The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repressionNSP1 매개 억제의 바이러스 탈출에 필요한 SARS-CoV-2 리더 및 NSP1의 주요 기능Article Published on 2022-05-012022-09-11 Journal: RNA (New York, N.Y.) [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis Antiviral ASO binding blockade carried cellular mechanisms cellular mRNA cellular mRNAs component components cytosine Defense down-regulate early stage ENhance expresse expression feature functional global pandemic help Host host gene host genes Infection inhibit interfere mechanism mRNA mRNAs nonstructural protein 1 nsp1 overcome Pathways Replication required residue responsible ribosome SARS-CoV-2 Spread targets the SARS-CoV-2 translation translational repression translational repression. viral escape viral mRNAs Viral RNA virus viruses [DOI] 10.1261/rna.079086.121 PMC 바로가기 [Article Type] Article
Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interactionSARS-CoV-2 스파이크 단백질의 수용체 결합 도메인에 있는 Y380Q 신규 돌연변이는 C379W와 함께 중화 항체 상호작용을 방해합니다Article Published on 2022-04-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] All participant All participants B.1.1.28 B.1.1.33 binding Brazil children circulating COVID-19 CR3022 cycle threshold domain enrolled EY6A High-throughput sequencing Interaction interfere Lineage Mutation Neutralizing antibodies neutralizing antibody novel Novel mutation Older pandemic participant performed Porto positive RBD Receptor-binding domain RT-PCR assay S gene SARS-CoV-2 SARS-CoV-2 spike protein Sequencing Signs and symptoms Spike protein submitted symptoms of COVID-19 tested the receptor-binding domain the SARS-CoV-2 the spike protein variants Viral viral spike protein [DOI] 10.1016/j.diagmicrobio.2022.115636 PMC 바로가기 [Article Type] Article
Humoral response to SARS-CoV-2 infection among liver transplant recipients간 이식 환자의 SARS-CoV-2 감염에 대한 체액 반응Multicenter Study Published on 2022-04-012022-09-11 Journal: Gut [Category] Coronavirus, COVID19(2023년), SARS, 치료기술, 치료법, [키워드] anti-S antibody antibody Antibody Response Antibody testing Antibody titre assigned B lymphocytes case-control study Cohort cohorts controls COVID-19 COVID-19 symptom COVID-19 symptoms criteria detectable expected functional humoral Humoral response immune immune response Immunosuppression Immunosuppressive agents interfere less liver liver transplant Liver transplantation majority mounted multicentre neutralising ability Neutralising activity no difference nucleocapsid protein Patient Prospective Protein recipient recipients required SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection Serologic response significantly lower subject Symptoms Testing the antibody response with COVID-19 [DOI] 10.1136/gutjnl-2021-326609 PMC 바로가기 [Article Type] Multicenter Study
Differences and Similarities Among COVID-19 Patients Treated in Seven ICUs in Three Countries Within One Region: An Observational Cohort StudyObservational Study Published on 2022-04-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] Admission admitted to ICU age Analysis applied approval assessment Belgium Characteristics chronic Clinical characteristics Comorbidities complications coronavirus disease COVID-19 COVID-19 patient criteria Descriptive statistics Diagnosis difference disease severity driver European failure female Frequency Genetic Germany healthcare Healthcare system ICU independent interfere International Laboratory Logistic regression measurement Mortality mortality rate Netherlands Observational cohort study organ support outcome pandemic Patient patient group performed Physiology retrieved Sex significantly Support supported Therapies therapy variance Variation [DOI] 10.1097/CCM.0000000000005314 PMC 바로가기 [Article Type] Observational Study
Quantification of trace elements in surgical and KN95 face masks widely used during the SARS-COVID-19 pandemicSARS-COVID-19 대유행 기간 동안 널리 사용된 외과용 및 KN95 안면 마스크의 미량 원소 정량화Article Published on 2022-03-252022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Concentration Contact contact with coronavirus coronavirus disease COVID-19 detectable determine element elements equipment experiments Face mask Face masks Heavy metals human body ICP-MS Inhaled interfere limits Mask Masks mass mass spectrometry metal Metal leaching mouth pandemic Protective reported Saliva SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spectrometry surgical trace Trace element trace elements transfer user void while [DOI] 10.1016/j.scitotenv.2021.151924 PMC 바로가기 [Article Type] Article
Relation of fever intensity and antipyretic use with specific antibody response after two doses of the BNT162b2 mRNA vaccineBNT162b2 mRNA 백신 2회 접종 후 발열 강도 및 해열제 사용과 특이 항체 반응의 관계Article Published on 2022-03-182022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acquisition Adverse reaction Adverse reactions age Analysis analyzed antibody Antibody Response Antipyretic antipyretics association BNT162b2 mRNA vaccine body temperature collected correlated COVID-19 COVID-19 vaccine degree dose female Fever FIVE healthcare worker highest hospital IgG IgG titer IgG titers intensity interfere investigated medication mitigate Multivariate analysis of BNT162b2 participant positive correlation questionnaire reactogenicity reactogenicity event relation reported responses SARS-CoV-2 second dose serum sample Sex significantly spike-specific IgG the SARS-CoV-2 Vaccine was measured [DOI] 10.1016/j.vaccine.2022.02.025 PMC 바로가기 [Article Type] Article
