Antiviral metabolite 3′-deoxy-3′,4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19항바이러스 대사 산물 3'-deoxy-3',4'-didehydro-cytidine은 혈청에서 검출 가능하며 COVID-19를 포함한 급성 바이러스 감염 식별Article Published on 2022-03-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] 95% CI acute infection acute viral infection Admission an area Antiviral AUC Bacterial Bacterial infection Bacterial infections Biomarker characteristic CMPK2 Cohort correlated COVID-19 Critical cytidine ddhC detectable Diagnosis diagnostic diagnostics emergency department enzyme Enzymes examined FIVE Gene Expression healthy controls High-resolution highlight identify implicated in viral in vivo independent inflammatory conditions interferon Liquid chromatography management marker mass spectrometry metabolite metabolome metabolomics NIHR pandemic Patient precursor Profiling receiver operating characteristic receiver operating characteristic curve responsible sera serum significantly small molecule Support transcripts validation cohort viperin Viral viral infection viral infections [DOI] 10.1016/j.medj.2022.01.009 PMC 바로가기 [Article Type] Article
On the single and multiple associations of COVID-19 post-acute sequelae: 6-month prospective cohort studyCOVID-19의 단일 및 다중 연관성에서 급성 후유증 : 6 개월 전망 코호트 연구Article Published on 2022-03-012022-09-01 Journal: Scientific Reports [Category] MERS, 진단, 치료기술, [키워드] assigned association Bilateral bronchiectasis Characteristics Chest CT cohort study Computed tomography conducted correlated COVID-19 COVID-19 patients diagnosing discharged Effect elderly patients fatigue Follow-up functional Gender ground-glass opacity High-resolution hospital Hospitalized imaging abnormality impairment induce Laboratory lung lung involvement lung lesions manuscript Medical research mental health Outcomes research Patient patients with COVID-19 predictor prospective cohort study Pulmonary function Respiratory signs and symptoms Risk factors robust Scientific data Spain statistically Statistics subpleural Symptom syndrome thromboembolic Thromboembolic event university variables viral infection X-ray [DOI] 10.1038/s41598-022-07433-8 PMC 바로가기 [Article Type] Article
Heat-related mortality amplified during the COVID-19 pandemicObservational Study Published on 2022-03-012022-10-05 Journal: International journal of biometeorology [Category] SARS, 임상, [키워드] addressed Admission amplification amplified cause caused changes in collected COVID-19 COVID-19 pandemic death excess expected expressed extreme fraction healthcare facility healthcare service Healthcare system Heatwaves High-resolution lockdown magnitude measure Mortality mortality data pandemic performed Portugal prevented Public public health reached reported shown statistical model temperature virus while [DOI] 10.1007/s00484-021-02192-z PMC 바로가기 [Article Type] Observational Study
Simulating COVID19 transmission from observed movementArticle Published on 2022-02-232022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] assumed average children Complex networks COVID-19 COVID-19 transmission COVID19 current directional High-resolution identification Infection infections Interaction interaction pattern interactions Metrics observation Patient physical predict Prophylactic proportion Psychology and behaviour radio reported risk Simulation symptomatic individuals Threats time lag Transmission Transmission dynamics Transmission model transmission rate vaccination Vaccinations viral infection [DOI] 10.1038/s41598-022-07043-4 PMC 바로가기 [Article Type] Article
Discovery of SARS-CoV-2 3CL Pro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein–Ligand InteractionsArticle Published on 2022-02-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), SARS, [키워드] 3CL accumulating acute respiratory syndrome anti-SARS-CoV-2 Antiviral assays binding energy breakthrough infections catalytic dyad cellular conserved coronavirus coronavirus disease covalent inhibitor drug candidate drug design dyad Efficacy effort etiological agent examined exhibited FIVE High-resolution histidine inhibitor inhibitors inhibitory Medicines molecular dynamics simulations molecule design Pro protease residue SARS-CoV-2 significantly structures Vaccine development Viral load viral replications [DOI] 10.3390/ijms23042392 PMC 바로가기 [Article Type] Article
ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in MenACE 및 ACE2 유전자 변이는 남성의 심각한 COVID-19 결과와 관련이 있습니다Immunology Published on 2022-02-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] 95%CI ACE ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted affecting age association clinical manifestation clinical manifestations Clinical manifestations of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Critical Critical illness death develop diabetes diagnosed died disease severity DNA evaluated explain Factor genetic background Genetic variant genetic variants Genomic DNA Genotype genotyped High-resolution Host hypertension IMPROVE individual insertion/deletion involved Logistic regression analysis male men Mild obesity Odds ratio outcome outcomes oxygen oxygen supplementation pandemic Peripheral blood polymorphism Polymorphisms probes respiratory respond responsible reverse transcription PCR risk factor rs2285666 RT-PCR Saliva SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity severity of COVID-19 Sex single-nucleotide single-nucleotide polymorphism SNP study population T allele TaqMan type 2 diabetes Variability variant [DOI] 10.3389/fimmu.2022.812940 PMC 바로가기 [Article Type] Immunology
Identification of milk from different animal and plant sources by desorption electrospray ionisation high-resolution mass spectrometry (DESI-MS)Article Published on 2022-02-112022-10-04 Journal: NPJ Science of Food [Category] 바이오마커, [키워드] absence Accuracy analysed Analysis approach Authenticity Biomarker complex cow detect feature FIVE High-resolution identification linear marker mass spectrometry methodology sensitivity Small molecules unique [DOI] 10.1038/s41538-022-00129-3 PMC 바로가기 [Article Type] Article
A Lateral Flow Immunoassay Coupled with a Spectrum-Based Reader for SARS-CoV-2 Neutralizing Antibody DetectionArticle Published on 2022-02-102022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Accuracy acute respiratory syndrome addition approach approaches AstraZeneca caused collected coronavirus coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 antibody COVID-19-related death demonstrated detect detection detection rate diagnoses diagnosing Diagnosis diagnostic effective enzyme-linked immunosorbent exhibited feasible Flow high correlation High-resolution Infection Lateral lateral flow immunoassay limitation mild case Negative predictive value neutralizing antibody Patient patients plasma sample polymerase chain Positive predictive value protocols ROC Curve SARS-CoV-2 SARS-COV-2 infection sensitivity Serological assay serum sample Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) severe cases shown specificity Stage tested the disease [DOI] 10.3390/vaccines10020271 PMC 바로가기 [Article Type] Article
Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profilingArticle Published on 2022-02-092022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Accuracy Algorithm applied Autoimmune disease basophils Blood Cancer Cell cells cellular change complex datasets disease DNA DNA methylation DNA methylation level enhanced eosinophils Epigenetics in immune cells estimate expand facilitate flow cytometry Health High-resolution identify Immune profile immune profiling immune-cell include Including leukocyte memory memory B cells Microarray Microarrays Monocytes naïve natural killer Neutrophils Peripheral blood predict profile provide subtype T regulatory cells tissues Translational research variables was used [DOI] 10.1038/s41467-021-27864-7 PMC 바로가기 [Article Type] Article
Three Month Follow-Up of Patients With COVID-19 Pneumonia Complicated by Pulmonary EmbolismMolecular Biosciences Published on 2022-02-032022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] 6MWT abnormality addition adult COVID-19 patient carried chronic lung disease clinical history complication of COVID-19 Computed tomography conducted COVID - 19 COVID-19 COVID-19 patient demonstrated Diagnosis diffusion capacity DLCO Dyspnoea Embolism evaluated Exercise capacity feature Follow-up functional consequence High-resolution HRCT impairment KCO lung Lung function mMRC Month Patient Pneumonia predicted previous study pulmonary pulmonary angiography Pulmonary embolism Pulmonary function Pulmonary function test Respiratory function retrospective significant difference significantly lower six minute walk test spirometry subject the patient those without PE were excluded [DOI] 10.3389/fmolb.2021.809186 PMC 바로가기 [Article Type] Molecular Biosciences