체 반응Immunology Published on 2021-06-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] Adults age antibodies Asymptomatic asymptomatic infection Betacoronavirus circulating Cohort comparable COVID-19 cross-reactivity disease domain Endemic enrolled focus healthy Humoral response humoral responses IgA antibodies IgA antibody IgG IgG antibodies IgG antibody Infection investigated Longitudinal studies longitudinal study Mild Mild disease mild SARS-CoV-2 infection mild symptoms Multiplex assay neutralization activity Neutralizing activity no decrease nucleocapsid outbreak participant polyclonal Population positive positive correlation Protein RBD recruit remained reported respiratory Respiratory illness response S protein S proteins SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 spike sera serological response significantly spring tested young adults zoonotic [DOI] 10.3389/fimmu.2021.681586 PMC 바로가기 [Article Type] Immunology