effector

[키워드] (+) ssRNA virus, positive-sense single-stranded RNA virus (+) ssRNA viruspositive-sense single-stranded RNA virus a one-hour low-cost multipurpose highly efficient system ABACAS AIOD-CRISPR, all-in-one dual CRISPR-Cas12a AIOD-CRISPRall-in-one dual CRISPR-Cas12a all-in-one dual CRISPR-Cas12a Antiviral antivirals approach Cas3-operated nucleic acid detection caused clustered regularly interspaced short palindromic repeats combating complementary component CONAN, Cas3-operated nucleic acid detection CONANCas3-operated nucleic acid detection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19, Coronavirus disease 2019 COVID-19coronavirus disease 2019 CRISPR CRISPR and CRISPR-associated proteins CRISPR RNAs CRISPR-Cas system CRISPR-Cas, CRISPR and CRISPR-associated proteins CRISPR-CasCRISPR and CRISPR-associated proteins CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats CRISPR/Cas12a-based-detection with naked eye readout CRISPR/Cas12a-NER, CRISPR/Cas12a-based-detection with naked eye readout CRISPR/Cas12a-NERCRISPR/Cas12a-based-detection with naked eye readout CRISPRclustered regularly interspaced short palindromic repeats crRNAs, CRISPR RNAs crRNAsCRISPR RNAs death Degradation DETECTR DETECTR, DNA endonuclease-targeted CRISPR trans reporter DETECTRDNA endonuclease-targeted CRISPR trans reporter Diagnosis diagnostic diagnostics direct repeat disease Diseases DNA DNA double-strand break DNA endonuclease-targeted CRISPR trans reporter DR, direct repeat DRdirect repeat DSB, DNA double-strand break DSBDNA double-strand break effector enzyme genomes GFP, green fluorescent protein GFPgreen fluorescent protein green fluorescent protein highlight HOLMES, a one-hour low-cost multipurpose highly efficient system HOLMESa one-hour low-cost multipurpose highly efficient system in vivo Infectious disease knockdown MFE, minimum free energy MFEminimum free energy minimum free energy NLS, nuclear localization sequence NLSnuclear localization sequence novel nuclear localization sequence outbreak PAC-MAN PAC-MAN, prophylactic antiviral crispr in human cells PAC-MANprophylactic antiviral crispr in human cells PAM, protospacer adjacent motif PAMprotospacer adjacent motif pathogenicity platform point of care Positive-sense single-stranded RNA virus prophylactic antiviral crispr in human cells Protein protospacer adjacent motif replication-transcription complex respiratory reverse transcription simultaneous with isothermal amplification by using loop-mediated amplification RNA RNA virus robust RT-LAMP, reverse transcription simultaneous with isothermal amplification by using loop-mediated amplification RT-LAMPreverse transcription simultaneous with isothermal amplification by using loop-mediated amplification RTC, replication-transcription complex RTCreplication-transcription complex SARS-CoV-2 SARS-CoV-2-infected cells SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2severe acute respiratory syndrome coronavirus 2 selective severe acute respiratory syndrome coronavirus 2 SHERLOCK SHERLOCK, specific high sensitive enzymatic reporter unlocking SHERLOCKspecific high sensitive enzymatic reporter unlocking single-stranded single-stranded RNA virus Single-stranded RNA viruses specific high sensitive enzymatic reporter unlocking ssRNA ssRNA viruses, single-stranded RNA viruses ssRNA virusessingle-stranded RNA viruses the SARS-CoV-2 therapeutic Therapeutic approach therapy Treatment Type virus viruses widespread
[DOI] 10.1016/j.virusres.2020.198282 PMC 바로가기 [Article Type] Review