Repurposing prolactin as a promising immunomodulator for the treatment of COVID-19: Are common Antiemetics the wonder drug to fight coronavirus?COVID-19 치료를 위한 유망한 면역 조절제로 프로락틴 용도 변경: 일반적인 항구토제는 코로나바이러스와 싸우는 놀라운 약물입니까?Article Published on 2020-11-012022-08-31 Journal: Medical Hypotheses [Category] SARS, 신약개발, 치료제, [키워드] adaptive Adaptive immunity antagonist Antiemetics Autoimmune diseases Blood clinical trial conditions conducted coronavirus Course COVID COVID-19 Critical death Domperidone Dopamine drug elevated evade explained hyperprolactinemia hypoprolactinemia Hypothesis immune function immune modulation immune-stimulatory Immunity immunological immunomodulator Immunotherapy in some induce Infection lactogenic lactogenic hormone lead limit long term Metoclopramide Mild nausea nausea and vomiting observation opportunistic infection outcome pathological condition Patient physiological PRL Prolactin Prophylactic reported repurposing SARS-CoV-2 serum Seven survival the patient therapeutic Treatment vomiting women [DOI] 10.1016/j.mehy.2020.110208 PMC 바로가기 [Article Type] Article
A potential role for cyclophosphamide in the mitigation of acute respiratory distress syndrome among patients with SARS-CoV-2SARS-CoV-2 환자의 급성 호흡 곤란 증후군 완화에서 사이클로포스파미드의 잠재적 역할Article Published on 2020-11-012022-09-12 Journal: Medical Hypotheses [Category] MERS, 진단, [키워드] acute respiratory distress approach ARDS Autoimmune diseases CCR5 Cell COVID Cyclophosphamide cytokine death deplete develop effective IL-6 immunological immunomodulator imperative investigated investigator less majority mitigate monoclonal antibodies monoclonal antibody patients with SARS-CoV-2 Population Pragmatic pro-inflammatory Regulatory T cell SARS-CoV-2 syndrome T cell the SARS-CoV-2 therapeutic strategy TNF-alpha Treg Tregs Vaccine while [DOI] 10.1016/j.mehy.2020.109850 PMC 바로가기 [Article Type] Article
Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19COVID-19 치료에서 레닌-안지오텐신 시스템의 면역 조절제 및 조절제로서의 펜톡시필린의 재배치Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 신약개발, 치료법, [키워드] activate adenosine adenosine monophosphate alveolar epithelial cells angiotensin Anti-inflammatory approach AT1R balance cells circulation Concentration COVID-19 cyclic adenosine monophosphate Cytokines damage deleterious effect deleterious effects Endothelium epithelial cells Evidence expression helping highlight immune response immune system immunomodulator IMPROVE in vitro increase Inflammatory cytokine Inflammatory cytokines inhibiting inhibitor Microvascular thrombosis monophosphate mRNA offer patients with COVID-19 Pentoxifylline Prevent Proinflammatory cytokine proinflammatory cytokines Protein protein kinase RAS receptor reduce reduction in Renin renin-angiotensin system repositioning safety profile synthesis Therapeutic treatment thrombosis TNF-α Treatment treatment of COVID-19 turn ventilatory parameters Viral viral clearance [DOI] 10.1016/j.mehy.2020.109988 PMC 바로가기 [Article Type] Article
Guidance for Restarting Inflammatory Bowel Disease Therapy in Patients Who Withheld Immunosuppressant Medications During COVID-19Practice Guideline Published on 2020-10-212023-07-06 Journal: Journal of Crohn's & colitis [Category] SARS, [키워드] biologic Crohn’s De-escalation IBD immunomodulator [DOI] 10.1093/ecco-jcc/jjaa135 PMC 바로가기 [Article Type] Practice Guideline
Traditional Herbal Medicine Candidates as Complementary Treatments for COVID-19: A Review of Their Mechanisms, Pros and ConsReview Article Published on 2020-10-102022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] acute respiratory syndrome addition Antiviral candidate caused Cinchona clinical trial Compound conducted coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patients Curcuma drug candidate Echinacea effective evaluate the effect experiments Factor Herbal immune regulation immunomodulator immunomodulators Impaired Infectious disease Medicine outcome pandemic Pathogenesis plants Prevent Pro recommendation reported review SARS-CoV-2 significantly the disease Traditional Treatment [DOI] 10.1155/2020/2560645 PMC 바로가기 [Article Type] Review Article
