Immunological Response Against SARS-COV-2 After BNT162b2 Vaccine Administration Is Impaired in Allogeneic but Not in Autologous Stem Cell Transplant RecipientsOncology Published on 2021-09-062022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] administration Against Allogeneic allogeneic HSCT Antibody Response Antibody titer autologous autologous HSCT B cell B lymphocyte BNT162b2 CD19 CD19+ CD20 CD56+ Cell control group correlated correlation COVID-19 immunity cyclosporine Cytometry develop Efficacy evaluate Flow glycoprotein healthy subjects HSCT HSCT recipients immune response immunosuppressive Impaired mRNA-based natural killer negatively affected NK cell NK cells Patient performed Peripheral blood Pfizer-BioNTech platform Prospective Study recipient response rituximab SARS-CoV-2 IgG SARS-CoV-2 vaccine SARS-CoV2 second dose Seroconversion serum sample STEM Stem cell transplantation submitted T cells tested the antibody response the Spike Transplant vaccination Vaccine [DOI] 10.3389/fonc.2021.737300 PMC 바로가기 [Article Type] Oncology
Preliminary evidence of blunted humoral response to SARS-CoV-2 mRNA vaccine in multiple sclerosis patients treated with ocrelizumab오크렐리주맙으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 mRNA 백신에 대한 체액 반응 둔화의 예비 증거Article Published on 2021-09-012022-09-11 Journal: Neurological Sciences [Category] MERS, SARS, 진단, 치료기술, [키워드] all subject all subjects Anti-spike anti-Spike IgG Antibody Units baseline BAU binding antibody units BNT162b2 Case series case sery collected COVID-19 COVID-19 infection develop DiaSorin disease expand first dose geometric geometric mean health-care healthy subject healthy subjects humoral Humoral response IgG antibodies IgG antibody immunogenicity Infection International international standard majority mounted mRNA mRNA vaccine Multiple multiple sclerosis Ocrelizumab patients treated preliminary evidence relapsing SARS-CoV-2 SARS-CoV-2 mRNA vaccine SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARSCoV-2 second dose second dose of vaccine sera serum sample serum samples Spike protein tested Therapies treated unit Vaccine were expressed [DOI] 10.1007/s10072-021-05397-7 PMC 바로가기 [Article Type] Article
Absence of hypercoagulability after nCoV-19 vaccination: An observational pilot studynCoV-19 백신 접종 후 과응고의 부재: 관찰 파일럿 연구Observational Study Published on 2021-09-012022-09-11 Journal: Thrombosis research [Category] SARS, 임상, 치료기술, [키워드] activating Activation ADP age aggregation BNT162b2 BNT162b2 vaccine BNT162b2 vaccines Care carriers ChAdOx1 ChAdOx1 vaccine ChAdOx1 vaccines clinically Coagulation Cohort comparable control group controls COVID-19 COVID-19 vaccine COVID-19 vaccines eligible endogenous evaluated fibrinogen first dose Gender groups Health Health care healthy subject healthy subjects hypercoagulability hypercoagulable induce no difference no differences oral contraceptive oral contraceptives parameter peptide pilot study plasma Platelet platelet aggregation Platelet count predisposition professional prothrombotic state receptor SARS-CoV-2 subject thrombin Thrombin generation thrombin receptor Thrombophilia thrombosis TRAP university vaccination Vaccine Volunteer Whole blood women [DOI] 10.1016/j.thromres.2021.06.016 PMC 바로가기 [Article Type] Observational Study
Safety, tolerability, pharmacokinetic characteristics, and immunogenicity of MW33: a Phase 1 clinical study of the SARS-CoV-2 RBD-targeting monoclonal antibodyMW33의 안전성, 내약성, 약동학 적 특성 및 면역 원성 : SARS-COV-2 RBD- 표적 모노클로 날 항체의 1 상 임상 연구Clinical Trial Published on 2021-08-182022-08-13 Journal: Emerging Microbes & Infections [Category] SARS, 임상, 진단, 치료제, [키워드] adverse event adverse events AEs Antibody titre antibody titres AUC C max clinical study Concentration concentration-time curve conducted coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated Diseases disorders dose dose-escalation double-blind enrolled evaluate Evidence evidence of follow-up period fully humanized IgG1κ monoclonal neutralizing antibody GRADE Grade 1 group healthy subjects humanized Identifier immunogenicity incidence Infectious diseases infused Laboratory Laboratory test linear kinetic relationship linear PK maximum concentration monoclonal monoclonal antibody MW33 MW33 injection NCT04427501 neutralizing antibody no evidence of participant pharmacokinetic characteristics pharmacokinetics Phase 1 Phase 1 clinical trial phase 1 study PK parameters Placebo placebo-controlled plasma half-life positive rate positive rates Randomized Safety SARS-CoV-2 serum ADA serum ADAs severity subject the SARS-CoV-2 Tolerability Treatment Trial registration Vascular vascular and lymphatic disorders [DOI] 10.1080/22221751.2021.1960900 PMC 바로가기 [Article Type] Clinical Trial
Sustained expression of inflammatory monocytes and activated T cells in COVID‐19 patients and recovered convalescent plasma donorsOriginal Article Published on 2021-08-062022-10-30 Journal: Immunity, Inflammation and Disease [Category] COVID-19, MERS, SARS, [키워드] activated T cell activated T cells activating acute respiratory syndrome Analysis analyzed B cell B‐cell Biliary CCR2 CD8 cellular response chemotactic convalescent plasma coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 CX3CR1 cytokine cytokine production Cytokines disease Donor endothelial expected expression flow cytometry group growth healthy individual healthy subjects IL‐6 Immune cell immune cells immune response Immunity Infection infiltration Inflammatory marker inflammatory monocyte inflammatory protein inhibitory Leptin Ligand Lung injury Macrophage main mechanism Migration Mild MIP moderate monocyte Monocyte activation Monocytes New Patient patients performed Plasma cytokine positive Protein Proteins proteomics receptor recovered patient recovered patients recruited reduction in Result Saa1 serum significant increase sustained T cells target tissue Vascular [DOI] 10.1002/iid3.476 PMC 바로가기 [Article Type] Original Article
