Long-term impact of delayed follow-up due to COVID-19 lockdown on patients with neovascular age-related macular degeneration신생혈관성 연령 관련 황반변성 환자에 대한 COVID-19 잠금으로 인한 지연된 추적관찰의 장기적인 영향Article Published on 2022-05-202022-09-12 Journal: BMC ophthalmology [Category] MERS, 진단, [키워드] accelerated age Age-related macular degeneration Analysis anti-vascular Anti-vascular endothelial growth factor (anti-VEGF) Anti-VEGF anti-VEGF treatment association Care clinical trial coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 pandemic database detrimental distance endothelial female First wave Follow-up growth factor Health Intervention intravitreal injection lockdown Loss male median Missed Neovascular age-related macular degeneration (nAMD). no correlation Optical coherence tomography outcome pandemic Patient patients Predictive progression reduced reduction Registered regression analysis Retrospective study significantly significantly increased treated Treatment VEGF visual acuity was performed were assessed [DOI] 10.1186/s12886-022-02453-4 PMC 바로가기 [Article Type] Article
Markers of endothelial cell activation are associated with the severity of pulmonary disease in COVID-19내피 세포 활성화의 마커는 COVID-19에서 폐 질환의 중증도와 관련이 있습니다Article Published on 2022-05-192022-09-11 Journal: PLoS ONE [Category] 바이오마커, [키워드] activate activated Activation acute respiratory distress acute respiratory distress syndrome Antigen association Biomarker Biomarkers biomarkers of inflammation characterized chemokines coronavirus coronavirus disease Coronavirus disease-19 Coronavirus infection correlated COVID-19 cytokine Cytokines D-dimer death endothelial Endothelial cell endothelial cells endothelial injury Factor Hypothesis individual Inflammatory response inflammatory state low-flow oxygen Lung disease mechanical ventilation nasal nasal cannula obstruction oxygen Oxygen requirement Oxygenation participant patients with COVID-19 plasma Plasma levels pro-inflammatory cytokine pro-thrombotic Proinflammatory cytokine proinflammatory cytokines Protein Proteins pulmonary disease released respiratory distress Respiratory distress syndrome selectin severe coronavirus disease severe COVID-19 severity single center Support syndrome tested thrombosis vascular disease vascular inflammation vWF with COVID-19 worsening [DOI] 10.1371/journal.pone.0268296 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular researchSARS-CoV-2 수용체 ACE2는 마우스 혈관주위세포에서 발현되지만 내피세포에서는 발현되지 않습니다: COVID-19 혈관 연구에 대한 시사점Article Published on 2022-05-102022-09-12 Journal: Stem Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 expression Alveolar Type II analyzed angiotensin Angiotensin converting enzyme 2 (ACE2) Brain Bronchial epithelium cells CNS COVID-19 COVID-19 complications COVID-19 pathogenesis endothelial Endothelial cell endothelial cells enzyme Establishing Express expressed fibroblasts heart pericyte increasingly lung mapped mouse model mouse-adapted SARS-CoV-2 not express organ other organs pancrea pericyte pericytes perineurial postnatal development receptor ACE2 Research SARS-CoV-2 SARS-CoV-2 receptor Single-cell RNA-sequencing single-cell RNA-sequencing. the SARS-CoV-2 Vascular vasculature virus [DOI] 10.1016/j.stemcr.2022.03.016 PMC 바로가기 [Article Type] Article
Shared Inflammatory Pathology of Stroke and COVID-19뇌졸중 및 COVID-19의 공유 염증 병리학Review Published on 2022-05-052022-09-12 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Affect Alter association astrocytes blood-brain barrier Central nervous system characterized CNS COVID-19 COVID-19 infection dysfunction Effect endothelial endothelial cells Endothelial dysfunction inflammasome activation Inflammatory inflammatory pathways inflammatory protein Injury Macrophage matrix metalloproteinase matrix-metalloproteinases molecular mechanism molecular mechanisms neurological overlap SARS-COV-2 infection similarity stroke Symptom the SARS-CoV-2 virus therapy [DOI] 10.3390/ijms23095150 PMC 바로가기 [Article Type] Review
Post-COVID-19 patients show an increased endothelial progenitor cell productionResearch article Published on 2022-05-012022-10-05 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 6-minute walk test 6MWT6-minute walk test abnormal increase ACE-2Angiotensin-Converting Enzyme 2 Admission angiotensin-converting enzyme 2 Arterial hypertension blood circulation BMIbody mass index body mass index C-reactive protein Carbon monoxide diffusing capacity cardiovascular complications Cell clinical parameter colony colony forming cell Control COVID-19 COVID-19 patient CRPC-reactive protein damaged DDDimer-D Diabetes Mellitus Dimer-D DLCOCarbon monoxide diffusing capacity DLPDyslipidemia DMDiabetes mellitus dyslipidemia ECFCEndothelial colony forming cell elevated endothelial Endothelial colony forming cell Endothelial dysfunction Endothelial progenitor cell Endothelium EPCEndothelial progenitor cell EPOerythropoietin erythropoietin evaluate FEVForced expiratory volume FIBFibrinogen fibrinogen forced expiratory volume forced vital capacity FVCForced vital capacity Gender HbHemoglobin healthy controls hematocrit hemoglobin HTAArterial hypertension HTCHematocrit hypertension Injury Isolation lactate dehydrogenase LDHlactate dehydrogenase LymLymphocytes Lymphocytes male Maximum ferritin MFMaximum ferritin no difference PaO2 PaO2Partial pressure of oxygen Partial pressure of oxygen Patient PBMC'sPeripheral blood mononuclear cells PEPulmonary Embolism Peripheral blood mononuclear cells Post-COVID-19 patients Postinfection progenitor cell Pulmonary embolism recruited Residual volume RVResidual volume SARS-CoV-2 SARS-COV-2 infection significant increase significantly subject the patient TLCTotal lung capacity Total lung capacity Vascular Vascular damage [DOI] 10.1016/j.trsl.2022.01.004 [Article Type] Research article
