Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 infection: optimizing the therapeutic potentialReview Published on 2021-03-012023-07-12 Journal: Expert review of respiratory medicine [Category] SARS, [키워드] acute respiratory distress syndrome advanced Therapeutic Medicinal Product ARDS ATMP COVID-19 Mesenchymal stromal cell MSC Sepsis Septic shock [DOI] 10.1080/17476348.2021.1848555 [Article Type] Review
Stem cells and COVID-19: are the human amniotic cells a new hope for therapies against the SARS-CoV-2 virus?줄기 세포와 COVID-19: 인간 양막 세포는 SARS-CoV-2 바이러스에 대한 치료법에 대한 새로운 희망입니까?Review Published on 2021-03-012022-09-10 Journal: Stem Cell Research & Therapy [Category] 임상, [키워드] Amnion amniotic anti-inflammatory properties applied caused Cell Cell therapy clinical trial clinical trials coronavirus COVID-19 COVID-19 treatment cytokine Diseases effective epithelial cell epithelial cells hAEC Health Human amniotic epithelial cells Human amniotic mesenchymal stromal cells in some in vivo models Inflammatory response Lung disease Lung diseases Lung infection Lung injury membrane Mesenchymal stem cells MSC MSCs New coronavirus pandemic Patient patients with COVID-19 Placenta positioned preclinical studies preclinical study problems producing Proinflammatory cytokine reduced regenerative respiratory Respiratory disease respiratory diseases restored Safe SARS-CoV-2 SARS-CoV-2 virus severe patients stem cell Stem cell therapy stem cells stromal cell stromal cells suggested term tested the SARS-CoV-2 the SARS-CoV-2 virus therapy therapy for COVID-19 tissue Treatment Trigger triggers [DOI] 10.1186/s13287-021-02216-w PMC 바로가기 [Article Type] Review
Challenges and advances in clinical applications of mesenchymal stromal cells간엽 기질 세포의 임상 응용 분야에서의 도전과 발전Review Published on 2021-02-122022-09-10 Journal: Journal of Hematology & Oncology [Category] Fulltext, MERS, 비임상, [키워드] approach Artificial intelligence (AI) breath challenge Clinical applications clinical trial COVID-19 COVID-19 pandemic criteria disease disease models Diversity Extracellular vesicles Factor heterogeneity highest human disease human diseases identity improvement investigated majority Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells modify MSC MSC therapy MSCs outcome overcome pandemic disease Registered stem cells stromal cell stromal cells therapeutic potential [DOI] 10.1186/s13045-021-01037-x PMC 바로가기 [Article Type] Review
Therapeutic Potential of Mesenchymal Stem Cells and Their Products in Lung Diseases—Intravenous Administration versus InhalationReview Published on 2021-02-072022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome addressed administration caused cell damage cohorts coronavirus COVID-19 decrease extracellular vesicle Extracellular vesicles extracorporeal membrane oxygenation feasible heterogeneity Infection inhalation inhalation treatment inhalers Intravenous injection intravenous treatment lack limitation Lung disease Lung diseases Major Mesenchymal stem cells MSC MSCs Non-invasive Potential Prevent product repeated respiratory diseases SARS-CoV-2 STEM stem cell Stress syndrome target cell the patient therapeutic use thrombus formation Treatment Treatment protocol vasculature [DOI] 10.3390/pharmaceutics13020232 PMC 바로가기 [Article Type] Review
Human Dental Pulp Stem Cells Modulate Cytokine Production in vitro by Peripheral Blood Mononuclear Cells From Coronavirus Disease 2019 PatientsCell and Developmental Biology Published on 2021-02-052022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] activated acute respiratory syndrome co-culture Concentration conditions Contact coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine dental dental pulp stem cells deregulated DPSC DPSCs form GM-CSF granulocyte healthy subject Human hyper-inflammation IFNγ IL-10 IL-12 IL-13 IL-17A IL-18 IL-1β IL-2 IL-21 IL-22 IL-23 IL-27 IL-4 IL-5 IL-6 IL-9 immune response immunomodulation in vitro interleukin investigated Macrophage mechanism mesenchymal stem cell Mesenchymal stem cells modulate modulation mononuclear cell MSC MSCs Multi-organ damage not affected Patient PBMC PBMCs peripheral Peripheral blood Pneumonia Production promote Pulp Real-time PCR Result SARS-CoV-2 STEM stem cell subset supernatant tissue regeneration TNFα [DOI] 10.3389/fcell.2020.609204 PMC 바로가기 [Article Type] Cell and Developmental Biology
‘Primed’ Mesenchymal Stem Cells: a Potential Novel Therapeutic for COVID19 Patients'프라이밍된' 중간엽 줄기세포: COVID19 환자를 위한 잠재적인 신규 치료제Review Published on 2021-02-012022-09-12 Journal: Stem cell reviews and reports [Category] MERS, 진단, [키워드] approach complications coronavirus COVID19 COVID19 patients effective Effectiveness Epidemic Health heterogeneous Hospitalized immunomodulation immunopathological IMPROVE in vivo Mesenchymal stem cells microenvironment MSC MSC priming MSCs novel pandemic pathology Potential priming public health crisis regimen regulated response SARS-CoV-2 STEM the disease therapeutic Treatment Variability WHO World Health Organization [DOI] 10.1007/s12015-020-09999-0 PMC 바로가기 [Article Type] Review
