the cell – Page 7 – Communicable Diseases Research

ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues

ACE2 Nascence, 인신매매 및 SARS-CoV-2 발병 기전: 이야기는 계속됩니다

Review

Published on 2021-01-292022-09-10
Journal: Human Genomics [Category] 변종,

Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors

SARS-CoV-2 감염에 대한 숙주 전사 반응의 메타 분석은 인간 종양에서의 발현을 나타냅니다

Meta-Analysis

Published on 2021-01-282022-09-01
Journal: Scientific Reports [Category] 유전자 메커니즘, 진단,

[키워드] A549 activated adenocarcinoma bronchial epithelial cell Calu Calu-3 Cancer cancer cell Cancer cells Cell cell line cell line data common Data integration defined eight epithelial cells Gene regulatory networks histopathological Host immune response host response host responses Host transcriptional response IL-6 immune Immune cell infiltration immune response immune responses implicated Infection Inflammation interferon signaling lung adenocarcinoma lung cancer manifested model system Molecular biology NF-κB NHBE pathway Pathways Patient reveal SARS-CoV-2 SARS-COV-2 infection similarity subset the cell the SARS-CoV-2 Therapeutic strategies therapeutic strategy transcriptional transcriptomic Tumor Tumour immunology type II interferon Viral viral infection viral infections virus viruses
[DOI] 10.1038/s41598-021-82221-4 PMC 바로가기 [Article Type] Meta-Analysis

A PCR amplicon-based SARS-CoV-2 replicon for antiviral evaluation

Article

Published on 2021-01-262022-10-04
Journal: Scientific Reports [Category] 치료제,

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

S1/S2 절단 부위에 돌연변이가 있는 SARS-CoV-2 변이체는 TMPRSS2 결핍 세포에서 증식하는 동안 시험관 내에서 생성됩니다

Research Article

Published on 2021-01-212022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, COVID-19,

[키워드] alteration antivirals bind Cell cell lines cell tropism cleavage cleavage site cleaved Coronaviruses Critical de novo demonstrated direct fusion dominant entry pathway exhibited experiments facilitate generate Host host cell host cell receptor host protease in vitro inefficient infect motif mutant mutants Mutation performed plaque plaques polybasic Protein proteolytic cleavage researcher respiratory S gene S protein S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 propagation SARS-CoV-2 S gene SARS-CoV-2 variant SARS-CoV-2 variants screened Serine Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 shown target cells the cell the S protein TMPRSS2 transmembrane serine protease Transmissibility type strain undergo Vaccine variant Vero Cell Vero cells Viral viral entry virus virus strains virus variants viruses wild-type strain
[DOI] 10.1371/journal.ppat.1009233 PMC 바로가기 [Article Type] Research Article

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

SARS-CoV-2 진입의 Hydroxychloroquine 매개 억제는 TMPRSS2에 의해 약화됩니다

Research Article

Published on 2021-01-192022-08-13
Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences,

[키워드] ablated activate activated activating antiviral activities antiviral activity Autoimmune disorders block cathepsin L Cathepsins cause Cell cell entry cell surface cell-culture studies cell-culture systems Chloroquine cleave clinically Combination combinations coronavirus COVID-19 COVID-19 patient dependent on Efficacy endocytosis Endosomal acidification endosomal protease explain functional furin furin cleavage site furin-cleavage site global public health human clinical trial human clinical trials Hydroxychloroquine identify in vivo Infection inhibit inhibit SARS-CoV-2 interfere introduced lack malaria membrane fusion observé pathogenic coronavirus pathway plasma plasma membrane Prevent protease TMPRSS2 Protein Proteins proteolytic activity Receptor binding reversed S protein S proteins SARS Coronavirus SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 spike shown target cell target cells tested the cell the SARS-CoV-2 these compounds TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor TMPRSS2 pathway treat treated treatment for COVID-19 utility Viral viral entry viral infection
[DOI] 10.1371/journal.ppat.1009212 PMC 바로가기 [Article Type] Research Article

Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion

미세융합 억제 시험: 바이러스 매개 세포-세포 융합의 항체 중화 정량화

Research Article

Published on 2021-01-152022-09-10
Journal: The Journal of General Virology [Category] SARS, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibodies antibody Antibody neutralization Antibody Response Antibody responses Antibody-mediated neutralization applicability bimolecular canonical Cell cell–cell fusion cells characterized complexes consequence convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated enveloped virus fusion fusion protein GFP in vivo induce infected cells Infection inhibit inhibition test lack Live virus mAb mAbs mechanism membrane-bound mFIT monoclonal antibody multinucleated cell multinucleated cells natural infection Neutral neutralization Neutralizing antibodies Nipah virus pathogenic performed PIGS plasma quantification receptor engagement Renilla repertoire reported reporter respiratory respiratory syncytial virus RSV SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus specific antibodies Spike protein Spread Syncytia syncytia formation the cell the spike protein triggering vaccination Vaccine immunization Vaccines Viral viral pathogenesis viral spread virus Virus neutralization viruses
[DOI] 10.1099/jgv.0.001506 PMC 바로가기 [Article Type] Research Article

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

COVID-19 및 Toll-Like Receptor 4(TLR4): SARS-CoV-2는 TLR4에 결합하고 활성화하여 ACE2 발현을 증가시켜 진입을 촉진하고 과염증을 유발할 수 있습니다

Review

Published on 2021-01-142022-09-10
Journal: Mediators of Inflammation [Category] 치료제,

