Severe Coronavirus Disease 2019 That Recovered from Respiratory Failure by Treatment That Included High-dose Intravenous Immunoglobulin고용량 정맥 면역 글로불린을 포함한 치료로 호흡 부전에서 회복 된 중증 코로나 바이러스 질병 2019Case Reports Published on 2021-02-012022-09-12 Journal: Internal medicine (Tokyo, Japan) [Category] MERS, SARS, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome caused Clinical improvement coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm decrease Deterioration effective Effects Factors failure High-dose immunosuppressive effect in viral Infection inhibiting interleukin-6 intravenous Intravenous immunoglobulin IVIG occurred proinflammatory proinflammatory cytokines pulmonary inflammation radiological recovered respiratory SARS-CoV-2 severe acute respiratory syndrome-coronavirus-2 severe coronavirus disease Treatment tumor necrosis factor-α [DOI] 10.2169/internalmedicine.6326-20 PMC 바로가기 [Article Type] Case Reports
Lung adenocarcinoma patients have higher risk of SARS-CoV-2 infection폐 선암 환자는 SARS-CoV-2 감염 위험이 더 높습니다Research Paper Published on 2021-01-312022-09-10 Journal: Aging (Albany NY) [Category] 유전자 메커니즘, [키워드] ACE2 addition Alter Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assumed Atla AZU1 Bioinformatics analysis center coronavirus disease Coronavirus disease 2019 correlated COVID-19 CXCL9 enzyme expressed FCN3 followed by functional Gene Expression Omnibus higher risk HYAL1 IL6 immunological IRAK3 lung adenocarcinoma mechanism microRNA MicroRNAs miR-125b-5p miRNA MMP12 mRNA mRNAs network Patient patients profile pulmonary inflammation receptor risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility screened signaling pathway tissue Toll-like receptor was increased [DOI] 10.18632/aging.202375 PMC 바로가기 [Article Type] Research Paper
COVID-19: Integrating the Complexity of Systemic and Pulmonary Immunopathology to Identify Biomarkers for Different OutcomesCOVID-19: 다양한 결과에 대한 바이오마커 식별을 위한 전신 및 폐 면역병리학의 복잡성 통합Review Published on 2021-01-292022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] affected Biomarker Biomarkers caused clinical clinical evidence clinical outcomes Clinical studies clinical study complexity comprehension contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 illness Critical damage tolerance dysregulation effort Evidence exceptional high viral load highlight hyperinflammation interface lung immunopathology Mild moderate pandemic peripheral immune response pulmonary pulmonary immunopathology pulmonary inflammation reduce Scientific community severe COVID-19 systemic the disease therapeutic strategy Tolerance Viral Viral load [DOI] 10.3389/fimmu.2020.599736 PMC 바로가기 [Article Type] Review
Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infectionsArticle Published on 2021-01-072022-10-04 Journal: Cell Death & Disease [Category] 진단, [키워드] Activation administration alleviate anti-inflammatory property biological processe Bronchoalveolar lavage fluid chemokine circulating co-culture co-cultured Concentration correlated counteract COVID-19 patients disease severity Effect Host implication in viral in vitro indicate Inflammation Inflammatory diseases Inflammatory response Influenza inhibiting innate immune response Interleukins lung Lung injury Lymphocytes Macrophage MAPK microenvironment mitigate neutrophil NF-κB signaling Pathways Pneumonia pro-inflammatory cytokine pulmonary inflammation reduced respiratory epithelial cell Respiratory tract diseases respiratory viral infection respiratory viral infections shown significantly Stat1 STAT3 therapeutic therapeutic target transcriptomic virus [DOI] 10.1038/s41419-020-03283-2 PMC 바로가기 [Article Type] Article
Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample sizeCOVID-19 치료에서 토실리주맙과 파비피라비르 병용: 소규모 표본 크기의 다기관 시험Randomized Controlled Trial Published on 2021-01-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 임상, 진단, 치료법, 치료제, [키워드] 95 % CI Absorption addition assigned Blood routine clinical symptom Clinical symptoms Combination Combined therapy COVID-19 COVID-19 patient COVID-19 patients cumulative Deterioration drug Efficacy and safety elevated Favipiravir help IL-6 IMPROVE indicated inhibit interleukin interleukin-6 lung Lung CT Lung inflammation lung lesion Multicenter trial no significant difference Patient patients with COVID-19 Primary outcome pulmonary inflammation Randomly reported SARS-CoV-2 Serious Adverse Event Serious Adverse Events significant difference significantly significantly higher small sample size spread to the disease theory Tocilizumab Treatment treatment of COVID-19 with COVID-19 [DOI] 10.1016/j.biopha.2020.110825 PMC 바로가기 [Article Type] Randomized Controlled Trial
