ACE-2 receptor – Page 6 – Communicable Diseases Research

Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways

Review Article

Published on 2020-11-282022-10-30
Journal: International Journal of Endocrinology [Category] COVID-19,

The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure

Review

Published on 2020-11-142022-10-28
Journal: The Cochrane database of systematic reviews [Category] COVID-19,

[키워드] ACE-2 ACE-2 receptor Activation acute respiratory syndrome adipocyte adipocytes administration adverse outcome amplification amplify antioxidant Cell complex Concentration coronavirus coronavirus disease COVID COVID-19 Cytokine storm Cytokines Cytokines storm death degrade demonstrated development drug enzyme exacerbate Express expression failure fat form global pandemic group heart heart failure heme oxygenase increase infected with COVID-19 Infection Inflammatory cytokine Inflammatory mediators Laboratory Modification Na/K-ATPase obese obese patients obesity pandemic Patient peptide Proteins reactive oxygen species reactive oxygen specy receptor reduction regulate renal responsible risk RNA role ROS ROS production SARS-CoV-2 selective shown Signaling subjects subunit susceptibility systemic systemic cytokine systemic inflammation tissue virus white with COVID-19
[DOI] 10.3390/antiox9111129 PMC 바로가기 [Article Type] Review

Static all-atom energetic mappings of the SARS-Cov-2 spike protein and dynamic stability analysis of “Up” versus “Down” protomer states

Research Article

Published on 2020-11-102022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

[키워드] ACE-2 receptor acting Amino acid Analysis backbone atom binding characteristic conducted conserved COVID-19 Critical cross demonstrated determine disrupting distal domain dominant example experimental structure human epithelial cells inactive include independent Interaction interactions intrachain involved Molecular dynamics simulation Mutation NTD pandemic performed Point mutation prefusion Protein provided proximal RBD Receptor binding domain reduced reported residue responsible S1 domain SARS-CoV-2 sequence spike Spike protein stability Static the RBD the SARS-CoV-2 trimeric turn Van der Waals Variation virion virus
[DOI] 10.1371/journal.pone.0241168 PMC 바로가기 [Article Type] Research Article

Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14

심각한 Covid-19 감염의 일반적인 결정 요인은 CD33 관련 Siglec, Siglec-3 및 Siglec-5/14와 SARS-CoV-2 분비 당단백질 상호작용으로 설명할 수 있습니다.

Article

Published on 2020-11-012022-09-11
Journal: Medical Hypotheses [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 치료제,

[키워드] ACE-2 receptor activated allele Alzheimer's disease Anosmia Asian Bame binding black can not Cancer cancers CD33 Cell cells CNS common conjunction contribute COVID-19 infection cribriform plate Critical demography determinant deviation disease Europeans expansion explain expressed expression Genotype glycan glycoprotein greater group Host immune immune cells immune deviation immune function immune regulators induce Infection Inflammasome inhibitory Interaction Ligand mechanism microglia NLRP3 inflammasome North occur pathophysiological mechanism penetration Population porous progression promote receptor regulate residues risk SARS-CoV SARS-CoV-2 SARS-CoV-2 glycoprotein SARS-CoV-2 spike secreted Severe COVID-19 Infection SGP sialic acid suppressor cells susceptibility Variation Viral viral clearance viral persistence
[DOI] 10.1016/j.mehy.2020.110168 PMC 바로가기 [Article Type] Article

The role of Interleukin-4 in COVID-19 associated male infertility – A hypothesis

Review article

Published on 2020-11-012022-10-05
Journal: Journal of reproductive immunology [Category] SARS, 유전자 메커니즘,

[키워드] abdominal pain ACE-2 ACE-2 receptor activate activated activating Activation ALT Apoptosis AST attenuate Bilirubin Cancer Chronic kidney disease CNS Comorbidity complex COVID-19 COVID-19 patient COVID-19 patients cytokine decrease deregulating Diabetes Mellitus diarrhea dysfunction Hematuria Hypothesis IgE IgG IL-12 IL-4 IL-6 Impaired Infection Inflammation interferons Interleukin-4 Jak-STAT JAK-STAT pathway JAK-STAT signaling Liver injury Lung injury male male infertility morbidity and mortality ocular pandemic pathway populations pro-inflammatory cytokine risk SARS-CoV-2 Signaling STAT Th2 Th2 cell Th2 cells the patient TNF-α triggering vomiting
[DOI] 10.1016/j.jri.2020.103213 [Article Type] Review article

Smart polymeric eye gear: A possible preventive measure against ocular transmission of COVID-19

