Evaluation of humoral immune status in porcine epidemic diarrhea virus (PEDV) infected sows under field conditionsShort Report Published on 2015-12-142022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] antibody association B cell response clinical disease clinical sample Comprehensive condition disease Disease diagnosis effective epidemic diarrhea humoral IgA IgG IgG antibody Immune status Immunity indicated infect information intestine Lymphoid Organ Mortality Neonatal Neonates PEDV plasma Post-infection PROTECT Reinfection required responses secreting spleen Vaccine virus Virus neutralization [DOI] 10.1186/s13567-015-0285-x PMC 바로가기 [Article Type] Short Report
Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative CrossResearch Article Published on 2015-10-092022-10-28 Journal: PLoS Genetics [Category] Coronavirus, [키워드] Animal host animal model approach assist candidate gene chromosome classical complex contribute contributing to disease disease severity E3 ubiquitin ligase evaluate fiber Genes Genetic genetic data Genetic variation genetics genome region Health highly pathogenic Host host gene identification identify Inflammation Inflammatory response knockout mice loci locus Lung pathology mice microbial mouse model New Noncoding RNAs outcome outcomes pathogen Pathogenesis Pathogens pathology phenotype phenotypic platform populations regulate resource respiratory viruses responses SARS patient SARS-CoV SARS-CoV infection single gene Spread statistical susceptibility loci the disease traits transcriptomic data utility Vascular viral titer virus replication viruses weight loss were used [DOI] 10.1371/journal.pgen.1005504 PMC 바로가기 [Article Type] Research Article
Evaluation of candidate vaccine approaches for MERS-CoVArticle Published on 2015-07-282022-10-29 Journal: Nature Communications [Category] Coronavirus, MERS, [키워드] Analysis antibodies approach atomic candidate vaccine complex Computerized tomography CoV demonstrated DNA effective elicit full-length S glycoprotein highlight immunization immunogen information Isolation mechanism MERS-CoV mice Middle East monoclonal antibody Multiple murine NAb neutralization neutralizing antibody non-human primates Pneumonia Protein Radiographic RBD respiratory syndrome coronavirus responses rhesus macaque robust S variant S1 and S2 S1 subunit Sequencing serological assays severe respiratory disease spike strain subunit supplementary material the receptor-binding domain Vaccine Vaccine development Vaccines viral infection Virology virus [DOI] 10.1038/ncomms8712 PMC 바로가기 [Article Type] Article
New Metrics for Evaluating Viral Respiratory PathogenesisResearch Article Published on 2015-06-262022-10-28 Journal: PLoS ONE [Category] Coronavirus, 신종인플루엔자, [키워드] change changes in clinically connection evaluate Evaluating highlight human disease Infection marker Measures methodology Metrics mice New Pathogenesis Pulmonary function respiratory Respiratory function respiratory viral infections respiratory virus responses SARS-CoV severe systemic disease utility viral pathogenesis virus was used [DOI] 10.1371/journal.pone.0131451 PMC 바로가기 [Article Type] Research Article
An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titrationResearch Article Published on 2015-03-152022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Administered caused Cell culture Complete Culture demonstrated diarrhea disease dose Efficacy ELISA enzyme-linked immunosorbent Epidemic epidemic diarrhea evaluate experimental design FIVE fluorescent foci Genome sequencing help highly pathogenic humoral immune response identity immunoassay immunogenic immunogenicity inactivated Inactivated vaccine infective intramuscularly log microsphere monovalent vaccine negative controls Neutralization assay nucleotide PEDV performed pig Porcine Protective responses Result selected sera significantly higher strain TCID tissue vaccinate Vaccine vaccine candidate virus [DOI] 10.1186/s12917-015-0357-1 PMC 바로가기 [Article Type] Research Article
Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolatesResearch Article Published on 2014-12-222022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] Activation acute respiratory syndrome Amino acid Analysis analyzed approach Atypical Calu-3 caused Cell cell line changes changes in clinical Clustering Computational topology coronavirus Cytokine simulation differential expression epithelial Extracellular feature filtered Gene Expression highly pathogenic homology host response human airway epithelial human Calu-3 humans IFN IL-1α in viral include Infection innate immune Innate immunity isolate kinetic magnitude MERS MERS-CoV MERS-CoV infection Middle East modulate Novel coronavirus pathogenic patients performed persistence Pneumonia post infection pro-inflammatory pro-inflammatory responses progressive respiratory failure Protein respiratory virus responses Result SARS-CoV Signaling STAT3 statistical analysis strain Strains supplementary material syndrome TNF transcriptional transcriptional change transcriptional difference transcriptomics zoonotic [DOI] 10.1186/1471-2164-15-1161 PMC 바로가기 [Article Type] Research Article
