epithelial cell – Page 8 – Communicable Diseases Research

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

Article

Published on 2021-12-072022-10-04
Journal: Nature Communications [Category] SARS, 임상, 진단,

Flagellin From Pseudomonas aeruginosa Modulates SARS-CoV-2 Infectivity in Cystic Fibrosis Airway Epithelial Cells by Increasing TMPRSS2 Expression

Immunology

Published on 2021-12-072022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

[키워드] Activation AEC airway angiotensin-converting enzyme 2 Calu-3 cell calu-3 cells CFTR chronic respiratory disease coronavirus disease Course COVID-19 COVID-19 severity COVID19 Critical Cystic cystic fibrosis deficiency develop epithelial cell Factor fibrosis flagella flagellin Health host protease identify immune response increase Increasing infect Infection Infectivity MAPK modulation P. aeruginosa Patient patients populations protease Protein Pseudomonas aeruginosa receptor recommendation reduce released risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection susceptibility TLR5 TMPRSS2 TMPRSS2 expression transmembrane transmembrane serine protease urgency virus particle
[DOI] 10.3389/fimmu.2021.714027 PMC 바로가기 [Article Type] Immunology

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

Research Article

Published on 2021-12-062022-10-31
Journal: eLife [Category] COVID-19, SARS,

[키워드] abrogated activate Activation administration CCL2 chemokines co-cultured COVID-19 CXCL1 CXCL2 Cytokine storm elicited epithelial cell expressing S protein Extracellular Hyperinflammatory IFN IL-1β IL-6 induce Inflammation Inflammatory cytokine inflammatory function Inflammatory response investigated lung epithelial cell Macrophage macrophages mechanism membrane mice mouse macrophages NF-κB pathway nucleocapsid pathogenesis of COVID-19 potential therapeutic target produced Protein Proteins S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Spike protein stimulated structural protein the cytokine storm These data TLR1 TLR2 TLR6 TNF-α TNFα Trigger viruses wild-type
[DOI] 10.7554/eLife.68563 PMC 바로가기 [Article Type] Research Article

SARS‐CoV‐2 N Protein Induces Acute Kidney Injury via Smad3‐Dependent G1 Cell Cycle Arrest Mechanism

SARS -COV -2 N 단백질은 SMAD3- 의존적 G1 세포주기 정지 메커니즘을 통해 급성 신장 손상을 유도합니다.

Research Article

Published on 2021-11-232022-09-10
Journal: Advanced Science [Category] MERS, SARS, 유전자 메커니즘, 치료법,

[키워드] activate Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AKI arrest cause Cell cell cycle cell cycle arrest cell death coronavirus COVID‐19 COVID‐19 patients Critically ill cycle death Deletion develop ENhance epithelial epithelial cell G1 cell cycle identify in vitro in vivo induce inhibit inhibitor kidney knockout mice mechanism mediator mice MOST N protein organ organ injury overexpressing p21 pharmacological PROTECT respiratory SARS‐CoV‐2 SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus Signaling significantly Smad3 target organs targeting TGF‐β therapy Treatment
[DOI] 10.1002/advs.202103248 PMC 바로가기 [Article Type] Research Article

Human nasal wash RNA-Seq reveals distinct cell-specific innate immune responses in influenza versus SARS-CoV-2

Clinical Medicine

Published on 2021-11-222022-10-30
Journal: JCI Insight [Category] COVID-19, MERS, SARS,

[키워드] “COVID-19 acute COVID-19 airway Analysis appear B cell Cell cell interaction cell type clinical manifestation collected contribute courses COVID-19 COVID-19 sample COVID-19 samples deaths decrease Department disease Donor epithelial epithelial cell epithelial cells Evidence expansion foundation funding healthy controls Host Human Hypothesis IAV immune immune cell response immune sensing individual Infection Infectious disease Influenza innate immune response Innate immunity Interaction Local Macrophage macrophages Massachusett nasal neutrophil Neutrophils pandemic performed readiness response Result reveal SARS-CoV-2 Single-cell RNA sequencing subset subtype transcript transcriptional activity virus with COVID-19
[DOI] 10.1172/jci.insight.152288 PMC 바로가기 [Article Type] Clinical Medicine

SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis

SARS-CoV-2는 STAT1-IRF1-NLRC5 축을 표적으로 하여 MHC 클래스 I 경로의 유도를 억제합니다

Article

Published on 2021-11-152022-09-10
Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료제,

Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19

Medicine

Published on 2021-11-042022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

OM-85 Broncho-Vaxom ® , a Bacterial Lysate, Reduces SARS-CoV-2 Binding Proteins on Human Bronchial Epithelial Cells

Article

Published on 2021-10-262022-10-28
Journal: Biomedicines [Category] COVID-19,

[키워드] ACE2 ADAM17 Bacterial binding bronchial bronchial epithelial cell bronchial epithelial cells Cell cellular Clinical studies Concentration COVID-19 Dipeptidyl peptidase-4 DPP4 Effect ELISA enzyme epithelial cell expression expression of SARS-CoV-2 glycosaminoglycans host cell membrane Human Infection Interaction investigated lentivirus lysate Modification OM-85 Broncho-Vaxom protease Protein Proteins Quantitative receptor reduce reduced RT-PCR S-protein sACE2 SARS-CoV-2 SARS-CoV-2 spike protein Serine significantly Spike protein spike-protein therapy TMPRSS2 transmembrane treated upregulated viral respiratory was reduced were assessed western blotting
[DOI] 10.3390/biomedicines9111544 PMC 바로가기 [Article Type] Article

The Role of Epithelial Damage in the Pulmonary Immune Response

폐 면역 반응에서 상피 손상의 역할

Review

Published on 2021-10-152022-09-12
Journal: Cells [Category] MERS, SARS, 진단,

[키워드] Acute inflammation cell death cell type cellular senescence Chronic diseases chronic obstructive chronic obstructive pulmonary disease (COPD) contributing to COPD coronavirus Coronavirus Disease (COVID)-19 COVID-19 damage damage-associated molecular pattern damage-associated molecular patterns (DAMPs) DAMPs disease pathogenesis dysregulation epithelial epithelial cell epithelial damage fibroblast hallmark highlight idiopathic pulmonary fibrosis (IPF) Immune cell immune response Inflammatory Injury innate immune response IPF lung necroptosis Necrosis necrotic cell death pathway promote pulmonary pulmonary disease pulmonary fibrosis Respiratory disease response responsible role senescence subsequent tissue wound healing
[DOI] 10.3390/cells10102763 PMC 바로가기 [Article Type] Review

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

새로운 종류의 TMPRSS2 억제제는 SARS-CoV-2 및 MERS-CoV 바이러스 진입을 강력하게 차단하고 인간 상피 폐 세포를 보호합니다

410

Published on 2021-10-112022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 신약개발,

[키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antiviral antiviral drug block broad-spectrum antivirals Calu Calu-3 calu-3 cells camostat can be used cell entry chimeric clinical development coronavirus COVID-19 COVID-19 treatment Cytopathic effect cytopathic effects drug drug candidate drug design Drug discovery drugs Efficacy epithelial epithelial cell epithelial cells full-length half-life half-maximal effective concentration half-maximal inhibitory concentration help host cell human lung in vivo Influenza influenza viruses inhibiting inhibitor lead lung lung cell lung tissue mechanism MERS-CoV mice Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus nafamostat other coronavirus other coronaviruses Pathogenesis pharmacokinetics plasma probe protease Protease inhibitor PROTECT Protein PS-SCL respiratory respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 virus selective Serine serine protease TMPRSS2 severe acute respiratory syndrome Coronavirus Significance significantly specificity Spike protein stability structure-based drug discovery the Spike therapeutic target TMPRSS2 TMPRSS2 inhibitor TMPRSS2 inhibitors TMPRSS2 protein treat Treatment Viral viral entry viral pathogenesis Viral protein viral spread virus
[DOI] 10.1073/pnas.2108728118 PMC 바로가기 [Article Type] 410