Efficacy evaluation of intravenous immunoglobulin in non-severe patients with COVID-19: A retrospective cohort study based on propensity score matching중증이 아닌 코로나19 환자에서 정맥주사 면역글로불린의 효능 평가: 성향 점수 매칭을 기반으로 한 후향적 코호트 연구Article Published on 2021-04-012022-09-12 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, [키워드] absence acute respiratory syndrome antiviral therapy baseline characteristics benefit control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 died disease duration of fever effective Efficacy Efficacy evaluation enrolled Hospital stay Intravenous immunoglobulin median Mortality mortality rates non-severe patient outcome Patient progressed propensity score matching PSM retrospective cohort study Retrospective study secondary severe acute respiratory syndrome coronavirus 2 severe disease severity Standard therapy statistically significant difference therapy use of antibiotics virus clearance with COVID-19 [DOI] 10.1016/j.ijid.2021.01.009 PMC 바로가기 [Article Type] Article
Diabetes and COVID-19Review Article Published on 2021-03-252022-10-28 Journal: Open Life Sciences [Category] COVID-19, [키워드] ACE2 addition Affect age approach Bacteria binding affinity blood sugar Cancer cardiovascular diseases Care Cell chronic obstructive Comorbidities Complication COVID-19 COVID-19 in patient COVID-19 patient CVD Cytokine storm Degradation diabete diabetes Diabetes Mellitus Factor Frequency Gender glycosylation Healthcare system help higher risk hyperglycemia hypertension ICU immune response increase in Increased Inflammation inflammatory markers male Mortality neutrophil chemotaxis obesity Patient patients phagocytosis physician problems Protein pulmonary disease reduce risk severity of COVID-19 significant effect susceptible Treatment Ventilation viral infections virus clearance [DOI] 10.1515/biol-2021-0034 PMC 바로가기 [Article Type] Review Article
Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies중화항체가 발생하는 SARS-CoV-2 감염 아동의 바이러스 및 면역학적 특징Article Published on 2021-03-162022-09-12 Journal: Cell Reports [Category] SARS, 진단, [키워드] Ab-mediated neutralization activity adaptive analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Antigen-specific B cells antigen-specific CD4 T cells association B cell CD244 CD4 CD40L cellular children CLEC4G COVID-19 COVID-19 pandemic demonstrated develop faster feature Frequency humoral humoral anti-SARS-CoV-2 response Humoral response immune correlate Immunity immunization immunological in vitro individual Infection knowledge magnitude measure neutralization Neutralizing activity neutralizing antibody Patient pediatric pediatric COVID-19 plasma PRNT proteome proteomic proteomic profiling. quarantine reduced SARS-CoV-2 SARS-CoV-2 immunity SLAMF1 symptom onset T cell to define trial endpoint vaccination Viral load viral signal virus clearance [DOI] 10.1016/j.celrep.2021.108852 PMC 바로가기 [Article Type] Article
Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infectionIFN-γ에 대한 상피 반응은 SARS-CoV-2 감염을 촉진합니다Report Published on 2021-03-032022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 expression Affect agent angiotensin Antiviral cause cell differentiation cellular cellular differentiation characterized Colon colonic COVID‐19 Culture differentiation disease elevated Enterocyte enterocytes epithelial epithelial cell epithelial cells expressed expressing gastrointestinal mucosa IFN‐γ immune response immune responses immunology induce Inducing inefficient infected cells Infection Inflammation Inflammatory response interferon interferon signaling KRT20 maturation mechanism mediator Microbiology, Virology & Host Pathogen Interaction mouse Organoid organoids outcome patients promote promoted receptor Replication respiratory response robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Severe case severe cases subset susceptibility susceptibility to infection Treatment virus clearance virus production virus replication virus transmission [DOI] 10.15252/emmm.202013191 PMC 바로가기 [Article Type] Report
Adverse Outcomes Associated With Corticosteroid Use in Critical COVID-19: A Retrospective Multicenter Cohort StudyMedicine Published on 2021-02-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Admission Adverse adverse outcomes alanine aminotransferase ARDS assessment caused contributed coronavirus disease correlation Corticosteroid corticosteroid treatment COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill critically ill patients Cytokine storm determine died enrolled failure Fatality rate gluocorticoid hospital Hospital stay Hospitalized immune incidence inflammatory reaction Laboratory Liver injury Logistic regression Mortality much higher multi-organ failure Neutrophil-to-lymphocyte ratio Neutrophils no difference outcome outcomes Patient patients patients treated performed pulmonary fibrosis reduce SARS-CoV-2 SARS-COV-2 infection steroid Surveillance treated treated patient Treatment Viral load virus clearance White blood cells Wuhan [DOI] 10.3389/fmed.2021.604263 PMC 바로가기 [Article Type] Medicine
