Development of a high‐sensitivity ELISA detecting IgG, IgA and IgM antibodies to the SARS‐CoV‐2 spike glycoprotein in serum and saliva혈청 및 타액 내 SARS-CoV-2 스파이크 당단백질에 대한 IgG, IgA 및 IgM 항체를 검출하는 고감도 ELISA 개발Original Article Published on 2021-05-242022-09-10 Journal: Immunology [Category] SARS, 진단, 치료기술, 치료법, [키워드] amplification antibodies antibody antibody assay Antibody assays Antibody Response Antibody responses Antigen antigens asymptomatic infection asymptomatic infections contribute COVID‐19 detectable development disease effective ELISA glycoprotein highest hospitalized patient hospitalized patients IgA IgG IgG1 IgG3 IgM antibody immune response immune responses individual Infection less manuscript Mild disease nucleocapsid response responses RT‐PCR Saliva SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected SARS‐CoV‐2 sensitivity Seroepidemiology Serological assay serum serum antibodies severe disease spike glycoprotein subject subjects symptomatic individuals the antibody response trimeric spike virus with mild disease [DOI] 10.1111/imm.13349 PMC 바로가기 [Article Type] Original Article
Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release AssaySARS-CoV-2 감염 후 구조 단백질의 광범위한 T 세포 표적화: 자동화된 인터페론 감마 방출 분석을 사용한 T 세포 반응성의 높은 처리량 평가Immunology Published on 2021-05-202022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] Antibody titer Antigen antigens approach assessment automated body mass body mass index breadth C-terminus characteristic comparable confirmed case confirmed cases Control control subjects convalescent coronavirus disease Coronavirus disease 2019 correlated COVID-19 days post infection Elecsy Elecsys facilitate followed by fresh whole blood Gamma groups high accuracy high through put IgG immune response immune responses Infection interferon gamma interferon gamma release assay (IGRA) large cohort less magnitude membrane nucleocapsid PCR positive Protein reactivity Release Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody SCT seropositive seropositive individual Seropositivity Sex significantly specific antibodies structural protein structural proteins subject T cell T cell response T cell responses T cells targeting targets tested throughput virion virus was performed were assessed Whole blood [DOI] 10.3389/fimmu.2021.688436 PMC 바로가기 [Article Type] Immunology
Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenzaArticle Published on 2021-05-202022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 신종인플루엔자, 치료기술, 치료법, [키워드] Co-infection Combined COVID-19 COVID-19 pathogenesis demonstrated disease effective ferret ferrets flu vaccine H1N1 hACE2 Host immune responses immunization indicated Infection Infectious diseases Influenza influenza A K18 lung mammalian mice Mortality Neutralizing antibody titer no significant difference outcome PiCoVacc Pneumonia prevention of COVID-19 pulmonary damage reduced Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine the SARS-CoV-2 virus throat swab vaccination Viral load viral shedding virus was increased was performed [DOI] 10.1038/s41392-021-00618-z PMC 바로가기 [Article Type] Article
Understanding COVID-19: are children the key?COVID-19 이해: 어린이가 핵심입니까?Review Published on 2021-05-192022-09-11 Journal: BMJ Paediatrics Open [Category] SARS, 변종, [키워드] acute COVID-19 acute respiratory distress acute respiratory distress syndrome adaptive immune responses Adults Affect Asymptomatic Cell Cell Biology children combating community transmission COVID-19 COVID-19 infection COVID-19 pandemic Critical current Cytokine storm Epidemiology Evidence Health help hyperinflammation identify Immune escape immune response immune responses in some infected with SARS-CoV-2 Infection infection rate infection rates Inflammatory less Microbiology mild illness Mortality pandemic Pandemics Pathogenesis pathogenesis of SARS-CoV-2 patients phenotype Proinflammatory cytokine Reinfection Research respiratory distress Respiratory distress syndrome risk factor SARS-CoV-2 SARS-COV-2 infection severe disease significant survival advantage situation stability sustained syndrome the cytokine storm Treatment undergo understanding vaccination Variability variants of concern Virology with COVID-19 zoonotic [DOI] 10.1136/bmjpo-2021-001063 PMC 바로가기 [Article Type] Review
Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infectionSARS-CoV-2 및 풍토성 코로나바이러스 감염의 스파이크 단백질에 대한 교차 반응성 혈청 및 기억 B 세포 반응Article Published on 2021-05-192022-09-12 Journal: Nature Communications [Category] SARS, 진단, [키워드] activated antibodies antibody Antibody Response Antibody responses assays B cells betacoronaviruses binding Cell cell population consequence convalescent coronavirus Coronavirus infection coronavirus spike protein coronavirus spike proteins Coronaviruses cross-reactive cross-reactivity Donor donors Endemic endemic human coronaviruses Evidence evidence of functional Human identify immune response immune responses Immunity in viral Infection memory B memory B cell memory B cells memory B-cell monoclonal antibodies natural infection neutralizing antibody pre-existing immunity related virus response S protein S2 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 serum serum antibodies serum antibody Spike protein the S protein vaccination Vaccinations viral infection viral infections [DOI] 10.1038/s41467-021-23074-3 PMC 바로가기 [Article Type] Article
Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seqLIBRA-seq를 통한 회복기 COVID-19 환자의 SARS-CoV-2 특이적 기억 B 세포의 신속한 분리 및 면역 프로파일링Article Published on 2021-05-172022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 진단, [키워드] activated Adaptive immunity analyzed antibody Antigen B cell response BCR binding affinity CD11c Cell convalescent COVID-19 patient convalescent COVID-19 patients convalescent individuals Critical Diversity domain ELISA assay exhibited FIVE Frequency heterogeneity immune profiling immune responses Immunoglobulin in vitro Infectious diseases Isolation memory memory B memory B cell memory B cells Neutralizing activity nucleoprotein performed plasma B cell plasma B cells proportion provide pseudotyped Rapid RBD SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 virus Sequencing single-cell level Single-cell RNA sequencing specificity Spectrum transcriptional VDJ Via [DOI] 10.1038/s41392-021-00610-7 PMC 바로가기 [Article Type] Article
Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface임신 중 산모 호흡기 SARS-CoV-2 감염은 산모-태아 경계면에서 강력한 염증 반응과 관련이 있습니다Article Published on 2021-05-142022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] absence ACE2 ACE2 expression Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed Cell cells center Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detectable early pregnancy exhibited full term Genes had no healthy histology Hofbauer cells immortalized cell line immortalized cell lines immune immune activation immune mechanism immune responses immunohistochemistry in vitro in vivo increased expression increased risk Infection Inflammatory response Local majority marker Maternal morbidity natural killer NIH outcome pathophysiology performed Placenta placental Placentas precursor precursors preeclampsia Pregnancy pregnancy complications pregnant women PROTECT respiratory robust SARS-CoV-2 SARS-COV-2 infection shielding single-cell stem cell stem cells Support T cells transcriptomics Viral viral infection viral invasion Viral RNA women [DOI] 10.1016/j.medj.2021.04.016 PMC 바로가기 [Article Type] Article
Intestinal Microbiota—A Promising Target for Antiviral Therapy?장내 미생물군—항바이러스 치료의 유망한 표적인가?Review Published on 2021-05-122022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] abundance Adaptive immune response Anti-viral immunity Antibiotics Antiviral Antiviral effect antiviral effects balance changed clinical trials component COVID-19 curative curative effects Effect facilitate gut microbiota immune responses Immunity inhibit inhibitory Interaction intestinal intestinal microbiota microbiota oral administration Participation Pathogens primary mechanism Probiotics Research SARS-CoV-2 shown target therapeutic strategy therapeutic target thought Viral viral infection viral infections viral invasion virus viruses [DOI] 10.3389/fimmu.2021.676232 PMC 바로가기 [Article Type] Review
Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival증상이 있는 COVID-19에서 SARS-CoV-2에 대한 항체 반응 중화는 지속되고 생존에 중요합니다Article Published on 2021-05-112022-09-10 Journal: Nature Communications [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] age antibody Antibody Response Antibody responses Antibody titer Antibody titers Antigen antigens Antimicrobial responses best beta-coronavirus Care co-morbidities Cohort common cold conditions COVID-19 COVID-19 patient COVID-19 symptomatic patient Critical detectable Disease progression eight flu H1N1 hemagglutinin Heterologous Humoral immunity IgG immune response immune responses Immunity increased risk Infection Influenza lack majority morbidities neutralization Neutralizing antibodies neutralizing antibody neutralizing antibody titers neutralizing capacity not affected nucleoprotein outcome Patient care Planning recognizing recovered patient recovered patients S2 antigen SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2 spike SARS-CoV-2 spike antigen SARS-CoV-2 spike protein seasonal coronavirus seasonal coronaviruses severe COVID-19 Spike protein survival Swab symptom onset symptomatic symptoms onset the antibody response the SARS-CoV-2 Therapeutic approach therapeutic approaches therapy understanding vaccination viral infection virus worsening [DOI] 10.1038/s41467-021-22958-8 PMC 바로가기 [Article Type] Article
Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patientsArticle Published on 2021-05-112022-10-04 Journal: Nature Communications [Category] 바이오마커, 유전자 메커니즘, [키워드] activated Activation Adaptive immune response antibody antibody-secreting cell B-cell CD4 CD8 Cell cellular cellular immunity characterisation circulating Cohort cytokine disease Diseases Factors follicular Genetic hospitalized patient immune immune responses immunological parameter increases in Infection infections Influenza influenza infection Influenza virus investigated memory B-cell number parameters Patient patients hospitalized phenotype real time responses severity T cell Translational immunology viral infection Virological [DOI] 10.1038/s41467-021-23018-x PMC 바로가기 [Article Type] Article