COVID-19: In the Eye of the Cytokine StormImmunology Published on 2020-09-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] “cytokine storm” acute respiratory distress Administering aging Alleviating ARDS characterized Comorbidity condition COVID-19 COVID-19 case COVID-19 disease severity COVID-19 severity cytokine disorders drug dysregulated eye Factor hyperinflammation identify immune response immunomodulator immunosenecence immunosenescence imperative IMPROVE improvement Inflammation Inflammatory inflammatory state key factor knowledge Lungs MERS Mortality multi-organ failure other disease outcome overactive pathology Patient patients with comorbidities Prognosis Pulmonary edema reducing Research risk risk factor SARS-CoV-1 SARS-CoV-2 Sepsis severe COVID-19 storm the cytokine storm Therapeutic approach therapy with COVID-19 [DOI] 10.3389/fimmu.2020.558898 PMC 바로가기 [Article Type] Immunology
Exploring links between vitamin D deficiency and COVID-19Pearls Published on 2020-09-182022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] acute respiratory distress acute respiratory syndrome affected Alter clinical coronavirus Course COVID-19 COVID-19 patients curative deficiency disease severity drug ecological Effectiveness hyper-inflammatory response immunomodulator infections investigated lung tissue Mortality pandemic promote public health threat SARS-CoV-2 syndrome upper respiratory virus Vitamin D Vitamin D supplementation [DOI] 10.1371/journal.ppat.1008874 PMC 바로가기 [Article Type] Pearls
Understanding the complexities of SARS-CoV2 infection and its immunology: A road to immune-based therapeuticsArticle Published on 2020-09-082022-11-01 Journal: International immunopharmacology [Category] COVID-19, SARS, [키워드] “cytokine storm” 2019-nCoV Abstract ACE2 affected affecting Animal host Antiviral antiviral immune response approval Asymptomatic bat changed China Chinese horseshoe bat Chinese Horseshoe bats clinical clinical symptom coronavirus CoV COVID-19 COVID-19 convalescent patient COVID-19 patients Cytokines develop Drug discovery drugs Emerging infectious disease Evolution example expressing Factor FIVE generate hACE2 healthy Host host cell Host immune response host’s immune response Human humans immune response Immune status immune system Immunity immunomodulation immunomodulator immunomodulatory infecting Infection Measures mice Mild moderate pandemic Patient phenotype Prophylaxis receptor Replication SARS-CoV2 SARS-CoV2 infection SARSr-CoV scientist Section severe COVID-19 Severe infection severity subsequent susceptibility symptomatic symptoms of COVID-19 targeting transfer transgenic Treatment understanding Vaccine Vaccines viral disease viral infection virus Wuhan zoonotic [DOI] 10.1016/j.intimp.2020.106980 PMC 바로가기 [Article Type] Article
Cardiovascular Damage in COVID-19: Therapeutic Approaches Targeting the Renin-Angiotensin-Aldosterone SystemReview Published on 2020-09-042022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ACE2 ACE2/Ang-(1–7)/MasR Activation acute respiratory syndrome age agonist alterations angiotensin-converting enzyme inhibitor anomalies Antiviral apoptotic ARB association blocker cardiovascular cardiovascular damage Cell clinical trial components Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patients damage decrease disease endothelial cells Genetic help homeostasis hypercoagulable hyperinflammation Hyperinflammatory hypertension hypertensive immunomodulator IMPROVE individual infect Infection liver lung Mortality multiple tissue outcome Pathologies pathology pathway peptides plasma polymorphism RAAS receptor reduce regulate responses SARS-CoV-2 SARS-COV-2 infection severity sex hormone soluble ACE2 Stage susceptibility System targeting Therapies therapy thrombotic Treatment Vaccine vessel viral particle viral propagation [DOI] 10.3390/ijms21186471 PMC 바로가기 [Article Type] Review
Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesisReview article Published on 2020-09-012022-10-05 Journal: Journal of infection and public health [Category] SARS, 유전자 메커니즘, [키워드] addition adenine Affect Ageing alteration antigen-presenting cell biological function Cellular immune response change chromosome circulating pro-inflammatory cytokine Complication COVID 19 COVID-19 COVID-19 patient Cytokine storm death dinucleotide Effects elderly Factor Gas exchange Hospitalization Hypothesis immune Immune cell immune function immune system immunomodulator impairment increase in Increasing influence inhibitory effect lung lymphocyte morbidity and mortality NAD+ positive Prevent pro-inflammatory cytokine Respiratory function risk sensitivity Severe infection stability susceptibility telomere telomeres [DOI] 10.1016/j.jiph.2020.06.004 [Article Type] Review article