Drug-repurposing against COVID-19 by targeting a key signaling pathway: An in silico study주요 신호 경로를 표적으로하여 COVID-19에 대한 약물 보장 : In Silico StudyArticle Published on 2021-10-012022-08-31 Journal: Medical Hypotheses [Category] MERS, SARS, 신약개발, 치료제, [키워드] accumulated AKT1 AKT1-HSP90AB1-BCL2 Akti-1/2-HSP990-S55746 alleviate anti-inflammatory effect Anti-inflammatory effects BCl2 concerning COVID-19 COVID-19 symptom COVID-19 symptoms element Estrogen Estrogen signaling pathway. Hsp90 HSP90AB1 Human in silico Infection information lung cells pathway Pathways plethora provide PubChem retrieved S55746 Signaling signaling pathway suggested target targets the strongest Transmission [DOI] 10.1016/j.mehy.2021.110656 PMC 바로가기 [Article Type] Article
Evaluation of the prophylactic effect of hydroxychloroquine on people in close-contact with patients with COVID-19Research article Published on 2021-10-012022-10-05 Journal: Pulmonary pharmacology & therapeutics [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory distress age Anti-inflammatory effects attack caused clinical examination close contact Contact control group coronavirus coronavirus disease COVID-19 disease evaluate evaluated FIVE Follow-up had no HCQ Hydroxychloroquine in vitro study individual Laboratory laboratory data lung tissue manifestation Mortality nasal swab pandemic participant patient with COVID-19 patients with COVID-19 polymerase chain positive Prophylactic reported Result Sex Side effect Side effects syndrome underlying disorders were excluded [DOI] 10.1016/j.pupt.2021.102069 [Article Type] Research article
Pimenta dioica (L.) Merr. Bioactive Constituents Exert Anti-SARS-CoV-2 and Anti-Inflammatory Activities: Molecular Docking and Dynamics, In Vitro, and In Vivo Studies피 멘타 디오카 (L.) 메르.생물 활성 성분은 항 -SARS-COV-2 및 항 염증 활성을 발휘합니다 : 분자 도킹 및 역학, 시험 관내 및 생체 내 연구Article Published on 2021-09-272022-08-31 Journal: Molecules [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Pimenta Acetate acute respiratory distress anti-inflammatory agent anti-inflammatory agents anti-inflammatory effect Anti-inflammatory effects anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Anti-viral chloride chlorogenic acid Clinical studies clinical study Combination Compound compounds Constituent coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patients Critical cytokine cytotoxicity docking and dynamics simulations Dynamics Effect ethyl acetate Evidence expression ferulic acid G-CSF gallic acid Genetic IL-10 IL-1β IL-2 Immunological response in vitro and in vivo studies Infection inhibitory concentration isolate lead life-threatening lung management mechanism of action mercuric chloride miRNA molecular docking MPro patients with COVID-19 performed RATs respiratory distress rutin SARS-CoV-2 SARS-CoV-2 main protease tested TNF-α Toxicity Treatment Viral viral infection were recorded [DOI] 10.3390/molecules26195844 PMC 바로가기 [Article Type] Article
Immunomodulatory Role of Nutrients: How Can Pulmonary Dysfunctions Improve?Nutrition Published on 2021-09-072022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] activating acute respiratory syndrome addition Affect allergies Anti-inflammatory Anti-inflammatory effects antioxidant antiviral role Asthma Can can be used changes chronic disease chronic inflammatory disease chronic inflammatory diseases chronic lung diseases chronic obstructive Complication Compound contribute COPD coronavirus COVID-19 decrease deficiency Diseases Effect Epigenetic Factor fatty acids HDAC Health Health status help homeostasis immune response immune system IMPROVE in vitro Infection infections Inflammatory response influence inhibit involved lower risk lung Lung function lung health mechanism microbiota mineral Modification modulate Nutrients nutrition Pathogens Patient patients Perspective progression proinflammatory cytokines promote pulmonary pulmonary chronic diseases pulmonary complication pulmonary disease pulmonary viral reducing Regulatory risk role SARS-CoV-2 SARS-COV-2 infection severe disease shown substrate Transcription Treatment viral infections viral replication Vitamin vitamins [DOI] 10.3389/fnut.2021.674258 PMC 바로가기 [Article Type] Nutrition
A Novel Bifunctional Fusion Protein, Vunakizumab-IL22, for Protection Against Pulmonary Immune Injury Caused by Influenza VirusOriginal Research Published on 2021-08-242023-06-08 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] Anti-inflammatory effects bifunctional fusion protein H1N1 influenza A virus IL-17A IL-22 Lung injury tissue repair [DOI] 10.3389/fimmu.2021.727941 PMC 바로가기 [Article Type] Original Research
