Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis차등 유전자 발현 패턴 분석에 의한 COVID-19와 당뇨병 사이의 일반적인 병원성 과정 발견Case Study Published on 2021-11-172022-09-01 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] analyses Analysis biological processe biological processes blood gene expression caused characterized Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient dataset DEGs diabete diabetes Diabetes Mellitus Differential gene expression differentially expressed gene downregulated dysregulated followed by functional Functional assessment Gene ontology GO term identify implicated Increased Infectious disease involved islets modulated molecular pathways mononuclear cell mononuclear cells Ontology Organoid pancrea pancreas pathway Pathways patients with diabete PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells prediction RELA SARS-CoV-2 severity of COVID-19 T1D T2D transcription factor transcription factors transcriptional transcriptional signatures transcriptomic Treatment Type 1 diabetes type 2 diabete type 2 diabetes upregulated upregulation whole-genome [DOI] 10.1093/bib/bbab262 PMC 바로가기 [Article Type] Case Study
Furin cleavage of the SARS-CoV-2 spike is modulated by O -glycosylationSARS-COV-2 스파이크의 푸린 절단은 O- 글리코 실화에 의해 조절된다.407 Published on 2021-11-032022-08-13 Journal: Proceedings of the National Academy of Sciences of [Category] Biochemistry, COVID-19, SARS, [키워드] O- abrogate Alpha alpha and delta variants Amino acid amino acids cells circumvent cleavage coronavirus decrease delta variant Delta variants dependent on expressed family members furin furin cleavage furin cleavage of S furin cleavage site GALNT GALNT enzyme global pandemic glycosylating S glycosylation highlight host O -glycosylation host-mediated O -glycosylation human respiratory cell human respiratory cells increase insertion insertion site modulated modulating Mutation O -glycosylation P681 P681 mutation P681 mutations position position 681 proline pseudoviral infectivity respiratory responsible resulting SARS-CoV-2 coronavirus SARS-COV-2 infection shown Significance spike Spike protein syncytia formation target targets the SARS-CoV-2 the spike protein tropism unique Viral viral infectivity viral infectivity/tropism [DOI] 10.1073/pnas.2109905118 PMC 바로가기 [Article Type] 407
Impact of SARS-CoV-2 Infection (COVID-19) on Cytochromes P450 Activity Assessed by the Geneva CocktailClinical Trial Published on 2021-11-012022-10-05 Journal: Clinical Pharmacology and Therapeutics [Category] 임상, [키워드] activity Acute inflammation acute respiratory syndrome administration Blood C-reactive protein Capillary blood sample caused clinically cocktail collected conducted coronavirus Coronavirus disease 2019 COVID-19 CRP CYP1A2 CYP2B6 CYP2C19 CYP2C9 CYP2D6 cytochrome demonstrated Diagnosis evaluate expected Geneva University Hospital Hospitalization IL-6 Impact impacted Infection inflammatory state moderate modulate modulated MRS P450 patients patients hospitalized patients with COVID-19 prospective observational study SARS-CoV-2 SARS-COV-2 infection Serum level severe COVID-19 significantly statistical significance substrates Switzerland the disease TNF-α treat Treatment tumor necrosis factor-α Variation [DOI] 10.1002/cpt.2412 PMC 바로가기 [Article Type] Clinical Trial
Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity선택된 SARS-CoV-2 신흥 변이체에 대한 단일 돌연변이의 기여는 항원성을 증가시킵니다.Article Published on 2021-11-012022-09-11 Journal: Virology [Category] SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 receptor antigenicity binding contribute coronavirus COVID-19 D614G variant decrease demonstrated Efficacy facilitate Interaction modulated observation observé Off-rate Pathogenesis phenotype Protein RBD SARS-CoV-2 selected single mutant single mutation single mutations spike spike glycoproteins Spike protein spikes temperature tested the Spike Transmissibility Transmission Vaccine vaccine efficacy Vaccines variant variants variants of concern variants of interest VOCs VOIs Wuhan-Hu-1 [DOI] 10.1016/j.virol.2021.09.001 PMC 바로가기 [Article Type] Article
Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patientsMulti-omic 접근법은 COVID-19 암 환자의 혈액에서 증식에 대한 타고난 면역 반응을 결합하는 전사 네트워크를 식별합니다.Article Published on 2021-10-292022-09-12 Journal: Cell Death & Disease [Category] MERS, 임상, 진단, [키워드] Alter alteration analyses Analysis analyzed approach Blood Cancer cancer patient Cancer patients cancer type CD4 CD8 Cell cell population central memory circulating clinical co-morbidities Cohort conducted contribute controls COVID-19 COVID-19 disease COVID-19 patient cytokine Cytometry Diseases Donor eight elevated enrichment analysis expression Gene Expression Genes highlight homeostasis identify IL-13 IL-6 IL-8 Immune cell immune function immune system immunological parameter immunology Infection Infectious diseases inflammation response innate immune response investigated IP-10 modulated mononuclear cell mortality rates multiplex natural killer outcome Patient PBMC PBMCs performed Peripheral blood plasmablast pro-inflammatory factor proliferation reduced Regulation SARS-COV-2 infection serum cytokine Signaling solid cancers Stage subpopulation T cell T lymphocyte transcriptional worsened [DOI] 10.1038/s41419-021-04299-y PMC 바로가기 [Article Type] Article
