The preparation of N-IgY targeting SARS-CoV-2 and its immunomodulation to IFN-γ production in vitroSARS-CoV-2를 표적으로 하는 N-IgY의 제조 및 시험관 내 IFN-γ 생산에 대한 면역 조절Article Published on 2021-07-012022-09-11 Journal: International immunopharmacology [Category] SARS, 신약개발, 진단, 치료법, 치료제, [키워드] antibody Antibody-dependent enhancement binding ability Conservative COVID-19 COVID-19 epidemic COVID-19 pandemic diagnose Effect Egg Egg yolk immunoglobulin Y (IgY) foundation hyperimmune IFN-γ immune response Immunoglobulin immunomodulatory in vitro interferon mass modulated nucleocapsid protein Nucleocapsid protein (NP). produced Protein SARS-CoV-2 secretion Specific specific antibodies stimulated structural protein titer Treatment type II interferon was increased was obtained [DOI] 10.1016/j.intimp.2021.107797 PMC 바로가기 [Article Type] Article
Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and ThromboembolismImmunology Published on 2021-06-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 48 hour ACE2 ANPEP Apoptosis Autoimmune disease cancers cardiovascular comorbidity cardiovascular disease CEACAM1 cell death changes in complexes contribute controls coronavirus Coronavirus infection Coronaviruses COVID-19 CSF1 CSF3 CVD Cytokine storms DAMP DAMPs dataset death DPP4 Endothelial cell enzyme Epigenetic ER stress examined Express expressed expression facilitate Factor Ferroptosis hours post-infection Human hyperlipidemia IL6 Immunity Inflammation innate immune innate immune responses LPS majority marker MERS-CoV Microarray mitochondrial mitotic modulated monocyte Myelopoiesis Nrf2 nucleic acid oxidative phosphorylation PAMP Proinflammatory cytokine Proinflammatory response protein complex pyroptosis receptor regulate ROS stimulated Stimulation storm Stress subsequent Thromboembolism thrombosis TMPRSS2 TNFα trained immunity transcriptomic upregulated upregulation Viremia virus entry [DOI] 10.3389/fimmu.2021.653110 PMC 바로가기 [Article Type] Immunology
Dexamethasone for Severe COVID-19: How Does It Work at Cellular and Molecular Levels?중증 COVID-19에 대한 덱사메타손: 세포 및 분자 수준에서 어떻게 작용합니까?Review Published on 2021-06-232022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] accompanied activity anti-inflammatory property Bacterial sepsis cause caused characteristic coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 develop Dexamethasone Diseases effective encoding proteins facilitate glucocorticoid glucocorticoid dexamethasone glucocorticoid receptor (GR) Glucocorticoids host cell Hypothesis hypothetical impacted infected cells Infection Infectious diseases Inflammation Influenza influenza pneumonia Innate immunity interfere life-threatening Local mechanism modulated modulating non-infected not affect pathologic Pneumonia potential molecular Protein Replication reported respiratory Respiratory failure respiratory syndrome coronavirus SARS-CoV-2 SARS-COV-2 infection Sepsis Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) severe COVID-19 severe respiratory syndrome significantly steroid systemic inflammation Treatment type I interferons (IFNs) unique Viral Viral diseases viral replication virus viruses work [DOI] 10.3390/ijms22136764 PMC 바로가기 [Article Type] Review
SARS-CoV-2 can recruit a heme metabolite to evade antibody immunitySARS-CoV-2는 항체 면역을 피하기 위해 헴 대사 산물을 모집할 수 있습니다Research Article Published on 2021-05-282022-09-12 Journal: Science Advances [Category] SARS, 진단, [키워드] access Antibody binding antibody immunity Bilirubin Biliverdin bind binding cleft concentrations conformational change Coronaviral distal dominant dominant epitope epitope evade flexible heme heme metabolism immune inhibited Interaction linear mapped mechanism metabolism metabolite Microscopy modulated N-terminal domain nanomolar affinity Neutralizing antibodies NTD physiological reactivity recruit recruitment regulated Relocation SARS-CoV-2 SARS-CoV-2 spike sera significantly subset target tetrapyrrole Viral antigen X-ray crystallography [DOI] 10.1126/sciadv.abg7607 PMC 바로가기 [Article Type] Research Article