Antcins from Antrodia cinnamomea and Antrodia salmonea Inhibit Angiotensin-Converting Enzyme 2 (ACE2) in Epithelial Cells: Can Be Potential Candidates for the Development of SARS-CoV-2 Prophylactic AgentsBrief Report Published on 2021-08-232022-10-28 Journal: Plants [Category] COVID-19, [키워드] Antrodia salmonea ACE2 activities acute respiratory syndrome agent antcin Anti-inflammatory effects Antrodia cinnamomea Can candidate caused characterized Compound control group coronavirus COVID-19 development disease onset Endemic enzyme global public health host cell human epithelial cells inhibited inhibitory effect investigated pandemic pharmacological Potential Prevent receptor required SARS-CoV-2 SARS-CoV-2 host cell significantly Support Treatment [DOI] 10.3390/plants10081736 PMC 바로가기 [Article Type] Brief Report
Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and AgeusiaReview Published on 2021-08-182022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] Ageusia Anosmia Anti-inflammatory Anti-inflammatory effects anti-viral effects can be used clinical settings Combination Compound compounds coronavirus COVID-19 develop diets disease essential oils expand IMPROVE Inflammatory less olfactory sense outbreak phytochemical phytochemicals plant SARS-CoV-2 selected shown Smell smell training Symptom taste training the SARS-CoV-2 unique worldwide pandemic [DOI] 10.3390/ijms22168912 PMC 바로가기 [Article Type] Review
A bilirubin-derived nanomedicine attenuates the pathological cascade of pulmonary fibrosis빌리루빈 유래 나노의약은 폐 섬유증의 병리학적 캐스케이드를 약화시킵니다Article Published on 2021-08-012022-09-11 Journal: Biomaterials [Category] SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome Anti-inflammatory Anti-inflammatory effects antioxidant antioxidants Antioxidative ARDS attenuate bile acid Bilirubin Bilirubin nanoparticles Biomarkers Bleomycin blood circulation cascade caused Clinical sign Clinical signs COVID-19 COVID-19 infection disease fibrosis histological Immune cell immune cells incidence life-threatening mice nanomedicine outbreak oxidative damage pulmonary pulmonary fibrosis reduce respiratory distress SARS-CoV-2 SARS-COV-2 infection shown syndrome the disease therapeutic options therapeutic potential [DOI] 10.1016/j.biomaterials.2021.120986 PMC 바로가기 [Article Type] Article
Could pulmonary low-dose radiation therapy be an alternative treatment for patients with COVID-19 pneumonia? Preliminary results of a multicenter SEOR-GICOR nonrandomized prospective trial (IPACOVID trial)폐 저용량 방사선 요법이 COVID-19 폐렴 환자에게 대안 치료가 될 수 있습니까?다기관 지구-지정기 비 랜덤 화 전망 시험의 예비 결과 (Ipacovid 시험)Clinical Trial Published on 2021-07-062022-08-13 Journal: Strahlentherapie Und Onkologie [Category] MERS, SARS, 임상, [키워드] Admission adverse effect adverse effects age Anti-inflammatory effects appear arterial oxygen partial pressure bilateral pulmonary infiltrate bilateral pulmonary infiltrates candidate Chest Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia criteria CT scan Dexamethasone dose Efficacy and safety Endpoint enrolled evaluate evaluated fractional inspired oxygen Hospitalization intensive care intensive care unit interstitial pneumonia irradiation low-dose Low-dose radiation therapy lung lung involvement Lung irradiation material men multicenter nonrandomized oxygen oxygen partial pressure PaO parameter partial pressure Patient patients with COVID-19 Pneumonia primary endpoint Prospective trial pulse oximetry Radiation radiation therapy radiation treatment reported respiratory Result Safe supplementary material systemic inflammatory those who survived Treatment Treatment outcome Trial was increased with COVID-19 women [DOI] 10.1007/s00066-021-01803-3 PMC 바로가기 [Article Type] Clinical Trial
Comparative Anti-Inflammatory Effects of Salix Cortex Extracts and Acetylsalicylic Acid in SARS-CoV-2 Peptide and LPS-Activated Human In Vitro SystemsSARS-COV-2 펩티드 및 LPS- 활성화 된 인간 시험 관내 시스템에서 살릭 피질 추출물 및 아세틸 살리실산의 비교 항 염증 효과Comparative Study Published on 2021-06-232022-08-31 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 치료제, [키워드] Salix species Acetylsalicylic acid acetylsalicylic acid (ASA) acid activated Anti-inflammatory anti-inflammatory drug Anti-inflammatory drugs Anti-inflammatory effects anti-inflammatory treatment Cell cells co-culture Comparative compounds cortex COVID-19 patient Culture cytokine Cytokines Effect Efficacy enzyme activity Extract Fever Human human body human PBMC IL-10 IL-1β IL-6 IMPROVE in vitro in vitro data Inflammation Inflammatory ingredient intestinal liver cell LPS-activated mediator metabolism outcome Pain PBMCs peptide peptides PGE PGE2 precursor prostaglandin prostaglandin E2 protein expression retained salicin salicylic acid SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides suppressed suppression System therapy Willow willow bark [DOI] 10.3390/ijms22136766 PMC 바로가기 [Article Type] Comparative Study