A Novel Quantitative Multi-Component Serological Assay for SARS-CoV-2 Vaccine EvaluationSARS-CoV-2 백신 평가를 위한 새로운 정량적 다성분 혈청학적 분석Article Published on 2022-03-152022-09-11 Journal: Analytical Chemistry [Category] MERS, SARS, 진단, 치료법, [키워드] Accuracy Algorithm Analysis anti-SARS-CoV-2 array assays carried clinical trials conditions COVID-19 exposure times fluorescent generate house humoral Humoral response IgA IgG IgM Immunoglobulin immunoglobulins International international standard linear linearity methodology Microarray naïve normalized novel Nucleocapsid proteins positive Precision q-RT-PCR qRT-PCR quantitation Quantitative Receptor binding domain Result SARS-CoV-2 SARS-CoV-2 patients SARS-CoV-2 spike SARS-CoV-2 vaccines sera seroconverted serum Specific specificity the microarray the SARS-CoV-2 the WHO unique Vaccine [DOI] 10.1021/acs.analchem.1c05264 PMC 바로가기 [Article Type] Article
Seroprevalence of COVID-19 infection among vaccine naïve population after the second surge (June 2020) in a rural district of South India: A community-based cross-sectional study남인도 농촌 지역에서 두 번째 급증(2020년 6월) 후 백신 경험이 없는 인구 사이에서 COVID-19 감염의 혈청 유병률: 지역 사회 기반 횡단면 연구Research Article Published on 2022-03-102022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] 95% CI adjusted antibody conducted COVID-19 COVID-19 infection cross-sectional cross-sectional study determine District effort Elecsy family member FIVE Health herd immunity house IFR IgG IgM Immunity Infection naïve objective past population density positive COVID-19 presence of antibody Prevalence Protein Randomly Rate RBD Receptor-binding domain recruited relief Result Roche Rural health SARS CoV SARS CoV-2 SARS-CoV-2 self Seropositivity Seroprevalence Serosurvey significantly South south India Symptom tested the receptor-binding domain thought Vaccine [DOI] 10.1371/journal.pone.0265236 PMC 바로가기 [Article Type] Research Article
Detection of anti-Histoplasma capsulatum antibodies and seroconversion patterns in critically ill patients with COVID-19: An underdiagnosed fungal entity complicating COVID-19?COVID-19에 감염된 중환자에서 항히스토플라스마 캡슐화 항체 및 혈청전환 패턴의 검출: COVID-19를 복잡하게 만드는 과소 진단된 곰팡이 개체?Article Published on 2022-03-042022-09-11 Journal: Medical mycology [Category] MERS, SARS, 진단, 치료기술, [키워드] AIDS analyzed antibody Antibody titer Antibody titers Awareness baseline Bearing Buenos Aire Buenos Aires candidiasis classical clinician Co-infection COVID-19 pneumonia COVID-19-associated mycoses Critically ill Critically ill patient critically ill patients death detection Diagnosis died Endemic endemic area endemicity evaluated FIVE fungal fungal disease fungal infections fungus help Histoplasma Histoplasma capsulatum Histoplasmosis HIV/AIDS Hospitalized house ICU IgG antibodies IgG antibody in-house ELISA increased risk infections invasive Invasive pulmonary aspergillosis mind morbidity morbidity and mortality Mycoses Patient positive Prevent pulmonary aspergillosis reduce respiratory Respiratory failure Respiratory function risk risk factor SARS-CoV-2 Sepsis sera Seroconversion seronegative seropositive serum sample serum samples severe COVID-19 Severe COVID-19 pneumonia severe respiratory failure specific IgG antibodies Treatment with COVID-19 worsening [DOI] 10.1093/mmy/myac012 PMC 바로가기 [Article Type] Article
A thermostable Cas12b from Brevibacillus leverages one-pot discrimination of SARS-CoV-2 variants of concernBrevibacillus의 열안정성 Cas12b는 우려되는 SARS-CoV-2 변이체의 원팟 식별을 활용합니다.Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] SARS, 변종, 치료기술, [키워드] Accuracy activity Alicyclobacillus Alpha amplification applied B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Breast Breast cancer Cas12b center clinical samples college Complete Control COVID-19 CRISPR Ct value current Delta detection system diagnostics differential scanning fluorimetry disease control dissemination Dual-detection Engineering facilitate foundation fraction Gamma guide RNA high viral load house implementation isothermal amplification lack landscape Loop-mediated isothermal amplification Medicine Negative predictive value NIAID offer office omicron One-pot detection overcome P.1 Palindromic Pathogens platform point-of-care positive Predictive value President prevention primer Protein purified qPCR reaction reagent Real-time monitoring reverse transcription robust RT-LAMP S gene SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 variant Science sensitivity Sequencing SPADE specificity technology the SARS-CoV-2 Thermophillic university variants variants of concern veterinary medicine vice Vice President Viral load VoC VOCs were expressed [DOI] 10.1016/j.ebiom.2022.103926 PMC 바로가기 [Article Type] Article
Application and Validation of SARS-CoV-2 RBD Neutralizing ELISA AssaySARS-CoV-2 RBD 중화 ELISA 분석의 적용 및 검증Article Published on 2022-02-282022-09-11 Journal: Archives of Razi Institute [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% CI absorbance acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme anti-RBD anti-SARS-CoV-2 IgG antibody application approach biosafety clinical evaluation Coefficient of determination Cohort Concentration convalescent convalescent plasma coronavirus disease Coronavirus disease 2019 Coronavirus-2 correlation COVID-19 COVID-19 patients COVID-19 vaccine COVID-19 vaccines demonstrated detect different time point different time points disease severity domain Donor Efficiency ELISA ELISA assay enzyme-linked immunosorbent enzyme-linked immunosorbent assay gold gold standard healthy individual healthy individuals host cell host cell receptor house human Angiotensin-converting enzyme individual Interaction Laboratory Live virus live viruses log methodology NAb NAbs nAbs. Neutralizing Neutralizing antibodies neutralizing antibody optical optical density pandemic processed Protein purified Quantitative RBD respiratory Safe SARS-CoV-2 SARS-CoV-2 nAbs SARS-CoV-2 RBD SARS-COV-2-RBD neutralizing ELISA assay sensitivity Seroprevalence serum sample serum samples specificity Spike protein standard curve statistical the spike protein Treatment treatment of COVID-19 patients validation viruses [DOI] 10.22092/ARI.2021.356677.1890 PMC 바로가기 [Article Type] Article
Estimating SARS-CoV-2 Seroprevalence in Canadian Blood Donors, April 2020 to March 2021: Improving Accuracy with Multiple Assays2020년 4월부터 2021년 3월까지 캐나다 헌혈자의 SARS-CoV-2 혈청유병률 추정: 다중 분석으로 정확도 개선Research Article Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] 95% CI Abbott advent Analysis Antibody Response antibody tests approach Architect assays blood donor Blood donors can be used Chicago IL cross-sectional cross-sectional design cross-sectional study diagnostic diagnostic testing disease Epidemics evaluate evaluated fatality full-length spike glycoprotein gold gold standard house identify IgG IgG antibodies IgG ELISA Improving indicate Infection infections laboratory assay laboratory assays latent class latent class analysis less Multiple nucleocapsid nucleocapsid antigen occur Pandemics Prevalence provide public health random RBD Receptor binding domain recognizing reference standard Reference standards repeated resulting SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody Sensitivity and specificity sera serological data serological studies SEROLOGICAL STUDY Seropositivity Seroprevalence seroreversion silent spike spike glycoprotein Support Surveillance vaccination [DOI] 10.1128/spectrum.02563-21 PMC 바로가기 [Article Type] Research Article
