ACE2angiotensin-converting enzyme 2 – Communicable Diseases Research

Nervous system manifestations related to COVID-19 and their possible mechanisms

Review article

Published on 2022-09-012022-10-05
Journal: Brain research bulletin [Category] COVID19(2023년), SARS, 진단, 치료기술,

Roles of mitochondrial DNA in dynamics of the immune response to COVID-19

Review article

Published on 2022-08-012022-10-05
Journal: Gene [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] Absent in melanoma 2 ACE2angiotensin-converting enzyme 2 addition Affect AIM2Absent in melanoma 2 angiotensin-converting enzyme 2 ccf-mtDNAcirculating cell-free mitochondrial DNA CFcystic fibrosis cGASCyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase chronic obstructive pulmonary disease circulating circulating cell-free mitochondrial DNA COPDchronic obstructive pulmonary disease Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 Critical Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase cystic fibrosis damage-associated molecular pattern DAMPdamage-associated molecular pattern Diseases DNA Endoplasmic reticulum ERendoplasmic reticulum gasdermin D GSDMDgasdermin D HIVhuman immunodeficiency virus host cells HPVhuman papillomavirus Human immunodeficiency virus human papillomavirus ICUIntensive Care Unit Idiopathic pulmonary fibrosis immune function immune response Infection inflammasome activation Inflammatory response intensive care unit interferon stimulatory gene IPFidiopathic pulmonary fibrosis ISGinterferon stimulatory gene leucine rich repeat lncRNAlong non-coding RNA long non-coding RNA LRRleucine rich repeat MAVSmitochondrial antiviral signaling mesenchymal stem cell Mitochondria mitochondrial mitochondrial antiviral signaling mitochondrial DNA mitochondrial reactive oxygen species mitochondrial- damage-associated molecular pattern MSCMesenchymal stem cell Mt-DAMPmitochondrial- damage-associated molecular pattern MtDNAmitochondrial DNA mtROSmitochondrial reactive oxygen species MyD88myeloid differentiation factor 88 myeloid differentiation factor 88 NBDnucleotide binding domain NLRnucleotide binding domain and leucine rich repeat nucleotide binding domain nucleotide binding domain and leucine rich repeat Open reading frame ORFopen reading frame pathogen-recognition receptors Pathogens pathway Prognosis provide PRRpathogen-recognition receptors reactive oxidative stress Regulation role ROSreactive oxidative stress SARS-CoV-2 SARS-CoV-2severe acute respiratory coronavirus 2 severe acute respiratory coronavirus 2 severity signaling pathways stimulator of interferon genes STINGstimulator of interferon genes targeting therapeutic strategy TLRToll-like receptor TMPRSS2transmembrane serine protease 2 Toll-like receptor transmembrane serine protease 2
[DOI] 10.1016/j.gene.2022.146681 [Article Type] Review article

COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy

Review article

Published on 2022-08-012022-10-05
Journal: Translational research : the journal of laboratory [Category] SARS, 변종, 임상,

[키워드] ACE2angiotensin-converting enzyme 2 acute respiratory distress syndrome addressed angiotensin-converting enzyme 2 ARDSacute respiratory distress syndrome cells Characteristics clinical trials complications COVID-19 COVID-19 pandemic developmental effective Effectiveness Efficacy Entry mechanism feature genomic growth highlight Immune escape immune response increased risk indicate individual investigated mechanism mechanisms mRNA-based COVID-19 vaccine Neonates pathology placental Pregnancy pregnant Preterm birth proteomic RASRenin-angiotensin system renin-angiotensin system risk SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection SARS-CoV-2severe acute respiratory syndrome coronavirus-2 severe acute respiratory syndrome coronavirus-2 Stillbirth the vaccine Transmissibility Vaccine Vaccines variants of concern variants of SARS-CoV-2 vector VOCvariants of concern
[DOI] 10.1016/j.trsl.2022.08.007 [Article Type] Review article

Can l-carnitine reduce post-COVID-19 fatigue?

