Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus InfectionOriginal Research Published on 2021-12-092023-06-08 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] complement evasion complement system Cytokine storm human properdin influenza A virus innate immune system RNA viruses [DOI] 10.3389/fimmu.2021.747654 PMC 바로가기 [Article Type] Original Research
The crosstalk between viral RNA- and DNA-sensing mechanisms바이러스 RNA 및 DNA 감지 메커니즘 간의 누화Review Published on 2021-12-012022-09-11 Journal: Cellular and Molecular Life Sciences [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] adaptors amplify Antiviral COVID-19 Crosstalk Cytokines cytosolic detect Diseases DNA DNA and RNA DNA sensing endosomal highlight Host Human induce Infection innate immune system Innate immunity innate response interferon-stimulated gene interferon-stimulated genes mechanism nucleic acids overlap pandemic disease proinflammatory cytokines receptor recognize restrict RNA RNA sensing significantly Type type I interferon Viral diseases viral infection viral infections viral nucleic acid viral nucleic acids Viral RNA virus [DOI] 10.1007/s00018-021-04001-7 PMC 바로가기 [Article Type] Review
Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan전신 자가면역에서 치료적 mTOR 차단: 항바이러스 면역 및 수명 연장에 대한 시사점Review Published on 2021-12-012022-09-11 Journal: Autoimmunity reviews [Category] SARS, 치료제, [키워드] Activation adaptive Adaptive immune response aging Antigen antigen-presenting cell antiviral immunity APC Autoimmunity blockade Cell cell fate characterized clinical Clinical effect clinical trials cognate antigen conserved contraction COVID-19 infection Critical cytokine Cytokines disease Efficacy Engagement ENhance evaluate Evidence expansion extension form Health healthy highlight Immune cell lineage specification in viral Infection Inflammation Influenza Influenza virus innate immune system Lifespan extension Lineage lupus erythematosus Mechanistic target of rapamycin mTOR pathway Plasma cell Plasma cells preliminary evidence pro-inflammatory Protective protective immunity protein complex provide provided Rapamycin receptor reduce regulatory T cells responsiveness shown Sirolimus SLE SLE patient SLE patients subjects systemic systemic lupus erythematosus T cell T cell activation T cell receptor T cells TCR Th17 Treatment Trial vaccination viral infection viral infections [DOI] 10.1016/j.autrev.2021.102984 PMC 바로가기 [Article Type] Review
Neuroinflammation and Its Impact on the Pathogenesis of COVID-19Medicine Published on 2021-11-242022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] activating Activation acute respiratory syndrome astrocytes attack blood-brain barrier caused Cell cellular and molecular cellular mechanism change chemokines clinical manifestation CNS Consequences coronavirus Coronavirus disease 2019 COVID-19 cytokine levels death dry cough fatigue Fever free radical help highlight immune Immune cell infiltration immune system Impact include induce Infectious disease infiltration innate immune system investigated involved knowledge mechanism microglia molecular Neuroinflammation neurological neurological impairment neuronal neuronal death oxidative stress pathogenic Pneumonia Respiratory failure SARS-CoV-2 therapeutic intervention with COVID-19 [DOI] 10.3389/fmed.2021.745789 PMC 바로가기 [Article Type] Medicine
COVID-19 Infection Among Women in Iran Exposed vs Unexposed to Children Who Received Attenuated Poliovirus Used in Oral Polio Vaccine경구 소아마비 백신에 사용된 약독화된 소아마비 바이러스에 감염된 어린이와 노출되지 않은 이란 여성의 COVID-19 감염Research Published on 2021-11-242022-09-12 Journal: JAMA Network Open [Category] MERS, 진단, 폴리오, [키워드] 95% CI age Analysis Care Chain Reaction children cohort study conducted COVID-19 COVID-19 infection COVID-19 vaccine develop diagnosed diagnosed with COVID-19 evaluate exclusion criteria exposure exposure to finding Follow-up group had no Health Health care Health Organization Importance incidence of COVID-19 Inclusion inclusion and exclusion criteria individual Infection Infectious disease Infectious diseases innate immune system IQR Iran less Live attenuated vaccine Live attenuated vaccines longitudinal cohort study measure median mother objective OPV oral organization participant Petroleum Point polio Polio vaccine Poliovirus Probability protective effect Received receiving Relevance Result SARS-CoV-2 setting significantly Stimulation study period study population survival curve Survival curves symptomatic symptomatic COVID-19 symptomatic infection Vaccine with COVID-19 women [DOI] 10.1001/jamanetworkopen.2021.35044 PMC 바로가기 [Article Type] Research
