SARS-CoV-2 lateral flow assays for possible use in national covid-19 seroprevalence surveys (React 2): diagnostic accuracy study국가 covid-19 혈청유병률 조사에 사용 가능한 SARS-CoV-2 측면 흐름 분석(React 2): 진단 정확도 연구Research Published on 2021-03-022022-09-10 Journal: The BMJ [Category] Fulltext, SARS, 진단, 치료기술, [키워드] 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Analysis antibody Antibody titre antibody titres antigen binding antigen binding assay clinical sample Clinical use clinics cohorts college community transmission coronavirus coronavirus disease Coronavirus disease 2019 diagnostic Diagnostic accuracy enzyme evaluate evaluated finger Finger prick IgG immunoassay Immunoglobulin Immunoglobulin G Inclusion Infection Laboratory laboratory analyses Laboratory analysis lateral flow lateral flow immunoassay LFIA LFIAs London lowest minimum National NHS objective outcome measure PanBio participant performed positive sample real time Reference standards respiratory Result SARS-CoV-2 SARS-COV-2 infection sensitivity Sensitivity analyses Sensitivity and specificity sera seroprevalence survey serum serum sample serum samples setting Seven significantly higher Spike protein Surescreen tested titre United Kingdom were used [DOI] 10.1136/bmj.n423 PMC 바로가기 [Article Type] Research
False-positive results of SARS-CoV-2 IgM/IgG antibody tests in sera stored before the 2020 pandemic in Italy이탈리아에서 2020년 대유행 이전에 보관된 혈청에서 SARS-CoV-2 IgM/IgG 항체 검사의 위양성 결과Article Published on 2021-03-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody detection Antibody test Aside be positive carried Chain Reaction collected conditions Control control patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect diagnostic value ELISA ELISA test enzyme enzyme-linked immunosorbent assays False-positive FIVE highlight human serum IgG IgG antibodies IgG positivity IgM IgM/IgG IgM/IgG antibodies Immunoglobulin Immunoglobulin G immunoglobulin M individual Infection Italy Lateral flow test Lateral flow tests nine oral swab outbreak pandemic pathologic Patient polymerase chain reaction positive positive controls positive sample Rapid reactivity real-time reverse transcription-polymerase chain reaction respiratory rRT-PCR SARS-CoV-2 SARS-CoV-2 virus sera serological test Serological testing Serological tests severe acute respiratory syndrome Coronavirus shown specimen specimens test results the SARS-CoV-2 virus Treatment urea utility variety virus [DOI] 10.1016/j.ijid.2020.12.067 PMC 바로가기 [Article Type] Article
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patientsInflammasomes는 SARS-CoV-2 감염에 반응하여 활성화되며 환자의 COVID-19 중증도와 관련이 있습니다.Article Published on 2021-03-012022-09-12 Journal: The Journal of Experimental Medicine [Category] SARS, 진단, [키워드] activated Activation Autopsy caspase-1 characterized cleavage Clinical outcome correlated COVID-19 COVID-19 patients COVID-19 severity disease severity IL-18 IL-1β IL-6 Inflammasome inflammasome activation Inflammation Inflammatory inflammatory process LDH marker moderate molecular NLRP3 inflammasome Organ failure outcome pathophysiology Patient patient death PBMC platform potential therapeutic target promote SARS-COV-2 infection sera severe COVID-19 patients severity the disease tissue with COVID-19 [DOI] 10.1084/jem.20201707 PMC 바로가기 [Article Type] Article
Evaluation of a new simultaneous anti-SARS-CoV-2 IgA, IgM and IgG screening automated assay based on native inactivated virus네이티브 비활성화 바이러스를 기반으로 한 새로운 동시 anti-SARS-CoV-2 IgA, IgM 및 IgG 스크리닝 자동화 분석 평가Article Published on 2021-03-012022-09-11 Journal: International immunopharmacology [Category] MERS, SARS, 진단, 치료기술, [키워드] addition anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antigens automated automated instrument coated with control group COVID-19 COVID-19 patient cross-reactivity early infection ELISA kit epitope Epitopes focus group groups healthcare healthy help identify IgA IgM and IgG IgM/IgG Immunity immunoassay inactivated individuals Infection knowledge molecular mucosal Native Native antigens Patient performed positive positive sample recombinant antigens SARS-CoV-2 sensitivities sera serologic assays Serological assay Specificities Swab Viral viral infection viral infections virus [DOI] 10.1016/j.intimp.2020.107330 PMC 바로가기 [Article Type] Article