[키워드] ACE2 activate Activation alveolar cell antagonist Antiviral appear ARDS bind binding cause causes causing Cell cell surface cells clinical trial contribute COVID-19 COVID-19 patients Cytokines decrease entry receptor Evidence expressed expression Facilitating heart failure hyperinflammation Immune cell immune cells include increase Infection Inflammation Injury innate immune innate immune response interferons lung Lungs Mortality multiorgan failure multiple-organ myocarditis PAMPs pathogen pathogen-associated molecular pattern pathogen-associated molecular patterns Pathogenesis pathogenesis of SARS-CoV-2 pathophysiological Proinflammatory cytokine proinflammatory cytokines promise protein-protein interaction Pulmonary surfactants receptor recognize reported Respiratory failure SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike glycoprotein secrete Sepsis severe COVID-19 significantly spike glycoprotein Spike protein surface tension tension the cell the SARS-CoV-2 the spike protein the strongest therapeutic target TLR4 Treatment Trigger triggers type I interferon type I interferons Viral Viral protein Viral proteins
[DOI] 10.1155/2021/8874339 PMC 바로가기 [Article Type] Review

A novel type of colistin resistance genes selected from random sequence space

무작위 서열 공간에서 선택된 새로운 유형의 콜리스틴 내성 유전자

Research Article

Published on 2021-01-072022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence activating Activation activity addition Analysis antibiotic Antibiotic resistance antibiotic treatments auxiliary Bacteria Cell cell envelope chimeric clinical isolates colistin d e novo de novo de novo gene described determinant determine dissemination DNA DNA sequence DNA sequences domain dominant E . coli Escherichia coli Evolution examined example expand expressed expression generate growth growth defects idea in vivo Interaction isolate kinase kinases limit lipopolysaccharide low expression levels mechanism Modification modifications non-coding DNA non-coding region non-coding regions Open reading frame open reading frames Pathogens peptide peptides provided random Randomly resistance gene resistance genes selected sequence Spread subsequent substrate Support Surveillance the cell transfer transmembrane domain Treatment variant
[DOI] 10.1371/journal.pgen.1009227 PMC 바로가기 [Article Type] Research Article

Double-blind, randomized, controlled, trial to assess the efficacy of allogenic mesenchymal stromal cells in patients with acute respiratory distress syndrome due to COVID-19 (COVID-AT): A structured summary of a study protocol for a randomised controlled trial

COVID-19(COVID-AT)로 인한 급성 호흡 곤란 증후군 환자에서 동종 간엽 기질 세포의 효능을 평가하기 위한 이중 맹검, 무작위, 대조 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-01-062022-09-10
Journal: Trials [Category] MERS, 바이오마커, 임상, 치료제,

[키워드] 1:1 24 hours 7-point ordinal scale acute respiratory distress acute respiratory distress syndrome Administered administration Admission Adult patient Adult patients Adverse Adverse drug reactions AEs age All trial participants all-cause mortality allergy Allogeneic ARDS assessment assigned baseline Biomarker blinded Blinding C-reactive protein carcinoma carcinoma in situ carried cellular chain change childbearing potential Chloroquine Clinical practice clinical status clinical trial coagulation test coagulation tests conducted Control control arm Course COVID COVID-19 CRF criteria CT scan cumulative incidence current Cytokines D-dimer Day death described determined by Diagnosis disease dissemination double-blind drug Duration ECMO Efficacy Efficacy and safety element eligible End endpoints enrolment EudraCT evaluate evaluate the effect event exclusion criteria Extracorporeal extracorporeal membrane oxygenation failure ferritin fibrosis FiO2 form GRADE grade 3 greater Haemodialysis handling hemofiltration history hospital Hospitalization hydroxy ICU ICU admission IMPROVE include inclusion criteria Informed consent intravenous Intravenous administration intravenous dose intubation Invasive mechanical ventilation invasive ventilation investigational medicinal product involved laboratory confirmation laboratory-confirmed SARS-CoV-2 infection lactation LDH less Level Local Lopinavir Lopinavir/ritonavir lung disorder lymphocyte marker Mechanical mechanical ventilation Medicine Medicines Mesenchymal stromal cells moderate to severe Mortality MSC negative pregnancy test neoplasm neutrophil neutrophil counts Non-invasive number objective occur off-label opinion Ordinal Scale organ oropharyngeal swab oropharyngeal swabs Other outcome oxygen oxygen saturation Oxygen therapy PaO2 PaO2/FiO2 ratio parameters participant Patient PCR percentage Placebo polymerase chain reaction Pregnancy primary endpoint product Production profile progression protocol Pulmonary embolism pulmonary fibrosis Pulmonary function tests randomised randomised controlled trial randomization Randomized Randomly Rapid antigen tests reaction receive recruitment Registered Remdesivir report respiratory Respiratory distress syndrome Resuscitation Ritonavir SAEs Sample size SARS-COV-2 infection secondary Secondary endpoints Sequential Organ Failure Assessment Serious Adverse Events SOFA Spain specificity specimen Sponsor Standard of care status stromal cell stromal cells Study protocol subpopulations supplemental oxygen supplementary material syndrome the cell the disease the patient the primary endpoint the WHO time Tocilizumab Tolerability Treatment treatment arm treatment for COVID-19 treatment group Treatment protocol Trial trial participant Trial registration unit website women worldwide pandemic written consent
[DOI] 10.1186/s13063-020-04964-1 PMC 바로가기 [Article Type] Letter

Polycations and polyanions in SARS-CoV-2 infection

SARS-CoV-2 감염의 다중양이온 및 다중음이온

Review

Published on 2021-01-012022-09-11
Journal: Medical Hypotheses [Category] 치료제,