Repurposing functional inhibitors of acid sphingomyelinase (fiasmas): an opportunity against SARS-CoV-2 infection?산 스 핑고 마이 엘리나 제 (Fiasmas)의 기능적 억제제를 재구성 : SARS-COV-2 감염에 대한 기회?Review Published on 2021-10-012022-08-31 Journal: Journal of clinical pharmacy and therapeutics [Category] SARS, 신약개발, [키워드] ABCB1 ABCB1 transporter acid sphingomyelinase Antiviral antiviral activity approved caused Compound coronavirus COVID-19 COVID-19 pandemic drug Drug repurposing Drug-drug interactions effective evaluate functional functional inhibitors of acid sphingomyelinase in vitro in vitro activity in vitro and in silico Infection infections inhibitor Medicines Patient rationale regimen repurposing responsible SAR-CoV-2 SARS-CoV-2 translation Treatment Viral viral kinetics virus viruses [DOI] 10.1111/jcpt.13390 PMC 바로가기 [Article Type] Review
“Impact of pentaglobin in severe COVID 19 pneumonia- a prospective study.”"심각한 COVID 19 폐렴에서 펜타글로빈의 영향-전향적 연구."Article Published on 2021-10-012022-09-12 Journal: International immunopharmacology [Category] MERS, 진단, [키워드] 95% CI added addition administration APACHE II score average control group COVID COVID 19 COVID pneumonia COVID-19 COVID-19 pandemic COVID-19 pneumonia death disease effective Effectiveness global public health group Hospital stay immunomodulation imperative independent predictor Inflammation Inflammatory intravenous invasive ventilation laboratory parameter mean difference mechanical ventilation Mortality no significant difference no significant effect Open-label Patient patients Pentaglobin Pneumonia quantified reducing reduction risk SAR-CoV-2 severity of illness Severity Score SOFA score Standard of care Standard therapy standard treatment the study group Treatment two groups worsening [DOI] 10.1016/j.intimp.2021.107968 PMC 바로가기 [Article Type] Article
Lack of Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spillover in Free-Living Neotropical Non-Human Primates, Brazil중증 급성 호흡기 증후군 코로나 바이러스 2 (SARS-COV-2) 브라질의 자유 생활 네오 트로마 비인간 영장류의 유출 증거 부족Communication Published on 2021-09-252022-09-01 Journal: Viruses [Category] Fulltext, SARS, 조류인플루엔자, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus agent association bats Brazil coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 effort emerging virus event Evidence evidence of globe Health hotspot human coronaviruses human population human populations humans implication infect Infection infection with SARS-CoV-2 Like molecular no evidence of non-human primate non-human primates pandemic populations primates raise respiratory responsible Rio SAR-CoV-2 SARS-CoV-2 serological test Serological tests severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 species spillback Spread Surveillance susceptible sustained variety while wildlife [DOI] 10.3390/v13101933 PMC 바로가기 [Article Type] Communication
Methodological limitations in studies assessing the effects of environmental and socioeconomic variables on the spread of COVID-19: a systematic reviewReview Published on 2021-09-102022-11-01 Journal: Environmental Sciences Europe [Category] COVID-19, [키워드] Abstract article articles carried concerning COVID-19 COVID-19 pandemic database Effect eligible Environmental (meteorological and air pollutants) variables evaluated excluded greater high risk include limitation Measurement error methodological limitation methodological limitations moderate outcomes Prevent question Regression model risk of bia Risk of bias SAR-CoV-2 social contact Social contacts Socioeconomic variables Spread spread of COVID-19 statistical model supplementary material systematic review variable variables Web of Science while [DOI] 10.1186/s12302-021-00550-7 PMC 바로가기 [Article Type] Review
COVID-19 mRNA vaccination leading to CNS inflammation: a case seriesArticle Published on 2021-09-042023-06-15 Journal: Journal of Neurology [Category] MERS, SARS, [키워드] COVID-19 Demyelination Inflammation multiple sclerosis Neuromyelitis Optica SAR-CoV-2 vaccination [DOI] 10.1007/s00415-021-10780-7 PMC 바로가기