Role of senescence in the chronic health consequences of COVID-19Review article Published on 2022-03-012022-10-05 Journal: Translational research : the journal of laboratory [Category] SARS, 변종, [키워드] A phase 2 placebo-controlled pilot study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes acute COVID-19 alleviate alterations AMP-activated protein kinase AMPKAMP-activated protein kinase caloric restriction Cell cell removal cellular senescence chronic disease consequence contribute Coronavirus disease 2019 COVID-19 COVID-19 symptom COVID-19coronavirus disease 2019 COVID-FISA phase 2 placebo-controlled pilot study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes CRcaloric restriction Defense deregulated dysfunction Epigenetic facility for geroscience analysis FGAFacility for Geroscience Analysis generate genomic greater Health ICUIntensive Care Unit IFintermittent fasting ill patients Immune system dysfunction increased risk indicated Infection infections Innate intensive care unit Intercellular communication interfere intermittent fasting Intervention Long-term care facility low-grade inflammation LTCFlong-term care facility mammalian target of rapamycin MCCmultiple chronic conditions MERS-CoVmiddle east respiratory syndrome coronavirus Middle East respiratory syndrome Coronavirus mitochondrial dysfunction Mortality mTORmammalian target of rapamycin Multimorbidity multiple chronic conditions NAD+nicotinamide adenine dinucleotide nicotinamide adenine dinucleotide nicotinamide mononucleotide nicotinamide riboside NMNnicotinamide mononucleotide NRnicotinamide riboside Older outcome PACSpostacute sequalae of SARS-CoV-2 infection PAMPspathogen-associated molecular profile factors pathogen-associated molecular profile factors Patient postacute sequalae of SARS-CoV-2 infection predictor reactive oxygen species risk risk factor role ROSreactive oxygen species SARS-CoV-1severe acute respiratory syndrome coronavirus 1 SARS-COV-2 infection SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SARSSevere Acute Respiratory Syndrome SASPsenescence-associated secretory phenotype senescence-associated secretory phenotype senescent senescent cell Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 1 severe acute respiratory syndrome coronavirus 2 skilled nursing facility SNFskilled nursing facility susceptibility TGNtranslational geroscience network Translational Geroscience Network viral infection viral infections while WHOWorld Health Organization World Health Organization [DOI] 10.1016/j.trsl.2021.10.003 [Article Type] Review article
A sigh of relief: vaccine-associated hypermetabolic lymphadenopathy following the third COVID-19 vaccine dose is short in duration and uncommonly interferes with the interpretation of [ 18 F]FDG PET-CT studies performed in oncologic patients안도의 한숨: 세 번째 COVID-19 백신 접종 후 백신 관련 대사과다 림프절병증은 지속 기간이 짧고 드물게 종양 환자에서 수행된 [ 18 F]FDG PET-CT 연구의 해석을 방해합니다Article Published on 2022-03-012022-09-11 Journal: European Journal of Nuclear Medicine and Molecular [Category] SARS, 치료기술, [키워드] administration age BMI BNT162b2 BNT162b2 vaccine correlation COVID-19 COVID-19 vaccine dose dose administration doses GRADE High-grade Humoral immunity immune response incidence incidence of COVID-19 independent predictor independent predictors interfere Interpretation IQR less Lymphadenopathy median time multivariable logistic regression obese obese patients Older Oncologic imaging Patient patients performed PET-CT reported separation time interval unlikely vaccination vaccine dose were recorded [DOI] 10.1007/s00259-021-05579-7 PMC 바로가기 [Article Type] Article
Food for thought: Eating before saliva collection and interference with SARS‐CoV‐2 detectionResearch Article Published on 2022-02-232022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome children collected coronavirus detection determine diagnostic diagnostics dietary habit eating enzyme fasting food healthy children interfere Interference intrinsic MALDI‐TOF molecular noninvasive nucleic acid oral microbiota performed polymerase chain provided replicate required resolved RT‐PCR Saliva saliva specimens SARS‐CoV‐2 SARS‐CoV‐2 selected specimen unique upper respiratory infection variety viral nucleic acid virus Volume was reduced [DOI] 10.1002/jmv.27660 PMC 바로가기 [Article Type] Research Article
Influenza A(H1N1)pdm09 Virus but Not Respiratory Syncytial Virus Interferes with SARS-CoV-2 Replication during Sequential Infections in Human Nasal Epithelial CellsArticle Published on 2022-02-152022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), Fulltext, SARS, 신종인플루엔자, [키워드] acute respiratory syndrome alleviate Co-infection combinations coronavirus D614G described evaluated HAE Human Human airway epithelium human nasal epithelium Infection infection with SARS-CoV-2 Influenza Influenza virus inhibitor Interaction interfere interferon involved mechanism mutant nasal other respiratory virus pandemic Post-infection reduce reduced replication Replication replication kinetics respiratory respiratory syncytial virus respiratory viruses RSV RT-qPCR SARS-CoV-2 SARS-CoV-2 replication subsequent viral interference virus [DOI] 10.3390/v14020395 PMC 바로가기 [Article Type] Article