Longitudinal Analysis of Human Memory T-Cell Response According to the Severity of Illness up to 8 Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection중증급성호흡기증후군 코로나바이러스 2 감염 후 최대 8개월까지 질병의 중증도에 따른 인간 기억 T 세포 반응의 종단 분석Article Published on 2021-07-022022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, 치료법, [키워드] 8 months acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antigen Asymptomatic Asymptomatic disease CD4+ T cell CD4+ T-cell coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 cytometry analysis Flow cytometry analysis Frequency greater healthy volunteer healthy volunteers Human illness Longevity longitudinal membrane membrane protein memory memory response memory T-cell response Mild Mild disease mononuclear cell mononuclear cells Month nucleocapsid Patient patients with COVID-19 PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells persist post-symptom onset protective effect protective immunity PSO Reinfection respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus severe disease severity severity of illness T cell T cells T-cell T-cell Response T-cell responses understanding vaccination with mild disease [DOI] 10.1093/infdis/jiab159 PMC 바로가기 [Article Type] Article
Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality인터페론으로 유도된 막횡단 단백질-3 유전자 변이체 rs12252는 COVID-19 사망률과 관련이 있습니다Article Published on 2021-07-012022-09-11 Journal: Genomics [Category] SARS, 변종, 유전자 메커니즘, [키워드] allele Clinical outcome COVID-19 COVID-19 phenotypes death examined Genetic variant genetics Genotype genotyped heterogeneous higher risk Hospital admission IFITM IFITM3 IFNγ individual interferon less log-rank test membrane protein Mortality Patient PCR-confirmed Plasma level Plasma levels Precision Probability public health risk factor SARS-CoV-2 SARS-COV-2 infection significantly lower subset survival transmembrane underlie variant Viral diseases with COVID-19 [DOI] 10.1016/j.ygeno.2021.04.002 PMC 바로가기 [Article Type] Article
Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4 + T cell helpSARS-CoV-2 스파이크 단백질을 표적으로 하는 기억 B 세포와 CD4 + T 세포 도움에 대한 의존성Article Published on 2021-06-292022-09-11 Journal: Cell Reports [Category] MERS, SARS, 진단, 치료법, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affinity maturation antibody association B cell memory best CD4 CD4(+) T cell CD40L coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop Exhaustion functions Generation identify IL-21 Immunity individual individuals Infection membrane protein memory B memory B cell memory B cells Mild Nucleocapsid proteins recognizing recovered respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 spike-specific SARS-CoV-2 spike-specific memory B cells severe acute respiratory syndrome Coronavirus severely ill spike Spike-specific memory B cells T cell T cell help T cell subset T cells these cell These cells [DOI] 10.1016/j.celrep.2021.109320 PMC 바로가기 [Article Type] Article
Rapidly emerging SARS-CoV-2 B.1.1.7 sub-lineage in the United States of America with spike protein D178H and membrane protein V70L mutationsResearch Article Published on 2021-06-262022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] accounted acquisition Affect Alter America Analysis antibodies appear B.1.1.7 B.1.1.7 isolate B.1.1.7 lineage characterized COVID-19 COVID-19 case D178H defined Europe identify include Lineage membrane protein Mutation mutations N terminal domain N501Y mutation neutralization Nextstrain NTD Protein RBD reported SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-CoV-2 variant Spike protein the receptor-binding domain the S protein the Spike the United State Transmission tyrosine V70L Washington [DOI] 10.1080/22221751.2021.1943540 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1SARS-COV-2 엔벨로프 (E) 단백질은 숙주 단단한 접합 단백질 ZO1의 PDZ- 도메인 -2와 상호 작용한다.Research Article Published on 2021-06-092022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 변종, 진단, [키워드] airway amplified approach approaches array binding Biotin C-terminal cell layer chloride complementary consolidation contribute contributing to COVID-19 patients disease severity domain dysfunction E protein ECT envelope epithelial epithelial cell epithelial cells epithelial tissues extreme Fluorescence fusion protein global pandemic homogenous Host HTRF humans interact Interaction Intervention lead Lungs membrane protein mitigate molecular morbidity motif multifunctional mutant Pathogenesis Pathologies peptide Protein reduce respiratory Respiratory disease respiratory tract SARS-CoV-1 SARS-CoV-2 screened secretion sequence severe pneumonia severe respiratory disease singular target the lungs a the SARS-CoV-2 tight junction tissues virus virus spread Zona [DOI] 10.1371/journal.pone.0251955 PMC 바로가기 [Article Type] Research Article