Estimating the cumulative incidence of SARS-CoV-2 with imperfect serological tests: Exploiting cutoff-free approaches불완전한 혈청 검사로 SARS-CoV-2의 누적 발생률 추정: 차단 없는 접근 방식 활용Research Article Published on 2021-02-262022-09-12 Journal: PLoS Computational Biology [Category] MERS, 진단, [키워드] Accuracy antibody Antibody Response Antibody responses approach Asymptomatic asymptomatic infection Blood can be used circumvent confirmed case confirmed cases controls cumulative cumulative incidence Cutoff determine distribution elicit error estimate estimation False negative false negative results False positive fraction Guidance identify incidence individual individuals Infection leads less marker measure Measures Mild mixture model outperform pandemic parameter pathogen Pathogens Population Prevalence provided quantitative test required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody Sensitivity and specificity sera serological serological test Serological testing Serological tests seropositive seropositive individual seropositive individuals Serosurvey Serosurveys serum specific antibodies specific type specific types statistical statistical inference the SARS-CoV-2 to define yielding [DOI] 10.1371/journal.pcbi.1008728 PMC 바로가기 [Article Type] Research Article
Breadth and function of antibody response to acute SARS-CoV-2 infection in humans인간의 급성 SARS-CoV-2 감염에 대한 항체 반응의 범위와 기능Research Article Published on 2021-02-262022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, 진단, 치료법, [키워드] ACE2 ACE2-blocking response acute SARS-CoV-2 infection acute viral infection analysed anti-non-RBD S1 Anti-RBD antibodies Anti-RBD antibody Anti-RBD MAb Anti-RBD MAbs anti-receptor-binding domain anti-S2 Anti-spike anti-spike MAbs antibody Antibody Response Antibody responses Antibody-mediated immunity average Betacoronavirus binding blockade blocked clone Clusters combinations Complete COVID-19 outbreak COVID-19 patient cross-react elicited epitope Epitopes expansion Fever FIVE glycoprotein Health Human human coronavirus human coronavirus OC43 humans Humoral response IgG Immunity independent assays mAbs memory B cell memory B cells monoclonal antibody neutralise neutralising Neutralising activity Neutralising Antibodies neutralising antibody neutralising antibody response non-overlapping epitope non-overlapping epitopes non-RBD S1 nucleocapsid offer outbreak Patient peripheral plasmablast response plasmablast plasmablast response plasmablast responses potent Prolonged fever Prophylactic RBD reactive Receptor-binding domain recovered patient Region responses SARS-CoV-2 SARS-COV-2 infection separate cluster sera serological Serological and plasmablast responses serology somatic mutations spike glycoprotein subset tested the RBD the receptor-binding domain therapeutic agent therapeutic agents titre Viral viral infection Virus spike wild-type SARS-CoV-2 [DOI] 10.1371/journal.ppat.1009352 PMC 바로가기 [Article Type] Research Article
A Novel DNA Vaccine Against SARS-CoV-2 Encoding a Chimeric Protein of Its Receptor-Binding Domain (RBD) Fused to the Amino-Terminal Region of Hepatitis B Virus preS1 With a W4P MutationW4P 돌연변이가 있는 B형 간염 바이러스 preS1의 아미노 말단 영역에 융합된 수용체 결합 도메인(RBD)의 키메라 단백질을 암호화하는 SARS-CoV-2에 대한 새로운 DNA 백신Immunology Published on 2021-02-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, 변종, 진단, [키워드] Against BAL Blood Bronchoalveolar lavage caused cell-mediated immune response Cellular immune response chimeric coronavirus coronavirus SARS-CoV-2 COVID-19 demonstrated develop disease DNA DNA vaccine domain effective encoding evaluated experiment expressing feasibility fused global public health HBV HBV preS1 hepatitis B Hepatitis B virus highlighting humoral IgA IgG IL-6 immune responses Infection lung mice multiple cell line Mutation N-terminal neutralize novel pandemic Pneumonia PROTECT Protein RBD RBD protein Receptor-binding domain Receptor-binding domain (RBD) Region robust S1 protein Safe SARS-CoV-2 SARS-COV-2 infection sequence sera significantly TNFα Transcription translation Vaccine Viral Viral pneumonia W4P-RBD wild-type [DOI] 10.3389/fimmu.2021.637654 PMC 바로가기 [Article Type] Immunology
Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection난소암과 관련된 동반 질환 및 염증 및 SARS-CoV-2 감염에 대한 영향Review Published on 2021-02-252022-09-12 Journal: Journal of Ovarian Research [Category] MERS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age aldosterone among others androgen angiotensin Cancer patients caused cellular Characteristics chemokine chemokines chronic inflammation colony-stimulating factor comorbid condition comorbid conditions Comorbidities Comorbidity condition contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms Cytokines death develop disease dysregulated early stage G-CSF gonadotropin granulocyte granulocyte colony-stimulating factor greater Hormones Hospitalization hospitalizations IL-10 IL-2 IL-6 Immunocompromised Increased Infection Inflammation Inflammatory cytokine Inflammatory cytokines interferon involved IP-10 M-CSF Macrophage macrophage colony-stimulating factor MCP-1 mechanism microenvironment molecular monocyte monocyte chemoattractant protein-1 Necrosis organs outcome ovarian cancer Pathogenesis Patient pro-inflammatory Protein public health RAAS Renin renin-angiotensin-aldosterone system risk risk factor SARS-CoV-2 SARS-COV-2 infection sera Severe case severe cases significantly subject TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α upregulation vulnerable population women [DOI] 10.1186/s13048-021-00787-z PMC 바로가기 [Article Type] Review
Antibody Response against SARS-CoV-2 and Seasonal Coronaviruses in Nonhospitalized COVID-19 Patients입원하지 않은 COVID-19 환자의 SARS-CoV-2 및 계절성 코로나바이러스에 대한 항체 반응Research Article Published on 2021-02-242022-09-10 Journal: mSphere [Category] MERS, 진단, 치료기술, 치료법, 치료제, [키워드] 229E addition addressed ADE antibody Antibody Response antibody response against Antibody responses Antibody-dependent enhancement antibody-dependent enhancement (ADE) Asymptomatic breadth conducted contribute coronavirus coronavirus 229E correlated Course COVID-19 cross-protection detect develop diagnostic diagnostic test difficulty Dilution disease experiments highlight Hospitalization human cell human cells Immunity individual infected individuals Infection involved majority marker Mild neutralization Neutralizing activity Neutralizing antibodies Neutralizing antibody response neutralizing antibody responses nucleocapsid Patient phenomenon positive predictor quantified question receptor binding site response S protein SARS-CoV-2 SARS-CoV-2 neutralization seasonal seasonal coronaviruses sera serological Serological assay serological survey Serum Neutralization Spike protein surrogate markers symptomatic targets the S protein the spike protein to define Vaccine development Virus neutralization western blot [DOI] 10.1128/mSphere.01145-20 PMC 바로가기 [Article Type] Research Article
Rapid Development of SARS-CoV-2 Spike Protein Receptor-Binding Domain Self-Assembled Nanoparticle Vaccine CandidatesSARS-CoV-2 스파이크 단백질 수용체 결합 도메인 자가 조립 나노입자 백신 후보의 신속한 개발Article Published on 2021-02-232022-09-12 Journal: ACS Nano [Category] MERS, 진단, [키워드] ACE2 adjuvant adopted angiotensin-converting enzyme 2 Antisera binding blocked candidate caused coronavirus disease covalent conjugation COVID-19 development domain effective exhibited flexible greater Health highlight immunization immunized in vitro membrane fusion mice monomeric RBD MOST nanoparticle Nanoparticles Neutralizing activity pandemic platform produced pseudovirus Rapid RBD receptor Receptor binding Receptor binding domain resulting SARS-CoV-2 SARS-CoV-2 coronavirus sera sigma spike SpyTag-SpyCatcher System the RBD the SARS-CoV-2 the spike protein the vaccine Vaccine vaccine candidate vaccine candidates Vaccine development virus [DOI] 10.1021/acsnano.0c08379 PMC 바로가기 [Article Type] Article