Assessment of Growth Factors, Cytokines, and Cellular Markers in Saliva of Patients with Trigeminal NeuralgiaArticle Published on 2021-05-172024-09-02 Journal: Molecules [Category] 대상포진, [키워드] Cytokines Growth factors salivary biomarkers trigeminal neuralgia [DOI] 10.3390/molecules26102964 PMC 바로가기 [Article Type] Article
Pulmonary Procoagulant and Innate Immune Responses in Critically Ill COVID-19 Patients중환자 COVID-19 환자의 폐 응고 촉진제 및 선천성 면역 반응Clinical Trial Published on 2021-05-142022-09-12 Journal: Frontiers in Immunology [Category] SARS, 임상, 진단, [키워드] activated Activation acute respiratory distress Antigen Biomarker bronchoalveolar Bronchoalveolar lavage fluid bronchoalveolar space C1-Inhibitor CD40 ligand chemokine Coagulation complement complexes COVID-19 COVID-19 patient Critically ill Cytokines declined domain evaluate FIVE Follow-up functional growth factor Growth factors healthy controls host response Ill implicated Inflammatory Inflammatory response inhibitor Innate innate immune response Local lung measurement mechanical ventilation mechanism objective P-selectin pathogenesis of COVID-19 pathway Patient patients patients with COVID-19 persistent ARDS plasma plasma sample procoagulant pulmonary rationale response Result severe COVID-19 significantly increased stratified syndrome systemic tissue type I ventilated patient were measured with COVID-19 [DOI] 10.3389/fimmu.2021.664209 PMC 바로가기 [Article Type] Clinical Trial
Plasma biomarker profiling of PIMS-TS, COVID-19 and SARS-CoV2 seropositive children – a cross-sectional observational study from southern India.PIMS-TS, COVID-19 및 SARS-CoV2 혈청양성 아동의 혈장 바이오마커 프로파일링 - 인도 남부의 횡단면 관찰 연구.Observational Study Published on 2021-04-022022-08-31 Journal: EBioMedicine [Category] MERS, 바이오마커, 유전자 메커니즘, 임상, [키워드] acute COVID-19 Analysis Biomarker Care CCL11 CCL19 CCL2 CCL20 CCL5 chemokine chemokines Chennai children Children's Hospital clinical phenotype clinical phenotypes conditions controls correlated country COVID-19 COVID-19 infection cross-sectional CRP CXCL10 cytokine Cytokine storm Cytokines elevated finding GM-CSF granzyme granzyme B growth factor Growth factors hospital Hyperinflammatory IFNα IFNβ IFNγ IL-1 IL-10 IL-15 IL-17A IL-1α IL-2 IL-33 IL-6 immune India Infection Inflammatory lymphocyte Lymphocyte count management MIS-C multiplex negative correlation paediatric inflammatory multisystem syndrome Pathogenesis performed PIMS PIMS-TS plasma biomarker positive correlation presenting pro-inflammatory cytokines SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 seropositive significantly sodium sodium levels syndrome TNFα trajectory unique VEGF [DOI] 10.1016/j.ebiom.2021.103317 PMC 바로가기 [Article Type] Observational Study
Interferons and other cytokines, genetics and beyond in COVID-19 and autoimmunityCOVID-19 및 자가면역에서의 인터페론 및 기타 사이토카인, 유전학 및 그 이상Review Published on 2021-04-012022-09-11 Journal: Cytokine & growth factor reviews [Category] 유전자 메커니즘, [키워드] Alpha antibodies antibody antiviral agent Antiviral agents autoantibodies autoantibody Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity B cell cascade Citrullination complement COVID-19 COVID-19 patient COVID-19: antibody cytokine Cytokines Degradation deletions develop Epitopes Extracellular gene defect Gene segment Genetic genetic defect genetic defects genetics glycosylation growth factor Growth factors hematological homozygous hypotheses immunological Immunological studies in vitro induce Infection innate immune interferon Interferon-beta interferons intracellular content intracellular protein intracellular proteins involved lupus erythematosus mechanism MOST neutralization Neutralizing Neutralizing antibodies neutralizing antibody Occurrence Patient POLE posttranslational modifications protease PROTECT proteolysis question regulated Release Research SARS-CoV-2 Seven severe COVID-19 severe inflammation Signaling systemic lupus erythematosus the SARS-CoV-2 Tolerance type 1 interferons virus virus infection virus replication [DOI] 10.1016/j.cytogfr.2021.01.004 PMC 바로가기 [Article Type] Review
Neuropsychiatric Symptoms of COVID-19 Explained by SARS-CoV-2 Proteins’ Mimicry of Human Protein InteractionsNeuroscience Published on 2021-03-232022-10-31 Journal: PeerJ [Category] COVID-19, [키워드] accumulating addition Analysis Autoimmune Autoimmune disorders binding cellular classification clinical symptom conducted coronavirus disease COVID-19 delirium Diseases elements Encephalitis Evidence explain Growth factors Host Human human protein human proteins in vitro study in vivo Inflammation Interaction mechanism methodology microbial mimicry mitochondrial molecular molecular functions Neuropsychiatric pathway Protein Protein Data Bank protein interaction protein-protein interaction Respiratory failure SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins Seizures stroke Structure supported Symptoms synaptic System target thrombosis Transport Vesicle viruses was used [DOI] 10.3389/fnhum.2021.656313 PMC 바로가기 [Article Type] Neuroscience
Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19COVID-19에서 호흡기 위험 증가를 나타낼 수 있는 비만 2형 당뇨병에서 대식세포 활성화 관련 바이오마커 식별Clinical Trial Published on 2021-03-192022-09-10 Journal: Scientific Reports [Category] 바이오마커, 임상, [키워드] activated Activation acute respiratory distress syndrome aptamer ARDS basal basal state baseline Biomarker CD163 CD38 CD80 change changed characterized chemokine chemokines clinical control subject control subjects Conventional COVID-19 CXCL1 CXCL10 CXCL5 CXCL9 cytokine Cytokines determine diabete diabetes Diabetic elevated Endocrine system and metabolic diseases endocrinology ENhance expression Glucose glycemia growth factor Growth factors Hyperactivation identification IFN-γ IL-13 IL-4 immune system individual Infection insulin insulin clamp M1/M2 macrophage M2 macrophage M2 macrophages Macrophage macrophage activation macrophages marker matrix metalloproteinase matrix metalloproteinases mediators MMP7 MMP9 Normalisation not altered obese obesity pilot study plasma Plasma levels plasma protein Protein RANTES registration date released respiratory respiratory distress Respiratory distress syndrome risk serum severity slow subject subjects surface proteins Trial type 2 diabete type 2 diabetes [DOI] 10.1038/s41598-021-85760-y PMC 바로가기 [Article Type] Clinical Trial
Platelet Lysate Nebulization Protocol for the Treatment of COVID-19 and Its Sequels: Proof of Concept and Scientific RationaleCOVID-19 및 그 후속작의 치료를 위한 혈소판 용해물 분무 프로토콜: 개념 증명 및 과학적 근거Article Published on 2021-02-122022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] absence acting acute respiratory distress acute respiratory distress syndrome administration Anti-inflammatory antifibrotic biological activity cell cultures clinical trials concept coronavirus disease Coronavirus disease 2019 COVID-19 Defense Effect effective Effects evaluate fibroblast growth factor Growth factors healthy donor healthy donors help immunomodulatory Inflammation lung lung disorder lung disorders Lung function lung tissue lysate modulating molecular nebulization nebulized pathology Platelet platelet lysate platelet-rich plasma Platelets proof protocol rationale respiratory respiratory disorder respiratory disorders respiratory distress resulting Structure syndrome the disease the patient therapeutic targets therapy Viral viral infections virus viruses [DOI] 10.3390/ijms22041856 PMC 바로가기 [Article Type] Article
Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sexCOVID-19의 사이토카인 방출 증후군: 선천성 면역, 혈관 및 혈소판 병원성 요인은 질병의 중증도와 성별이 다릅니다.Clinical Trial Published on 2021-01-012022-09-25 Journal: Journal of leukocyte biology [Category] SARS, 바이오마커, 임상, 진단, [키워드] Activation acute illness addition age Analysis analyzed association Biomarker CD40L Characteristics clinical feature Clinical features Cluster Cohort controls COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines disease disease pathology disease severity examined Factor females FGF fibroblast fibroblast growth factor growth Growth factors Health Health crisis highlight Hospitalized ICU admission identify IL-13 IL-4 immune immune response immune responses Immunopathogenesis Inflammatory cytokines Innate Innate immunity IP10 male pathogenic Patient PDGF Plasma cytokine Platelet platelet-derived growth factors Protein public health crisis risk severe disease Severity of disease Sex significant increases in syndrome Treatment understanding Vascular Vasculitis with COVID-19 [DOI] 10.1002/JLB.3COVA0820-410RRR PMC 바로가기 [Article Type] Clinical Trial
The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial중증 코로나19 환자에서 중간엽 줄기세포 치료의 체계적인 효과: 전향적 이중 대조 시험Controlled Clinical Trial Published on 2021-01-012022-09-11 Journal: Cell transplantation [Category] 유전자 메커니즘, 임상, [키워드] Analysis anti-inflammatory cytokine anti-inflammatory cytokines Apoptosis Biochemical parameters CD16 CD19 CD3 CD4 CD45 CD56 CD8 Cell cellular chemokines clinical manifestation clinical manifestations clinical trial Controlled COVID-19 COVID-19 patient COVID-19 patients Critical critical cases Critically ill critically ill COVID-19 patients critically ill patients CRP level CRP levels cytokine Cytokine storm Cytokines demonstrated died dose Effect evaluate evaluated fibrinogen group groups growth growth factor Growth factors HLA-DR IFNγ IL-10 IL-12 IL-13 IL-17A IL-1ra IL-2 IL-6 immunomodulatory effect immunomodulatory effects intravenously investigated KGF lymphocyte Lymphocyte subsets marker matrix metalloproteinases mechanism of action mesenchymal stem cell Mesenchymal stem cells moderate MSC MSCs Neutrophils NGF overall mortality Patient positive proinflammatory proinflammatory cytokines Prospective reducing mortality separated Serum ferritin significantly statistical STEM stem cell TGF-β the cytokine storm therapy tissue regeneration treated Treatment VEGF [DOI] 10.1177/09636897211024942 PMC 바로가기 [Article Type] Controlled Clinical Trial
The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing DiabetesReview Published on 2020-11-232022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] ACE2 Activation acute respiratory syndrome adhesion molecules caused chemokines coronavirus coronavirus disease COVID-19 diabete diabetes Diabetes Mellitus diabetic patient elevated expression finding furin Growth factors Hormones host cell implicated increased risk individual metabolic dysfunction Mortality osteopontin outcome pandemic phenotype Potential precursors Premature progression Protein Proteolytic processing receptors reducing mortality Replication reported role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient serum severity upregulation viral infection [DOI] 10.3390/cells9112528 PMC 바로가기 [Article Type] Review