Study of the effects of interferon β-1a on hospitalized patients with COVID-19: SBMU Taskforce on the COVIFERON study입원한 COVID-19 환자에 대한 인터페론 β-1a의 효과 연구: COVIFERON 연구에 대한 SBMU 태스크포스Article Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] addition Antiviral conducted control group coronavirus disease Coronavirus disease 2019 COVID-19 died Effect Efficacy group hospital Hospital admission Hospital stay Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients IFN-β1a immunomodulatory functions IMPROVE indicated innate immune system interferon Interferon β-1a interferons Iran median Mortality mortality rate no statistically significant difference outcome P-value Patient patients treated progression Randomized controlled trial regimen Retrospective study selected Severe case severe cases severe COVID-19 standard care standard treatment statistically statistically significant difference Tehran the interferon two group two groups [DOI] 10.1002/jmv.27475 PMC 바로가기 [Article Type] Article
Myocarditis following COVID-19 vaccination: incidence, mechanisms, and clinical considerationsReview Published on 2022-04-012023-07-08 Journal: Expert review of cardiovascular therapy [Category] COVID19(2023년), [키워드] clinical COVID-19 in vitro transcribed mRNA incidence innate immune system molecular mimicry myocarditis Vaccine [DOI] 10.1080/14779072.2022.2066522 PMC 바로가기 [Article Type] Review
SARS-CoV-2 infection in dialysis and kidney transplant patients: immunological and serological response투석 및 신장 이식 환자의 SARS-CoV-2 감염: 면역학적 및 혈청학적 반응Article Published on 2022-04-012022-09-11 Journal: Journal of Nephrology [Category] COVID19(2023년), SARS, 치료법, [키워드] alteration anti-spike antibodies anti-spike antibody anti-spike antibody response B cells B-cell baseline baseline characteristics CD4 CD8 chemokine chemokines controls COVID-19 cytokine Cytokines DCs dendritic cell dialysis expression groups healthy subject healthy subjects Hemodialysis high mortality rate Hospitalization IFN-α IL10 IL6 immunological immunology innate immune system involved kidney transplant kidney transplant recipient kidney transplant recipients lymphocyte Lymphocyte subsets Lymphocytes moderate-severe monocyte Monocyte activation monocyte HLA-DR neutrophil neutrophil recruitment Patient patients patients with COVID-19 populations proportion SARS-CoV-2 SARS-COV-2 infection serological response severe disease symptom onset T cells terminally differentiated the disease two groups uninfected was increased were measured [DOI] 10.1007/s40620-021-01214-8 PMC 바로가기 [Article Type] Article
Diagnostic and Therapeutic Potential for HNP-1, HBD-1 and HBD-4 in Pregnant Women with COVID-19COVID-19에 감염된 임산부에서 HNP-1, HBD-1 및 HBD-4에 대한 진단 및 치료 가능성Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] affected Alpha AMPs anti-inflammatory cytokine antimicrobial peptide antimicrobial peptides Beta Biochemistry biological activities characterized Coagulation Confirmed COVID-19 infection COVID-19 COVID-19 infection cytokine cytokine profile Cytokines defensin Defensins deficiency defined ELISA assay evaluated fetus Gene Expression generate help highlight IL-10 IL-2 IL-6 IL-8 immune immune system immunological change increase in Infection innate immune system Interleukins involved Laboratory Laboratory medicine lipoprotein lipoprotein-a mechanism mother peptides Potential Pregnancy pregnant women pro-inflammatory factor pro-inflammatory factors problem problems PROTECT risk factor TGF-β TNF-α virus attacks Vitamin vitamins with COVID-19 [DOI] 10.3390/ijms23073450 PMC 바로가기 [Article Type] Article
How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment혈액의 타고난 면역 체계가 COVID-19 유발 ARDS의 전신 병리에 기여하고 치료를 위한 잠재적인 표적을 제공하는 방법Review Published on 2022-03-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation Acute kidney injury acute respiratory distress acute respiratory distress syndrome AMY-101 Angiogenesis apoptotic cells ARDS Biomarker bradykinin candidate drug candidate drugs cascade cascade system characterized chemokines Coagulation Coagulation system complement Complement inhibitor complement inhibitors Compound COVID-19 Crosstalk cytokine Cytokines damaged demonstrated dysregulation ecallantide eculizumab Evidence favor ground glass opacities heparin High dose high risk Icatibant IL-6 IL-6 levels in some incidence include Influenza influenza-like symptom Influenza-like symptoms inhibitor initiated Innate innate immune system intensive care treatment Kallikrein lanadelumab lead leukocytes life-threatening LMWH Lung injury mechanical ventilation mechanism moderate MOST oxygen oxygen saturation pandemic pathophysiology Patient patients Phase I plasma plasma proteins Platelets Potential predict Prevent Prognostic value pulmonary damage pulmonary inflammation receptor reduced Regulation respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 infected patient severity Support survival syndrome System systemic target the disease therapeutic option therapeutic options Thromboembolism thrombosis thrombotic Thrombotic complications translated Treatment treatment of COVID-19 Trial Usage Vascular ventilator virus [DOI] 10.3389/fimmu.2022.840137 PMC 바로가기 [Article Type] Review