Review article

Published on 2022-01-012022-10-05
Journal: Annals of Medicine and Surgery [Category] 임상,

Identification of tear-based protein and non-protein biomarkers: Its application in diagnosis of human diseases using biosensors

Review article

Published on 2021-12-012022-10-05
Journal: International journal of biological macromolecules [Category] SARS, 바이오마커,

[키워드] ACE2angiotensin-converting enzyme 2 acetylcarnitine ADAlzheimer's disease advanced glycation end product AGEadvanced glycation end product Alzheimer's disease angiotensin-converting enzyme 2 antibody binding Biomarker Complication Coronavirus disease-19 COVID-19Coronavirus disease-19 diabetes Diabetic Diabetic retinopathy Diagnosis diagnosis and monitoring disease Diseases DRdiabetic retinopathy early diagnosis enzyme eye GOgraves orbitopathy graves orbitopathy highlight human disease human diseases identification IFN-γInterferon- γ Interferon- γ interleukin-6 lactotransferrin lysophospholipid metabolites MONITOR NCPnovel coronavirus pneumonia non-proliferative diabetic retinopathy novel coronavirus pneumonia NPDRnon-proliferative diabetic retinopathy ocular PACGprimary angle closure glaucoma Parkinson's Disease PDParkinson's disease PDRproliferative diabetic retinopathy PEGpsedoexfoliation glaucoma PEXpsedoexfoliation syndrome POAGprimary open angle glaucoma Potential biomarker primary angle closure glaucoma primary open angle glaucoma progression proliferative diabetic retinopathy Protein psedoexfoliation glaucoma psedoexfoliation syndrome Repository reverse transcription polymerase chain reaction robust RT-PCRreverse transcription polymerase chain reaction selective specific biomarker Tear Thyroid TNF-αtumor necrosis factor α tumor necrosis factor α vascular endothelial growth factor VEGFvascular endothelial growth factor
[DOI] 10.1016/j.ijbiomac.2021.10.198 [Article Type] Review article

MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients

Research article

Published on 2021-10-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 바이오마커,

[키워드] ACE2angiotensin-converting enzyme 2 ACEangiotensin-converting enzyme ACEiangiotensin-converting enzyme inhibitors Acute kidney injury affected age AKIAcute Kidney Injury Analysis Angangiotensin angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitors ARBangiotensin receptor blockers association BMI Clinical outcome Comorbidity Control Coronavirus disease 2019 corticosteroid treatment COVID-19 COVID-19 group COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19coronavirus disease 2019 diabetes Hospital admission Hospitalization hypertension hypertensive COVID-19 patient ICU In-hospital death inhibitors of the renin-angiotensin system iRAAsinhibitors of the renin-angiotensin system lung Manifestations Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 metalloproteinase metalloproteinases MMP-2Matrix Metalloproteinase 2 MMP-9Matrix Metalloproteinase 9 MMPsmetalloproteinases Mortality not affected obesity pathophysiologic Patient patients with COVID-19 plasma predicted predictor prognostic RASRenin-angiotensin system renin-angiotensin system respiratory risk SAPS3Simplified Acute Physiology Score III SARS-CoV-2severe acute respiratory syndrome coronavirus 2 sequential organ failure assessment score severe acute respiratory syndrome coronavirus 2 severe COVID-19 Sex Simplified Acute Physiology Score III SOFA score SOFAsequential organ failure assessment score study group survival Symptom treated were measured
[DOI] 10.1016/j.biopha.2021.112067 [Article Type] Research article

MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19

Research article

Published on 2021-08-012022-10-05
Journal: Journal of Mass Spectrometry and Advances in the Clinical Lab [Category] 바이오마커, 변종, 진단,

[키워드] liquid chromatography mass spectrometry ACE2angiotensin-converting enzyme 2 Analysis analyzed angiotensin-converting enzyme 2 area under the curve Asymptomatic AUCarea under the curve Biomarker Cohort Concordance controls Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 testing COVID-19coronavirus disease 2019 CT cycle threshold demonstrated develop diagnostic Diagnostic method dithiothreitol DTTdithiothreitol E Proteinenvelope protein Emergency use authorization envelope protein EUAemergency use authorization FDAFood and Drug Administration Food and Drug Administration human donor human serum IgAimmunoglobulin A IgGimmunoglobulin G IgMimmunoglobulin M immunoglobulin A Immunoglobulin G immunoglobulin M immunoglobulins inactivated LC-MS limit of detection limitation LoDlimit of detection M Proteinmembrane protein MALDI-ToF MSmatrix-assisted laser desorption/ionization-time of flight mass spectrometry matrix-assisted laser desorption/ionization-time of flight mass spectrometry membrane protein N Proteinnucleocapsid protein nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Non-invasive NPnasopharyngeal nucleocapsid protein pilot study platform positive individuals Protein proteome RBDReceptor Binding Domain receiver operating characteristic Receptor binding domain Reverse transcriptase quantitative polymerase chain reaction Ribonucleic acid RNARibonucleic acid ROCreceiver operating characteristic RT-qPCR S Proteinspike protein Saliva SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 virus SARS-CoV-2severe acute respiratory syndrome coronavirus 2 sensitivity severe acute respiratory syndrome coronavirus 2 specificity specimen Spike protein VEPviral envelope protein viral envelope protein WHOWorld Health Organization with COVID-19 World Health Organization
[DOI] 10.1016/j.jmsacl.2021.09.001 [Article Type] Research article

