Case Report: Human Umbilical Cord Mesenchymal Stem Cells as a Therapeutic Intervention for a Critically Ill COVID-19 PatientMedicine Published on 2021-07-082022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Antibiotics ARDS Case report China Chinese CORD Corticosteroid COVID-19 COVID-19 patient Critically ill Critically ill patient cured diagnosed disease Follow-up Hospitalization Human IL-10 IL-4 IL-6 Ill Mesenchymal stem cells modulated MSC NK cells past medical history Patient Pulmonary edema SARS-COV-2 infection Septic shock Severe COVID-19 pneumonia SIRS STEM Symptom the cytokine storm the patient therapeutic therapy Treatment with COVID-19 [DOI] 10.3389/fmed.2021.691329 PMC 바로가기 [Article Type] Medicine
Periodic thermomechanical modulation of toll-like receptor expression and distribution in mesenchymal stromal cellsResearch Letter Published on 2021-07-082022-10-30 Journal: Mrs Communications [Category] COVID-19, [키워드] Abstract Actuation Antiviral biomaterial combating COVID-19 Culture distribution driven by expressing expression F-actin highlight immune response Immunity modulation MSC MSCs Periodic Polymer promoted proportion provided receptor recruited retained SARS-CoV-2 Shape memory stromal cell synchronous TLR TLR4 TLR7 TLRs Toll-like receptor virus was increased [DOI] 10.1557/s43579-021-00049-5 PMC 바로가기 [Article Type] Research Letter
Updates on clinical trials evaluating the regenerative potential of allogenic mesenchymal stem cells in COVID-19Review Article Published on 2021-06-302022-10-04 Journal: NPJ Regenerative Medicine [Category] 임상, 치료제, [키워드] acute respiratory distress acute respiratory syndrome Adaptive immune response alleviate ARDS caused clinical clinical study clinical trial clinics coronavirus coronavirus disease COVID-19 COVID-19 patient cytokine production Cytokine storm death decrease develop effective Efficacy enrolled evaluate fraction hypoxia immunomodulatory IMPROVE infected patient Inflammatory cytokine lack majority Mesenchymal stem cells Mild-to-moderate mortality rate MSC MSCs multiple organ failure outcome pandemic Patient patients performed placebo-controlled reduce regenerative potential Safe SARS-CoV-2 severe COVID-19 patients severe COVID-19 symptoms severe symptoms Standard of care statistically stem cell Support survival Symptoms syndrome therapeutic therapeutic potential Treatment uncontrolled viral infection [DOI] 10.1038/s41536-021-00147-x PMC 바로가기 [Article Type] Review Article
Targeted Mitochondrial Therapy With Over-Expressed MAVS Protein From Mesenchymal Stem Cells: A New Therapeutic Approach for COVID-19Cell and Developmental Biology Published on 2021-06-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 addition affecting approach cause Cell cellular cellular immunity COVID-19 damaged cell damaged tissue disease Diseases element expression expression of SARS-CoV-2 healthy host cell IFN immune immune response Impaired IMPROVE induce Inflammation innate immune response innate immune responses innate immune system interferon Ligand MAVS mesenchymal stem cell Mitochondria mitochondrial mitochondrial antiviral-signaling protein MSC MSCs New outer membrane pathogenesis of COVID-19 Probability Protein pulmonary involvement reduce regenerative regulate Regulatory rejection Replication S protein SARS-CoV-2 STEM stem cell Stress Symptom the SARS-CoV-2 these cell tissue inflammation transferring Transport viable treatment viral spike protein virus [DOI] 10.3389/fcell.2021.695362 PMC 바로가기 [Article Type] Cell and Developmental Biology
Characteristics and Developments in Mesenchymal Stem Cell Therapy for COVID-19: An UpdateReview Article Published on 2021-06-022022-10-29 Journal: Stem Cells International [Category] COVID-19, [키워드] ACE2 acute respiratory distress acute respiratory syndrome Angiotensin-converting enzyme Anti-inflammatory approaches ARDS caused Cell Characteristics clinical clinical manifestations clinical symptom coronavirus coronavirus disease cough COVID-19 current Cytokine storm development drug Evidence Fever Health help highlight humans immune function include information measure MSC MSC therapy MSCs outbreak pathogenic virus Prevent Providing receptor respiratory tract SARS-CoV-2 shown STEM stem cell syndrome target the disease transmitted treat Treatment virus [DOI] 10.1155/2021/5593584 PMC 바로가기 [Article Type] Review Article