RAC1 nitration at Y 32 IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury지질다당류 매개 급성 폐 손상과 관련된 내피 장벽 파괴에 관여하는 Y 32 IS에서의 RAC1 니트로화Article Published on 2021-01-012022-09-11 Journal: Redox Biology [Category] SARS, 유전자 메커니즘, 진단, [키워드] Activation acute lung injury alveolar approach attenuate contractile COVID-19 dependent on determine effective therapy endothelial Endothelial cell endothelial cells functional high mortality human lung identify increase induce inhibitor involved junction lipopolysaccharide Local LPS lung Lung function Lung inflammation Lung injury mass spectrometry mechanism molecular murine model Nitration nucleotide peptide phenotype prevented pulmonary inflammation Rac1 Rac1. reduce reduced Rho GTPase Rho GTPases RHOA Sepsis severe pneumonia shielding shown switch systemic inflammation therapeutic target tyrosine vascular permeability [DOI] 10.1016/j.redox.2020.101794 PMC 바로가기 [Article Type] Article
Mesenchymal Stem Cells (MSCs) as a Potential Therapeutic Strategy in COVID-19 Patients: Literature ResearchCell and Developmental Biology Published on 2020-11-192022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] anti-inflammatory activity ARDS Biology cell-based therapies Cell-based therapy Characteristics China coronavirus COVID-19 COVID-19 disease COVID-19 patients Critical Critical case Cytokine storm dimension effective therapy Engineering Health literature lung Medicine mesenchymal stem cell Mesenchymal stem cells MSC MSCs outbreak outcome pandemic Pathologies Pneumonia positive Potential Pulmonary edema pulmonary inflammation raised reported representing respiratory responsible SARS-CoV-2 Secretome shown specific treatment STEM Strategy Symptoms symptoms of COVID-19 therapeutic potential therapeutic strategy these cell Treatment Vaccine were used [DOI] 10.3389/fcell.2020.602647 PMC 바로가기 [Article Type] Cell and Developmental Biology
Risk of hospitalization for Covid-19 outpatients treated with various drug regimens in Brazil: Comparative analysisResearch article Published on 2020-11-012022-10-05 Journal: Travel medicine and infectious disease [Category] SARS, 치료제, [키워드] age antiviral medication approach benefit Brazil Cardiac arrhythmia Comparative analysis COVID-19 death disease drug regimen Efficacy emergency room ENhance EREmergency Room HCQ HCQhydroxychloroquine Health Maintenance Organization HMOHealth Maintenance Organization hospital Hospitalization Hydroxychloroquine magnitude medication medications mortality risk not significant obesity Older oseltamivir Outpatient pandemic patients physician Prednisone presenting protocol pulmonary inflammation reduce reduced reduced risk Result risk SARS-CoV-2-positive patient significantly Symptom treat treated Treatment type-2 diabete [DOI] 10.1016/j.tmaid.2020.101906 [Article Type] Research article
SARS-CoV-2-Related Kidney Injury: Current Concern and ChallengesCovid-19 Published on 2020-09-232022-10-29 Journal: Sn Comprehensive Clinical Medicine [Category] COVID-19, [키워드] ACE2 Blood purification cause caused challenge Characteristics Chronic kidney disease CKD concern Coronavirus disease 2019 COVID-19 current Diagnosis highlight Immunotherapy kidney kidney damage Kidney function Kidney injury kidney tissues mechanism organ Pathogenesis Patient problem pulmonary inflammation recent finding receptor reducing SARS-CoV-2 SARS-COV-2 infection Therapeutic approach therapy Treatment virus [DOI] 10.1007/s42399-020-00529-0 PMC 바로가기 [Article Type] Covid-19
Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19Physiology Published on 2020-09-182022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] ACE2 ACE2 expression adipose aggravate angiotensin angiotensin-converting enzyme 2 cardiovascular disease caused cells changes in chronic disease clearance correlated COVID-19 COVID-19 pandemic dataset described diabete dysregulated expression expression of gene Host host cell in silico in vitro in vitro result increased risk infected with SARS-CoV-2 Inflammation Injury involved knowledge lipid metabolism lung lung epithelial cell Lungs mechanism Mortality novel coronavirus SARS-CoV-2 obese obese patient obesity pathway Patient Protein pulmonary inflammation receptor regulated Regulation risk factor SARS-CoV-2 severe complication shown Signaling significant increase smoking subject subjects suppression tissue TMPRSS2 transcriptomic data upregulation validation viral entry viral replication virus [DOI] 10.3389/fphys.2020.555039 PMC 바로가기 [Article Type] Physiology