Heparin: A simplistic repurposing to prevent SARS-CoV-2 transmission in light of its in-vitro nanomolar efficacy

Research article

Published on 2021-07-012022-10-05
Journal: International journal of biological macromolecules [Category] SARS, 신약개발,

[키워드] ACE2 ACE2 binding ACE2angiotensin-converting enzyme 2 Analysis angiotensin-converting enzyme 2 Anti-SARS-CoV-2 Activity antiviral activity Antiviral compound available data CDCCenters for Disease Control and Prevention Cell Centers for Disease Control and Prevention Complete Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 disrupting drug Drug repurposing Eagle's Minimum Essential Medium Efficacy EMEMEagle's Minimum Essential Medium epithelia evaluated FBSfetal bovine serum FDA FDAU.S. Food and Drug Administration fetal bovine serum high throughput virtual screening HTVShigh throughput virtual screening IC50 identity IDidentity in-silico In-vitro include independent indicated interact Interaction LMWHlow-molecular-weight heparin Low-molecular-weight heparin mutant nasal Neuropilin-1 Novel coronavirus NRP1neuropilin-1 P/Spen strep pandemic Pathogens pathology PBSphosphate-buffered saline PDBProtein Data Bank pen strep phosphate-buffered saline potential transmission Prevent Protein Data Bank RBDReceptor Binding Domain Receptor binding domain reducing reported SARS-CoV-2 SARS-CoV-2 transmission SARS-CoV-2severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 Spike protein Spike proteins Support thrombotic event TMPRSS2transmembrane serine protease 2 transmembrane serine protease 2 Transmission treat U.S. Food and Drug Administration UFHunfractionated heparin unfractionated heparin United States variant viral entry Viremia Virtual screening virus assay with COVID-19
[DOI] 10.1016/j.ijbiomac.2021.04.148 [Article Type] Research article

Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: A randomized, controlled clinical trial

Randomized Controlled Trial

Published on 2021-06-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 유전자 메커니즘, 임상, 치료법,

[키워드] 95% CI 95% confidence interval ACE2 ACE2angiotensin-converting enzyme 2 activities Acute kidney injury acute respiratory syndrome Admission adult COVID-19 patient adverse events Affect angiotensin-converting enzyme 2 Anti-inflammatory anti-inflammatory agents assigned caffeic acid phenethyl ester CAPEcaffeic acid phenethyl ester Care clinical benefit Clinical improvement Control control group Controlled clinical trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 defined dose Effect enrolled Evidence evidenced group High dose Hospital stay Hospitalized hospitalized COVID-19 hospitalized COVID-19 patients human transmembrane protease 2 immune immunoregulation Inflammatory intensive care lower dose median need for oxygen NF-kBnuclear factor-kappa B nuclear factor-kappa B Odds ratio Open-label outcome Oxygen therapy p21-activated kinase 1 PAK1 PAK1 blocker PAK1p21-activated kinase 1 Patient post-intervention primary end point promote Propolis Randomized receive reduce reduction in SARS-CoV-2 SARS-CoV-2severe acute respiratory syndrome coronavirus 2 secondary Seven severe acute respiratory syndrome coronavirus 2 significantly single-center Standard standard care targets tested therapeutic therapy TLR4toll like receptor 4 TMPRSS2 TMPRSS2human transmembrane protease 2 toll like receptor 4 treated Treatment Trial vasoactive drugs
[DOI] 10.1016/j.biopha.2021.111526 PMC 바로가기 [Article Type] Randomized Controlled Trial

The possible mechanisms of action of 4-aminoquinolines (chloroquine/hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): A role for iron homeostasis?

