Identification of potential therapeutic targets and mechanisms of COVID-19 through network analysis and screening of chemicals and herbal ingredients화학 물질 및 약초 성분의 네트워크 분석 및 스크리닝을 통한 COVID-19의 잠재적 치료 목표 및 메커니즘의 확인Article Published on 2022-01-172022-08-31 Journal: Briefings in Bioinformatics [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] Analysis applied approved drugs candidate Candidates COVID-19 COVID-19 disease COVID-19 pandemic data-driven disease disease module drug Drug repurposing Drug screening drug target enrichment analysis feasibility herbal ingredients hub protein identification ingredient Invasion mechanism Metrics molecular docking network analysis network pharmacology Network proximity Outbreaks pandemic potential therapeutic target PPI predict target the disease therapeutic effect virus [DOI] 10.1093/bib/bbab373 PMC 바로가기 [Article Type] Article
Commercial SARS-CoV-2 Targeted, Protease Inhibitor Focused and Protein–Protein Interaction Inhibitor Focused Molecular Libraries for Virtual Screening and Drug DesignReview Published on 2021-12-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Analysis applied approaches caused Compound computer-aided drug design COVID-19 disease docking drug drug design evaluated Final focused libraries functional global pandemic High-throughput virtual screening IMPROVE in silico drug design Inclusion information inhibitor lack library Ligand majority molecular molecular docking offered potential therapeutic target Protein protocol provided raised receptor reported SARS-CoV-2 Screening structure-based design target targeted libraries Virtual screening were given [DOI] 10.3390/ijms23010393 PMC 바로가기 [Article Type] Review
Multi‐omics of the expression and clinical outcomes of TMPRSS2 in human various cancers: A potential therapeutic target for COVID‐19인간의 다양한 암에서 TMPRSS2의 발현 및 임상 결과의 멀티오믹스: COVID-19의 잠재적 치료 표적Original Article Published on 2021-12-242022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, 바이오마커, [키워드] TMPRSS2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Analysis bioinformatics Biomarker Blood Brain Breast Cancer cancer progression cancers clinical consequence clinical consequences Clinical outcome Colorectal cancer contribute coronavirus coronavirus disease correlated correlation COVID‐19 DEGs effective Evidence expressed gene expression Genes Genetic variations humans Immune cell infiltration immune infiltration incidence Infection lung molecular multi‐omics analysis network analysis outbreak ovarian Pathway analysis Pathways Patient potential therapeutic target Prevent Prognosis prognostic prognostic analysis Prognostic biomarkers Prognostic value progression Protein regulate respiratory Respiratory system SARS‐CoV‐2 SARS‐CoV‐2 infection severe acute respiratory syndrome Coronavirus shown significantly Soft tissue therapeutic target tissue tissues TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Tumours [DOI] 10.1111/jcmm.17090 PMC 바로가기 [Article Type] Original Article
COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factorsCOVID-19는 분비된 대사 인자의 조절을 통해 새로운 발병 인슐린 저항성 및 지질 대사 조절 장애를 유발합니다Article Published on 2021-12-162022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Apelin Cohort complications COVID-19 COVID-19 patient Diseases dysregulation Endocrine system and metabolic diseases expression Glucose HDL-C hyperglycemia induce Infectious diseases insulin insulin resistance investigated isobutyric acid lipid metabolism lipids mechanism mechanisms metabolic factor metabolism modulated myeloperoxidase myostatin patients Perturbation Potential biomarker potential biomarkers potential therapeutic target potential therapeutic targets propionic acid Regulation reported REST resulting SARS-COV-2 infection secreted transcription factor transcriptional level [DOI] 10.1038/s41392-021-00822-x PMC 바로가기 [Article Type] Article
Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replicationResearch Article Published on 2021-12-062022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] Anti-viral approach Cell contribute contributed coronavirus Coronavirus replication CoV CoV infection CoV replication CoVs CRISPR CRISPR screen Critical disease disease pathogenesis effort Evidence Factor gastroenteritis Health highly pathogenic CoVs Host host gene identification identify Infection inhibit involved kidney performed potential therapeutic target progression Protein provide regulate Replication required reveal RNA virus RNA viruses susceptibility TGEV therapeutic target Tmem41b Vesicle viral infection virus virus replication [DOI] 10.1371/journal.ppat.1010113 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathwayResearch Article Published on 2021-12-062022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] abrogated activate Activation administration CCL2 chemokines co-cultured COVID-19 CXCL1 CXCL2 Cytokine storm elicited epithelial cell expressing S protein Extracellular Hyperinflammatory IFN IL-1β IL-6 induce Inflammation Inflammatory cytokine inflammatory function Inflammatory response investigated lung epithelial cell Macrophage macrophages mechanism membrane mice mouse macrophages NF-κB pathway nucleocapsid pathogenesis of COVID-19 potential therapeutic target produced Protein Proteins S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Spike protein stimulated structural protein the cytokine storm These data TLR1 TLR2 TLR6 TNF-α TNFα Trigger viruses wild-type [DOI] 10.7554/eLife.68563 PMC 바로가기 [Article Type] Research Article