The Nuclear Immune Receptor RPS4 Is Required for RRS1 SLH1 -Dependent Constitutive Defense Activation in Arabidopsis thaliana핵 면역 수용체 RPS4는 Arabidopsis thaliana에서 RRS1 SLH1 -의존적 구성 방어 활성화에 필요합니다Research Article Published on 2014-10-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activate Activation Agrobacterium allele Amino acid Analysis Arabidopsis Arabidopsis thaliana Bacterial C-terminal Cell complex conducted Defense disease DNA binding domain dominant downstream effector effectors ENCODE function Genes Genetic genetic screen growth hypotheses identify Immune receptor immune receptors immune responses Immunity inactive insertion leucine loss-of-function mutation loss-of-function mutations mammalian mechanism motif mutant mutants Mutation NLR NLRs nuclear nucleotide overlap pathogen performed plant plants Protein Pseudomona Pseudomonas R genes receptor Recognition recognize required rescued responses RRS1 secretion Signaling significantly temperature transcribed transcriptional transcriptional activation transcriptional change Trigger triggers type III wild type [DOI] 10.1371/journal.pgen.1004655 PMC 바로가기 [Article Type] Research Article
Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunityResearch Article Published on 2014-10-152022-10-29 Journal: Protein & Cell [Category] Coronavirus, [키워드] Antiviral antiviral immune response antiviral immunity autophagic autophagy Beclin1 coronavirus Coronavirus replication Host IFN signaling induce Infection inhibitory effect Innate immunity interact Interaction knockdown Lysosomes mechanism modulate modulating Papain-like protease PLP2 promote Protein regulate Regulation responses resulting STING suggested turn viral replication [DOI] 10.1007/s13238-014-0104-6 PMC 바로가기 [Article Type] Research Article
Coronavirus virulence genes with main focus on SARS-CoV envelope geneArticle Published on 2014-08-022022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activated activated T cell activating Activation acute respiratory distress Adaptive immune response addressed Affect animal model antagonist Apoptosis ARDS attenuate B cell binding cause cellular cellular pathway coronavirus CoV CoV genome CoV infection CoV protein cytokine death deleted deletion mutant described disease disease severity domain driver E protein edema elicit elicited envelope gene envelope protein exacerbated Host Host immune response humans IFN immune response immunopathological induce Infection inflammasome activation Inflammation Inflammatory response influence inhibiting innate immune responses innate immune system Innate immunity Interaction interferon interferon regulatory factor involved lung parenchyma manuscript MERS-CoV MHV mice Modification motif NF-κB NF-κB pathway nuclear Pathogenesis pathogenic pathogenicity pathway patients priming proinflammatory Proinflammatory cytokine promote proportion Protein Regulation Replication responses responsible SARS-CoV SARS-CoV E sequence shown Signaling signaling pathway Stress subgenomic mRNA synthesis syndrome TGEV transcription factor transmembrane transmembrane domain triggered vaccine candidates viral infections Viral protein virulence virulence gene virus virus infection [DOI] 10.1016/j.virusres.2014.07.024 PMC 바로가기 [Article Type] Article
Findings from the SASA! Study: a cluster randomized controlled trial to assess the impact of a community mobilization intervention to prevent violence against women and reduce HIV risk in Kampala, UgandaSASA의 발견! 연구: 우간다 캄팔라에서 여성에 대한 폭력을 예방하고 HIV 위험을 줄이기 위한 지역사회 동원 개입의 영향을 평가하기 위한 클러스터 무작위 통제 시험Research Article Published on 2014-07-312022-08-09 Journal: BMC Medicine [Category] 임상, [키워드] 95% CI 95% confidence interval adjusted baseline Cluster Community Community mobilization conducted Controlled trial Cross-sectional surveys defined Drivers East Africa eight Evidence finding Follow-up Gender based violence greater HIV Impact evaluation impacts implementation intention-to-treat analysis Intervention Intimate partner violence men outcome physical post intervention Prevalence Prevent Primary outcome protocol public health random Random sample Randomized controlled trial receive reduce replicated responses Result risk risk ratio Sex significantly significantly lower Study protocol sub-Saharan Africa supplementary material Trial registration Uganda Violence Violence prevention while woman women [DOI] 10.1186/s12916-014-0122-5 PMC 바로가기 [Article Type] Research Article