Escape and Over-Activation of Innate Immune Responses by SARS-CoV-2: Two Faces of a CoinSARS-CoV-2에 의한 타고난 면역 반응의 탈출 및 과잉 활성화: 동전의 두 얼굴Review Published on 2022-03-042022-09-11 Journal: Viruses [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] addition cellular receptor coin coronavirus CoV COVID-19 pathogenesis CoVs Cytokines Defense disease dysregulated escape evade face Host human population IFN IFN signaling pathways IL-1 IL-1 family cytokine IL-1 family cytokines IL-18 IL-1β immune responses Inflammasome inflammasome activation inflammasomes Innate innate immune innate immune response innate immune responses innate immune system Innate immunity interferon invading pathogens MERS MERS-CoV Multiple Pathogenesis Pathogens potential mechanism potential mechanisms Prognosis pyroptosis Recognition response SARS-CoV-1 SARS-CoV-2 with COVID-19 [DOI] 10.3390/v14030530 PMC 바로가기 [Article Type] Review
Multisystem inflammatory syndrome in adults: a case report and review of the literature성인의 다기관 염증 증후군: 증례 보고 및 문헌 검토Review Published on 2022-03-032022-09-12 Journal: Journal of Medical Case Reports [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Adults African American Antibiotics blood pressure Case report ceftriaxone coronavirus coronavirus disease COVID de novo diagnosed Diagnosis discharged home distress emergency department end organ end organ damage example female Fever heart rate hospital Hypotension Immunoglobulin Infection Inflammatory initial initiated intensive care intensive care unit intravenous fluid intravenous fluids management minute MIS-A mmHg Neck swelling normal saline organ damage Organ failure outcomes pandemic pathophysiology Patient presenting rapid response Recognition reported Research respiratory distress severe acute respiratory syndrome Coronavirus sore throat syndrome temperature transferred treated Treatment vancomycin Vasopressor vasopressors viral infection while [DOI] 10.1186/s13256-022-03295-w PMC 바로가기 [Article Type] Review
Emotional Speech Recognition Method Based on Word Transcription단어 전사에 기반한 감성 음성 인식 방법Article Published on 2022-03-022022-09-10 Journal: Sensors (Basel, Switzerland) [Category] MERS, SARS, 치료기술, [키워드] Accuracy affective computing applied artificial intelligence can be used carried Complete computational resources conducted COVID-19 crowd crowd emotion recognition described develop Distance learning e-learning Effectiveness emotion recognition emotional example experiment Hypothesis Kazakh language knowledge knowledge base message negative emotion negative emotions occur positive public transport Recognition recognize recognizing Schools shown signal speech speech recognition threat Transcription Transport universities widespread [DOI] 10.3390/s22051937 PMC 바로가기 [Article Type] Article
Screening of potential spike glycoprotein / ACE2 dual antagonists against COVID-19 in silico molecular docking인실리코 분자 도킹에서 COVID-19에 대한 잠재적 스파이크 당단백질/ACE2 이중 길항제의 스크리닝Article Published on 2022-03-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료제, [키워드] ACE2 antagonist Antiviral antiviral drugs Candidates caused Chinese Chrysophanol component coronavirus disease COVID-19 Dual antagonists effective effective drug effective drugs glycoprotein in silico inhibitory activity Invasion investigated medical resource Medicine molecular docking Novel coronavirus novel coronavirus disease oleanolic acid Recognition rhein SARS-CoV-2 Screening spike spike glycoprotein Spike protein Spread sustained TCM the epidemic Traditional Traditional Chinese medicine Treatment treatment of COVID-19 [DOI] 10.1016/j.jviromet.2021.114424 PMC 바로가기 [Article Type] Article
Bayesian-based optimized deep learning model to detect COVID-19 patients using chest X-ray image data흉부 X선 영상 데이터를 이용한 코로나19 환자 검출을 위한 베이지안 기반 최적화 딥러닝 모델Article Published on 2022-03-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료기술, [키워드] Accuracy Analysis artefact artificial artificial intelligence assist Bayesian Bayesian optimization changed chest X-ray Chest X-ray image Chest X-ray images CNN components Convolutional neural network coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical dataset deep deep learning detect domain domains Features globe Image image classification intelligence learning optimization provided recent Recognition Research Research question researchers shown suggested variety [DOI] 10.1016/j.compbiomed.2022.105213 PMC 바로가기 [Article Type] Article
