REGN-COV2 antibody cocktail in patients with SARS-CoV-2: Observational study from a single institution in JapanSARS-CoV-2 환자의 REGN-COV2 항체 칵테일: 일본 단일 기관의 관찰 연구Observational Study Published on 2022-07-012022-09-12 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] acute respiratory syndrome addition Administered adverse effect antibody cocktail approved Casirivimab Comorbidity coronavirus coronavirus disease COVID-19 death diabetes diagnosed with COVID-19 disease onset duration of symptom Hospitalization hypertension Imdevimab investigated Japan monoclonal neutralizing antibody neutralizing monoclonal antibodies obesity observational study oxygen saturation Patient REGN-CoV2 risk risk factor Safe SARS-CoV-2 severe COVID-19 severe disease Severe infection treated Treatment [DOI] 10.1016/j.jiac.2022.03.029 PMC 바로가기 [Article Type] Observational Study
A case report of moderate COVID 19 patient managed through integrative approach (Siddha and conventional medicine)Case report Published on 2022-07-012022-10-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] 바이오마커, 치료제, [키워드] adverse effect antiviral properties approach breathlessness Case report caused cough Course COVID COVID 19 CRP CT chest Day diagnosed effective Efficacy elevated Fever high mortality history Infection Integrative management laboratory investigation Loss of Smell male management moderate morbidity neutrophilia NLR Patient Pneumonia raised rapidly spreading disease severity Siddha tiredness treated Treatment [DOI] 10.1016/j.jaim.2022.100623 [Article Type] Case report
Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severityResearch article Published on 2022-07-012022-10-05 Journal: EBioMedicine [Category] 신약개발, 유전자 메커니즘, 임상, [키워드] adverse effect African applied approach clinical investigation Colocalization complex complications conducted coronavirus disease COVID-19 COVID-19 severity COVID-19 treatments drug drug target drug targets Effect ENTPD5 European Europeans event Evidence FCRL3 finding funding genetics GWAS highlight ICAM1 ICAM5 immune system information mendelian randomization Multi-ancestry OAS1 Odds ratio other disease populations Protein protein targets provide provided recent reduce replicated risk sensitivity analysis SERPINA1 severity suggested target targets transcript Trial [DOI] 10.1016/j.ebiom.2022.104112 [Article Type] Research article
Neuropsychiatric manifestation of the drugs used in the treatment of SARS-2-CoV-2019 (COVID-19) infection and their management: An overview and practice implicationsSARS-2-CoV-2019(COVID-19) 감염 치료에 사용되는 약물의 신경정신병적 발현 및 그 관리: 개요 및 실행 의미Review Published on 2022-07-012022-09-11 Journal: Asian journal of psychiatry [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] Adverse adverse effect Adverse reaction Affect Anti-COVID-19 medications complicate complications consequence COVID COVID-19 COVID-19 treatment dose drug drug-drug interaction drugs hcp Healthcare professional healthcare professionals help highlight implication Infection lAbel management manifestation medication medications myriad Neuropsychiatric off-label off-label use physical Primary infection Prognosis review risk factor Risk factors SARS-2-CoV-2019. Symptom Symptoms Topic Treatment treatment guideline treatment guidelines variant virulence virus [DOI] 10.1016/j.ajp.2022.103101 PMC 바로가기 [Article Type] Review
Safety considerations of chloroquine in the treatment of patients with diabetes and COVID-19Research article Published on 2022-07-012022-10-05 Journal: Chemico-biological interactions [Category] COVID19(2023년), SARS, 신약개발, 치료법, 치료제, [키워드] adverse effect Cardiotoxicity caused changed Chloroquine Chloroquine phosphate coronavirus disease COVID-19 death diabetes Diabetic dosage dose Drug safety effective Electrocardiograms elevated hepatic enzyme High dose High-dose high-dose group humans IL-1β IL-6 levels increased risk intervals kidneys leukocyte liver observation Ocular toxicity Patient patients with diabete produced Protein QTc regimen Safety serum Severe case significantly spleen T2D total mortality treat Treatment type 2 diabete underlying disease [DOI] 10.1016/j.cbi.2022.109954 [Article Type] Research article
