Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19감염성 질환 치료를 위한 면역조절제로서의 약물 전달 시스템: COVID-19와 관련성Review Published on 2021-11-012022-09-11 Journal: Advanced drug delivery reviews [Category] MERS, 신약개발, 진단, 치료제, [키워드] Activation adaptive approach approaches blocking agents cellular Coagulation complement complex complex interplay COVID-19 damage drug delivery system drug delivery systems endothelial Endothelium global pandemic identify immune Immune cell immune cells Immune suppression immunomodulator immunomodulatory IMPROVE improvement Inflammasome inflammasomes Inflammation Interaction involved limit moderate to severe molecular nanomedicine not limited outcome pathogen clearance pathology pathophysiology Patient patients with moderate Prognosis Relevance SARS-CoV-2 severe COVID-19 survival rates Therapeutic approach therapeutic approaches therapeutic option therapy tissue damage [DOI] 10.1016/j.addr.2021.113848 PMC 바로가기 [Article Type] Review
A review of the presentation and outcome of sarcoidosis in coronavirus disease 2019Review Article Published on 2021-10-262022-10-29 Journal: Journal of Clinical and Translational Research [Category] COVID-19, [키워드] acute respiratory syndrome added Admission article articles average Case report Case series case sery clinical manifestation Cohort Comorbidity conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Diagnosis drug General population Google High dose higher risk Hospital admission Hospitalization Hypothesis Immunocompromised patient immunomodulator Immunosuppressant increased risk intensive care management methotrexate mitigate moderate Mortality mortality rate multisystemic observation observational studies outcome overall mortality pandemic Patient patients Precaution presenting Prognosis Pulmonary function Relevance Research risk risk factor sarcoidosis significant difference Steroids Treatment Web of Science with COVID-19 PMC 바로가기 [Article Type] Review Article
Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD인플릭시맙은 IBD 환자에서 BNT162b2 및 ChAdOx1 nCoV-19 SARS-CoV-2 백신에 대한 면역원성 약화와 관련이 있습니다.Article Published on 2021-10-012022-09-12 Journal: Gut [Category] MERS, SARS, 진단, [키워드] 95% CI age anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody antibody concentration Antibody concentrations Antibody Response Autoimmune Autoimmune disease BNT162b2 BNT162b2 vaccine bowel ChAdOx1 ChAdOx1 nCoV-19 CLARITY Cohort Concentration concentrations COVID-19 cut-off defined Delayed disease dose Effectiveness Elecsy Evidence Fold change geometric mean IBD Immunity immunomodulator Infection Inflammatory Inflammatory bowel disease Inflammatory diseases infliximab investigated monoclonal antibody Multivariable models of BNT162b2 outcome Patient patients patients treated Primary outcome SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines second dose secondary Seroconversion seroconversion rate serological response single dose smoking TNF treated vaccination Vaccine Vaccines vedolizumab [DOI] 10.1136/gutjnl-2021-324789 PMC 바로가기 [Article Type] Article
Therapeutic Approaches in Modulating the Inflammatory and Immunological Response in Patients With Sepsis, Acute Respiratory Distress Syndrome, and Pancreatitis: An Expert Opinion ReviewGastroenterology Published on 2021-09-302022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress Alpha Alter approach ARDS Clinical outcome conditions COVID-19 COVID-19 patients Critically ill Critically ill patient expert greater help immune response immunoglobulins immunomodulation immunomodulator immunomodulators Immunopathogenesis IMPROVE intravenous majority novel coronavirus disease opinion organ dysfunction outcome pandemic Pathogenesis Patient physician respiratory response review Sepsis serine protease inhibitor Shock shown steroid Steroids syndrome the cytokine storm Therapeutic plasma exchange therapy Ulinastatin [DOI] 10.7759/cureus.18393 PMC 바로가기 [Article Type] Gastroenterology
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVA에피토프 스파이크, 에피토프 봉투 단백질 및 에피토프 막 단백질 SARS-COV-2, Honey, Saussurea Lappa 및 Nigella Sativa로 세포 및 체액 처리에서 면역을 생성합니다.Article Published on 2021-09-012022-09-10 Journal: African Journal of Infectious Diseases [Category] 비임상, [키워드] Sausseria lappa administration animal model breath Cellular immune response cellular immune responses cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immune responses immunomodulator Indonesia lung marker material membrane protein mice mouth Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein TGF-β β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