Assessment of thyroid function of newly diagnosed SARS-CoV-2 infected patients in NigeriaResearch Published on 2021-09-022022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, [키워드] Affect analysed assessment carried changes Concentration Control controls coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cross-sectional diagnosed ELISA euthyroid euthyroidism global pandemic healthy hormone hs-CRP impair Infection Nigeria organ outbreak participant plasma recruited Result SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 infected patient sick significantly higher Spread SPSS statistical significance Subclinical hypothyroidism syndrome the mean Thyroid thyroid function thyroid stimulating hormone thyroxine Treatment tri-iodothyronine TSH uninfected uninfected control were measured [DOI] 10.11604/pamj.2021.40.9.26358 PMC 바로가기 [Article Type] Research
Monitoring the presence and persistence of SARS-CoV-2 in water-food-environmental compartments: State of the knowledge and research needs물-식품-환경 구획에서 SARS-CoV-2의 존재 및 지속성 모니터링: 지식 및 연구 요구 사항 현황Review Published on 2021-09-012022-09-11 Journal: Environmental research [Category] Coronavirus, SARS, 변종, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus Aerosols claimed Contact coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 effective environmental contamination face masking food Health Organization implementation include infectious information integration Interaction knowledge measure Measures media monitoring Pandemics pathway persistence persistent Persistent viral molecules required Research risk SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus social distancing speculation Spread state Transmission transmission pathway transmission pathways variant viral outbreak virus virus spread virus transmission water Water-food safety. World Health Organization [DOI] 10.1016/j.envres.2021.111373 PMC 바로가기 [Article Type] Review
The Impact of Risk-Adjusted Heparin Regimens on the Outcome of Patients with COVID-19 Infection. A Prospective Cohort StudyBrief Report Published on 2021-08-302022-10-28 Journal: Viruses [Category] Coronavirus, MERS, SARS, [키워드] 95% CI adjusted Administered anticoagulation bleeding clinical symptom Complication consecutive patient contraindications Course COVID-19 daily dose defined died dose Eligible patients event heparin high risk hospital Hospitalization hospitalized patient Impact induce Infection intensity Italian less Major major bleeding moderate objective Patient patients patients with COVID-19 performed pharmacological prediction Prophylaxis Prospective Pulmonary embolism receive regimen reported risk SAR-CoV-2 score severity Stratification thrombosis Venous Thromboembolism venous thromboembolism (VTE) VTE was used with COVID-19 [DOI] 10.3390/v13091720 PMC 바로가기 [Article Type] Brief Report
Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 ReplicationBrief Report Published on 2021-08-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Antiviral Antiviral agents Antiviral assays block caused COVID-19 demonstrated derivative disease enzyme inhibit SARS-CoV-2 inhibitor molecular target non-nucleotide inhibitor pandemic of COVID-19 polymerase Potential treatment RdRP Replication RNA RNA-dependent RNA polymerase SAR-CoV-2 SARS-CoV-2 significantly targets Viral RNA [DOI] 10.3390/v13081585 PMC 바로가기 [Article Type] Brief Report
Electrocardiographic manifestations of COVID-19: Effect on cardiac activation and repolarizationResearch article Published on 2021-08-062022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, [키워드] abnormality Activation administration Analysis baseline Biomarker BNP cardiac involvement control group COVID-19 COVID-19 disease discharged disease course disease severity drugs ECG Effect electrocardiogram elevated evaluated finding foundation Francis funding heart tissue ICU identify increase in Inpatient interval Intervention manifestation marker Mortality multivariable analysis NT pro-BNP NTPRO BNP Patient patients with COVID-19 patients with influenza peptide performed predict predicted predictor progression Prolonged QRS QT interval QTc QTc interval QTC prolongation Repolarization reported Retrospective study SAR-CoV-2 troponin troponin level virus particle was used were measured with COVID-19 [DOI] 10.1016/j.eclinm.2021.101057 [Article Type] Research article