Severe patient – Page 7 – Communicable Diseases Research

Profound Treg perturbations correlate with COVID-19 severity

420

Published on 2021-09-142022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19,

Persistent High Percentage of HLA-DR + CD38 high CD8 + T Cells Associated With Immune Disorder and Disease Severity of COVID-19

COVID-19의 면역 장애 및 질병 중증도와 관련된 HLA-DR + CD38 높은 CD8 + T 세포의 지속적인 높은 비율

Immunology

Published on 2021-09-092022-09-11
Journal: Frontiers in Immunology [Category] SARS, 바이오마커,

[키워드] apoptotic Beijing blood sample Blood samples Care caused CD38 CD8 chemokines Clinical and laboratory data collected coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patients critical cases Cytokines died disease severity disease severity of COVID-19 dysregulation Ebola evaluated examined expression Factor flow cytometric Growth factors Health crisis heterogeneous HLA-DR Hospital admission Hospitalization immune disorder immune disorders indicated infected with SARS-CoV-2 Influenza influenza infection inhibitory killing laboratory data lymphopenia manifested Mild moderate Multiplex assay outbreak overactivation Patient percentage persistent Progressive public health crisis recruited reported Result Retrospective study SARS-COV-2 infection sensitivity Serum level serum levels severe cases severe COVID-19 severe COVID-19 patients Severe patient severe patients severity stimulatory subset supported systemic inflammation T cell T cells tissue injury transcriptional regulation
[DOI] 10.3389/fimmu.2021.735125 PMC 바로가기 [Article Type] Immunology

Uric acid as a prognostic factor and critical marker of COVID-19

COVID-19의 예후 인자이자 중요한 마커인 요산

Observational Study

Published on 2021-09-072022-09-10
Journal: Scientific Reports [Category] 바이오마커, 임상, 치료제,

[키워드] 95% CI acid Admission analyzed can be used carried collected Concentration COVID-19 Critical dead dead patient dead patients demographic disease disease severity groups hospital Hospitalization In-hospital death laboratory data Logistic regression analysis lowest marker mean survival time Mortality multicenter multivariate multivariate logistic regression analysis novel corona virus observational study Patient patients with COVID-19 predict Predictive markers primary end point Prognostic factor prognostic indicator retrospective Retrospective study risk Sensitivity and specificity Severe patient severe patients significantly lower survival time Survivors the dead uric acid viral infection Virus Disease with COVID-19 Wuhan
[DOI] 10.1038/s41598-021-96983-4 PMC 바로가기 [Article Type] Observational Study

Evaluation of the relationship between KIM-1 and suPAR levels and clinical severity in COVID-19 patients: A different perspective on suPAR

COVID-19 환자의 KIM-1과 suPAR 수치 및 임상 중증도 간의 관계 평가: suPAR에 대한 다른 관점

Article

Published on 2021-09-012022-09-11
Journal: Journal of medical virology [Category] SARS, 바이오마커,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age C-reactive protein Clinical course Clinical severity control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients D-dimer Defense defense mechanism diagnosed elevated ELISA endocytosis ferritin fibrinogen fibrinogen level Fibrinogen levels fibrinolysis Health health problems health worker health workers Kidney injury KIM-1 knowledge Lactose lymphocyte mechanism moderate neutrophil PaO Patient PCR Perspective poor prognosis problem prognostic prothrombin Prothrombin time receptor respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease Severe patient severe patients significantly higher suPAR the disease therapeutic target variable was measured
[DOI] 10.1002/jmv.27099 PMC 바로가기 [Article Type] Article

Are saliva and deep throat sputum as reliable as common respiratory specimens for SARS-CoV-2 detection? A systematic review and meta-analysis

타액과 인후 가래는 SARS-CoV-2 검출을 위한 일반적인 호흡기 표본만큼 신뢰할 수 있습니까? 체계적인 검토 및 메타 분석

Review

Published on 2021-09-012022-09-11
Journal: American journal of infection control [Category] SARS, 치료기술,

[키워드] 95% CI 95% confidence interval Analysis Asymptomatic Asymptomatic cases asymptomatic patients Bronchoalveolar lavage fluid COVID-19 COVID-19 infection COVID-19 pandemic definitive diagnosis diagnostic diagnostic sensitivity diagnostic test diagnostic value disease severity DTS Evidence inclusion criteria Infection Laboratory Meta-analysis Mild nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs oropharyngeal swab oropharyngeal swabs patients with COVID-19 performed provide Quantitative analysis raise random-effects model reliability respiratory specimen retrieved RT-PCR RT-PCR diagnostic test RT-PCR tests Saliva sampling SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection sensitivity Severe patient severe patients severity specimen specimens sputum Stata Stata software Support swabs symptomatic patient Symptomatic patients systematic review Systemic review the disease Viral load was performed
[DOI] 10.1016/j.ajic.2021.03.008 PMC 바로가기 [Article Type] Review

Cytokine storm in severe COVID-19 pneumonia

심각한 COVID-19 폐렴의 사이토카인 폭풍

Article

Published on 2021-09-012022-09-11
Journal: Journal of medical virology [Category] SARS, 바이오마커,