Escape and Over-Activation of Innate Immune Responses by SARS-CoV-2: Two Faces of a CoinSARS-CoV-2에 의한 타고난 면역 반응의 탈출 및 과잉 활성화: 동전의 두 얼굴Review Published on 2022-03-042022-09-11 Journal: Viruses [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] addition cellular receptor coin coronavirus CoV COVID-19 pathogenesis CoVs Cytokines Defense disease dysregulated escape evade face Host human population IFN IFN signaling pathways IL-1 IL-1 family cytokine IL-1 family cytokines IL-18 IL-1β immune responses Inflammasome inflammasome activation inflammasomes Innate innate immune innate immune response innate immune responses innate immune system Innate immunity interferon invading pathogens MERS MERS-CoV Multiple Pathogenesis Pathogens potential mechanism potential mechanisms Prognosis pyroptosis Recognition response SARS-CoV-1 SARS-CoV-2 with COVID-19 [DOI] 10.3390/v14030530 PMC 바로가기 [Article Type] Review
Marked increase of interferon-β after BNT162b2 mRNA vaccination: a case of polyarthritis with pleurisyBNT162b2 mRNA 예방접종 후 인터페론-β의 현저한 증가: 흉막염을 동반한 다발성관절염 1예Case Reports Published on 2022-03-022022-09-12 Journal: BMJ case reports [Category] MERS, SARS, 진단, [키워드] association BNT162b2 mRNA comparable COVID-19 cytokine disease elevated Exacerbation had no healthy subjects IFN-β immunological immunological products and vaccines immunology increase in innate immune system interferon mRNA vaccine mRNA vaccines Musculoskeletal musculoskeletal syndromes. one patient Other Patient polyarthritis Prednisolone receiving reported Rheumatic diseases SARS-CoV-2 serum Treatment vaccination [DOI] 10.1136/bcr-2021-246533 PMC 바로가기 [Article Type] Case Reports
Role of toll-like receptors in modulation of cytokine storm signaling in SARS-CoV-2-induced COVID-19SARS-CoV-2로 유발된 COVID-19에서 사이토카인 폭풍 신호전달의 조절에서 톨 유사 수용체의 역할Review Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료법, [키워드] Balanced Blood circulation COVID-19 cytokine Cytokine storm Cytokine storms Cytokines death driving dsRNA Elimination endosomal Factor help IL-1β IL-4 IL-6 IL-8 Imbalance immune regulation individual Inflammatory inflammatory signaling innate immune system interferon interleukin killing MAPK membrane-bound modulation multiple organ failure multiple organ failures multiple-organ multiple-organ failure Necrosis NF-κB nonself other organs pathogen Pro-inflammatory genes pro-inflammatory mediator pro-inflammatory mediators recognize recognizing replicate role SARS-CoV-2 Signaling ssRNA ssRNA. systemic circulation the cytokine storm TLR TLR3 TLR4 TLR7 TLR7/8 TLR8 TLRs Toll-like receptor Toll-like receptors Transcription translation TRIF Tumor tumor necrosis tumor necrosis factor [DOI] 10.1002/jmv.27405 PMC 바로가기 [Article Type] Review
Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses Reviews Published on 2022-02-242022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 비임상, [키워드] acute respiratory syndrome Adaptive immune response adaptive immune responses adjuvant age approach cellular contribute coronavirus Coronaviruses effective Efficacy environmental factor Factor failure Fighting Genetic geographical location heterogeneity humoral immune response Humoral immunity immune protection impair innate immune innate immune response innate immune system long-lived plasma cell mechanism memory T cell metabolite microbiome composition MOST pandemic SARS-CoV-2 Sex the SARS-CoV-2 Vaccine vaccine response Vaccines vectors [DOI] 10.1038/s41590-022-01130-4 [Article Type] Reviews
Trained Immunity: An Overview and the Impact on COVID-19Immunology Published on 2022-02-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] activate alleviate approach B-glucan Bacillus BCG cell type cells clinical study clinical trials component Corona COVID-19 COVID-19 crisis COVID-19 pandemic develop disease pathogenesis effective greater Health immune immune protection immune response immune system Immunity Impact in vitro in vivo Infection Infectious disease innate immune cell innate immune system Innate immunity involved LPS mechanism monocyte Monocytes natural killer natural killer (NK) non-specific Pathogens pathway potential therapeutic target Protective respiratory SARS-CoV-2 SARS-COV-2 infection signaling pathway therapeutic target trained immunity understanding [DOI] 10.3389/fimmu.2022.837524 PMC 바로가기 [Article Type] Immunology