Emotional and Cognitive Responses and Behavioral Coping of Chinese Medical Workers and General Population during the Pandemic of COVID-19Article Published on 2020-08-262022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] Affect affected Anxiety behavioral coping Characteristics check Chinese Cognition cognitive coping Corona corona virus disease 2019 COVID-19 COVID-19 pandemic Depression emotion emotional Epidemic information knowledge multivariate outbreak Panic participant Population positive prevention of COVID-19 psychological health public health emergency questionnaire recruited reduced response responses scale significantly were assessed were used widespread worker Y-BOCS [DOI] 10.3390/ijerph17176198 PMC 바로가기 [Article Type] Article
The impact of the COVID-19 pandemic on patients awaiting spinal cord stimulation surgery in the United Kingdom: a multi-centre patient surveyArticles Published on 2020-08-212022-10-28 Journal: British Journal of Pain [Category] COVID-19, [키워드] analysed categories chi-square test chronic pain count COVID-19 COVID-19 pandemic COVID-19 testing increases in intractable medication mental health National neuropathic Pain pandemic Patient patients percentage reported Responder responses risk SCS selected self-isolate severity spinal cord spinal cord stimulation Support telephone survey therapy treated Treatment undergo View [DOI] 10.1177/2049463720948092 PMC 바로가기 [Article Type] Articles
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal modelResearch Article Published on 2020-08-212022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 binding site acute respiratory syndrome angiotensin-converting enzyme 2 animal model antibodies antibody binding Cohort convalescent coronavirus coronavirus disease countermeasure COVID-19 develop disease donors enrolled epitope facilitate hamster hamsters Health High-dose host cell indicated lung viral titer monoclonal antibody MOST NAb Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody overlap Participants passive transfer Prevent produced Prophylaxis proportion Protective Protein provide provided RBD RBD-binding antibody receptor Receptor binding domain Region responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody Science selected survivor tested Therapies therapy transfer treat treated Vaccine design viral spike protein [DOI] 10.1126/science.abc7520 PMC 바로가기 [Article Type] Research Article
An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaquesArticle Published on 2020-08-212022-10-04 Journal: Nature Communications [Category] MERS, 비임상, 임상, 치료기술, [키워드] Adenovirus antibody Antibody Response candidate vaccine cell-mediated immune clinical evaluation CMI coronavirus SARS-CoV-2 COVID-19 vaccine dosage Effectiveness elicit Experimental models of disease expressing gene encoding generate global public health immune response Infection intramuscular Intramuscular injection intramuscularly intranasal intranasally Live attenuated vaccines macaque mice non-human primates Prophylactic Protein responses reveal rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike serotype single vaccination spike Spread subsequent vaccination Vaccine viral infection Viral particles [DOI] 10.1038/s41467-020-18077-5 PMC 바로가기 [Article Type] Article
Harnessing Memory NK Cell to Protect Against COVID-19Pharmacology Published on 2020-08-202022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] adaptive adaptive NK cell addition Against Allogeneic antiviral activity approach Cell chemokine chimeric antigen receptor coronavirus disease COVID-19 cytotoxicity early stage effective antiviral treatment Evidence exhibit function globe HCMV Human Cytomegalovirus hyper inflammation immune system immunization immunopathology Immunotherapy imperative Infection infections Inflammatory cytokine innate immune system Interaction lung tissue memory memory NK cell MERS natural NK cell NK cells offer pathogen-specific Perspective Prevalence progression Proinflammatory cytokine protective role public health crisis residue respiratory infection Responder responses SARS-CoV-2 severe lung pathology subset suppresse therapeutic potential Treatment vaccination Vaccine vaccine-induced immune response viral infections virus viruses [DOI] 10.3389/fphar.2020.01309 PMC 바로가기 [Article Type] Pharmacology
Presence of Genetic Variants Among Young Men With Severe COVID-19Case Reports Published on 2020-08-182022-10-04 Journal: JAMA [Category] MERS, 변종, [키워드] acute respiratory syndrome affected age Analysis Blood carried case sery caused Cell chronic disease Control controls coronavirus coronavirus disease COVID-19 criteria died downregulated downstream experiments exposure Final finding Follow-up functional Genetic Genetic variant hospital ICU identify IFN IFN-γ IFNB1 immune defects immunodeficiency immunological Immunological test Importance individual intensive care interferon interferon signaling IRF7 ISG15 loss-of-function male measure mechanical ventilation Medical conditions men missense variant mononuclear cell mRNA expression Netherland Netherlands objective occur one patient participant pathogenesis of COVID-19 Patient patients patients hospitalized patients with COVID-19 performed Peripheral blood Point preliminary finding Presence primary immune cell Rapid Relevance responses Result SARS-CoV-2 setting severe coronavirus disease severe COVID-19 Severe infection Signaling significantly the mean the patient TLR7 transcriptionally type I type I interferon type II IFN variant ventilatory support whole-exome sequencing [DOI] 10.1001/jama.2020.13719 PMC 바로가기 [Article Type] Case Reports
Impact of a Brief Educational Intervention on Knowledge, Perceived Knowledge, Perceived Safety, and Resilience of the Public During COVID-19 CrisisArticle Published on 2020-08-172022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] benefit concerning coronavirus disease COVID-19 COVID-19 outbreak crisis cross-sectional disease educational intervention effective examined Extraordinary Impact include increase in infection rate Intervention knowledge measure outbreak pandemic Perceived practices Protective Public public health measure questionnaire reducing Resilience responses Safety Spread Trust variables was used [DOI] 10.3390/ijerph17165971 PMC 바로가기 [Article Type] Article
ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection Research Published on 2020-08-172022-10-05 Journal: Nature Immunology [Category] SARS, 진단, [키워드] antibodies antibody Antibody Response caused Cluster COVID-19 COVID-19 sample determine develop diagnose diagnostic test disease elicit Frame help immune response IMPROVE Infection lack Luciferase immunoprecipitation system nucleocapsid ORF3b ORF8 pathogenicity patients with COVID-19 Population pre-existing immunity responses SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 virus Serological assay serological marker serology testing specificity target the antibody response Vaccine worldwide pandemic [DOI] 10.1038/s41590-020-0773-7 [Article Type] Research
High seroprevalence for SARS-CoV-2 among household members of essential workers detected using a dried blood spot assay건조 혈반 분석을 통해 검출된 필수 근로자의 가구 구성원 중 SARS-CoV-2에 대한 높은 혈청 유병률Research Article Published on 2020-08-142022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] acute COVID-19 Analysis antibody Antibody responses Blood blood collection clinical setting clinical settings collected Community community settings convalescent COVID-19 COVID-19 case DBS sample DBS samples diagnoses ELISA epidemiological essential worker facilitate feasible Filter Paper finger Health care health care workers household IgG antibodies IgG antibody individual Infection limit MONITOR objective participant provide Receptor binding domain Reinfection responses Result Sample SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-CoV-2 spike protein Seroconversion serological test Serological testing seropositive serum/plasma Spike protein stick the SARS-CoV-2 the spike protein Transmission transmission of SARS-CoV-2 utility venous venous blood Whole blood [DOI] 10.1371/journal.pone.0237833 PMC 바로가기 [Article Type] Research Article
Social Policy Responses to the Covid-19 Crisis in China in 2020Article Published on 2020-08-142022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, [키워드] approach benefit caused China Chinese coronavirus COVID-19 crisis driven by favor Intervention mitigate organization outcome pandemic Policy response responses reveal risk Social policy Social service state [DOI] 10.3390/ijerph17165896 PMC 바로가기 [Article Type] Article