Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell‐free products and human pluripotent stem cell‐derived mesenchymal stem cellsMesenchymal Stem Cells Published on 2021-05-192022-10-28 Journal: Stem cells translational medicine [Category] Coronavirus, SARS, [키워드] addition advance Allogeneic Autoimmune diseases autologous Cell clinical trial clinical trials COVID‐19 demonstrated Efficacy Endpoint Evidence Exosome Exosomes Extracellular vesicles graft rejection Human human pluripotent stem cells immune Immune cell immunomodulatory property Increasing indication Inflammatory inflammatory disease inflammatory disorders liver Liver cirrhosis mesenchymal stem cell mesenchymal stem/stromal cell therapy MSC MSCs organ transplantation Osteoarthritis outcome prevalent pulmonary disease pulmonary inflammation rejection stem cell Stem cell therapy supported therapeutic therapeutic use therapy tissue Trial while [DOI] 10.1002/sctm.21-0021 PMC 바로가기 [Article Type] Mesenchymal Stem Cells
Stem cell therapies and benefaction of somatic cell nuclear transfer cloning in COVID-19 era코로나19 시대의 줄기세포 치료제와 체세포 핵이식 복제의 장점Review Published on 2021-05-122022-09-12 Journal: Stem Cell Research & Therapy [Category] SARS, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome Anti-inflammatory antivirals ARDS being benefit Bio-pharming boost caused Cell cell type Cell-based therapy cellular Clinical studies cloned COVID-19 COVID-19 patient COVID-19 patients damage dependence develop Drug testing Embryo embryonic embryos generate Genome reprogramming Health health emergency immunomodulatory effect immunomodulatory effects Interaction mesenchymal stem cell Mesenchymal stem cells MSC MSCs nuclear organ Organoid organoids potential benefit potential benefits prominence regenerative regenerative medicine Research respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection SCNT somatic cell STEM stem cell stem cells structures syndrome therapeutic Therapies therapy transfer transgenic treat unique Vaccinations Vascular [DOI] 10.1186/s13287-021-02334-5 PMC 바로가기 [Article Type] Review
Efficacy and safety of umbilical cord mesenchymal stem cells for the treatment of patients with COVID-19Research article Published on 2021-05-112022-10-05 Journal: Clinics [Category] SARS, 바이오마커, 치료법, [키워드] acute respiratory syndrome allergic reaction baseline Biomarker Cell changes in Clinicians Computerized tomography control group coronavirus coronavirus disease COVID-19 Decreased demonstrated drug Effect effective Efficacy evaluated healthy hematology tests IgM Immunoglobulin Inflammatory intravenous infusion large cohort lung mesenchymal stem cell Mesenchymal stem cells MSC MSC therapy MSC-treated MSCs Occurrence outbreak oxygenation index patients with COVID-19 pilot study public health pulmonary inflammation Randomized controlled trial reducing restored Serious Adverse Events significant changes in significantly stem cell Stem cell therapy therapeutic potential therapy tissue treated Treatment umbilical [DOI] 10.6061/clinics/2021/e2604 [Article Type] Research article
Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment급성 호흡곤란 증후군에서 중간엽 줄기세포의 치료 기전은 Covid-19 치료의 가능성을 보여줍니다Review Published on 2021-05-102022-09-10 Journal: Journal of Translational Medicine [Category] SARS, 비임상, [키워드] acute respiratory distress acute respiratory distress syndrome adipose Adipose tissue administration adverse effect adverse effects Allogeneic analyzed animal experiments ARDS attenuate Bone marrow breath cell infusion cells Clinical studies clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients cytokine Cytokines Effects Endoplasmic reticulum Evidence Exosome Exosomes experiment fibrosis highlight inflammatory cells inhibit mechanism mesenchymal stem cell Mesenchymal stem cells modulate mortality rate MSC MSC therapy MSCs paracrine patients with ARDS pulmonary fibrosis raising recent respiratory distress severe COVID-19 stem cell Stress syndrome therapeutic tissue Treatment umbilical Umbilical cord [DOI] 10.1186/s12967-021-02862-x PMC 바로가기 [Article Type] Review
Mesenchymal Stem Cells and COVID-19: Cure, Prevention, and VaccinationReview Article Published on 2021-05-062022-10-29 Journal: Stem Cells International [Category] COVID-19, [키워드] acute respiratory distress approved Cell Clinical outcome clinical study COVID-19 COVID-19 disease cure Cytokine storm damaged cell Defense disease effort Evidence Health host immune system Hyperinflammatory immune disorder Inflammatory cytokines Intervention lung cell mesenchymal stem cell MSC MSCs Patient platform Prevent prevention provided Research Safe severe cases Spread STEM stem cell syndrome the disease therapy tissue regeneration Treatment treatment for COVID-19 vaccinate vaccination against COVID-19 Vaccine viral disease virus infection [DOI] 10.1155/2021/6666370 PMC 바로가기 [Article Type] Review Article
Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles in COVID-19-induced ARDS: Mechanisms of action, research progress, challenges, and opportunitiesReview Published on 2021-04-282022-11-01 Journal: International immunopharmacology [Category] COVID-19, MERS, [키워드] KGF, Keratinocyte Growth Factor LDH, Lactate Dehydrogenase LIF, Leukemia Inhibitory Factor LPS, Lipopolysaccharide MERS-CoV, The Middle East Respiratory Syndrome Coronavirus MIP-2, Macrophage Inflammatory Protein-2 MOD, Multiple Organ Dysfunction MSC, Mesenchymal Stromal/Stem Cell MVB, Multi Vesicle Body NGF, Nerve Growth Factor NK cell, Natural Killer Cell PDGF, Platelet-Derived Growth Factor PGE2, Prostaglandin E2 ROS, Reactive Oxygen Species SARS-CoV, Severe Acute Respiratory Syndrome Coronavirus SPA, Surfactant Protein A SPC, Surfactant Protein C TGF-β, Transforming Growth Factor-Β Th, T Helper TMPRSS2, Transmembrane Protease Serine 2 TNF- α, Tumor Necrosis Factor- Α UC-MSC, Umbilical Cord MSC VEGF, Vascular Endothelial Growth Factor WBC, White Blood Cell Abstract ACE2, angiotensin-converting enzyme 2 acute respiratory distress acute respiratory distress syndrome AD-MSC, Adipocyte-Derived MSC administration AFC, Alveolar Fluid Clearance ALI, Acute Lung Injury ALT, alanine aminotransferase alveolar fluid clearance Ang-1, Angiopoietin-1 Anti-inflammatory effects approach ARDS ARDS, acute respiratory distress syndrome AST, aspartate aminotransferase AT II, Type II Alveolar Epithelial attenuate BDNF, Brain-Derived Neutrophilic Factor BM-MSC, Bone Marrow MSC caused Cell China Coagulopathy COPD, Chronic obstructive pulmonary disease coronavirus disease COVID-19 COVID-19 patients CRP, C-reactive protein CT, Computerized Tomography Cytokine storm DC, dendritic cell DIC, disseminated intravascular coagulation endothelial ENhance EV, extracellular vesicle Evidence EVs extracellular vesicle Extracellular vesicles global public health GVHD, Graft-versus-host disease hESC, Human Embryonic Stem Cell HGF, Hepatocyte Growth Factor HIF1-α, Hypoxia-Induced Factor 1-Α IFN, interferon immune response immunomodulation IMRC, Immunity and Matrix-Regulatory Cell incidence IPF, Idiopathic pulmonary fibrosis ISG, Interferon-Stimulated Genes IV, Intravenous lung injuries mechanism Mesenchymal stem cells MSC MSC therapy MSCs Novel coronavirus Probability Research resolved SARS-CoV-2 severity suggested syndrome therapeutic Therapeutic approach Treatment viral infections worldwide pandemic Wuhan [DOI] 10.1016/j.intimp.2021.107694 PMC 바로가기 [Article Type] Review
Comparison of the Effectiveness of an Abbreviated Program versus a Standard Program in Mindfulness, Self-Compassion and Self-Perceived Empathy in Tutors and Resident Intern Specialists of Family and Community Medicine and Nursing in Spain가정 및 지역 사회 의학 및 간호의 가정 및 지역 사회 의학 및 간호의 가정교사 및 레지던트 인턴 전문가의 Mindfulness, Self-Compassion 및 Self-Perceived Empathy에서 약식 프로그램과 표준 프로그램의 효과 비교Article Published on 2021-04-202022-08-13 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] Administered Analysis ANCOVA caused Community Medicine Controlled clinical trial covariate crisis disease Effect Effectiveness Emotional exhaustion empathy Facet family Follow-up global pandemic group Health implementation IMPROVE include intern Intervention long-lasting MBSR Medicine mindfulness MSC New Nursing participant participated physician problems professional Program promote Randomized resident resident intern specialists scale self-compassion significant increase Spain Spanish specialist Standard Stress Support System Tutor tutors [DOI] 10.3390/ijerph18084340 PMC 바로가기 [Article Type] Article
Therapeutic potential of mesenchymal stem cells in multiple organs affected by COVID-19Review Article Published on 2021-04-152023-06-15 Journal: Life sciences [Category] MERS, SARS, [키워드] Cell therapy Cytokine storm immunomodulation MSC SARS-CoV-2 [DOI] 10.1016/j.lfs.2021.119510 PMC 바로가기 [Article Type] Review Article
Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Treatment of Viral DiseasesReview Published on 2021-04-012022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] activate antibody production Antigen antigen-presentation antiviral immune response B cells CD4+ CTLs cytokine cytotoxicity damage-associated molecular pattern Diseases elicit ENhance Factors Immune cell immunomodulation immunomodulatory immunoregulatory cytokine infected cell Inflammatory cytokine interferon knowledge macrophages mesenchymal stem cell Mesenchymal stem cells modulate molecular mechanism MSC MSCs NK cell Prevent promote regulate released responsible Secretome STEM stem cell T helper cell therapeutic potential therapy tissue repair tissues Treatment Viral diseases viral pathogens virus-infected cells viruses [DOI] 10.3390/pathogens10040409 PMC 바로가기 [Article Type] Review
Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disordersReview Published on 2021-03-182022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, SARS, [키워드] adipocyte adipose Bone marrow CD105 CD14 CD34 CD45 CD73 Cell cell type chemokines chondrocyte conditions Coronavirus disease 2019 (COVID-19) COVID-19 criteria Crohn’s disease Culture Cytokines disease disorder disorders effective eligible evaluated exceptional expression feature global scientific community Graft versus host diseases (GVHD) GVHD HLA-DR homing Host identify Immune cell Immune-mediated immunomodulatory in vitro Infectious disease infiltration Inflammatory response involved ISCT lack leucocyte Mesenchymal stem/stromal cells (MSCs) Migration modulate molecular mechanism MSC MSCs multiple sclerosis Multiple sclerosis (MS) novel coronavirus disease Osteoarthritis Osteoarthritis (OA) over pathway Patient plasticity recent finding regulated released required Secretome signaling molecule Society Source suggested synergy target cell therapeutic Therapeutic molecule therapeutic option tissue Treatment umbilical [DOI] 10.1186/s13287-021-02265-1 PMC 바로가기 [Article Type] Review