How Immunosenescence and Inflammaging May Contribute to Hyperinflammatory Syndrome in COVID-19Review Published on 2021-11-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] accumulation aging alteration B-cell characterized CMV contribute coronavirus disease COVID-19 Cytokine storm Factor Hematopoiesis Hyperinflammatory syndrome Immune cell immune cells immune responses immune stimulation immune system immunosenescence Infection inflammaging Inflammatory mediators innate immune system low-grade inflammation Lymphocytes memory memory T modulate naïve occur peripheral circulation Phenotypes Population pro-inflammatory cytokines proportion reduced secrete secreting senescence-associated secretory phenotype (SASP) senescent severity stressors T-cell thymic [DOI] 10.3390/ijms222212539 PMC 바로가기 [Article Type] Review
An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine AdjuvantsSARS-COV-2 감염에 대한 TLR의 반응에 대한 최근의 통찰력과 SARS-COV-2 백신 보조제로서 TLR 작용제의 잠재력에 대한 개요Review Published on 2021-11-182022-08-31 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity addition adjuvant adjuvants agonist approach chemokine coronavirus coronavirus disease COVID-19 COVID-19 vaccine COVID-19 vaccines Critical cytokine death Defense downstream dysregulated Efficacy ENhance focus Health Host host defense host innate immunity human disease immune responses Immune-mediated Immunity Immunopathogenesis initial innate immune response innate immune system Innate immunity insight Interaction invading pathogen invading pathogens pandemic pathogen pathogen-associated molecular pattern pathogen-associated molecular patterns Pathogens pathology Potential pro-inflammatory cytokine recent recognize respiratory response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shaping Signaling therapeutic TLR TLR agonist TLR agonists TLR response TLRs Toll-like receptor Toll-like receptors Vaccine [DOI] 10.3390/v13112302 PMC 바로가기 [Article Type] Review
Opinion of German Immunologists on SARS-CoV-2: Results of an Online SurveyPsychology Published on 2021-11-092022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome addition competent coronavirus COVID-19 vaccination dataset determine Factor Factors Fatality rate flu Germany greater health system Host host factors immune system immunological immunologically immunologist immunology covid-19 Infection infective information innate immune system Intervention majority male opinion over pandemic primary survey professional respondent Result returned SARS-CoV-2 Scale validation seasonal flu Support supported survey Switzerland vaccination Vaccine development variable virulence virus [DOI] 10.7759/cureus.19393 PMC 바로가기 [Article Type] Psychology
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19초기 IFN-α 시그니처와 지속적인 기능 장애는 심각한 COVID-19에서 NK 세포의 구별되는 특징입니다Multicenter Study Published on 2021-11-092022-09-11 Journal: Immunity [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anti-SARS-CoV-2 Antiviral Cell Clinical course Cohort coronavirus coronavirus disease COVD-19 COVID-19 disease Diseases dysfunction elevated exhibited expression feature fibrosis functional IFN IFN-stimulated gene IFN-stimulated genes IFN-α Immunopathogenesis independent indicate induced genes innate immune system interferon involved ISGs longitudinal Longitudinal analyses lung Lung disease Lung fibrosis moderate Moderate COVID-19 natural killer Necrosis NK cell NK cells outcome Patient performed plasma Plasma levels proteomics respiratory scRNA-seq severe severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling single-cell Single-cell transcriptomics symptom onset TNF TNF response TNF responses transcriptomics Tumor tumor necrosis tumor necrosis factor type 1 IFN. upregulation [DOI] 10.1016/j.immuni.2021.09.002 PMC 바로가기 [Article Type] Multicenter Study
Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infectioncGAS에 의한 세포질 염색질 감지는 SARS-CoV-2 감염에서 타고난 면역 반응을 활성화합니다Article Published on 2021-11-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition caused Cell Cell fusion cellular cGAS chromatin contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytoplasmic cytosolic Defense DNA expression Host host antiviral response host antiviral responses host cell host cells host defense host immune system immune system induce infected cells Infectious diseases inhibit innate immune response innate immune system Innate immunity interferon knowledge MAVS mechanism nucleic acids nucleus offer pandemic pathway positive-sense RNA virus pro-inflammatory gene expression recognize reported required respiratory respond RNA virus SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein STING targeting therapeutic treating COVID-19 Trigger Viral viral infection viral replication Viral RNA [DOI] 10.1038/s41392-021-00800-3 PMC 바로가기 [Article Type] Article