Respiratory distress syndrome – Page 8 – Communicable Diseases Research

Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes

Public Health

Published on 2021-12-222022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS,

Positive end-expiratory pressure in COVID-19 acute respiratory distress syndrome: the heterogeneous effects

Research

Published on 2021-12-162022-11-01
Journal: Critical Care [Category] COVID-19, SARS,

[키워드] acute respiratory distress Affect age applied ARDS changes in Characteristics collected Compliance COVID-19 dead diagnosis of SARS-CoV-2 driving early phase Effect End-Expiratory Pressure enrolled fraction Gas exchange hemodynamic heterogeneity heterogeneous Hypoxemia investigated Keeping lung lung mechanics Mechanical power mechanically ventilated patient oxygen Oxygenation PaO pathophysiological feature PEEP predicted raising Respiratory distress syndrome Respiratory mechanics respiratory rate Respiratory system Result SARS-CoV-2 selected severity significantly increased Stress subgroup of patient subgroup of patients supplementary material the disease the median variable venous Ventilator-induced lung injury ventilatory Volume
[DOI] 10.1186/s13054-021-03839-4 PMC 바로가기 [Article Type] Research

Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic

차등 공동 발현 네트워크 분석, 코로나19 팬데믹에 대한 잠재적인 치료 표적으로 핵심 허브-높은 트래픽 유전자 밝혀

Immunology

Published on 2021-12-152022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Acute kidney injury acute lung injury ADRB2 AhR AKI Analysis analyzed approach approaches ARDS Asthma cardiovascular disease cardiovascular diseases CASP1 caused CCL5 co-expressed co-expression co-expression network analysis coagulation disorders Combination Comorbidities Comorbidity complications COVID-19 COVID-19 pandemic COVID-19 patient cytokine Cytokine storm Diabetic diabetic complications distress Factors functional enrichment Functional enrichment analysis GDI2 gene co-expression network gene expression matrix gene networks generate Genes GzmB healthy healthy sample healthy samples HIF1a highest Host Host immune response HSP90AA1 HSPA5 HSPD1 hub genes hub-high traffic genes ICAM1 identify IFNg IL10 IL1B IL6 Immunopathogenesis information IRAK3 knowledge liver disorder Liver disorders Lung injury lymphopenia MAPK1 mechanism Mild molecular molecular mechanism molecular mechanisms mononuclear cell mononuclear cells network NFkB1 OASL Pathways PBMCs Peripheral blood Peripheral blood mononuclear cells Perturbation Potential PPI Pregnancy pregnancy complications PRF1 protein-protein interaction provide PTEN RAB5A Regulatory respiratory distress Respiratory distress syndrome Result RHOA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions signaling pathway signaling pathways SOCS1 SOCS3 Spread SUMO1 syndrome Systems biology systems immunology target Therapeutic strategies therapeutic target therapeutic targets therapeutic targets in infectious diseases thrombosis TNF TNFRSF1A TP53 Traffic transcriptional transcriptomics transfer was used were used WGCNA with COVID-19
[DOI] 10.3389/fimmu.2021.789317 PMC 바로가기 [Article Type] Immunology

Anakinra reduces lung inflammation in experimental acute lung injury

Original Article

Published on 2021-12-092022-10-30
Journal: Immunity, Inflammation and Disease [Category] Coronavirus, COVID19(2023년), MERS, SARS,

[키워드] Abstract acute lung injury alveolar macrophage Anakinra animal model approach ARDS BAL BAL fluid blockade Bronchoalveolar lavage caused classical COVID‐19 patients COVID‐19 Day distress dysregulated Effect evaluate evaluated fluids Frequency general health status groups hallmark hypoxaemia IL‐1 IL‐1 IL‐1Ra immunomodulatory Immunotherapy IMPROVE infiltrating Inflammation Inflammatory cytokine inflammatory immune responses leukocyte Lung disease Lung inflammation lung tissue mice Mortality neutrophil nine NK cell pathogen potential treatment option Protein protein level reduce reduced Research Respiratory distress syndrome Result resulting Support syndrome therapeutic potential trauma treated Treatment variety weight loss
[DOI] 10.1002/iid3.548 PMC 바로가기 [Article Type] Original Article

The inflammatory biomarkers profile of hospitalized patients with COVID-19 and its association with patient’s outcome: A single centered study

COVID-19를 가진 입원 환자의 염증성 바이오 마커 프로파일 및 환자의 결과와의 연관성 : 단일 중심 연구

Research Article

Published on 2021-12-022022-09-10
Journal: PLoS ONE [Category] 바이오마커,

[키워드] Absolute lymphocyte count acute respiratory distress acute respiratory distress syndrome addition Admission ALC Analysis ARDS association C-reactive protein classical Clinical characteristics Clinical course Clinical outcome Cohort correlation count COVID-19 COVID-19 illness COVID-19 patient COVID-19 severity Critical CRP D-dimer death direction disease disease severity Dubai ferritin help hospitalized patient hyper-inflammatory response ICU ICU admission IMPROVE incidence Infection Inflammation Inflammatory biomarker inflammatory biomarkers Inflammatory marker inflammatory markers Injury intensive care intensive care unit investigated Kuwait laboratory biomarker laboratory biomarkers Lactate lactate dehydrogenase LDH lymphocyte lymphopenia marker multiple organs dysfunction neutrophil Neutrophils organ outcome pandemic Pathogenesis Patient patient cohort patient’s death PCT predict Predictive Predictive value procalcitonin resource respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 Stratification syndrome the disease the patient Therapeutic approach triggered turn Ventilation ventilator virus WBC white cell with COVID-19
[DOI] 10.1371/journal.pone.0260537 PMC 바로가기 [Article Type] Research Article

