Comprehensive Profiling of Inflammatory Factors Revealed That Growth Differentiation Factor-15 Is an Indicator of Disease Severity in COVID-19 Patients염증 인자의 포괄적 인 프로파일 링은 성장 분화 인자 -15가 COVID-19 환자의 질병 중증도의 지표임을 보여 주었다.Immunology Published on 2021-07-152022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] Admission Alanine alanine aminotransferase analyzed aspartate Aspartate aminotransferase Asymptomatic Bioinformatics analysis Biomarker blood cell candidate CD200 change Comprehensive convalescent COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient COVID-19 patients Critical differentiation discharge disease severity Elevation ELISA eosinophil eosinophil counts expression level expression levels FABP2 Factor functional GDF15 group groups healthy control identify include Indicator inflammatory factors lymphocyte Mild moderate neutrophil neutrophil count NLR Occurrence Patient patient sera Potential biomarker potential biomarkers predict Prevent Profiling progression Remission Revealed severe COVID-19 severe group severity severity of COVID-19 the disease TRAIL Transferrin VCAM-1 were measured White blood cell white blood cell count [DOI] 10.3389/fimmu.2021.662465 PMC 바로가기 [Article Type] Immunology
In Silico Identification of miRNA–lncRNA Interactions in Male Reproductive Disorder Associated with COVID-19 InfectionCOVID-19 감염과 관련된 남성 생식 장애에서 miRNA-lncRNA 상호 작용의 Silico 식별Article Published on 2021-06-122022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 ARHGAP26 ARHGAP26-AS1 association Bioinformatics analysis BSN-AS1 CACNA1C CACNA1C-IT3 caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients disorder dysregulated enzyme explain expression facilitate FGF14 FGF14-IT1 Gene Expression global pandemic GRM7 GRM7-AS3 GS1-24F4.2 identification indicate infertility Interaction interactions KRBOX1 KRBOX1-AS1 lncRNA long non-coding RNA male male infertility men microRNA MicroRNAs miR-125a-5p miRNA miRNAs modulator molecular mechanism molecular mechanisms pathway post-transcriptional level Potential biomarker potential biomarkers predicted receptor Regulation reproductive respiratory SARS-CoV-2 Serine severe acute respiratory syndrome Coronavirus susceptible testes Testis tissue-specific expression TMPRSS2 TMPRSS2 expression transmembrane serine protease transmembrane serine protease 2 virus entry with COVID-19 [DOI] 10.3390/cells10061480 PMC 바로가기 [Article Type] Article
Longitudinal proteomic profiling provides insights into host response and proteome dynamics in COVID-19 progression세로 프로테옴 프로파일링은 COVID-19 진행에서 숙주 반응 및 프로테옴 역학에 대한 통찰력을 제공합니다Article Published on 2021-06-012022-09-11 Journal: Proteomics [Category] MERS, 바이오마커, 유전자 메커니즘, [키워드] acute phase response biological processe biological processes BNC2 collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 progression degranulation Disease progression expand high risk host response humoral immune response identify IGLV3-19 interferon involved Keywords lipid metabolism longitudinal longitudinal change longitudinal changes marker metabolism non-severe patients Patient patients with COVID-19 performed Platelet Potential biomarker potential biomarkers Prognosis prognostic prognostic indicator progressed progression Protein proteome proteomic proteomics provide Real-time monitoring SARS-COV-2 infection sera serum severe COVID-19 severity Support the disease [DOI] 10.1002/pmic.202000278 PMC 바로가기 [Article Type] Article
Dysregulation of Pulmonary Responses in Severe COVID-19심각한 COVID-19에서 폐 반응의 조절 장애Communication Published on 2021-05-212022-09-01 Journal: Viruses [Category] SARS, 바이오마커, 진단, [키워드] B cells BALF Bronchoalveolar lavage fluid Cell cells contribute coronavirus disease Coronavirus disease 2019 COVID-19 dataset epithelial cell epithelial cells expressing HAS2 high mortality Hyaluronan IFN-I IFNA1 IgA IgA-expressing lower expression macrophages matrix metalloproteinase matrix metalloproteinases Mild disease PAI-1 Patient Potential biomarker potential biomarkers predict pulmonary Pulmonary pathology respiratory Respiratory failure respiratory tract infection response risk factor Risk factors severe COVID-19 severe disease single-cell susceptibility Symptom Th17 TLR7 TLR8 Toll-like receptor toll-like receptor 7 type I interferon with mild disease [DOI] 10.3390/v13060957 PMC 바로가기 [Article Type] Communication
Metabolite reanalysis revealed potential biomarkers for COVID-19: a potential link with immune response대사 산물 재분석은 COVID-19에 대한 잠재적인 바이오마커를 밝혔습니다: 면역 반응과의 잠재적 연결Research Article Published on 2021-05-112022-09-10 Journal: Future Microbiology [Category] SARS, 바이오마커, [키워드] Alanine applied betaine bioinformatics Biomarkers Classifier COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients glucuronate healthy healthy individuals immune response information metabolite metabolomic profiling metabolomics patients Potential biomarker potential biomarkers receiver operating characteristic reported sulfate taurochenodeoxycholic acid Treatment unique β-alanine [DOI] 10.2217/fmb-2021-0047 PMC 바로가기 [Article Type] Research Article
