Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic fieldArticle Published on 2024-05-182024-09-05 Journal: Zoological research [Category] update2024, [키워드] acetaminophen Acute liver injury DNA synthesis oxidative stress Static magnetic fields [DOI] 10.24272/j.issn.2095-8137.2023.410 PMC 바로가기 [Article Type] Article
The Dangers of Acetaminophen for Neurodevelopment Outweigh Scant Evidence for Long-Term BenefitsReview Published on 2023-12-292024-09-05 Journal: Children [Category] update2024, [키워드] acetaminophen autism Fever Pain Paracetamol Postnatal prenatal [DOI] 10.3390/children11010044 PMC 바로가기 [Article Type] Review
Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence그래프 신경망을 사용하여 COVID-19에 대한 약물 용도 및 여러 증거 조화Article Published on 2021-11-302022-08-31 Journal: Scientific Reports [Category] 신약개발, 임상, 치료법, 치료제, [키워드] 2019 novel coronavirus 2019 novel coronavirus disease acetaminophen albuterol approach Aspirin atorvastatin Azithromycin candidate drug candidate drugs clinical trial collected conducted coronavirus disease COVID-19 COVID-19 knowledge COVID-19 patient COVID-19 treatment demonstrated disease drug drug combination drug combinations Drug development Drug repurposing drugs Efficacy Evidence facilitate FDA approval Genetic highlight host genes in vitro integration Interaction interactions Knowledge graph Novel coronavirus novel coronavirus disease outbreak pandemic Pathways Phenotypes profiles Research Treatment Virtual screening virus was used [DOI] 10.1038/s41598-021-02353-5 PMC 바로가기 [Article Type] Article
Self-medication practices to prevent or manage COVID-19: A systematic reviewCOVID-19를 예방하거나 관리하기위한 자체 치료 관행 : 체계적인 검토Research Article Published on 2021-11-022022-09-10 Journal: PLoS ONE [Category] MERS, 치료제, [키워드] acetaminophen Antibiotics Characteristics Chloroquine conducted COVID-19 cross-sectional Cross-sectional studies eight Fever General population Google Google Scholar heterogeneous Hydroxychloroquine ibuprofen Ivermectin medication medications MOST NOS objective performed Population Prevalence Prevent Previous studies previous study question ranged recall reported Result risk of bia scale searched Self-medication Seven specific symptom systematic review Topic Vitamin vitamins Web of Science [DOI] 10.1371/journal.pone.0259317 PMC 바로가기 [Article Type] Research Article
A randomized, open-label, multicentre, comparative study of therapeutic efficacy, safety, and tolerability of BNO 1030 extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb, in the treatment of mild forms of COVID-19Original Contribution Published on 2021-08-282022-10-31 Journal: Clinical Phytoscience [Category] COVID-19, [키워드] 1:1 acetaminophen addition Adverse drug reaction analysed Anosmia antipyretics average baseline benefit BNO 1030 both group clinical trial clinically comparable control group coughing COVID 19 COVID-19 COVID19 decrease defined diagnosed discharge effective Efficacy evaluation criteria Fever Final form greater decrease groups Hospitalization hospitalized patient ibuprofen Imupret® increase in Laboratory Mild mild case mild COVID-19 mild COVID-19 symptom moderate Most patient multicentre myalgia nasal nasal congestion NSAIDS offer open label Open-label Outpatient Patient phytotherapy positive patient primary endpoint randomised Randomized recovered patient reduction Registered reported respiratory infection Result Safe screened severity of symptom Significant sore throat Symptom symptomatic Symptomatic treatment the patient therapeutic efficacy therapy Tolerability treated Treatment Trial Visual Analogue Scale were assessed [DOI] 10.1186/s40816-021-00308-x PMC 바로가기 [Article Type] Original Contribution
The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis시간 순서 Transcriptomic 분석을 기반으로 한 다발성 장기 기능 장애의 분자 메커니즘 및 COVID-19의 표적 개입Immunology Published on 2021-08-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] acetaminophen Activation addition Algorithm Angiogenesis B2M BFS algorithm Bioinformatics analysis biological process biological processe biological processes Brain caused CD40 CD40LG cell-mediated immune cell-mediated immune response changes in Comparative Compound Coronavirus disease 2019 COVID-19 CSF1 Curcumin CXCL10 cytokine Cytokine storm database defined determine Dexamethasone DNA downloaded drug energy metabolism enrichment analysis FCER1G FIVE gene co-expression network Gene Expression gene expression profile Gene expression profiles Gene ontology Genes heterogeneous high mortality hub genes ICAM1 identify immune gene immune response Immunity initial gene IRF7 LAT Lcn2 lead leukocyte lung metabolism molecular mechanism morphology Multiple multiple organ dysfunction multiple organ heterogeneity myeloid leukocyte neuronal Novel coronavirus olfactory organ organs other compound PageRank pandemic pattern PLAU predicted protein metabolism Protein–protein interaction Regulation Research response resveratrol RHOA rRNA second Spread SRC statins Stress stress response targeted intervention the cytokine storm TNFRSF1A TO-GCN Toxicogenomics Trachea tracheal Transmission Treatment unique was performed was used [DOI] 10.3389/fimmu.2021.729776 PMC 바로가기 [Article Type] Immunology