Limited Recognition of Highly Conserved Regions of SARS-CoV-2SARS-CoV-2의 고도로 보존된 지역에 대한 제한된 인식Research Article Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antigen-specific CD8+ T cells approach CD8 circulating Community Comparative conservation conserved conserved regions convalescent coronavirus coronavirus disease coronavirus strains COVID-19 Critical cross-protective immunity cross-reactive disease encoded protein epitope epitope mapping Epitopes exposure to FIVE Frame generate immune protection immune response immune responses immunodominant implication individuals less likelihood Limited memory memory T cells nucleocapsid observation Open reading frame ORF1 ORF1ab overcome pandemic Participants polyprotein Preexisting immunity protective role Protein Recognition Region required respiratory robust SARS-CoV-2 SARS-CoV-2 infected cells seasonal coronaviruses Sequence analysis severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease T cell T cell response T cell responses T cells T-cell epitope T-cell epitopes T-cell Response T-cell responses understanding unlikely vaccination volunteers [DOI] 10.1128/spectrum.02780-21 PMC 바로가기 [Article Type] Research Article
The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication2019년 코로나바이러스 질환의 폐외 합병증의 기저 메커니즘 및 치료적 의미Review Published on 2022-02-232022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 임상, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect caused clinical implication clinical implications Complication complications complications of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Disease progression Effect feature global public health host inflammatory response immunological indirect mechanism Infectious diseases management mechanism multifactorial Pathogenesis pathophysiologic patients with COVID-19 Perspective potential therapeutic target potential therapeutic targets provide Recognition respiratory respiratory distress Respiratory system Respiratory tract diseases SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe cases severe pneumonia syndrome therapeutic Therapeutic strategies [DOI] 10.1038/s41392-022-00907-1 PMC 바로가기 [Article Type] Review
CNN-LSTM Hybrid Real-Time IoT-Based Cognitive Approaches for ISLR with WebRTC: Auditory Impaired Assistive TechnologyResearch Article Published on 2022-02-212022-10-31 Journal: Journal of Healthcare Engineering [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] Algorithm Analysis audible sound auditory average Community COVID-19 expressions facial feature globe healthcare help hybrid Impaired impairment individual Internet ISLR means memory platform provided Recognition Research SIGN technology WebRTC [DOI] 10.1155/2022/3978627 PMC 바로가기 [Article Type] Research Article
Comparison between Nasal and Nasopharyngeal Swabs for SARS-CoV-2 Rapid Antigen Detection in an Asymptomatic Population, and Direct Confirmation by RT-PCR from the Residual Buffer무증상 집단에서 SARS-CoV-2 신속 항원 검출을 위한 비강 및 비인두 면봉의 비교 및 잔류 완충액에서 RT-PCR에 의한 직접 확인Comparative Study Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Ag-RDT Ag-RDTs Antigen applied approach Asymptomatic Asymptomatic individuals benefit Bilateral buffer confirmation Contact tracing Containment containment measures COVID-19 COVID-19 pandemic cycle threshold demonstrated detection diagnostic test Direct individual Isolation less measure molecular nasal nasopharyngeal NP swab offer participant performed Population positive positive individuals Rapid Rapid diagnostic test RDTs Recognition recollection residual returned reverse transcription-PCR RT-PCR RT-PCR testing SARS-CoV-2 screened sensitivity specimen Swab swabbing Viral viral loads [DOI] 10.1128/spectrum.02455-21 PMC 바로가기 [Article Type] Comparative Study
Heparin interacts with the main protease of SARS-CoV-2 and inhibits its activity헤파린은 SARS-CoV-2의 주요 프로테아제와 상호작용하여 그 활성을 억제합니다.Article Published on 2022-02-152022-09-11 Journal: Spectrochimica acta. Part A, Molecular and biomole [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro active site activity antiviral drug bind binding Characteristics demonstrated dependent on energy transfer Fluorescence Fluorescence quenching group heparin host cell host cells hydrogen hydrogen bond interaction hydrophobic information inhibit inhibiting inhibitory concentration Inhibitory effects interact Interaction M pro main protease molecular docking analysis parameter polyprotein precursor protease Protein proteolytic activity Recognition replicate SARS-CoV-2 SARS-COV-2 infection suggested thermodynamic [DOI] 10.1016/j.saa.2021.120595 PMC 바로가기 [Article Type] Article