Ultra-Long-term Follow-up of Interferon Alfa Treatment for HBeAg-Positive Chronic Hepatitis B Virus InfectionArticle Published on 2021-09-012023-06-13 Journal: Clinical gastroenterology and hepatology : the off [Category] B형 간염, [키워드] immunomodulator Long-term outcomes Prognosis Viral hepatitis [DOI] 10.1016/j.cgh.2020.09.004
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVAArticle Published on 2021-09-012022-10-27 Journal: African Journal of Infectious Diseases [Category] COVID-19, [키워드] Sausseria lappa administration animal model Cellular immune response cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immunomodulator Indonesia lung marker material membrane protein mice Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysisIL-6 길항제 투여와 COVID-19로 입원한 환자의 사망률 사이의 연관성: 메타 분석Meta-Analysis Published on 2021-08-102022-09-11 Journal: JAMA [Category] MERS, 임상, 진단, [키워드] 95% CI Administered administration all-cause mortality antagonist antagonists assessment assessment tool association assumed benefit Bia clinical clinical trial clinical trials contact with Corticosteroid Corticosteroids COVID-19 criteria data extraction database death Efficacy eligible Hospitalized IL-6 IL-6 antagonist immunomodulator inconsistency Infection Invasive mechanical ventilation language median age medians Meta-analysis Mortality mortality risk no effect occurred Odds ratio Odds ratios Other outcomes outcome outcomes Patient patients hospitalized patients randomized patients treated Placebo primary analysis primary outcome measure progression randomization randomly assigned patient receiving reported risk risk of bia sample sizes sarilumab Secondary infection secondary infections secondary outcome synthesis through contact Tocilizumab Trial trials usual care women [DOI] 10.1001/jama.2021.11330 PMC 바로가기 [Article Type] Meta-Analysis
High-dose intravenous immunoglobulins might modulate inflammation in COVID-19 patients고용량 정맥 면역 글로불린은 COVID-19 환자의 염증을 조절할 수 있습니다Research Article Published on 2021-07-282022-09-10 Journal: Life Science Alliance [Category] SARS, 바이오마커, 진단, [키워드] Activation administration analyzed C5a chemokine chemokines clinical evolution complement Complement activation Course COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines Factor Fatty acid FIVE hepatic growth factor High-dose high-dose IVIg hospitalized COVID-19 patient Hyperinflammatory hyperinflammatory status IL-10 IL-5 IL-7 immune response immune responses immunoglobulins immunomodulator immunomodulators immunomodulatory properties immunomodulatory property immunosuppressive IMPROVE individual individuals Inflammation Inflammatory Inflammatory biomarker inflammatory biomarkers intestinal Intravenous immunoglobulin IVIG Macrophage modulate modulating patients plasma sample plasma samples Protein reduced Respiratory function restored shown treated Treatment treatment initiation Tumor tumor necrosis tumor necrosis factor [DOI] 10.26508/lsa.202001009 PMC 바로가기 [Article Type] Research Article
The Influence of Corticosteroids, Immunosuppressants and Biologics on Patients With Inflammatory Bowel Diseases, Psoriasis and Rheumatic Diseases in the Era of COVID-19: A Review of Current EvidenceImmunology Published on 2021-07-082022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] 2019-nCoV anti-TNF antiviral immune response Autoimmune benefit biologics Corticosteroids COVID-19 COVID-19 epidemic current Cytokine storm death decision Hospitalization ICU Immune-mediated inflammatory diseases immunocompromised status immunomodulator immunomodulators Immunosuppressant Infection Inflammatory bowel disease influence lower risk mechanism Mortality pathway Patient patients patients treated potential risk psoriasis review rheumatic disease risk SARS-CoV-2 significant changes in suggested systemic corticosteroid therapy treated use of corticosteroids Ventilation [DOI] 10.3389/fimmu.2021.677957 PMC 바로가기 [Article Type] Immunology