Understanding Viral Infection Mechanisms and Patient Symptoms for the Development of COVID-19 TherapeuticsCOVID-19 치료제 개발을 위한 바이러스 감염 메커니즘 및 환자 증상 이해Review Published on 2021-02-092022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, 치료제, [키워드] ACE2 acute respiratory distress acute respiratory distress syndrome anti-inflammatory drug Anti-inflammatory drugs Antiviral ARDS basic camostat mesilate caused cells changes in clinician coronavirus disease Coronavirus disease 2019 cough Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptoms COVID-19 therapeutics death develop development drug fatigue Fever immunomodulation infect information inhibiting knowledge mechanism Mild mortality rate Organ failure Pathogenesis pathogenesis of COVID-19 Patient replicate Replication researcher respiratory distress SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 severe pneumonia Symptom Symptomatic treatment syndrome systemic inflammation the SARS-CoV-2 virus Therapeutics tissue damage TMPRSS2 treat treatment strategy understanding Viral viral titers virus virus clearance virus infection worldwide pandemic [DOI] 10.3390/ijms22041737 PMC 바로가기 [Article Type] Review
The dynamic changes of serum IgM and IgG against SARS-CoV-2 in patients with COVID-19COVID-19 환자에서 SARS-CoV-2에 대한 혈청 IgM 및 IgG의 동적 변화Article Published on 2021-02-012022-09-12 Journal: Journal of medical virology [Category] Fulltext, MERS, 진단, [키워드] acute respiratory syndrome antibody Antibody Response caused change coronavirus Coronavirus disease 2019 COVID-19 declined described discharge Dynamic changes hospital hospitalized patient humoral immune response IgG IgG level IgM IgM and IgG illness onset Immunity Immunoglobulin median Patient patients with COVID-19 previous study recovered patient Recovery stage reduction Reinfection reported robust SARS-CoV-2 SARS-CoV-2 nucleic acid serum serum IgG Significant significantly suggested sustained symptom onset Vaccine virus clearance with COVID-19 worldwide pandemic [DOI] 10.1002/jmv.26353 PMC 바로가기 [Article Type] Article
Systemic and intestinal porcine epidemic diarrhea virus-specific antibody response and distribution of antibody-secreting cells in experimentally infected conventional pigsResearch Article Published on 2021-01-042022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] antibody antibody production Antibody Response antibody-secreting cell antibody-secreting cells ASC B-cell characterized Colon contribute coronavirus disease Course Diagnostic method diarrhea distribution effective vaccine Efficacy epidemic diarrhea epithelial cell fecal samples fluctuation IgA immune response in vitro individual infect Infection Infectious disease intestinal Lymph node memory B cell mucosal mucosal immune responses PEDV Porcine epidemic diarrhea virus predict protective immunity replicate secrete serum Spread systemic Vaccine virus virus clearance [DOI] 10.1186/s13567-020-00880-z PMC 바로가기 [Article Type] Research Article
Risk factors for prolonged viral clearance in adult patients with COVID-19 in Beijing, China: A prospective observational studyObservational Study Published on 2020-12-012022-10-05 Journal: International immunopharmacology [Category] SARS, 임상, [키워드] analyzed Beijing center changes in clearance collected correlation Course COVID-19 COX elevated Factor hypertension IL-6 Laboratory lactate dehydrogenase lymphocyte median multivariable NK cell observation Patient patients with COVID-19 positive prospective observational study regression models remained risk factor Risk factors SARS-CoV-2 serum the disease the patient treated two group univariable viral clearance viral nucleic acid virus clearance [DOI] 10.1016/j.intimp.2020.107031 PMC 바로가기 [Article Type] Observational Study
Silent disease and loss of taste and smell are common manifestations of SARS-COV-2 infection in a quarantine facility: Saudi ArabiaResearch Article Published on 2020-10-302022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95% CI Asymptomatic Asymptomatic carrier Clinical presentations Contact Contact tracing COVID-19 cross-sectional study determine disease disease spread effective false-positive result first positive implication individual individuals Infection laboratory-confirmed Loss Loss of Smell loss of taste manifestation measure median median time Mild mild symptoms objective occurred participant PCR positive positive PCR Prevalence quarantine Result Saudi Arabia setting significantly subjects Symptom symptomatic symptomatic and asymptomatic Symptoms Travel two groups viral clearance virus virus clearance [DOI] 10.1371/journal.pone.0241258 PMC 바로가기 [Article Type] Research Article