An examination of gastrointestinal absorption using the acetaminophen absorption test in critically ill patients with COVID-19: A retrospective cohort study코로나19 중증환자를 대상으로 한 아세트아미노펜 흡수검사를 이용한 위장 흡수 검사: 후향적 코호트 연구Observational Study Published on 2021-08-012022-09-11 Journal: Nutrition in clinical practice : official publicat [Category] SARS, 임상, 치료기술, [키워드] absorption test acetaminophen bowel can be used Care clinical evidence collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critical Critical illness Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients described detectable determine direct method dysfunction Evidence evidence of Gastrointestinal gastrointestinal function Ileus indicated intensive care unit less malabsorption malabsorption. measure measurement mechanism observational study occur Patient positive prevalent provide radiologic retrospective cohort study Stool study cohort Tolerance undetectable Volume with COVID-19 [DOI] 10.1002/ncp.10687 PMC 바로가기 [Article Type] Observational Study
Do fever-relieving medicines have anti-COVID activity: an in silico insightResearch Article Published on 2021-03-242022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] acetaminophen acute respiratory syndrome Anti-inflammatory anti-inflammatory response Antiviral antiviral activity Coronavirus-2 determine disease domain drug drug repositioning high affinity immune immunostimulant in silico inhibitory inhibitory activity Interaction material Medicine naproxen Nonsteroidal anti-inflammatory drugs Novel coronavirus-19 predicted prediction of activity spectra for substances protease Proteins residue Result RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 spike glycoprotein stimulate was performed [DOI] 10.2217/fvl-2020-0398 PMC 바로가기 [Article Type] Research Article
Monitoring drug consumption in Innsbruck during coronavirus disease 2019 (COVID-19) lockdown by wastewater analysis폐수 분석을 통해 코로나바이러스 질병 2019(COVID-19) 폐쇄 기간 동안 인스부르크의 약물 소비 모니터링Article Published on 2021-02-252022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] 3,4-methylenedioxymethamphetamine acetaminophen affecting alcohol amphetamine Analysis change changes in cocaine codeine coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 pandemic curfew Decline diagnosed drug Epidemiology force Health Health status illicit drug information life load lockdown marker measure Medical doctor medical doctors methamphetamine monitoring pandemic partial lockdown Pharmaceuticals pharmacies quarantine reduced reducing required significant effect spread of COVID-19 these compound these compounds Tobacco trimethoprim was used wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2020.144006 PMC 바로가기 [Article Type] Article
Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 TherapyCOVID-19 치료의 잠재적 표적인 TMPRSS2 유전자의 구조적 다양성, 발현 프로필 및 약리학적 특성Article Published on 2020-12-252022-09-10 Journal: Genes [Category] MERS, SARS, 변종, 치료기술, 치료제, [키워드] ACE2 acetaminophen acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar cell alveolar cells Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Asian Basigin BSG co-expressed copy number copy number variant coronavirus COVID-19 COVID-19 therapy Curcumin distribution downregulate drug enzyme European populations ExoN expression expression levels frequencies Frequency genome-wide data human cells human population human populations Interaction interactions involved lung microRNA MicroRNAs Missense mutation Paracetamol pharmacotranscriptomics Polymorphisms Population Potential predicted priming profile profiles property Prostate cancer Protein ranged receptor regulate Regulation respiratory respiratory tract cells SARS-CoV-2 SARS-CoV-2 cell Serine serine 2 serine protease severe acute respiratory syndrome Coronavirus significantly higher Single-cell RNA sequencing single-nucleotide Single-nucleotide polymorphisms SNV target therapy tissue-specific expression TMPRSS2 Variability [DOI] 10.3390/genes12010019 PMC 바로가기 [Article Type] Article