SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees우려되는 SARS-CoV-2 변이체는 COVID-19 회복기 기증자와 백신에서 체액성 반응을 부분적으로 탈출하지만 T 세포 반응은 회피하지 않습니다Article Published on 2021-05-252022-09-11 Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단, 치료기술, [키워드] addition antibody antigens B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants BNT162b2 CD4 Cellular immune response cellular immune responses Cohort COVID-19 convalescent donor COVID-19 disease cross-reactivity detect elicited exhibited functional HCW Health care Health care worker homologous humoral Humoral and cellular immune responses Humoral immunity Immune escape immune response immune responses individuals Mild Mild COVID-19 disease mononuclear cell mononuclear cells mutated Mutation neutralizing capacity no difference no differences not affected peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells Protein raised recall Region required S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells second dose seronegative single vaccination Specific stimulated T cells T-cell activation T-cell Response T-cell-mediated immunity vaccination vaccinee variant variants virus virus-specific T cell wild type [DOI] 10.1126/sciimmunol.abj1750 PMC 바로가기 [Article Type] Article
Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival증상이 있는 COVID-19에서 SARS-CoV-2에 대한 항체 반응 중화는 지속되고 생존에 중요합니다Article Published on 2021-05-112022-09-10 Journal: Nature Communications [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] age antibody Antibody Response Antibody responses Antibody titer Antibody titers Antigen antigens Antimicrobial responses best beta-coronavirus Care co-morbidities Cohort common cold conditions COVID-19 COVID-19 patient COVID-19 symptomatic patient Critical detectable Disease progression eight flu H1N1 hemagglutinin Heterologous Humoral immunity IgG immune response immune responses Immunity increased risk Infection Influenza lack majority morbidities neutralization Neutralizing antibodies neutralizing antibody neutralizing antibody titers neutralizing capacity not affected nucleoprotein outcome Patient care Planning recognizing recovered patient recovered patients S2 antigen SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2 spike SARS-CoV-2 spike antigen SARS-CoV-2 spike protein seasonal coronavirus seasonal coronaviruses severe COVID-19 Spike protein survival Swab symptom onset symptomatic symptoms onset the antibody response the SARS-CoV-2 Therapeutic approach therapeutic approaches therapy understanding vaccination viral infection virus worsening [DOI] 10.1038/s41467-021-22958-8 PMC 바로가기 [Article Type] Article
Impaired performance of SARS-CoV-2 antigen-detecting rapid diagnostic tests at elevated and low temperatures고온 및 저온에서 SARS-CoV-2 항원 검출 신속 진단 검사의 성능 저하Article Published on 2021-05-012022-09-10 Journal: Journal of Clinical Virology [Category] 진단, 치료기술, [키워드] Ag-RDT Ag-RDTs ambient ambient temperatures analytical sensitivity Antigen Antigen-detecting rapid diagnostic tests Cell culture cell culture supernatant clinically complement condition conditions consequence COVID-19 culture supernatant diagnostic tests diagnostics eight elevated elevated temperature Emergency use exhibited exposure to false-negative false-positive result False-positive results FIVE Genome Health Organization Highlights impair Impaired include Incubation limit limits Limits of detection low temperature Low temperatures mean temperature mean temperatures molecular molecular diagnostics North not affected occurred operation pandemic quarantine ranged rapid antigen test Rapid diagnostic test RDTs reduce reduced respiratory respiratory virus respiratory viruses SARS-CoV-2 SARS-CoV-2 cell sensitivity South specificity storage temperature Temperature stability test results tested the WHO Transmission Tropics virus concentration Virus concentrations viruses Winter World Health Organization [DOI] 10.1016/j.jcv.2021.104796 PMC 바로가기 [Article Type] Article
Mortality attributable to COVID-19 in nursing home residents: a retrospective studyOriginal Article Published on 2021-04-242022-10-28 Journal: Aging Clinical and Experimental Research [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval all-cause mortality Analysis CIs COVID-19 death disease eligible evaluated Follow-up frailty Frailty comprehensive geriatric assessment groups hazard ratio higher risk HRs incidence increased risk increased the risk index Italy median Mortality mortality rate MPI Multidimensional prognostic index Nasopharyngeal swab not affected nursing home outcome Prognosis regression analysis Result Retrospective study stratified Venice was used widespread [DOI] 10.1007/s40520-021-01855-6 PMC 바로가기 [Article Type] Original Article