Review article

Published on 2020-08-012022-10-05
Journal: Pharmacological research [Category] SARS, 유전자 메커니즘,

[키워드] ACE2angiotensin-converting enzyme 2 acute respiratory distress syndrome acute respiratory syndrome angiotensin-converting enzyme 2 animal models annexinA5 Anti-inflammatory anti-malarial drug Anti-phospholipid anti-phospholipid syndrome anti-thrombotic properties Anti-viral anti-viral effect antigen-presenting cell AnxA5annexinA5 APCantigen-presenting cell aPLanti-phospholipid APSanti-phospholipid syndrome ARDSacute respiratory distress syndrome Autoimmune disease BMP/SMADbone morphogenetic/small mother against decapentaplegic bone morphogenetic/small mother against decapentaplegic caused Cell culture Chloroquine chloroquine/hydroxychloroquine chronic obstructive pulmonary disease Clathrin-mediated endocytosis Clinical course Clinical efficacy Clinical improvement CMEclathrin-mediated endocytosis COPDchronic obstructive pulmonary disease coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19Sars-Cov-2 infection CQChloroquine DCdendritic cell dendritic cell disease divalent metal-ion transporter 1 DMT1divalent metal-ion transporter 1 drug early endosome EEearly endosome Effects Efficacy Endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment endosomal NADPH oxidase endothelial nitric oxide synthetase eNOSendothelial nitric oxide synthetase eNOXendosomal NADPH oxidase EPOerythropoietin ERendoplasmic reticulum ERFEerythroferrone ERGICendoplasmic reticulum-Golgi intermediate compartment erythroferrone erythropoietin experimental evidence ferritin ferroportin 1 FPN1ferroportin 1 FTferritin HAEChuman aortic endotelial cell HAMPhepcidin haptoglobin HCMVHuman Cytomegalovirus HCQ HCQhydroxychloroquine HCVHepatitis C virus hemochromatosis hemochromatosis gene hemopexin hepatitis C virus hepcidin HFEhemochromatosis gene HHhemochromatosis HIV-1Human Deficiency Virus 1 HPhaptoglobin HPXhemopexin human aortic endotelial cell Human Cytomegalovirus Human Deficiency Virus 1 human umbilical vein endothelial cell HUVEChuman umbilical vein endothelial cell Hydroxychloroquine ICUIntensive Care Unit IDAiron deficiency anemia IDiron deficiency IDUinfectious disease unit IFN-γinterferon-γ IFN1type interferon IgGimmunoglobulin G IL-12interleukin-12 IL-13interleukin-13 IL-17interleukin-17 IL-1βinterleukin-1β IL-4interleukin-4 IL-6interleukin-6 Immunoglobulin G immunomodulatory Infection infectious disease unit intensive care unit interferon-γ interleukin-12 interleukin-13 interleukin-17 interleukin-1β Interleukin-4 interleukin-6 iron deficiency iron deficiency anemia iron homeostasis JAK/STAT3Janus kinase/signal transducers and activators of transcription 3 Janus kinase/signal transducers and activators of transcription 3 knowledge lactoferrin late endosome-lysosome LELlate endosome-lysosome less LFlactoferrin lipopolysaccharide LPSlipopolysaccharide mAbMonoclonal antibody major histocompatibility complex MAPKmitogen-activated protein kinase matrix metalloproteinase mechanism metalloreductase six-transmembrane epithelial antigen of the prostate 3 MHCMajor Histocompatibility Complex MHV-3mouse hepatitis virus type 3 mitogen-activated protein kinase MMPmatrix metalloproteinase MOImultiplicity of infection monoclonal antibody mouse hepatitis virus type 3 mucolipin 1 multiplicity of infection Mviral envelope membrane protein NADPH oxidase 2 natural killer NETneutrophil extracellular trap Neutrophil extracellular trap NKnatural killer NOX2NADPH oxidase 2 NPvirus nucleoprotein pandemic Patient pharmacological phosphatidylinositol binding clathrin assembly protein PICALMphosphatidylinositol binding clathrin assembly protein potential mechanism Randomized controlled studies RArheumatoid arthritis RBCred blood cell red blood cell regimen rheumatoid arthritis SARS-COV-2 infection severity SLEsystemic lupus erythematosus (SLE) STEAP3metalloreductase six-transmembrane epithelial antigen of the prostate 3 Sviral spike protein systemic lupus erythematosus (SLE) T helper TFR1transferrin receptor 1 TFtissue factor TGNtrans-Golgi network TGTthrombin generating time therapeutic thrombin generating time ThT helper Tissue Factor TLRToll-like receptor TMPRSS2transmembrane serine protease 2 TNF-αtumor necrosis factor-α Toll-like receptor trans-Golgi network transferrin receptor 1 transmembrane serine protease 2 treat Treatment TRPML1/MCOLN1mucolipin 1 tumor necrosis factor-α type interferon vascular cellular adhesion molecule 1 VCAM-1vascular cellular adhesion molecule 1 viral envelope membrane protein viral infections viral spike protein virus nucleoprotein β2-glicoprotein I β2GPIβ2-glicoprotein I
[DOI] 10.1016/j.phrs.2020.104904 [Article Type] Review article