Cytokine Profiles Before and After Immune Modulation in Hospitalized Patients with COVID-19COVID-19로 입원한 환자의 면역 조절 전후 사이토카인 프로필Article Published on 2021-05-012022-09-11 Journal: Journal of Clinical Immunology [Category] SARS, 바이오마커, 진단, [키워드] administration Admission Adult patients Algorithm association Care cluster analysis combination therapy COVID-19 Critical Critical disease CRP level CRP levels cytokine cytokine panel cytokine profile cytokine release Cytokine release syndrome Cytokines D-dimer disease severity dysregulation elevated Elevation elevations glucocorticoid Glucocorticoids HFNC Hospital stay hospitalized patient hospitalized patients Hyperinflammatory IFN-γ IL-10 IL-6 IL-6 inhibition IL-6 level immune immune dysregulation incidence increase in interleukin interleukin-10 interleukin-2 receptor (soluble) large cohort maintain marker moderate modulate modulating Mortality nippv oxygen Oxygen requirement pathway Patient performed Potential biomarker potential biomarkers profile receive receiving receptor response to treatment retrospective SARS-CoV-2 SARS-COV-2 infection severity significantly increased SpO2 Therapies therapy Tocilizumab treated Treatment with COVID-19 [DOI] 10.1007/s10875-020-00949-6 PMC 바로가기 [Article Type] Article
Isoprostanes in wastewater as biomarkers of oxidative stress during COVID-19 pandemicCOVID-19 전염병 동안 산화 스트레스의 바이오마커로서의 폐수 내 이소프로스탄Article Published on 2021-05-012022-09-11 Journal: Chemosphere [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Ammoniacal nitrogen based population analytical method Anxiety approach average Biomarker clinically Community COVID COVID pandemic COVID-19 COVID-19 pandemic Depression elevated Epidemiology estimation Injury Isoprostane Isoprostanes metabolism nitrogen oxidative oxidative stress PGE2 Potential biomarker potential biomarkers quantification quantified Quantitative significantly significantly increased suggested two-tailed ultra-performance liquid chromatography wastewater wastewater based epidemiology [DOI] 10.1016/j.chemosphere.2020.129489 PMC 바로가기 [Article Type] Article
Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19조절되지 않는 선천 및 적응 면역 반응이 COVID-19의 질병 중증도를 구별합니다Article Published on 2021-04-232022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] abrogated adaptive Adaptive immunity Analysis Biomarkers Cell Clustering analysis COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patients Critical Critically ill critically ill patients cytokine cytokine production Cytokines disease disease severity exhaustion markers flow cytometry hepatocyte growth factor highlight highlighting host response Hyperinflammatory immune response immune responses Inflammatory Inflammatory responses Innate innate immune innate immune response innate immune responses Innate immunity interferon interferon-γ interleukin interleukin-17 lymphopenia mononuclear cell performed Peripheral blood Plasma cytokine Potential biomarker potential biomarkers proinflammatory proteomics provide response Result stem cell stem cell factor T-cell exhaustion Variation Whole blood [DOI] 10.1093/infdis/jiab065 PMC 바로가기 [Article Type] Article
Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery다중 플랫폼 omics 분석은 COVID-19 발병기전, 예후 및 약물 표적 발견을 위한 분자 서명을 보여줍니다Article Published on 2021-04-152022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 바이오마커, 신약개발, 유전자 메커니즘, 임상, 치료기술, 치료제, [키워드] Analysis ANXA1 AUC Biomarker Biomarkers changes in chose CLEC3B Cohort collected coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 pathogenesis COVID-19 patient disease severity drug target discovery dysregulation effective function indicated Macrophage molecular non-severe patients Pathogenesis Patient patient treatment performed plasma plasma sample plasma samples Potential biomarker potential biomarkers potential therapeutic targets Predictive markers Prognosis progression reached reveal severe COVID-19 Severe patient severe patients suppression T cell therapeutic drug Urine [DOI] 10.1038/s41392-021-00508-4 PMC 바로가기 [Article Type] Article
Monitoring peripheral neutrophil and T-lymphocyte subsets could assist in differentiating the severity and disease progression of coronavirus disease 2019말초 호중구 및 T-림프구 하위 집합을 모니터링하면 코로나바이러스 질병 2019의 중증도와 질병 진행을 구별하는 데 도움이 될 수 있습니다Research Paper Published on 2021-03-312022-09-10 Journal: Aging (Albany NY) [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Analysis analyzed Antiviral assist AUC baseline CD3+ CD3+CD4+ CD3+CD4+ T cells CD3+CD8+ CD4+ CD4+ T lymphocyte CD8+ T cells center characteristic clinical Clinical significance clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Cytotoxic T cell Cytotoxic T cells disease Disease progression evaluate expression help helper helper T cells lymphocyte Lymphocytes monitoring neutrophil neutrophil to CD4+ T lymphocyte ratio/N4R NK cell NK cells patients with COVID-19 peripheral lymphocyte Potential biomarker potential biomarkers progression Public receiver operating characteristic respiratory SARS-CoV-2 SARS-CoV-2 RNA detection severe acute respiratory syndrome Coronavirus severity subset T cell T cells T lymphocyte T-cell test negative therapy [DOI] 10.18632/aging.202701 PMC 바로가기 [Article Type] Research Paper