cysteine protease – Page 4 – Communicable Diseases Research

Prioritisation of Compounds for 3CL pro Inhibitor Development on SARS-CoV-2 Variants

Article

Published on 2021-05-182022-10-30
Journal: Molecules [Category] COVID-19, SARS,

Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 Scaffold

Pharmacology

Published on 2021-05-132022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

Re I Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease

SARS-CoV-2 주요 시스테인 프로테아제에 대한 배위 공유 억제제로서의 Re I 트리카보닐 복합체

Article

Published on 2021-05-032022-09-11
Journal: Angewandte Chemie (International ed. in English) [Category] SARS, 치료제,

Targeting SARS-CoV-2: a systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2′-O-ribose methyltransferase

SARS-CoV-2 표적화: 3C-유사 프로테이나제 및 2'-O-리보스 메틸트랜스퍼라제에 대한 유망한 억제제를 식별하기 위한 체계적인 약물 용도 변경 접근법

Article

Published on 2021-05-012022-08-31
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발,

[키워드] 2′-O-ribose methyltransferase 3C-like proteinase 3CLpro active site antiviral drugs approach bictegravir binding candidate computational analysis contagious Coronaviridae family cysteine cysteine protease docking dolutegravir drug Drug repurposing drug target free energy functional host immune system house identify imperative inhibitor interacting residues lead life cycle MD simulation methyltransferase mRNA nucleotide number of infected Orientation pandemic parameter paritaprevir physiological state Protein protein-drug complex protein-drug complexes proteinase Proteins proteolysis raltegravir replicase polyprotein replicase polyproteins responsible resulting ribose SARS-CoV-2 screened selected targeting targets the Coronaviridae therapeutic drug Viral viral life cycle Virtual screening virus
[DOI] 10.1080/07391102.2020.1753577 PMC 바로가기 [Article Type] Article

Targeting SARS-CoV-2 viral proteases as a therapeutic strategy to treat COVID-19

COVID-19를 치료하기 위한 치료 전략으로 SARS-CoV-2 바이러스 프로테아제 표적화

Review

Published on 2021-05-012022-09-11
Journal: Journal of medical virology [Category] SARS, 치료제,

[키워드] 3 chymotrypsin-like cysteine protease 3CL pro acute respiratory syndrome Amino acid caused chymotrypsin coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus main protease COVID-19 COVID-19 infection CoVs cysteine cysteine protease death Epidemic Infection information MERS Middle East Middle East respiratory syndrome outbreak Papain papain-like cysteine protease. Papain-like protease protease Protein SARS Coronavirus SARS infection SARS-CoV SARS-CoV-2 SARS-CoV-2 viral Severe acute respiratory syndrome similarity Spread Support syndrome targeting the United State Therapeutic molecule therapeutic molecules therapeutic strategy treat treatment strategy United States Viral proteins virus
[DOI] 10.1002/jmv.26814 PMC 바로가기 [Article Type] Review

Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening

공유 도킹 기반 가상 스크리닝을 통한 SARS-CoV-2 주요 프로테아제 억제제의 선도적 발견

Article

Published on 2021-04-262022-09-11
Journal: Journal of Chemical Information and Modeling [Category] SARS, 치료제,

[키워드] acting acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approval candidate characterized chymotrypsin Clinical data coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cure cysteine cysteine protease database docking drug Economy effective drug effective drugs effort EMA enzyme European Medicines Agency FDA food Health house identify in silico inhibitor Ligand M pro Michael pandemic peptide predict predictive power risk SARS-CoV-2 Screening severe acute respiratory syndrome Coronavirus target protein the SARS-CoV-2 treat Vaccine Virtual screening
[DOI] 10.1021/acs.jcim.1c00184 PMC 바로가기 [Article Type] Article

SARS-CoV-2 M pro : A Potential Target for Peptidomimetics and Small-Molecule Inhibitors

SARS-CoV-2 M pro : 펩티드모방체 및 소분자 억제제의 잠재적 표적

Review

Published on 2021-04-192022-09-10
Journal: Biomolecules [Category] MERS, SARS, 변종, 신약개발, 치료제,

[키워드] Administered Analysis approved Candidates catalytic activity caused clinical complication compounds coronavirus COVID-19 COVID-19 pandemic cysteine cysteine protease debate drug drugs Ebola effective vaccine Efficacy and safety evaluated event FDA HCV Health Impact Infection inhibitor inhibitors interactions interruption Intervention limitation M pro mutate New coronavirus new coronavirus SARS-CoV-2 offer parasite peptidomimetics Potential Prevent priority protease protease inhibitors recommendation Remdesivir Replication Repurposed drug Repurposed drugs repurposing responsible SARS-CoV-2 SARS-CoV-2 M^pro SARS-CoV-2 variant SARS-CoV-2 variants social distancing Spread target Treatment treatment of COVID-19 treatment of HIV Viral viral infection viral replication while WHO’ world population
[DOI] 10.3390/biom11040607 PMC 바로가기 [Article Type] Review

The Use of In Silico Tools for the Toxicity Prediction of Potential Inhibitors of SARS-CoV-2

SARS-CoV-2의 잠재적 억제제의 독성 예측을 위한 In Silico 도구의 사용

Article

Published on 2021-04-122022-09-10
Journal: Alternatives to Laboratory Animals [Category] MERS, 신약개발, 치료법, 치료제,

[키워드] in silico toxicology adverse effects approval assist carcinogenicity Cardiotoxicity chymotrypsin Compound compounds computational toxicology Consensus Convalescent plasma therapy coronavirus coronavirus disease COVID-19 cysteine cysteine protease drug Drug development effort Endpoint exhibited hepatotoxicity in silico inhibitor inhibitors lead limitations Mutagenicity nucleocapsid protein positive Potential predict predicted prediction profiles protease Regulatory reported Repurposed drugs repurposing SARS-CoV-2 severe adverse effect silico studies therapeutic intervention Toxicity toxicity prediction were assessed were used
[DOI] 10.1177/02611929211008196 PMC 바로가기 [Article Type] Article

Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach

COVID-19의 그럴듯한 치료를 위한 SARS-CoV-2에 대한 다중 표적 제제로서 천연 폴리페놀 카테킨 식별: 통합 컴퓨터 접근

Article

Published on 2021-03-222022-09-11
Journal: Briefings in Bioinformatics [Category] SARS, 치료법,

[키워드] 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin anti-SARS-CoV-2 antiviral drug antiviral drugs approach binding affinity binding free energy binding pocket catechin cathepsin L caused chymotrypsin claimed coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infection COVID-19 CTSL cysteine cysteine protease determined by development Disease progression drug enzyme free energy free energy landscape global pandemic glycoprotein hACE2 Host human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrophobic hydrophobic interactions identify identifying interactions involved molecular molecular dynamics Molecular dynamics simulation molecular interaction multi-targeted drug. non-structural protein NSP6 nucleocapsid protein pandemic Proteins RBD RdRP Replication RNA-dependent RNA polymerase S protein SARS-CoV-2 SARS-CoV-2 proteins Seven severe acute respiratory syndrome Coronavirus target protein target proteins the SARS-CoV-2 therapy Transmission Vaccine viral-host interaction Virtual screening virus
[DOI] 10.1093/bib/bbaa378 PMC 바로가기 [Article Type] Article

Plant Products as Inhibitors of Coronavirus 3CL Protease

Pharmacology

Published on 2021-03-092022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,