A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine재조합 SARS-CoV-2 단백질 백신에 대한 강력한 항바이러스 면역 반응 유도를 위한 조합 보조제Immunology Published on 2021-09-162022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] activate Adaptive immune response adaptive immune responses adjuvant adjuvants antibody Antibody titers Antigen B.1.351 breadth candidate cellular response Combination cross-protection effective elicited ENhance Heterologous homologous Immune profile immune responses Immunity IMPROVE induction intranasal intranasal vaccine mice mucosal mucosal adjuvant N501Y mutation nanoemulsion (NE) neutralizing antibody titers NLRP3 P.1 variants passive transfer potent recombinant response RIG-I RIG-I agonist RNA robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants Spike protein TLR TLRs transfer vaccination variant variants variety Viral viral challenge virus-neutralizing antibody [DOI] 10.3389/fimmu.2021.729189 PMC 바로가기 [Article Type] Immunology
Mesenchymal stromal cells as a therapeutic intervention for COVID-19: a living systematic review and meta-analysis protocolCovid-19에 대한 치료 중재로서의 중간 엽 기질 세포 : 살아있는 체계적인 검토 및 메타 분석 프로토콜Protocol Published on 2021-09-152022-08-31 Journal: Systematic Reviews [Category] COVID-19, meta-analysis, SARS, [키워드] activated acute respiratory distress syndrome adverse event adverse events ARDS benefit Case series characterization Clinical outcome clinical study Community concerning conditioned media Controlled controlled trials Coronavirus disease 2019 COVID-19 CRD data extraction database determine Efficacy Evidence Exosomes extracellular vesicle Extracellular vesicles global pandemic Health Health policy immune response immune responses immunomodulatory information Isolation Laboratory lack life-threatening Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells meta-analyses Meta-analysis Microvesicles Mild MSC MSCs non-randomized outcomes pandemic Patient patient population performed Pneumonia populations protocol random-effect random-effects Random-effects meta-analysis Randomized real time SARS-CoV-2 SARS-COV-2 infection secreted Secretome Sepsis severe acute respiratory syndrome coronavirus 2 stromal cells subsequent supplementary material systematic literature search systematic review therapeutic intervention tissue repair treat trials [DOI] 10.1186/s13643-021-01803-5 PMC 바로가기 [Article Type] Protocol
Rapid induction of antigen-specific CD4 + T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination항원 특이적 CD4 + T 세포의 신속한 유도는 SARS-CoV-2 mRNA 백신 접종에 대한 체액 및 세포 면역의 조정과 관련이 있습니다.Article Published on 2021-09-142022-09-11 Journal: Immunity [Category] MERS, SARS, 바이오마커, 진단, [키워드] Activation activation induced markers AIM Analysis booster vaccination CD4 CD8 Cell cellular immunity Clinical efficacy correlated first dose follicular healthy highlight humoral immune response immune responses immunological Immunological memory individual individuals Kinetics Last magnitude mRNA mRNA vaccination mRNA vaccine mRNA vaccines naïve subjects Neutralizing antibodies performed prime and boost priming question Rapid induction response SARS-CoV-2 second dose shown subject subjects T cell T cell response T cell responses T cells T follicular helper Tfh Th1 trajectory vaccination vaccine dose [DOI] 10.1016/j.immuni.2021.08.001 PMC 바로가기 [Article Type] Article
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy항-CD20 요법을 받고 있는 다발성 경화증 환자에서 SARS-CoV-2 mRNA 백신 접종 후 세포 및 체액 면역 반응Article Published on 2021-09-142022-09-10 Journal: Nature Medicine [Category] MERS, SARS, 비임상, 진단, [키워드] activated ameliorated anti-CD20 anti-CD20 therapy Anti-RBD IgG antibodies antibody Antigen antigen-specific antibody B cell BNT162b2 breath CD4 CD8 CD8 T cell CD8 T cell responses Cell circulating COVID-19 domain follicular generate Health policy healthy control healthy controls healthy individuals humans humoral immune response immune immune protection immune responses Immunosuppressed immunosuppressed patient immunosuppressed patients implication in healthy individual investigated memory B memory B cell memory B cells Messenger RNA monoclonal antibody monotherapy Most patients mRNA mRNA vaccination mRNA vaccine mRNA-1273 multiple sclerosis Patient patients priming public health Receptor-binding domain reduced response responses RNA vaccines robust SARS-CoV-2 SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody significantly skewed specific antibodies T cell T cell response T cell responses T cells the SARS-CoV-2 These data treated Treatment type 1 helper vaccination vaccine-induced immune response [DOI] 10.1038/s41591-021-01507-2 PMC 바로가기 [Article Type] Article
New-onset IgG autoantibodies in hospitalized patients with COVID-19COVID-19로 입원한 환자에서 새로 발병한 IgG 자가항체Multicenter Study Published on 2021-09-142022-09-12 Journal: Nature Communications [Category] SARS, 변종, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] anti-cytokine anti-viral antibody anti-viral antibody response anti-viral antibody responses antibodies autoantibodies autoantibody autoantigen Autoantigens Autoimmune Autoimmunity cause clinical manifestations Connective tissue diseases coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines de novo develop disorder feature healthy controls hospitalised patient Hospitalised patients hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient IgG IgG antibodies IgG antibody immune response immune responses Influenza less magnitude myositis non-structural proteins overlap pathogenic viruses Patient positively correlated proportion Protein recognizing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins SARS-CoV2 seasonal coronavirus seasonal coronaviruses serum structural protein structural proteins subset Systemic sclerosis viral infection with COVID-19 [DOI] 10.1038/s41467-021-25509-3 PMC 바로가기 [Article Type] Multicenter Study
Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis비정상적인 FLIP/STAT3 축에 의한 치명적인 사이토카인 방출 증후군Article Published on 2021-09-132022-09-10 Journal: Cell Death and Differentiation [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] approach caspase caspase-8 characterized clinical phenotype Control COVID-19 CRS cytokine Cytokine release syndrome Cytokines death detect dysregulated elevated expressed expression homolog immune disorders immune response immune responses Inflammation Inflammatory inflammatory pathology Inflammatory responses inflammatory state Intervention life-threatening Lung injury Lungs lymphopenia mice multiple organ dysfunction myeloid cell myeloid cells organ dysfunctions Organ failure organ failures pandemic pathogen invasion pathophysiology pathway Pathways Protein provoke regulated response SARS-CoV-2 pandemic STAT3 suppress syndrome the SARS-CoV-2 triggered Viral [DOI] 10.1038/s41418-021-00866-0 PMC 바로가기 [Article Type] Article
Potential Therapeutic Effect of Micrornas in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2SARS-CoV-2에 대한 중간엽 줄기세포의 세포외 소포에서 Micrornas의 잠재적 치료 효과Article Published on 2021-09-122022-09-11 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter anti-SARS-CoV-2 anti-viral response binding cellular physiology complementary components conserved coronavirus COVID-19 Cytokine storm Cytopathic effect cytopathic effects differentiation Effect EVs expressed expression extracellular vesicle Extracellular vesicles FIVE human gene human genes immune response immune responses infected cell infected cells Infection inhibiting membrane-bound mesenchymal stem cell micro-RNA microenvironment miR-181a-5p miR-23a-3p miRNA miRNAs mRNAs mutated myriad nucleic acids peptides Potential Proinflammatory response proliferation Proteins Region regulate released rescue respiratory RNAs SARS-CoV-2 SARS-CoV-2 virus sequence severe acute respiratory syndrome Coronavirus STEM suppression tested therapeutic agent therapeutic agents UTR variant variety Vesicle vesicles Viral viral gene viral genome viral infection viral replication [DOI] 10.3390/cells10092393 PMC 바로가기 [Article Type] Article
COVID-19 Pandemic and Vaccines Update on Challenges and ResolutionsCOVID-19 팬데믹 및 백신 관련 과제 및 해결 방법 업데이트Review Published on 2021-09-102022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, [키워드] ACE-2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 all age group all age groups Alpha Antibody-dependent enhancement approach approval approved attenuated vaccine Attenuated Virus B.1.1.7 B.1.351 B.1.429 B.1.525 B.1.617 B.1.617.2 BCG being Beta booster dose candidate vaccine caused CD8 challenge China city clinical development clinical trial combating Compliance contrary Coronaviridae family coronavirus coronavirus disease Coronavirus-2 COVID-19 CTL Delta disease severity Effectiveness Efficacy elicit Emergency use Epsilon Eta Gamma herd immunity host cells immune activation immune response immune responses Immunity inactivated Inactivated Vaccines inhibit intracellular pathogen Live attenuated vaccine MOST Multiple multiple antigens multivariant vaccines Mutation mutations Neutralizing antibodies neutralizing antibody nucleic acids pandemic pathogen Phase III clinical trials platform potential limitations Prophylactic Replication Resolution RNA virus SARS CoV-2 variant SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein subunit vaccines T cell the Coronaviridae Vaccine vaccine candidate Vaccine hesitancy Vaccines variant variants Viral Viral antigen viral antigens viral entry viral spike protein viral vectors virus viruses WHO Wuhan [DOI] 10.3389/fcimb.2021.690621 PMC 바로가기 [Article Type] Review
Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamstersVaccinia 바이러스 기반 백신은 시리아 햄스터에서 SARS-COV-2 바이러스에 대한 보호 면역을 부여합니다.Research Article Published on 2021-09-092022-09-10 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adenovirus-based Beta C57BL/6 candidate Candidates cause caused cold chain Coronavirus-2 Coronaviruses COVID-19 disease effective Express full-length SARS-CoV-2 full-length SARS-CoV-2 spike protein hamster hamsters Human immune response immune responses induce infected individual infected individuals Infection mammalian cells mice Mortality MOST mRNA Neutralizing antibodies neutralizing antibody Prevent protective immunity recombinant vaccine recombinant vaccines regimen regimens respiratory Respiratory illness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe respiratory illness Spike protein vaccination Vaccine vaccine platform vaccinia vaccinia virus variant Viral viral spread viral strain viral strains virus [DOI] 10.1371/journal.pone.0257191 PMC 바로가기 [Article Type] Research Article
Degenerate CD8 Epitopes Mapping to Structurally Constrained Regions of the Spike Protein: A T Cell-Based Way-Out From the SARS-CoV-2 Variants Storm스파이크 단백질의 구조적으로 제한된 영역에 매핑되는 CD8 에피토프 변성: SARS-CoV-2 변이체 폭풍으로부터의 T 세포 기반 탈출구Review Published on 2021-09-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] Analysis analyzed arising B cell responses can not candidate CD8 CD8 T cell CD8 T cell epitopes CD8 T cell responses CD8 T cells CD8 T-cell Cell-mediated immunity compensated conserved COVID-19 vaccines cross-neutralization degenerate Efficacy ENhance epitope Epitopes Evolution expected HLA HLA class I HLA class I molecules immune response immune responses immunization immunodominant impairing inactivation limit maintain mapping mutate mutations Neutralizing antibodies Perspective Population Protective protective immunity Region response S-protein SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variants spike region stimulatory storm T cell T cell epitopes T cells the SARS-CoV-2 the Spike translational vaccination Vaccination strategies Vaccination strategy Vaccine Vaccines variant variants variants of concern Viral viral escape viral variant Viral variants [DOI] 10.3389/fimmu.2021.730051 PMC 바로가기 [Article Type] Review