The immune modulatory effects of umbilical cord-derived mesenchymal stromal cells in severe COVID-19 pneumoniaShort Report Published on 2021-06-022022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, MERS, SARS, [키워드] accompanied addition assays baseline bronchoalveolar cellular chemokine circulating circulating monocyte Coronavirus disease 2019 COVID-19 Cytokines decrease effective ELISA Exploratory analysis flow cytometry functional immune modulatory effect immune reaction immunological immunomodulatory property immunosuppressive Infection Inflammatory inflammatory neutrophils Inflammatory response intensive care unit interleukin-6 life-threatening low-density Mesenchymal stromal cells MSC MSCs myeloid cells neutrophil neutrophil recruitment Patient Peripheral blood plasma Pneumonia pro-inflammatory cytokines pro-thrombotic reduction renal scRNA-seq Serum level severe COVID-19 Severe COVID-19 pneumonia Single-cell RNA sequencing stromal cell supplementary material T lymphocyte treated Treatment Trial tumor necrosis factor-α umbilical were assessed [DOI] 10.1186/s13287-021-02376-9 PMC 바로가기 [Article Type] Short Report
Clinical applications of mesenchymal stromal cell-based therapies for pulmonary diseases: An Update and Concise ReviewReview Published on 2021-06-012022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, [키워드] Bacterial bronchopulmonary dysplasia Cell-based therapy chronic lung disease chronic obstructive clearance clinical clinical study clinical trial community-acquired pneumonia conditions Contact COPD curative treatment death disease disorder Effect effective Efficacy ILD immunomodulatory activities Interstitial lung disease lung cancer Lung diseases mechanisms Meta-analysis morbidity MSC MSCs offer paracrine pulmonary disease pulmonary diseases pulmonary fibrosis reported Research review stromal cell syndrome systematic review Therapeutic approach therapeutic option therapeutic potential therapy tissue regeneration Treatment [DOI] 10.7150/ijms.59218 PMC 바로가기 [Article Type] Review
Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report중증 코로나19 환자의 온정 간엽줄기세포 치료: 증례보고Case Reports Published on 2021-06-012022-09-10 Journal: Croatian Medical Journal [Category] MERS, SARS, 신약개발, [키워드] 49 days acute respiratory distress acute respiratory distress syndrome addition affected Allogeneic Antiviral ARDS attending physicians Bacterial infection Case report Cell Clinical course cold-like symptom cold-like symptoms compassionate use COVID-19 discharged Exhaustion family general condition hospital immunosuppressive intensive care intensive care unit mechanically ventilated Mesenchymal stem cells MSC MSC therapy Patient physician rapid clinical deterioration respiratory distress severe COVID-19 severe symptom severe symptoms Side effect stem cell supportive therapy syndrome therapy Treatment Trial [DOI] 10.3325/cmj.2021.62.288 PMC 바로가기 [Article Type] Case Reports
Exosomes contribution in COVID-19 patients’ treatmentCommentary Published on 2021-05-312022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] acute respiratory syndrome adipocyte adipose derived stem cells caused Cell clinical study coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 patients derivative effective endothelial Exosome Exosomes Factors growth growth factor human diseases immunomodulatory activity Inflammation insulin Mesenchymal stem cells morbidity and mortality MSC MSCs NGF patient safety potential therapeutic agent public health recent SARS-CoV-2 secretion stem cell the patient therapeutic option therapeutic potential therapy Treatment Vascular VEGF [DOI] 10.1186/s12967-021-02884-5 PMC 바로가기 [Article Type] Commentary
Medical School Education on Myalgic EncephalomyelitisArticle Published on 2021-05-282022-10-30 Journal: Medicina [Category] Coronavirus, SARS, [키워드] Biomedical research change changed complex Council creating diagnose disease education Encephalomyelitis exploratory study expressing General Medical Council GMC Guidance Health Act 1983 identify increase in International Long COVID majority material ME/CFS medical school Medical Schools Council MSC NICE Guidelines Patient patient safety patients Post-viral fatigue provided Quality of life questionnaire receiving Registered replacing reported response reveal School Seven Teaching treat [DOI] 10.3390/medicina57060542 PMC 바로가기 [Article Type] Article