Clinical Outcome Prediction in COVID-19 Patients by Lymphocyte Subsets Analysis and Monocytes’ iTNF-α ExpressionArticle Published on 2021-08-012022-10-28 Journal: Biology [Category] COVID-19, [키워드] Admission CD4+ CD8+ CD8+ T lymphocyte cellular change clinical Clinical sign collected conducted coronavirus disease COVID-19 cytokine decrease detect deteriorate eosinophil eosinophils evaluated expression Frequency group healthy subjects Hospitalization immune system Immunopathogenesis IMPROVE Infection inflammatory cell initial involved iTNF-α lymphocyte Lymphocyte count lymphocyte counts lymphocyte subpopulation Lymphocytes lymphopenia modulation monocyte Monocytes neutrophil Neutrophils Novel coronavirus observation onset of symptoms outcome outcomes parameters Pathogenesis Patient Peripheral blood phasic prediction Predictive preliminary finding progression reduction in retrospective SARS-CoV-2 Seven simple subject T lymphocyte the disease TNF-α expression Treatment Treg Tregs [DOI] 10.3390/biology10080735 PMC 바로가기 [Article Type] Article
COVID-19 cough classification using machine learning and global smartphone recordingsResearch article Published on 2021-08-012022-10-05 Journal: Computers in biology and medicine [Category] 유전자 메커니즘, [키워드] addressed approach AUC Classifier CNN convolutional neural network (CNN) cough Cough classification coughs COVID-19 COVID-19 negative dataset evaluate exhibited feature healthy healthy subjects identify include K-nearest neighbour (KNN) Laboratory limit Logistic regression Logistic regression (LR) long short-term memory (LSTM) machine learning memory Multilayer perceptron (MLP) oversampling positive recorded reduce ResNet50 ROC Curve SARS-CoV Self-isolation Seven SFS South Africa subject Support Support vector machine (SVM) SVM the healthy Transmission was collected was used [DOI] 10.1016/j.compbiomed.2021.104572 [Article Type] Research article
Age-Related Differences in the Expression of Most Relevant Mediators of SARS-CoV-2 Infection in Human Respiratory and Gastrointestinal TractPediatrics Published on 2021-07-282022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] ACE1 ACE2 ACE2 expression acute respiratory syndrome adult subject adult subjects Adults Analysis Angiotensin-converting enzyme angiotensin-converting enzyme 2 children clinical clinical feature Clinical severity coronavirus coronavirus disease COVID-19 difference differential expression evaluated expression feature functional Gastrointestinal healthy subjects Host Human Infection Interaction intestinal investigated mediator MOST nasal nasal epithelium Neuropilin-1 no difference NRP1 preventive measure promote quantitative real-time PCR receptor respiratory SARS-CoV-2 SARS-COV-2 infection Serine severity small intestine Symptom the SARS-CoV-2 These data TMPRSS2 TMPRSS2 expression tract transmembrane transmembrane serine protease-2 Treatment upper respiratory tract virus [DOI] 10.3389/fped.2021.697390 PMC 바로가기 [Article Type] Pediatrics
Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype심각한 COVID-19 회복은 골수 세포 면역 조절 표현형의 적시 획득과 관련이 있습니다Immunology Published on 2021-06-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, [키워드] Aberrant inflammatory responses acquisition Activation Admission age and sex alteration Analysis basophil basophils best CD14 CD163 CD80 CD86 Cell circulating contribute COVID-19 COVID-19 outbreak cytokine Cytokine storm demonstrated dendritic cell described detectable discharge evaluated expansion expression flow cytometry HCs healthy control healthy controls healthy subjects ICU ICU Patients IFN-γ IL-10 IL-12p40 IL1RA immune-regulation increased expression Inflammatory responses innate immune system Innate immunity intensive care intensive care unit admission M2-like differentiation management marker mDCs mediators monocyte Monocytes myeloid myeloid cell pandemic pathogenic mechanism Patient patients patients with COVID-19 PD-L1 pDCs phenotype plasma positively correlated Prognosis reduced reduction Regulatory respiratory insufficiency SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe disease significantly significantly higher Slan specific antibodies stratified subset Support therapeutic agent therapeutic agents therapeutic interventions Treatment Viral Viral load [DOI] 10.3389/fimmu.2021.691725 PMC 바로가기 [Article Type] Immunology
Evaluation of expression of VDR-associated lncRNAs in COVID-19 patientsCOVID-19 환자에서 VDR- 관련 LNCRNA의 발현 평가Research Published on 2021-06-192022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 치료기술, [키워드] acute respiratory distress syndrome ARDS circulation Control control subject control subjects coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients CYP27B CYP27B1 expression expression level expression levels female Health health problems healthy control healthy controls healthy subject healthy subjects hospitalized patients individual Linc00346 Linc00511 lncRNA male no significant difference non-ICU non-ICU patients p value pathophysiology Patient problem Ratio Real-time PCR receptor respiratory respiratory distress Respiratory distress syndrome Result severity shown Signaling Significant SNHG16 SNHG6 statistically subgroup subgroups syndrome transcript level transcript levels VDR Vitamin D Vitamin D receptor [DOI] 10.1186/s12879-021-06248-8 PMC 바로가기 [Article Type] Research