Targeting Inflammasome Activation in COVID-19: Delivery of RNA Interference-Based Therapeutic MoleculesReview Published on 2021-12-032022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] absence Activation approach clinical outcomes clinical trial complications Consequences COVID-19 COVID-19 patient COVID-19 patients Critical delivery dependent on Drug efficacy dysregulation effective Efficacy immune dysregulation Inflammasome inflammasome activation mechanisms microRNA modulating Molecular targets molecule morbidity NLRP3 NLRP3 inflammasome non-coding RNA Non-coding RNAs Numerous pathogenesis of COVID-19 potential therapeutic target pro-inflammatory cytokine pro-inflammatory mediator reduce Research RNA RNA interference RNAs significantly targeting the cytokine storm therapeutic agent Therapeutic molecule Treatment Treatment strategies Vaccines variants of SARS-CoV-2 vector with COVID-19 worsened [DOI] 10.3390/biomedicines9121823 PMC 바로가기 [Article Type] Review
Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ DamageCOVID-19 환자의 단일 세포 및 벌크 RNaseQ 프로파일 링은 감염에 의한 장기 손상의 면역 및 염증 메커니즘을 나타냅니다.Article Published on 2021-12-022022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] accounted Analysis analyzed cardiac hypertrophy correlated COVID-19 COVID-19 infection COVID-19 organ damage COVID-19 patients gene expression Critical Cytokines damage deleterious effect determine downregulated downstream Effect effective Effectiveness eIF2 eukaryotic eukaryotic initiation factor 2 fibrosis Host host protein host proteins hypercytokinemia hypertrophy IL-17A IL-2 IL-6 IL-8 immune and inflammatory mechanisms of COVID-19 imperative induce Inflammation Inflammatory inflammatory genes inhibitors inhibitory initiation factor innate immune response Interaction interleukin investigation lead lung Lungs mechanism Mild moderate multiple organ failure NF-κB organ Organ failure organ injury organs overactive pathway Pathways patients peptide peptides potential therapeutic target potential therapeutic targets pro-inflammatory cytokine pro-inflammatory cytokines Profiling reduced RNAseq SARS-CoV-2 SARS-CoV-2 virus severe and critical patients severely infected patients Severity of infection single and bulk RNASeq cell profiling and analysis single-cell Stimulation suppress suppression therapeutic targets tissues translation Treatment upregulation Viral viral infection Viral protein Viral proteins viral-host protein was increased [DOI] 10.3390/v13122418 PMC 바로가기 [Article Type] Article
Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?Review Published on 2021-11-232022-10-30 Journal: Molecular Biomedicine [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor activities angiotensin-converting enzyme-2 caused cells consequence coronavirus disease 19 COVID-19 COVID-19 disease Cytokine storm healthcare Host Infection Inflammation innate immune response Interaction mechanism Mitochondria mitochondrial outbreak pandemic Pathologies pathology potential therapeutic target progression receptor role SARS-CoV-2 SARS-CoV-2 entry scrutiny shown significant changes in Spread therapeutic treatment for COVID-19 understanding unique virus [DOI] 10.1186/s43556-021-00060-1 PMC 바로가기 [Article Type] Review
Inhibition of Autophagy Suppresses SARS-CoV-2 Replication and Ameliorates Pneumonia in hACE2 Transgenic Mice and Xenografted Human Lung Tissues자가포식 억제는 SARS-CoV-2 복제를 억제하고 hACE2 형질전환 마우스 및 이종이식 인간 폐 조직에서 폐렴을 개선합니다Article Published on 2021-11-232022-09-11 Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, [키워드] 3-MA accompanied Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin animal model animal models anti-SARS-CoV-2 therapeutics Atg13 ATG14 Atg5 autophagic autophagy autophagy-inhibiting agent autophagy-inhibiting agents block caused Combination complex complexes contribute coronavirus Crab-eating macaque Critical elements enzyme events experimental evidence global pandemic hACE2 Huh-7 cells Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human lung human lung tissue IMPROVE in vitro in vivo induce Infection inhibit inhibition insight interfere involved mechanism mice modulation mouse mTOR pathway Pneumonia potential therapeutic target potential therapeutic targets SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppresse therapeutic agent therapeutic agents thought tissues transgenic mice Transgenic mouse Vero E6 virus infection Virus-host interaction Virus-host interactions Vps34 [DOI] 10.1128/JVI.01537-21 PMC 바로가기 [Article Type] Article