In Silico Study of Mutational Stability of SARS-CoV-2 ProteinsSARS-CoV-2 단백질의 돌연변이 안정성에 대한 실리코 연구Article Published on 2021-06-012022-09-11 Journal: The protein journal [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis calculation Clustering coronavirus protein Coronavirus-2 Droplet infection envelope protein Evolution experiments functional future therapeutic Genome glycoprotein idea in silico indicate Infection membrane protein mind moderate Mutation Mutation profiling Mutation stability nucleoprotein ORF1ab ORF3a ORF6 ORF7a ORF7b ORF8 Phylogenetic Protein protein sequence protein sequences protein stability Region reported residue Respiratory system RNA virus SARS-CoV-2 SARS-CoV-2 proteins sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Shannon entropy spike glycoprotein therapeutic agent therapeutic agents Variation virus [DOI] 10.1007/s10930-021-09988-3 PMC 바로가기 [Article Type] Article
Insilico drug repurposing using FDA approved drugs against Membrane protein of SARS-CoV-2Article Published on 2021-06-012023-06-19 Journal: Journal of pharmaceutical sciences [Category] MERS, SARS, [키워드] docking membrane protein MM-PBSA molecular dynamics simulations pharmacokinetics SARS-CoV-2 [DOI] 10.1016/j.xphs.2021.03.004 PMC 바로가기
Scrutinizing Coronaviruses Using Publicly Available Bioinformatic Tools: The Viral Structural Proteins as a Case StudyMolecular Biosciences Published on 2021-05-242022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Analysis antibody antiviral molecule assumed beta-coronavirus Bioinformatic cause caused contribute COVID-19 DeepView molecular graphics program disease Effect effort envelope protein glycoprotein immunomodulator impair knowledge life-threatening Lung infection macromolecule membrane protein MERS-CoV molecular nucleocapsid protein other organ pandemic Protein SARS-CoV SARS-CoV-2 Spike protein stimulate structural protein the SARS-CoV-2 virus tissues Vaccine development viral spike virus viruses [DOI] 10.3389/fmolb.2021.671923 PMC 바로가기 [Article Type] Molecular Biosciences
Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activitySARS-CoV-2 외피 단백질과 아밀로라이드의 상호작용은 항바이러스 활성과 관련이 있습니다Research Article Published on 2021-05-182022-09-10 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] activity addition Amiloride amilorides antiviral activity antiviral potency Author binding binding affinity binding site biochemical budding C-terminal causative agent change channel inhibitors characterized chemical shift Complete complex conformation conformations contribute correlated COVID-19 COVID-19 treatment cytoplasmic domain Drug discovery E protein envelope exhibit form foundation full-length SARS-CoV-2 group Guidance Health hexadecylphosphocholine hydrophobic information inhibitor inhibitors Interaction interactions ion channel lack linker membrane protein molecular Mutation N-terminal NMR spectroscopy Novel coronavirus novel coronavirus SARS-CoV-2 pandemic pandemic of COVID-19 Pathogenesis Perturbation Protein Protein conformation pyrazine rapid progress residue residues respiratory respiratory infection responsible SARS-CoV-2 SARS-CoV-2 envelope structural protein structural proteins Structure threat transmembrane transmembrane domain Treatment truncation Vaccines Vero E6 VERO E6 cells Viral viral genome Viral proteins viral replication virion assembly virus-like particles while [DOI] 10.1371/journal.ppat.1009519 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1Immunology Published on 2021-05-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome causative pathogen caused complex Coronavirus-2 COVID-19 pandemic Degradation form Host IFN-I IFNβ Immunosuppression induce inhibit interferon-stimulated gene IRF3 M protein MDA5 mechanism membrane protein negative regulation pathogenicity Phosphorylation Production Protein reduced reported RIG-I SARS-CoV-2 suppress suppress the expression TBK1 the disease TRAF3 Type type I interferon ubiquitination [DOI] 10.3389/fimmu.2021.662989 PMC 바로가기 [Article Type] Immunology