analogue – Page 4 – Communicable Diseases Research

Addressing the ‘hypoxia paradox’ in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues

Review

Published on 2021-09-262022-10-30
Journal: Molecular Medicine [Category] COVID-19, SARS,

The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants

Antiviral Agents

Published on 2021-09-202022-10-27
Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19,

[키워드] ACE2 activity addition analogue Angiotensin-converting enzyme Antiviral Antiviral agents B.1.1.7 B.1.351 binding Compound Concentration coronavirus COVID-19 Cytopathic effect cytotoxicity effective effective inhibitor example expressing Host identify in vitro Infectious virus inhibited inhibitor inhibitory concentration interfere natural natural products pandemic pseudovirus pseudovirus assay RBD receptor Receptor binding domain reduction Remdesivir Replication reporter resveratrol SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 variant screened selective small molecule stilbenoid stilbenoids USA-WA1/2020 Vaccine variant variants of concern Vero-E6 cell viral entry viral spike
[DOI] 10.1128/AAC.00772-21 PMC 바로가기 [Article Type] Antiviral Agents

The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants

Antiviral Agents

Published on 2021-09-202022-10-27
Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, MERS, SARS,

[키워드] ACE2 activity addition analogue Angiotensin-converting enzyme Antiviral Antiviral agents B.1.1.7 B.1.351 binding Compound Concentration coronavirus COVID-19 Cytopathic effect cytotoxicity effective effective inhibitor example expressing Host identify in vitro Infectious virus inhibited inhibitor inhibitory concentration interfere natural natural products pandemic pseudovirus pseudovirus assay RBD receptor Receptor binding domain reduction Remdesivir Replication reporter resveratrol SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 variant screened selective small molecule stilbenoid stilbenoids USA-WA1/2020 Vaccine variant variants of concern Vero-E6 cell viral entry viral spike
[DOI] 10.1128/AAC.00772-21 PMC 바로가기 [Article Type] Antiviral Agents

The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants

천연 stilbenoid (-)-Hopeaphenol은 SARS-COV-2 USA-WA1/2020, B.1.1.7 및 B.1.351 변이체의 세포 진입을 억제합니다.

Antiviral Agents

Published on 2021-09-202022-09-10
Journal: Antimicrobial Agents and Chemotherapy [Category] 변종,

[키워드] ACE2 ACE2 binding activities activity addition Alpha analogue angiotensin Angiotensin-converting enzyme Antiviral Antiviral agents B.1.1.7 B.1.351 Beta binding Compound Concentration coronavirus COVID-19 Cytopathic effect cytotoxicity effective effective inhibitor example expressing Host identify in vitro Infectious virus inhibited inhibitor inhibitory concentration interfere natural natural products pandemic pseudovirus pseudovirus assay pseudovirus assays RBD receptor Receptor binding domain reduction Remdesivir Replication reporter resveratrol SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 variant screened selective selectivity index small molecule Small molecules stilbenoid stilbenoids USA-WA1/2020 Vaccine variant variants of concern Vero-E6 cell Vero-E6 cells Viral viral entry viral spike VSVΔG
[DOI] 10.1128/AAC.00772-21 PMC 바로가기 [Article Type] Antiviral Agents

Improved Synthesis of a Cyclic Glutamine Analogue Used in Antiviral Agents Targeting 3C and 3CL Proteases Including SARS-CoV-2 M pro

SARS-CoV-2 M pro를 포함한 3C 및 3CL 프로테아제를 표적으로 하는 항바이러스제에 사용되는 고리형 글루타민 유사체의 향상된 합성

Article

Published on 2021-09-172022-09-11
Journal: The Journal of organic chemistry [Category] SARS, 치료제,

[키워드] 3CL agent Alanine Amino acid analogue Antiviral Compound conditions cyclic form Glutamine Improved Including lack M pro methodology oxime preparation Protease inhibitor purification reagent SARS-CoV-2 synthesis targeting yielding
[DOI] 10.1021/acs.joc.1c01299 PMC 바로가기 [Article Type] Article

Inhaled prostacyclin analogues in COVID-19 associated acute respiratory distress syndrome: scientific rationale

Commentary

Published on 2021-09-162022-10-31
Journal: The Egyptian Heart Journal [Category] COVID-19,

Bioguided Isolation of Cyclopenin Analogues as Potential SARS-CoV-2 M pro Inhibitors from Penicillium citrinum TDPEF34

Article

Published on 2021-09-152022-10-28
Journal: Biomolecules [Category] COVID-19, SARS,

Therapeutic Potential of Annexins in Sepsis and COVID-19

Pharmacology

Published on 2021-09-092022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] adaptive analogue animal model Annexin annexin (A1, A2 and A5) Anti-inflammatory caused Cell cell membrane clinical trial Coagulation condition COVID-19 demonstrated disease Effect Efficacy healthcare Human Immunity IMPROVE Inflammation Inflammatory inflammatory mediator inhibit investigated involved Ischemia ischemic injury mechanism modulation mortality rate MOST Myocardial infarction organ function outcome pathophysiology Patient peptide phagocytosis physiological platelet activation positive Potential potential therapies potential therapy Prevalence PROTECT Protective reduce reduce mortality reperfusion injury Research Safety SARS-COV-2 infection Sepsis severe COVID-19 patients shielding Support systemic effects therapeutic agent Treatment
[DOI] 10.3389/fphar.2021.735472 PMC 바로가기 [Article Type] Pharmacology

Targeting virus-host interaction by novel pyrimidine derivative: an in silico approach towards discovery of potential drug against COVID-19

새로운 피리 미딘 유도체에 의한 바이러스-호스트 상호 작용 표적 : Covid-19에 대한 잠재적 약물의 발견을 향한 실리코 접근법

Article

Published on 2021-09-012022-08-31
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제,

[키워드] abundantly expressed acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analogue angiotensin angiotensin-converting enzyme-2 appear applied bind binding binding free energy binding free energy calculation binding site Cell cell surface receptor cell tropism characterized complex condition coronavirus coronavirus disease coronavirus disease-2019 COVID-19 derivative disrupt drug candidate drug target effective inhibitor free energy globe group hACE2 host cell host cells human Angiotensin-converting enzyme human population identify in silico Approach in vitro in vivo Infection inhibitor Interaction interface internalization lung tissues molecular molecular docking molecular dynamics molecules Pathogenesis phenol primary determinant pyrimidine pyrimidine derivatives receptor respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus spike glycoprotein Spread surface receptor targeting therapeutic virion virus virus entry
[DOI] 10.1080/07391102.2020.1794969 PMC 바로가기 [Article Type] Article

Coronavirus disease 2019 in patients with neuroendocrine neoplasms: Preliminary results of the INTENSIVE study

Observational Study

Published on 2021-09-012022-10-05
Journal: European journal of cancer (Oxford, England : 1990 [Category] 임상,