스마트 폴리머 아이 기어: COVID-19의 안구 전염에 대한 가능한 예방 조치

Article

Published on 2020-11-012022-08-31
Journal: Medical Hypotheses [Category] 치료제,

COVID-19 as an Immune Complex Hypersensitivity in Antigen Excess Conditions: Theoretical Pathogenetic Process and Suggestions for Potential Therapeutic Interventions

항원 과잉 조건에서 면역 복합 과민증으로서의 COVID-19: 이론적 병인 과정 및 잠재적 치료 개입에 대한 제안

Immunology

Published on 2020-10-212022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] ACE-2 receptor activated Activation anti-spike antibodies Antigen antigen excess antigenic nature Asymptomatic carried Coagulation complement Complement activation complement system complex component conditions COVID-19 Critical determine develop excess Factor FIBRIN homeostasis Human immune system hypersensitivity Hypothesis hypothetical IgM and IgG immune complex immune response immune response mechanisms induce Infection inflammatory factors innate immune interfere Kawasaki-like disease lung macrophages membrane neutrophil Neutrophils occur pathology Potential Process Severe patient Spike antigen subject suggestion supported symptomatic systemic disorders therapeutic intervention thrombi tissue tissue damage vascular inflammation Viral viral infection Viral proteins virus
[DOI] 10.3389/fimmu.2020.566000 PMC 바로가기 [Article Type] Immunology

A Testimony of the Surgent SARS-CoV-2 in the Immunological Panorama of the Human Host

Cellular and Infection Microbiology

Published on 2020-10-162022-10-31
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS,

Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics

Review Article

Published on 2020-10-102023-06-15
Journal: Life sciences [Category] MERS, SARS,

[키워드] ACE-2 receptor ACE2, Angiotensin-converting enzyme 2, acute respiratory distress syndrome Ag I, Angiotensin I ARSD, Acute respiratory distress syndrome AT-II, Alveolar epithelial type 2 cells AT1 R, Angiotensin receptor type I CD, cluster of differentiation CD209L, C-type 209 lecithin CM, Conditioned media COVID-19 COVID-19, Coronavirus disease 2019 DAMPs, Damage associated molecular patterns G-CSF, Granulocyte colony-stimulating growth factor GVHD, Graft-versus-host disease HLA, human leukocyte antigen IDO, Indoleamine 2,3-dioxygenase IFN- β, Interferon- β Ig E, Immunoglobulin E IL, interleukin immunomodulation IRF-3, Interferon regulatory factor-3 KGF, Keratinocyte growth factor Lung fibrosis MCP-1, Monocyte chemoattractant protein MERS-Cove, Middle East respiratory syndrome coronavirus Mesenchymal stem cells MIP, macrophage inflammatory protein MSC's, Mesenchymal stem cells MV's, Microvesicles NK, natural killer PAMPs, Pathogen-associated molecular pattern PGE-2, Prostaglandin E2 RAGE, Receptor for advanced glycation end products RAS, Renin-angiotensin system RT-qPCR, Reverse transcription real-time nucleic acid polymerase reaction: SARS-CoV-2 SARS-CoV-2, Severe Acute Respiratory Syndrome novel Cornovirus-2 SARS-CoV, severe acute respiratory syndrome coronavirus SLE, Systemic lupus erythematous TGF- β, Transforming growth factor- β TNF-α, Tumour necrosis factor WHO, World Health Organization
[DOI] 10.1016/j.lfs.2020.118588 PMC 바로가기 [Article Type] Review Article

Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis

갑상선 세포에서 SARS-COV-2 수용체 ACE-2 mRNA 검출: 코로나19 관련 아급성 갑상선염의 단서

Original Article

Published on 2020-10-062022-09-10
Journal: Journal of Endocrinological Investigation [Category] MERS, 진단, 치료제,

[키워드] ACE-2 ACE-2 receptor angiotensin Angiotensin-converting enzyme carboxypeptidase Cell cell cultures cells cellular entry clinical study coronavirus COVID-19 described detection enzyme Ex vivo expressed expression follicular follicular cell follicular cells Future GAPDH human tissue in vitro independent involved mRNA nodules pandemic pathogenic pathway Patient patients with COVID-19 primary culture receptor Renin Renin-Angiotensin pathway reporter reporter genes required responsible Result RT-PCR SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection surgical the mean Thyrocytes Thyroid thyroid follicular cells thyroid nodules thyroidectomy Thyroiditis tissue sample tissues transcript transmembrane type I was performed β-actin
[DOI] 10.1007/s40618-020-01436-w PMC 바로가기 [Article Type] Original Article