Heart-lung interactions in COVID-19: prognostic impact and usefulness of bedside echocardiography for monitoring of the right ventricle involvementCOVID-19의 심장-폐 상호작용: 우심실 침범 모니터링을 위한 병상 심장 초음파의 예후 영향 및 유용성Review Published on 2022-07-012022-09-11 Journal: Heart failure reviews [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition adverse effect Afterload appear avoidance circulation Clinical deterioration contribute COVID-19 Critically ill critically ill patients dysfunction echocardiography extracorporeal membrane oxygenation facilitate heart heart failure Heart–lung interaction hemodynamic instability high mortality high risk hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients Hypoxemia IMPROVE increase in Interaction involved limit Limited management mechanical ventilation medication optimization outcome pathophysiologic Patient patient survival patients with COVID-19 pressure overload prognostic progression pulmonary pulmonary circulation pulmonary vascular resistance Pulmonary vessel thrombosis reducing Respiratory failure right heart failure right ventricle RV dysfunction SARS-COV-2 infection severe COVID-19 small vessel the SARS-CoV-2 thrombosis thrombotic thrombotic microangiopathy tissue damage transthoracic echocardiography Treatment TTE Vascular Vascular resistance ventricular vessel widespread [DOI] 10.1007/s10741-021-10108-7 PMC 바로가기 [Article Type] Review
Mesenchymal stromal cell therapy for COVID-19-induced ARDS patients: a successful phase 1, control-placebo group, clinical trialClinical Trial Published on 2022-06-282022-10-05 Journal: Stem Cell Research & Therapy [Category] 임상, [키워드] acute respiratory distress syndrome addition adverse effect approach ARDS ARDS patient ARDS patients Cell change clinical clinical trial control group correlated COVID-19 pandemic COVID-19 patient CRP level CT scan Cytokine storm demonstrated disease distress Features follow-up period functions IFN-g IL-10 IL-17 IL-1B IL-6 Inflammatory cytokines injection Intervention intervention group intravenous intravenous infusion Mesenchymal stromal cells Mild-to-moderate MSC MSCs Open-label Patient Registered registry required respiratory Safe Safety Sample size serum CRP serum cytokine serum cytokine level significant decrease significant increase single-center SPO standard care stromal cell study period syndrome therapy TNF-α UC-MSC UC-MSCs umbilical were assessed [DOI] 10.1186/s13287-022-02920-1 PMC 바로가기 [Article Type] Clinical Trial
Influence of statin treatment in a cohort of patients admitted for COVID-19Observational Study Published on 2022-06-242022-10-05 Journal: Medicina clínica [Category] COVID19(2023년), SARS, 임상, [키워드] Admission Adverse adverse effect adverse effects age all-cause mortality association Clinical outcome cohort of patient consequence COVID-19 Critical care dose Efectos adversos Estatinas events Follow-up Hospital admission hospitalized COVID-19 patients hospitalized patient host response influence large cohort material modulating morbidity Morbilidad Mortalidad Mortality Neutral Patient patients died patients treated recommendation Retirada medicación SARS-COV-2 infection significantly statin statins Treatment treatment withdrawal whole sample Withdrawal [DOI] 10.1016/j.medcli.2021.07.003 PMC 바로가기 [Article Type] Observational Study
D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with RemdesivirD,L-리신-아세틸살리실레이트 + 글리신(LASAG)은 SARS-CoV-2 복제를 감소시키고 렘데시비르와 함께 추가 효과를 나타냅니다Article Published on 2022-06-212022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Acetylsalicylic acid acting acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Additive additive effect adverse effect adverse effects Antiviral approach approved Aspirin cell culture system chip model Coagulation factors Combination complex coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Cytokines disease Effect Efficacy expression glycine Healthcare system Healthcare systems in vitro inhibitory effect investigated L-lysine LASAG medication medications other diseases Patient pro-inflammation pro-inflammatory cytokine pro-inflammatory cytokines Remdesivir repurposing salt SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus show Therapeutic strategies therapeutic strategy these compound these compounds Vaccine viral infection while [DOI] 10.3390/ijms23136880 PMC 바로가기 [Article Type] Article
Repurposing Molnupiravir for COVID-19: The Mechanisms of Antiviral ActivityCOVID-19에 대한 Molnupiravir 용도 변경: 항바이러스 활성 메커니즘Review Published on 2022-06-202022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] activity Adults adverse effect Antiviral antiviral activity authorization clinical study clinical trial clinical trials clinical utility complementary COVID-19 COVID-19 severity disrupting Ebola effective Effects Efficacy etiological agent finding generate highlight in vitro experiments in vivo infection with SARS-CoV-2 Influenza mechanism Mild-to-moderate molnupiravir Mutagenesis mutagenic mutated N4-hydroxycytidine NHC Prophylactic repositioning repurposing RNA RNA virus SARS-CoV-2 SARS-CoV-2 replication Treatment viral replication Viral RNA viruses β-d-N4-hydroxycytidine [DOI] 10.3390/v14061345 PMC 바로가기 [Article Type] Review