[키워드] acute respiratory distress acute respiratory distress syndrome addition Alanine ALT Anemia anti-cytokine anti-cytokine therapy ARDS aspartate AST clinic Confirmed COVID-19 infection coronavirus COVID-19 COVID-19 infection COVID-19 patient COVID-19 pneumonia criteria Cytokine storm decrease determine develop disease elevated elevated lactate dehydrogenase feature ferritin help hemoglobin hemophagocytic lymphohistiocytosis Hospitalized Hyperferritinemia hyperfibrinogenemia Hyperinflammatory syndrome ICU ICU admission identify immnopathology immune immune responses in some include Inflammation intensive care intensive care unit Laboratory laboratory parameter Laboratory parameters Lactate lactate dehydrogenase LDH leukocyte Liver function Liver function test lymphocyte lymphocytopenia Macrophage macrophage activation syndrome Novel coronavirus occurred parameter parameters Patient patients Planning Platelet Pneumonia predict procalcitonin progression reduced respiratory distress Respiratory distress syndrome retrospective cohort study secondary hemophagocytic lymphohistiocytosis Severe COVID-19 pneumonia Severe patient severe pneumonia sHLH significant changes in significantly significantly increased Symptom syndrome the cytokine storm the patient thrombocytopenia transferred Triglyceride troponin two subgroups virus virus classification with COVID-19 worsened worsening
[DOI] 10.1002/jmv.27068 PMC 바로가기 [Article Type] Article

Recovery rate and factors associated with smell and taste disruption in patients with coronavirus disease 2019

Observational Study

Published on 2021-09-012022-10-05
Journal: American journal of otolaryngology [Category] 임상,

[키워드] age alterations Analysis Anosmia association clinical feature Clinical severity Cohort Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients defined detect determine diagnosed Diagnosis dysfunction evaluated Factor Follow-up Gustatory involved Isolated Logistic regression material Mild moderate Observational cohort study Occurrence olfactory Patient patients Prevalence Primary outcome Prognosis remained reported resolved SARS-CoV-2 Severe patient Sex significantly shorter Smell Symptom symptomatic Symptoms Taste tested these symptoms university was performed
[DOI] 10.1016/j.amjoto.2020.102648 PMC 바로가기 [Article Type] Observational Study

Immunometabolic signatures predict risk of progression to sepsis in COVID-19

Research Article

Published on 2021-08-302022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

[키워드] 95%CI amino acid metabolism Analysis AUC chemokines Clinical finding correlation COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill patients diabetes Diagnosis disease dysregulation early diagnosis Glycolysis help hyperinflammation IL-6 implementation In-hospital individuals Inflammatory cytokines lipid metabolism metabolism metabolite metabolomics Mild mild patient mitochondrial metabolism Mortality multisystemic neutrophil activation NLR Non-COVID-19 patients who survived plasma sample polyamine synthesis predict Prognosis progression quantified risk sensitivity Sepsis sepsis patient septic septic patients Severe patient severity specificity Treatment Type
[DOI] 10.1371/journal.pone.0256784 PMC 바로가기 [Article Type] Research Article

Different Profiles of Antibodies and Cytokines Were Found Between Severe and Moderate COVID-19 Patients

중증 및 중등도의 COVID-19 환자 사이에서 항체 및 사이토카인의 다양한 프로필이 발견되었습니다

Immunology

Published on 2021-08-192022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법,

[키워드] anti-S anti-S protein antibodies anti-S protein antibody antibody Antibody titer Antibody titers CCL2 Concentration COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical CXCL10 cytokine cytokine profile Cytokine storm Cytokines determine determined by distribution ELISA enrolled healthy individuals IFN-γ IgA IgE IgG IgG antibodies IgG subclasse IgG subclasses IgG3 IgG4 IgM IL-10 IL-2 IL-4 IL-6 Immunoglobulin immunoglobulin type in healthy individuals less live SARS-CoV-2 Mann-Whitney moderate N and S proteins Neutralization assay neutralizing antibody neutralizing antibody titers objective Patient patients positive positive rate positively correlated profile Protein Result S protein S proteins Sample SARS-CoV-2 severe COVID-19 Severe patient severe patients severity significant difference significantly significantly higher significantly more t-test T-tests tested titer TNF-α were measured with COVID-19
[DOI] 10.3389/fimmu.2021.723585 PMC 바로가기 [Article Type] Immunology

Research on Influencing Factors and Classification of Patients With Mild and Severe COVID-19 Symptoms

Cellular and Infection Microbiology

Published on 2021-08-182022-10-31
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS,

[키워드] Admission age analyzed average can be used categories changes in city classification clinical characteristic Clinical characteristics clinical symptom Clinical symptoms Cluster complement condition conducted cough COVID-19 COVID-19 cases COVID-19 patient COVID-19 severity D-dimer determine diabete diarrhea Dyspnea Epidemic epidemiological history Factor fatigue females Fever headache Hospital admission Hospital stay hypertension identify illness onset independent predictor indicate Infection infections information Laboratory Laboratory testing laboratory-confirmed Lasso-Logistic regression leukopenia Logistic regression lymphocyte Lymphocyte count lymphopenia male median Mild mild and severe mild illness mild patient mild patients neutrophil Ninth NLR non-specific objective Older other diseases oversampling parameter Patient patients patients with COVID-19 phosphate phosphocreatine predicted procalcitonin random Random forest Research Result Retrospective study Risk factors selected Severe COVID-19 Infection Severe patient severe patients severity severity of COVID-19 significantly subject Symptom the disease the patient Treatment underlying disease variable vomiting
[DOI] 10.3389/fcimb.2021.670823 PMC 바로가기 [Article Type] Cellular and Infection Microbiology