Peripheral and lung resident memory T cell responses against SARS-CoV-2SARS-CoV-2에 대한 말초 및 폐 상주 기억 T 세포 반응Article Published on 2021-05-212022-09-10 Journal: Nature Communications [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] acute infection Anti-inflammatory Antiviral antiviral response Apoptosis apoptotic Biopsy material Blood CCR7 Cell cellular immunity circulating Clinical outcome Convalescent patients COVID-19 Cytokines degranulation disease severity functional highlight identify IFNγ IL-10 IL-12p70 IL-4 IL-4 responses Infection Infectious diseases initial limit lung lung biopsy lung parenchyma Lungs memory T memory T cell memory T cells modulated Mucosal immunology outcome Patient patients with COVID-19 peptide peptides peripheral persistence positioned profiles reduce Reinfection required resident respiratory respiratory tract response responses against SARS-CoV-2 SARS-COV-2 infection secreting severity Spread T cell T cell response T cell responses T cells these cell These cells Viral viral infection Viral protein Viral proteins virus-specific T cell window [DOI] 10.1038/s41467-021-23333-3 PMC 바로가기 [Article Type] Article
Dolosigranulum pigrum Modulates Immunity against SARS-CoV-2 in Respiratory Epithelial CellsCommunication Published on 2021-05-212022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Dolosigranulum pigrum Activation addition Administered Calu-3 cell CCL5 cellular damage combating commensal bacteria coronavirus coronavirus 2 Coronavirus infection COVID-19 culture supernatant CXCL10 CXCL8 cytokine profile demonstrated evaluate IFN-β IL-6 Immunity immunological mechanism immunomodulatory effect IMPROVE innate immune response involved mice modify modulated modulation next generation probiotics reducing reduction in respiratory respiratory commensal bacteria respiratory epithelial cell respiratory epithelial cells RSV SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 stimulated strain TLR3 Toll-like receptor 3 triggered viral replication [DOI] 10.3390/pathogens10060634 PMC 바로가기 [Article Type] Communication
A Portrait of the OPE as a Biological Agent생물학적 제제로서의 OPE의 초상Review Published on 2021-05-212022-09-10 Journal: Molecules [Category] SARS, 치료기술, 치료제, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 agent antimicrobial Antiviral compounds Antiviral effect antiviral effects aromatic rings biocides Biological Cell coronavirus COVID-19 pandemic drug delivery systems Fluorescent probe induce living cells luminescent probe modulated oligomers oligophenylene ethynylenes organelle Pathogens photodynamic therapy Portrait position quantum yields researcher respiratory responsible selective sequence severe acute respiratory syndrome Coronavirus therapy Toxicity triple bonds virus [DOI] 10.3390/molecules26113088 PMC 바로가기 [Article Type] Review
mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA virusesReview Published on 2021-05-162022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome coronavirus coronavirus disease COVID-19 demonstrated Efficacy Evidence Frequently highlight in viral Infection infections inhibiting mammalian modulated modulation mTOR mTOR inhibitor mTORi pathway Rapamycin recent Replication RNA virus RNA viruses SARS-CoV-2 Support Treatment virus growth [DOI] 10.1002/jmv.26728 PMC 바로가기 [Article Type] Review
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell function코로나바이러스 네트워크 탐색기: SARS-CoV-2가 숙주 세포 기능에 미치는 영향에 대한 대규모 지식 그래프 마이닝Software Published on 2021-05-032022-09-10 Journal: BMC Bioinformatics [Category] 신약개발, 유전자 메커니즘, [키워드] Activation approach approaches Biological functions clinical observations clinical trial clinical trials co-morbidities co-morbidity coronavirus COVID-19 COVID-19 pathogenesis curated direction Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence exploration functional functions gene expression signature Host host cell host gene host genes human host hypothese identify immunological Interaction interfere knowledge Knowledge graph machine learning modulated morbidities network network biology observation offer pathway Pathways potential mechanism potential mechanisms Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Viral Viral proteins Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software