Cell-Based Therapy for Severe COVID-19 Patients: Clinical Trials and Cost-Utility중증 COVID-19 환자를 위한 세포 기반 치료: 임상 시험 및 비용 활용Review Published on 2021-02-012022-09-11 Journal: Stem cell reviews and reports [Category] SARS, 임상, [키워드] Abstract acute respiratory distress acute respiratory distress syndrome antigen recognition approach approved Cell Cell therapy Cell-based therapy cellular clinical clinical study clinical trial clinical trials cost country COVID-19 decrease dendritic cells develop Exosome Exosomes Government immune response immune system Immunotherapy infected cells Inflammatory introduced mesenchymal stem cell Mesenchymal stem cells moderate moderate to severe MSC MSCs natural outcomes pandemic promote regulate respiratory distress resulting stem cell stimulate syndrome T cell T cells Therapeutics therapy treating COVID-19 treating COVID-19 patient Treatment Trial Vaccine Viral viral disease Viral diseases viral infections virus-infected cell virus-infected cells [DOI] 10.1007/s12015-020-10046-1 PMC 바로가기 [Article Type] Review
Review of Trials Currently Testing Stem Cells for Treatment of Respiratory Diseases: Facts Known to Date and Possible Applications to COVID-19호흡기 질환 치료를 위해 현재 줄기 세포를 테스트하는 시험 검토: 현재까지 알려진 사실 및 COVID-19에 대한 가능한 적용Review Published on 2021-02-012022-09-11 Journal: Stem cell reviews and reports [Category] 임상, [키워드] acute respiratory distress syndrome acute respiratory syndrome application ARDS Bone marrow carried clinical clinical study clinical trial clinical trials Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cultured cell cultured cells cytokine Cytokine storm Date Fact feasibility health emergency Health Organization help immunomodulatory Inflammation inhibit International MERS Mesenchymal stem cells Microvesicles Middle East Middle East respiratory syndrome mitigate MSC MSCs outcome pharmacological treatment pharmacological treatments Phase 1 Phase 2 preclinical studies preclinical study Prevent public health emergency respiratory respiratory distress Respiratory distress syndrome review Severe acute respiratory syndrome STEM stem cell stem cells Testing the cytokine storm the disease therapeutic therapy Tolerability Treatment umbilical Umbilical cord WHO World Health Organization [DOI] 10.1007/s12015-020-10033-6 PMC 바로가기 [Article Type] Review
Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case seriesCOVID-19로 유발된 중증 ARDS 환자 치료를 위한 주산기 조직 유래 중간엽 줄기세포: 사례 시리즈Clinical Trial Published on 2021-01-292022-08-13 Journal: Stem Cell Research & Therapy [Category] 바이오마커, 임상, 진단, [키워드] acute renal and hepatic failure acute respiratory distress syndrome age Allogeneic allogeneic prenatal Alpha ARDS ARDS patients C-reactive protein C-reactive protein (CRP candidate Cardiac arrest Cardiomyopathy case sery cell infusion cell infusions Cell therapy cells chronic lymphocytic leukemia clinical trial CLL CMP Comorbidities Comorbidity Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill develop diabetes diagnosed died discharged distress Dyspnea eight enrolled fatal complication feasibility finding FIVE hepatic failure High dose hospital human umbilical cord MSCs hypertension Hypoxemia ICU ICUs IFN-γ IL-6 IL-6 level IL-6 levels IL-8 IMPROVE Inflammatory biomarker inflammatory biomarkers infusion intensive care unit intensive care units interferon gamma intravenous infusion Large randomized multicenter clinical trials leukemia Leukocytosis lung lymphocyte Lymphocytes mechanical ventilation men mesenchymal stem cell Mesenchymal stem cells Mesenchymal stromal cells MSC MSCs multi-organ failure multicenter one patient outcome Patient patients perinatal tissue Phase 1 PL-MSCs Placenta placental MSC placental MSCs Pneumonia Potential treatment Radiological parameter Radiological parameters Randomized reduce reduced renal reported required respiratory distress Respiratory distress syndrome Safe Sepsis Serious Adverse Event Serious Adverse Events Serum level serum levels Seven severe hypoxemia Significant reduction significant reductions SpO2 stem cell Stem cell therapy supplementary material survivor Survivors syndrome the cell therapeutic potential TNF-α Tolerability Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha UC-MSCs umbilical Umbilical cord women [DOI] 10.1186/s13287-021-02165-4 PMC 바로가기 [Article Type] Clinical Trial
Evaluation of the safety and efficacy of using human menstrual blood‐derived mesenchymal stromal cells in treating severe and critically ill COVID‐19 patients: An exploratory clinical trial중증 및 중환자 COVID-19 환자 치료에서 인간 월경혈유래 중간엽 기질 세포의 안전성 및 효능 평가: 탐색적 임상 시험Clinical Trial Published on 2021-01-272022-08-13 Journal: Clinical and Translational Medicine [Category] MERS, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adverse event adverse events AEs Allogeneic alternative method caused chest imaging clinical trial Concomitant medication concomitant medications control group coronavirus coronavirus disease Coronavirus disease 2019 coronavirus disease 2019 (COVID‐19) COVID‐19 COVID‐19 patients Critical Critically ill died Dyspnea effective Efficacy enrolled experimental group exploratory Frequency groups incidence lack menstrual Mesenchymal stromal cell Mesenchymal stromal cells Mortality MSC MSC therapy MSCs multicenter nonrandomized not differ open‐label Patient patients problems proliferation respiratory Safety safety and efficacy SARS‐CoV‐2 secondary endpoint Secondary endpoints severe acute respiratory syndrome Coronavirus severe and critical patients significantly significantly lower Spread stromal cell stromal cells therapy treat treated Treatment Trial was measured were assessed [DOI] 10.1002/ctm2.297 PMC 바로가기 [Article Type] Clinical Trial