Intranasal delivery of SARS-CoV-2 spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafishSARS-CoV-2 스파이크 단백질의 비강 내 전달은 제브라피쉬에서 후각 손상, 염증 및 후각 기능 장애를 유발하기에 충분합니다Article Published on 2022-05-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 치료기술, [키워드] animal animal models animals Anosmia bind cause Cell characterized cilia Cluster Combined damage Danio direct infection driven by edema endothelial EOG explained expression fish food functional hemorrhage hemorrhages Histopathology implication indicated Infection Inflammation Inflammatory response Inflammatory responses intranasal intranasally Loss of Smell mechanism myeloid cell nasal epithelium non-neuronal cell non-neuronal cells olfactory Olfactory damage olfactory dysfunction olfactory function Olfactory organ olfactory receptor Olfactory receptor expression organ prevalent Protein RBD receptor reduced response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 spike SARS-CoV-2 spike protein sensory neuron spike Spike protein Symptom treated Vaccine Viral protein Viral proteins widespread zebrafish Zebrafish (Danio rerio). [DOI] 10.1016/j.bbi.2022.03.006 PMC 바로가기 [Article Type] Article
Endothelial glycocalyx degradation in multisystem inflammatory syndrome in children related to COVID-19COVID-19와 관련된 어린이의 다기관 염증 증후군에서 내피 글리코칼릭스 분해Article Published on 2022-05-012022-09-11 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] MERS, 바이오마커, [키워드] acute respiratory syndrome Admission Adult patients affecting Biomarker Blood children children with MIS-C chondroitin chondroitin sulfate collected Complication Concentration controls coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 Cytokines Degradation Deterioration disease severity elevated endothelial Endothelial dysfunction Endothelium Future glycocalyx healthy hemodynamic heparan sulfate Infection Inflammation Inflammatory Injury intensive care lead marker MIS-C myocardial injury Necrosis Patient Potential biomarker potential biomarkers Predictive proinflammatory cytokines respiratory severe acute respiratory syndrome Coronavirus severe COVID-19 severity Shock suggested sulfate Support syndecan Syndecan-1 syndrome TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α Urine vasopressors [DOI] 10.1007/s00109-022-02190-7 PMC 바로가기 [Article Type] Article
Investigation of MBL2 and NOS3 functional gene variants in suspected COVID-19 PCR (-) patientsCOVID-19 PCR 의심 환자에서 MBL2 및 NOS3 기능 유전자 변이체 조사Article Published on 2022-05-012022-09-11 Journal: Pathogens and global health [Category] 변종, [키워드] absence allele can be used coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patient CT diagnosed with COVID-19 Early detection endothelial Endothelial nitric oxide synthase (eNOS) Factor functional gene Genotype healthy control healthy controls Infection initial investigation Isolation lung involvement mannose mannose-binding lectin 2 (MBL2). MBL2 nasopharyngeal nitric oxide nitric oxide synthase NOS3 Patient PCR PCR-negative PCR-positive performed polymorphism Research risk significantly higher statistical analysis university hospital variant viral loads [DOI] 10.1080/20477724.2021.1984726 PMC 바로가기 [Article Type] Article
Molecular Cross-Talk between Integrins and Cadherins Leads to a Loss of Vascular Barrier Integrity during SARS-CoV-2 InfectionSARS-CoV-2 감염 시 인테그린과 캐드헤린 간의 분자 상호작용으로 혈관 장벽 무결성 상실Article Published on 2022-04-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] abnormal coagulation barrier cadherin candidate cilengitide complex Complication contribute COVID-19 Cytokine storms dysregulation Effects elicit endothelial endothelial cells Endothelial dysfunction Endotheliitis event events expressed Extracellular homeostasis Hypoxemia inhibitor integrin integrin αVβ3 Integrins integrity internalization intracellular signaling life-threatening Loss mechanism motif multiple organ failure Pathways peptide phenotype phlogistic prevented Protein receptor redistribution RGD motif SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern Spike protein Support the spike protein thrombotic Thrombotic complications Trigger Vascular vascular dysfunction vascular leakage [DOI] 10.3390/v14050891 PMC 바로가기 [Article Type] Article
The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivoCOVID-19 무증상 환자의 혈청은 생체 외 순환하는 혈관 신생 세포에서 내피 기능 장애 및 바이러스 반응과 관련된 단백질을 상향 조절합니다Article Published on 2022-04-092022-09-12 Journal: Molecular Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] Activation acute respiratory syndrome applied approach Asymptomatic Asymptomatic COVID-19 asymptomatic individual Asymptomatic individuals asymptomatic patient caused Cell cellular change circulating Circulating angiogenic cells Coagulation coronavirus correlated COVID-19 COVID-19 negative critical COVID-19 patients death Donor donors endothelial Endothelial dysfunction Endothelial progenitor cells evaluated Ex vivo Factor highest ICAM-1 identify IgG immune response incubated individuals Infection infective Inflammatory Inflammatory response inhibitor initial machine learning algorithm marker pathway PCR platform positive potential long-term sequelae promote promoted Protein protein level proteomics provoke Quantitative responsible SARS-CoV-2 SARS-COV-2 infection serum significantly Stage Symptoms Thromboembolic event TLR2 transmissions treated triggered understanding up-regulate up-regulated Vascular Vascular damage viral infection virus virus entry while [DOI] 10.1186/s10020-022-00465-w PMC 바로가기 [Article Type] Article