Multiple house occupancy is associated with mortality in hospitalized patients with COVID-19Covid-19 Published on 2022-02-172022-11-01 Journal: The European Journal of Public Health [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 95% CI 95% confidence interval adjusted Admission age Analysis association C-reactive protein Care chronic obstructive cohort study Comorbidity COPE country covariate COVID-19 COVID-19 pandemic Cox regression CRP Day defined died discharge disease severity examined exhibited female frailty glomerular filtration rate hazard ratio heart failure hospital hospitalized patient house Logistic regression male median age Mortality multicentre Multiple outcome Patient patients hospitalized pulmonary disease reduce Result seeking Sex smoking Transmission with COVID-19 [DOI] 10.1093/eurpub/ckab085 PMC 바로가기 [Article Type] Covid-19
Accuracy of Real-Time Polymerase Chain Reaction in COVID-19 PatientsCOVID-19 환자의 실시간 중합효소 연쇄 반응의 정확도Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료법, 치료제, [키워드] RdRp-gene Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed Analysis assays caused CDC CDC N1, N2 center chain Characteristics Clinical practice clinical samples conducted Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cutoff value cycle threshold demonstrated Diagnosis diagnostic Diagnostic accuracy diagnostic specificity discrepancy disease control E gene enrolled followed by Health Organization highest house lowest majority Mild nasopharyngeal nasopharyngeal sample Nasopharyngeal samples NP gene nucleocapsid protein Numerous Oropharyngeal oropharyngeal samples pandemic prevention primer primer set primer sets Primers Prospective Study qPCR qPCR analysis RdRP reaction Real-time PCR real-time polymerase chain reaction Research respiratory Respiratory illness RT-PCR RT-qPCR RT-qPCRs Saliva SARS-CoV-2 SARS-CoV2 sensitivity Sensitivity and specificity Seroconversion severe acute respiratory syndrome Coronavirus severe respiratory illness significantly specificity specimen specimens sputum Sputum sample Viral Viral detection WHO World Health Organization [DOI] 10.1128/spectrum.00591-21 PMC 바로가기 [Article Type] Research Article
Mass Screening of SARS-CoV-2 Variants using Sanger Sequencing Strategy in Hiroshima, Japan일본 히로시마에서 Sanger 시퀀싱 전략을 사용한 SARS-COV-2 변이체의 질량 스크리닝Article Published on 2022-02-142022-09-01 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Alpha) Alpha amplification amplified amplified product amplified products applied assigned B.1.1.529 B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Cluster confirmed case country COVID-19 develop E484K effective Effectiveness Epidemiology feasible genome sequence Genome sequences HCoV Hiroshima house identify indicate isolates Japan less mass Mass screening mutant Mutation next generation sequencing NGS notable number of sample number of samples P.1 pandemic PCR-based techniques positive Prevention and control primer primer set primer sets Primers protocol Randomly readiness reliability repeated reported RT-PCR Sanger sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants screened Screening screening strategy selected single mutation Strategy variant [DOI] 10.1038/s41598-022-04952-2 PMC 바로가기 [Article Type] Article
A Cross-Sectional Study of Exposure Factors Associated with Seropositivity for SARS-CoV-2 Antibodies during the Second Epidemic Wave among a Sample of the University of Corsica (France)프랑스 코르시카 대학교 표본 중 2차 유행병 기간 동안 SARS-CoV-2 항체에 대한 혈청 양성과 관련된 노출 인자에 대한 단면 연구Article Published on 2022-02-102022-09-12 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% confidence interval Acute respiratory infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-SARS-CoV-2 IgG antibodies Blood blood sampling conducted Contact contact with Coronavirus-2 Corsica cross-sectional survey ELISA exposure Factor France house individual Infection Loss of Smell neutralization test participant Population positive Prevention and control questionnaire respiratory infection Sample SARS-CoV-2 second second wave sera seroneutralization Seropositivity Seropositivity for SARS-CoV-2 Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Symptom tested the epidemic university virus neutralization test VNT Wave [DOI] 10.3390/ijerph19041953 PMC 바로가기 [Article Type] Article