Continuous long-term wireless measurement of right ventricular pressures and estimated diastolic pulmonary artery pressure in patients with severe COVID-19 acute respiratory distress syndrome

중증 COVID-19 급성 호흡곤란 증후군 환자의 우심실압 및 확장기 폐동맥압 추정치를 장기간 무선으로 지속적으로 측정

Article

Published on 2021-12-012022-09-11
Journal: ESC heart failure [Category] SARS, 치료기술,

[키워드] acute respiratory distress acute respiratory distress syndrome amplitude ARDS Continuous Course COVID-19 detect diastolic disease ePAD. evaluated heart failure hypertension Iloprost Indicator Inhaled insertion left heart failure mechanically ventilated patient mechanically ventilated patients mmHg Mortality nitric oxide non-survivor Non-survivors outcome Patient percentile PPM probe pulmonary pulmonary artery pulmonary artery pressure pulmonary hypertension respiratory distress Respiratory distress syndrome Right ventricular right ventricular pressure severe COVID-19 significant decrease significantly higher significantly lower Sildenafil surviving patients survivor syndrome systolic pressure the patient treat two groups variable Ventilated ventricular Ventricular pressure
[DOI] 10.1002/ehf2.13600 PMC 바로가기 [Article Type] Article

Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

COVID-19 질병의 발병기전에서 ACE-2 수용체의 역할 이해: 치료적 개입을 위한 잠재적 접근

Review

Published on 2021-12-012022-09-11
Journal: Pharmacological Reports [Category] SARS, 변종,

[키워드] ACE ACE gene ACE-2 receptor ACE2 ACE2 receptor ACE2 receptors acute lung injury acute respiratory distress syndrome aldosterone angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 approach cardiovascular system Cell correlation COVID-19 COVID-19 pathogenesis disorders distress enzyme genomic variant homologue human cells hypertension intake lung Lung injury manifestation medications molecular pandemic of COVID-19 pathogenesis of COVID-19 pathophysiology pathway persistence Proteins question raised raising receptor Renin renin-angiotensin-aldosterone system researcher respiratory distress Respiratory distress syndrome rhACE2 SARS-CoV-2 SARS-CoV-2-infected patients therapeutic intervention these viruses understanding viral particle virus
[DOI] 10.1007/s43440-021-00303-6 PMC 바로가기 [Article Type] Review

Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9

COVID-19 후 지속적인 폐 병리학은 높은 바이러스 부하, 약한 항체 반응 및 높은 수준의 매트릭스 메탈 로프 로테네 아제 -9와 관련이 있습니다.

Randomized Controlled Trial

Published on 2021-12-012022-09-01
Journal: Scientific Reports [Category] SARS, 바이오마커, 임상, 진단, 치료법, 치료제,

[키워드] Admission antibody Antibody Response Antimicrobial responses association clinical trial COPD COVID-19 diffusion capacity disease severity Efficacy except for Ground-glass opacities HCQ high viral load hospital Hospital admission hospitalisation Hydroxychloroquine ICU treatment limit lung Lungs marker matrix metalloproteinase mediators no effect outcome outcomes parenchymal Patient performed persistent Predictive markers predictor Prevalence pro-fibrotic Pulmonary pathology randomised reduced Remdesivir respiratory Respiratory distress syndrome respiratory symptoms spirometry Trial Viral viral infection Viral load
[DOI] 10.1038/s41598-021-02547-x PMC 바로가기 [Article Type] Randomized Controlled Trial

Niclosamide for Covid-19: bridging the gap

Covid-19용 니클로사미드: 격차 해소

Review

Published on 2021-12-012022-09-11
Journal: Molecular biology reports [Category] SARS, 치료제,

[키워드] acute respiratory distress syndrome angiotensin Angiotensin-converting enzyme anthelminthic Anti-inflammatory anti-inflammatory effect Anti-inflammatory effects anti-SARS-CoV-2 Antiviral antiviral activities Antiviral effect antiviral effects biological processes clinical outcomes clinical study clinical trial clinical trials Concentration concerning COVID-19 COVID-19 severity Cytokines Cytopathic effect Direct disease distress Effect endosomal pH enzyme Google Scholar homeostasis immune in vivo Inflammasome inflammatory signaling inhibit interruption mandatory maturation mechanism modulate modulating mTOR mTOR signaling NCL neutralization NF-κB niclosamide NLRP3 NLRP3 inflammasome oral bioavailability oxidative phosphorylation pandemic pathway Patient pleiotropic pro-inflammatory cytokines Prospective protective role reduce reducing Regulatory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection Science Science Direct serum severity signaling pathway suppression therapeutic therapy treat viral proliferation Viral protein was done Web of Science
[DOI] 10.1007/s11033-021-06770-7 PMC 바로가기 [Article Type] Review

Arglabin could target inflammasome-induced ARDS and cytokine storm associated with COVID-19

Arglabin은 COVID-19와 관련된 inflammasome 유발 ARDS 및 사이토카인 폭풍을 표적으로 할 수 있습니다

Review

Published on 2021-12-012022-09-11
Journal: Molecular biology reports [Category] SARS, 치료제,