Platelet-derived sCD40L: specific inflammatory marker for early-stage severe acute respiratory syndrome coronavirus 2 infection혈소판 유래 SCD40L : 초기 단계의 심각한 급성 호흡기 증후군 코로나 바이러스 2 감염에 대한 특정 염증 마커Clinical Trial Published on 2021-10-292022-08-31 Journal: Virology Journal [Category] MERS, 바이오마커, 임상, [키워드] acute respiratory syndrome Admission Biomarker Biomarkers CD40L characterized clinical coagulation disorder coagulation disorders complications of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 death decrease early stage early stages elevated endothelial enzyme-linked immunosorbent enzyme-linked immunosorbent assay Evidence forms Human identify immunomodulatory molecule immunomodulatory molecules increase Infection Inflammation Inflammatory Inflammatory marker Inflammatory response inflammatory state Innate immunity lead leukocyte marker modulated observation observations observé on admission Organ failure overtime Patient plasma Plasma levels Platelet Platelets pro-inflammatory response registration date registration number registry regulate respiratory response Result SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV2 severe acute respiratory syndrome Coronavirus severe COVID-19 significantly the disease title Trial registration were used [DOI] 10.1186/s12985-021-01680-3 PMC 바로가기 [Article Type] Clinical Trial
K 2P 18.1 translates T cell receptor signals into thymic regulatory T cell developmentArticle Published on 2021-10-262022-10-04 Journal: Cell Research [Category] 신약개발, [키워드] Activation Autoimmune Autoimmunity Calcium signalling cell fate Clinical outcome developmental disorders dominant-negative driving expression facilitated gain-of-function identify in vitro in vivo increase in intracellular calcium Ion channel signalling Loss lymphoproliferative mice Mild Missense modulated modulation multiple sclerosis Mutation NF-κB Patient phenotype potassium channel provided reduced Regulatory Regulatory T cell selection process sustained T cell T cell receptor TCR therapeutic thymic thymic emigrant thymocyte transcription factor translate Treg upregulation urinary tract infections variant [DOI] 10.1038/s41422-021-00580-z PMC 바로가기 [Article Type] Article
The Potential Role of COVID-19 in the Pathogenesis of Multiple Sclerosis—A Preliminary ReportReview Published on 2021-10-172022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Affect cause caused Central nervous system CNS comparable coronavirus coughs COVID-19 COVID-19 patients COVID-19 symptom cytokine Cytokine storm diarrhea disease Encephalitis Encephalopathy fatigue fevers function glial cell Headaches hematogenous highlight include Infection Interaction interfere loss of taste Lungs mechanism microglia mitochondrial dysfunction modulated Multiple multiple sclerosis neurodegeneration Neuroinflammation Neuron neurotoxic neurotropic Parkinson’s disease Potential report Respiratory disease role SARS-CoV-2 sclerosis sore throat Spanish the SARS-CoV-2 [DOI] 10.3390/v13102091 PMC 바로가기 [Article Type] Review
Universal risk phenotype of US counties for flu-like transmission to improve county-specific COVID-19 incidence forecasts카운티 별 Covid-19 발병 예측을 개선하기위한 독감 유사 전송을위한 미국 카운티의 보편적 위험 표현형Research Article Published on 2021-10-142022-09-10 Journal: PLoS Computational Biology [Category] MERS, 유전자 메커니즘, [키워드] Applying Author automatically Behavior caused communicable communicable disease complex Course COVID-19 COVID-19 incidence COVID-19 pandemic demonstrated diagnostic disease dominant Effect Epidemic Epidemics Factor Factors flu Host identify illnesses Impact impacted IMPROVE incidence increase Infectious disease Infectious diseases Influenza influenza-like illnesses key factor knowledge Local machine learning mechanism mechanisms modulated Mortality Pandemics past pathogen Pathogens phenotype Predictive provided reduce risk seasonal flu Seasonal influenza sense Spread Transmission Universal while [DOI] 10.1371/journal.pcbi.1009363 PMC 바로가기 [Article Type] Research Article
Asymptomatic individuals can increase the final epidemic size under adaptive human behaviorArticle Published on 2021-10-052022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] adaptive Applied mathematics Asymptomatic consequence COVID-19 transmission driver Epidemic epidemiological Final human behavior Human behaviour include individual individuals Infection infection risk Infectious diseases mathematical modulated pre-symptomatic presenting produced reduce risk risk of infection symptomatic [DOI] 10.1038/s41598-021-98999-2 PMC 바로가기 [Article Type] Article