Robust Neutralizing Antibodies to SARS-CoV-2 Develop and Persist in Subjects with Diabetes and COVID-19 PneumoniaSARS-CoV-2에 대한 강력한 중화 항체, 당뇨병 및 COVID-19 폐렴 환자에서 개발 및 지속Article Published on 2021-04-232022-09-12 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] MERS, 진단, [키워드] absence acute respiratory syndrome analyzed characterized Cohort coronavirus correlated COVID-19 COVID-19 pathogenesis Demonstrating diabete diabetes early phase Glucose hazard ratio Hospital admission Hospitalization humoral Humoral response hyperglycemia include increased risk lentiviral Mortality Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody response not affect not affected Patient patients with diabete Pneumonia Randomly Reinfection SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 neutralization selected Spike protein survival rate the SARS-CoV-2 vaccination Vaccine development Variability [DOI] 10.1210/clinem/dgab055 PMC 바로가기 [Article Type] Article
Low Incidence and Mortality by SARS-CoV-2 Infection Among Healthcare Workers in a Health National Center in Mexico: Successful Establishment of an Occupational Medicine ProgramPublic Health Published on 2021-04-132022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affected caused center coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient critical condition decrease Efficiency evaluate HCW HCWs Health healthcare worker Healthcare workers implementation incidence infected with SARS-CoV-2 infection risk Medicine mitigate mitigate risk Mortality National negative test Nosocomial infection not affected occupational occupational medicine Personal protective equipment positive PPE Prevent Program respiratory diseases returned risk of infection Safe SARS-CoV-2 SARS-COV-2 infection significantly Support tested the mean the SARS-CoV-2 ventilator worker [DOI] 10.3389/fpubh.2021.651144 PMC 바로가기 [Article Type] Public Health
COVID-19 Management in the Pediatric Age: Consensus Document of the COVID-19 Working Group in Paediatrics of the Emilia-Romagna Region (RE-CO-Ped), ItalyReview Published on 2021-04-082022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] accumulated acute respiratory syndrome age approach Care carried caused Characteristics children clinical experience Clinical management Consensus coronavirus coronavirus disease COVID-19 COVID-19 pathology criteria database death defined develop document Emilia-Romagna group Health highlight hospital Hospitalization include infected children Italy knowledge literature majority management MIS-C not affected paediatrics pandemic pediatric pediatrics problem professional reduction in Region Research resulting SARS-CoV-2 SARS-COV-2 infection Severe case Spread structures the SARS-CoV-2 therapeutic Treatment working [DOI] 10.3390/ijerph18083919 PMC 바로가기 [Article Type] Review
The role of C-reactive protein as a prognostic marker in COVID-19COVID-19에서 예후 마커로서의 C 반응성 단백질의 역할Covid-19 Published on 2021-04-032022-09-10 Journal: International Journal of Epidemiology [Category] SARS, 바이오마커, [키워드] acute phase acute phase reactant Admission age analysed assist bimodal bimodal distribution Bootstrapping C-reactive protein C-reactive protein (CRP Care care planning Characteristics clinician Cohort collected COPE COVID-19 COVID-19 disease COVID-19 disease severity Cox regression criterion CRP cut-off determine diagnosis of COVID-19 distribution elevated Evidence hospital indicated Indicator Infection Inflammation information investigated linear mixture model mixture models Mortality non-specific not affected observation on admission Patient patients patients hospitalized performed predict prognostic Prognostic marker Result Severe infection threshold Treatment Trigger trimodal utility validation cohort was used with COVID-19 [DOI] 10.1093/ije/dyab012 PMC 바로가기 [Article Type] Covid-19
Prevalence and Risk Factors of Infection in the Representative COVID-19 Cohort MunichArticle Published on 2021-03-302022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval adjusted Asymptomatic Blood Complete COVID-19 defined disease estimate Factor First wave General population health authorities help Infection infection fatality ratio investigated linear mixed model Loss magnitude Mild Munich not affected Odds ratio Older pandemic PCR-positive Population-based cohort study Prevalence public health measures questionnaire Registered reported risk factor Roche SARS-CoV-2 SARS-CoV-2-specific antibody sense of smell sensitivity Seropositivity Seroprevalence specificity transmission pattern Underreporting [DOI] 10.3390/ijerph18073572 PMC 바로가기 [Article Type] Article
COVID-19-related cancellation of elective orthopaedic surgery caused increased pain and psychosocial distress levelsSports Traumatology Published on 2021-03-122022-10-31 Journal: Knee Surgery, Sports Traumatology, Arthroscopy [Category] COVID-19, MERS, SARS, [키워드] age Arthroplasty Arthroscopy Care caused coronavirus coronavirus disease COVID COVID-19 COVID-19 pandemic Depression Depressive symptoms distress Elective surgery European country Evidence exhibited female female patient groups Health Health care system Health status information Level male moderate National not affected orthopedic surgery Pain pandemic Patient patients PHQ-9 predominant Psychosocial distress questionnaire Result SARS-CoV-2 significant difference significantly higher significantly increased sociodemographic data supplementary material surgeon Treatment women [DOI] 10.1007/s00167-021-06529-4 PMC 바로가기 [Article Type] Sports Traumatology